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Case Trial Evaluations Of An Optimization Approach To Mental Health And Sport Performance For Adolescent Athletes, Dereck Davy Phrathep
Case Trial Evaluations Of An Optimization Approach To Mental Health And Sport Performance For Adolescent Athletes, Dereck Davy Phrathep
UNLV Theses, Dissertations, Professional Papers, and Capstones
This dissertation will consist of five chapters – an introduction (Chapter 1), three original empirical studies (Chapters 2-4), and a conclusion (Chapter 5). Chapter 2 was accepted for publication by the Sport Social Work Journal (Phrathep et al., 2022a). Chapter 3 was accepted for publication by Clinical Case Studies (Phrathep et al., 2022b). Chapter 4 was accepted for publication by Frontiers in Sports and Active Living (Phrathep et al., 2023). These three manuscripts are linked by a primary interest in the evaluation of an optimization approach as an efficacious intervention for optimizing mental health and sport performance among adolescent athletes …
Mining Gambling Data For Modeling Gambling Behavior Patterns, Piyush Aniruddha Puranik
Mining Gambling Data For Modeling Gambling Behavior Patterns, Piyush Aniruddha Puranik
UNLV Theses, Dissertations, Professional Papers, and Capstones
Understanding player behavior for responsible gambling research is a difficult task due to the lack of data on players’ activities. Past studies in this area are largely limited to publicly available behavioral data or aggregated players data. Problem gambling in gamblers is typically identified only after they have already been addicted or have already been engaging in problematic gambling behavior. Furthermore, “risky” gambling behavior has historically been difficult to define due to the varying patterns of gambling activity that could potentially be attributed to it.In this dissertation we illustrate the methodology and algorithms used to engineer financial data for further …
Under The Neon Lights: Examining The Memories Of Las Vegas' Route 91 Harvest Music Festival, William B. Ridgway
Under The Neon Lights: Examining The Memories Of Las Vegas' Route 91 Harvest Music Festival, William B. Ridgway
UNLV Theses, Dissertations, Professional Papers, and Capstones
The aim of the current study was to identify patterns of meaning in the trauma narratives of Route 91 Harvest survivors. We undertook a thematic analysis to examine survivors’ narratives collected shortly after the event (i.e., within one month), allowing for a more in-depth understanding of what survivors tended to emphasize or gravitate toward when recalling the episode of mass violence that resulted in the deadliest mass shooting in modern American history. From the rich thematic content emerged a dominant theme of memory for contextual details—specifically, sensory-perceptual features, time, and space. Specifically, Route 91 Harvest survivors reported vivid sensory experiences, …
The Role Of Cognitive Dysfunction In Late-Life Depression, Matthew Schurr
The Role Of Cognitive Dysfunction In Late-Life Depression, Matthew Schurr
UNLV Theses, Dissertations, Professional Papers, and Capstones
Depression is one of the most common psychiatric concerns in older adults. Because of the intersection of biological, emotional, social, and cognitive factors that are at play in depression, symptoms are often heterogeneous in presence and severity. In combination with the expected changes in cognitive abilities as one ages, late-life depression can be additive to these changes. The higher risks of neurodegenerative processes and vascular events in later life can cause, magnify, or accelerate cognitive decline. As such, individuals with late-life depression often present with a complex array of problems that can impact cognition and functioning, and thus complicate the …
Dynamic Model Of An Overhead Crane, Leonard Ruesga
Dynamic Model Of An Overhead Crane, Leonard Ruesga
UNLV Theses, Dissertations, Professional Papers, and Capstones
In this thesis a novel spatial model of an overhead crane was developed. The model includes: bridge, trolley, driving and follower wheels for the bridge and trolley, drum, cable, and the payload. The model accounts for the winding/unwinding of the cable around the drum as the payload is raised/lowered. The cable and the payload were considered as rigid bodies with uniformly distributed mass. First, the kinematic equations of the model were developed by using constraint equations. Second, the dynamic equations were derived through use of Newton’s Laws. Developing the rotational dynamic equations required the determination of the angular momentum vectors …
A Heuristic Approach To Operations And Control Of Btm-Ders For Bill Management And Grid Services, Md Arshad Rashid Shaon
A Heuristic Approach To Operations And Control Of Btm-Ders For Bill Management And Grid Services, Md Arshad Rashid Shaon
UNLV Theses, Dissertations, Professional Papers, and Capstones
Behind-The-Meter (BTM) distributed energy resources (DERs) have emerged as a critical and transformative force within the energy sector. These decentralized energy assets, which include solar photovoltaic (PV) systems, battery energy storage systems (BESS), and thermostatically controlled loads (TCLs), are increasingly essential for empowering customers by granting them greater control over their energy production and consumption, thereby reducing reliance on centralized power sources. Additionally, they have the potential to play a pivotal role in enhancing grid resilience by providing grid services. This study investigates the management of customer electricity bills and grid services through the integration of various BTM-DERs, particularly solar …
Uvc And Planetary Habitability: Insights From Desert Lichens And Cyanobacteria, Tejinder Singh
Uvc And Planetary Habitability: Insights From Desert Lichens And Cyanobacteria, Tejinder Singh
UNLV Theses, Dissertations, Professional Papers, and Capstones
An important question in astrobiology is whether life can exist under the levels of UVC radiation found on Archean Earth, Mars, and exoplanets. We investigated this question by studying the UVC survival of colonial cyanobacterium and lichens that grow in harsh desert environments and possess natural sunscreens. We irradiated them nonstop in a desiccated state with a UVC flux closely representing the upper limit on those planets: 55-60 W/m². After irradiation, we rehydrated and assessed their survival using chlorophyll fluorometry and by counting the number of viable colonies that formed on agar plates. All three study organisms survived two to …
Understanding The Role Of Discrimination In The Experience Of Traumatic Stress In Latine, Michelle Strong
Understanding The Role Of Discrimination In The Experience Of Traumatic Stress In Latine, Michelle Strong
UNLV Theses, Dissertations, Professional Papers, and Capstones
Introduction. Research has found that low provider culture knowledge leads to poor mental health outcomes for Latine clients (Duke et al., 2011). Further, the 2017 APA Multicultural Guidelines emphasize the need for clinicians and researchers to conceptualize clinical and empirical data from a culturally competent lens, especially considering clinician and researcher bias while understanding a psychological phenomenon. Despite this, limited research exists categorizing the unique factors that affect mental health symptoms among Latine living in the United States (U.S.) especially as it pertains to trauma stress and discrimination (Marmot, 2005; Nadal, 2018). As such, the current study used meditational statistical …
Probing The Ecological Functions Of Thermophiles Using Cultivation-Dependent And Cultivation-Independent Techniques, Dengxun Lai
Probing The Ecological Functions Of Thermophiles Using Cultivation-Dependent And Cultivation-Independent Techniques, Dengxun Lai
UNLV Theses, Dissertations, Professional Papers, and Capstones
High-temperature geothermal springs are ecosystems that resemble early Earth, offering insights into the origins and early evolution of life. In these unique ecosystems, thermophilic microorganisms thrive. However, our knowledge of thermophiles remains limited. A major challenge is that many thermophiles remain uncultivated. The primary goal of this dissertation was to explore the diversity, metabolism, and ecological functions of thermophiles using cultivation-dependent and cultivation-independent approaches. Chapter 1 provides a broad overview of geothermal spring ecosystems and thermophiles, along with a roadmap of the dissertation. Chapter 2 documents a study on the response of specific thermophiles from Gongxiaoshe (GXS) Hot Spring in …
Analyzing Fe/Mg-Silicate Chemical Gardens As Analogs To Silicate-Rich Hydrothermal Chimneys On Early Earth And Mars, Nancy Alejandra Carman
Analyzing Fe/Mg-Silicate Chemical Gardens As Analogs To Silicate-Rich Hydrothermal Chimneys On Early Earth And Mars, Nancy Alejandra Carman
UNLV Theses, Dissertations, Professional Papers, and Capstones
Hydrothermal systems have been proposed as environments for prebiotic chemistry on early Earth. Ancient Mars was an ocean world and could also have had hydrothermal vents supporting biological or prebiotic processes. The Strytan Hydrothermal Field (SHF) in Iceland is a basalt-hosted alkaline vent that forms massive hydrothermal Mg-saponite chimneys and is a potential analog to basalt-hosted alkaline vents that may have existed at the Eridania basin on Mars, where saponite deposits are thought to have formed from ancient hydrothermal activity. Chemical garden experiments have previously been used to simulate aspects of hydrothermal chimney growth for other types of vent systems; …
Characterizing Gsk3Β Interaction And Kinetics Via Isothermal Titration Calorimetry, W A Bhagya De Silva
Characterizing Gsk3Β Interaction And Kinetics Via Isothermal Titration Calorimetry, W A Bhagya De Silva
UNLV Theses, Dissertations, Professional Papers, and Capstones
Glycogen synthase kinase 3β (GSK3β) is a multifunctional serine/threonine kinase involved in several key signaling pathways, including glycogen metabolism, WNT/β-catenin, and Hedgehog signaling. Hyperactivity of GSK3β has been linked to Alzheimer’s disease, bipolar disorder, type II diabetes, and some cancers. Therefore, GSK3β is of interest as a target for therapeutics. Lithium ion (Li+) is a classical inhibitor of GSK3β. Structurally similar beryllium ion (Be2+) is ~1000-fold more potent. Lithium and beryllium have demonstrated pathway-specific and cell type-specific inhibition of GSK3β, prompting an investigation into the inhibitory mechanisms and thermodynamic characteristics of the metal-enzyme interaction.Isothermal titration calorimetry (ITC) is a label-free …
Relationships Between Psychopathology, Impulsivity, And Disordered Eating, Repairer Etuk
Relationships Between Psychopathology, Impulsivity, And Disordered Eating, Repairer Etuk
UNLV Theses, Dissertations, Professional Papers, and Capstones
Impulsivity is defined by behaviors that are often performed without foresight or consideration for consequences. For some individuals, impulsive behaviors are excessive or dysfunctional, and can become extremely problematic, ultimately leading to impairments in quality of life and lowered psychological functioning. Impulsivity is a multifaceted factor, comprising several different domains that have been explored in past studies (e.g., trait impulsivity, decision making, response inhibition). However, previous research shows that trait impulsivity in adults is consistently associated with several psychiatric problems including substance abuse, eating disorders, and compulsive sexual behaviors. To date, few studies have investigated impulsivity, compulsive sexual behavior. disordered …
The Phenomenon Of Creative Seeing As Discovered By Descriptive Experience Sampling: A Case Study, Amber Goto
The Phenomenon Of Creative Seeing As Discovered By Descriptive Experience Sampling: A Case Study, Amber Goto
UNLV Theses, Dissertations, Professional Papers, and Capstones
Descriptive Experience Sampling (DES) studies have found that people without known mental health conditions occasionally describe visual experiences that are distortions of reality. DES calls such visual-perceptual-distortion experiences creative seeing. Typically, participants don't realize that their perceptions are distorted until they note their descriptions, at which time they notice (with surprise) the discrepancy.We describe "Rhea," a female adult (between 25 and 30 years old) DES volunteer participant. Her DES sampling happened to produce a high frequency of creative seeing; the degree of detail provided by DES allows us to describe the creative-seeing phenomenon with otherwise unobtainable detail. The creative seeing …
Investigating Productivity Of Modular Buildings, Sibgat Mehedi Hasan
Investigating Productivity Of Modular Buildings, Sibgat Mehedi Hasan
UNLV Theses, Dissertations, Professional Papers, and Capstones
The modular construction industry has grown substantially, yet understanding of the relationships between project categories, sizes, and productivity remains limited. This study investigates these relationships in both permanent and relocatable modular construction projects across different sectors, including multifamily housing, dormitories, healthcare, education, retail, office, and workforce housing. Data from 303 permanent and 188 relocatable projects in the Modular Building Institute database were analyzed using Kendall's tau-b correlation and linear regression analyses. Key findings reveal that permanent projects outnumber and are generally larger than relocatable ones, with education being the most common project type. Significant positive correlations between project size and …
Exploring The Everyday Inner Experience Of Grapheme-Color Synesthetes, Cody Michio Kaneshiro
Exploring The Everyday Inner Experience Of Grapheme-Color Synesthetes, Cody Michio Kaneshiro
UNLV Theses, Dissertations, Professional Papers, and Capstones
Synesthesia is a rare, multivariant condition where the stimulation of one sensory or cognitive sense induces extraordinary inner experiences. Grapheme-color synesthesia is a kind of synesthesia where the presentation of letters and/or numbers induce automatic, directly apprehended color phenomena within synesthetes (i.e., individuals with synesthesia). Despite synesthesia’s being defined by remarkable color experiences, first-person investigations that directly study synesthetes’ inner experience are rare. We used descriptive experience sampling (DES) to describe the everyday inner experience of six grapheme-color synesthetes, each sampled for from 6 to 14 sampling days. Our idiographic findings showed that the salient features of each individual participant’s …
Psychological Pitfalls Of The Modern Percussionist: A Survey Of Coping Mechanisms For Downward Spirals In Mental Health, Andrew Naughton
Psychological Pitfalls Of The Modern Percussionist: A Survey Of Coping Mechanisms For Downward Spirals In Mental Health, Andrew Naughton
UNLV Theses, Dissertations, Professional Papers, and Capstones
This document explores three key facets of mental health significantly impacting percussionists in both educational and professional settings: Imposter Syndrome, sleep deprivation, and stress management. The primary focus is to understand the impact of these psychological conditions on percussionists and discover effective approaches to prevent, alleviate, or manage these ailments. This document is divided into four sections. The initial section delineates the concept of “Imposter Syndrome” and discusses its various manifestations as encountered by percussionists in both educational and professional environments. The second section discusses the consequences of sleep deprivation on mental well-being when it is disregarded. The third section …
Development Of A Passive Drag Reduction Modification For The 25° Ahmed Body Using Large Eddy Simulation, Skylar Polek
Development Of A Passive Drag Reduction Modification For The 25° Ahmed Body Using Large Eddy Simulation, Skylar Polek
UNLV Theses, Dissertations, Professional Papers, and Capstones
In the field of automotive aerodynamics, the Ahmed body is a generic vehicle-shaped bluff body which is meant to generalize the rear end of fastback and hatchback vehicles. Specifically, an Ahmed body with a rear slant angle of 25° has seen common use due to its resemblance of common rear windshield shapes as well as its notoriously complex wake structure. This research focuses on simulating the flow over a 25° in various situations with an ultimate goal of drag reduction. First, a simple benchmark of the k-ω shear stress transport (SST), large eddy simulation (LES) with the Smagorinsky-Lilly subgrid scale …
Automated Measurement Of The Water Drop Penetration Time For The Analysis Of Soil Water Repellency, Danxu Wang
Automated Measurement Of The Water Drop Penetration Time For The Analysis Of Soil Water Repellency, Danxu Wang
UNLV Theses, Dissertations, Professional Papers, and Capstones
In this work, we develop an innovative system for the automated measurement of Water Drop Penetration Time (WDPT) - a parameter that is conventionally used for evaluating soil water repellency (SWR). Increased SWR can be a reason for plant stress and poor crop yields, create a risk of potential water runoff and floods and thus can pose risks to life and property loss. Timely evaluation of soil conditions can save resources and win time for responding to environmental disasters. Manual measurements of WDPT are labor-intensive, subjective, tend to produce variability of outcomes, and also not always available in remote or …
Effects Of Climate Change On (Semi)-Arid Ecosystems In The Southwestern United States, Charlotte Van Der Nagel
Effects Of Climate Change On (Semi)-Arid Ecosystems In The Southwestern United States, Charlotte Van Der Nagel
UNLV Theses, Dissertations, Professional Papers, and Capstones
Climate change is considered amongst the most severe threats to terrestrial and aquatic ecosystems globally. Ecosystems in the southwestern United States have specifically been impacted by intense drought conditions since 2000. Higher temperatures combined with altered precipitation stresses many ecosystems; however, ecosystem specific responses to such stressors may vary. Here, the effects of climate change on semi-arid ecosystems are analyzed for some of the most vulnerable ecosystems in the southwestern United States: lacustrine, riparian, and dryland ecosystems.
Lakes and reservoirs in arid environments often serve as drinking water sources and recreational areas where high water quality is essential. Climate change …
Early Childhood Teacher Knowledge: Distinguishing Between Developmentally Appropriate Behavior And Maladaptive Behavior, Michela Carattini
Early Childhood Teacher Knowledge: Distinguishing Between Developmentally Appropriate Behavior And Maladaptive Behavior, Michela Carattini
UNLV Theses, Dissertations, Professional Papers, and Capstones
This dissertation investigates the effectiveness of a professional development program aimed at enhancing early childhood education (ECE) teachers' abilities to identify and address developmentally appropriate versus maladaptive behaviors in young children. Utilizing an explanatory sequential mixed methods design, the study involves pre- and post-intervention surveys, a post-intervention focus group, and the implementation of four asynchronous learning modules. The participants, pre-service teachers from a large urban university, were evaluated on their knowledge and application of distinguishing between behaviors in early childhood settings.The literature review highlights the struggles ECE teachers face in identifying maladaptive behaviors and the need for targeted professional development. …
New Insights Into The Diverse Intraplate Volcanism Present Within The Howland And Baker Island United States Exclusive Economic Zone, Nicholas Foresta
New Insights Into The Diverse Intraplate Volcanism Present Within The Howland And Baker Island United States Exclusive Economic Zone, Nicholas Foresta
UNLV Theses, Dissertations, Professional Papers, and Capstones
The origin of oceanic volcanism has been attributed to various mechanisms, such as upwelling mantle plumes, lithospheric extension driven decompression melting, and small-scale convective cells in the asthenosphere. Discovering the range of magmatic drivers present in the ocean basins aids in understanding mantle geodynamics and tectonic processes. A recent seafloor exploration campaign within the Howland and Baker Island (HBI) U.S. Exclusive Economic Zone (EEZ; approximately near the equator and the International Date Line) resulted in the collection of multiple lava flow samples, which offer valuable insights into the complex origins and dynamics of intraplate seamounts. According to current absolute plate …
The Effects Of Non-Invasive Brain Stimulation On Excitability Of The Primary Motor Cortices And Complex Motor Task Learning, Erik Woodruff Wilkins
The Effects Of Non-Invasive Brain Stimulation On Excitability Of The Primary Motor Cortices And Complex Motor Task Learning, Erik Woodruff Wilkins
UNLV Theses, Dissertations, Professional Papers, and Capstones
Transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are promising non-invasive brain stimulation techniques, particularly for clinical applications involving altered or impaired motor function, such as in stroke and Parkinson’s disease. Although tDCS and tACS are different modalities, both forms of stimulation operate on the same principle - weak electrical currents are delivered through electrodes placed on the scalp in specific configurations known as “montages”. The most commonly used montage for targeting the primary motor cortex (M1) is the M1-SO configuration. This montage leverages the established observation that cortical regions directly beneath the anode generally increase in …
Trauma-Related Cognitions And Discrimination As Predictors Of Maladaptive Coping Among Marginalized Maltreated Youth, Shadie Burke
Trauma-Related Cognitions And Discrimination As Predictors Of Maladaptive Coping Among Marginalized Maltreated Youth, Shadie Burke
UNLV Theses, Dissertations, Professional Papers, and Capstones
Maltreated youth are at an increased risk for engaging in direct or indirect self-injurious behavior to cope with the aftereffects of a traumatic event. These behaviors are often associated with negative health outcomes, substance use and premature death. Existing research proposes a link between child maltreatment and indirect self-harm but the mechanism into why this occurs is unclear. The present study examined two key research questions: (1) which specific trauma-related cognitions, sexual identity and cultural factors predict direct self-injurious behavior (previous suicide attempt(s) and NSSI) among marginalized maltreated youth?; and (2) which specific trauma-related cognitions, sexual identity and cultural factors …
The Effect Of An Occupational Balance Educational Module On Life Satisfaction And Occupational Balance For University Students, Unique Bowden
The Effect Of An Occupational Balance Educational Module On Life Satisfaction And Occupational Balance For University Students, Unique Bowden
UNLV Theses, Dissertations, Professional Papers, and Capstones
Engaging in a variety of occupations daily can support university students in feeling a sense of balance and satisfaction in their lives. This study aimed to evaluate the effectiveness of an occupational balance education module on improving the life satisfaction and occupational balance of university students ages 18-22 in a public university in the southwest region of the United States. Five participants were recruited using convenience sampling from a student support services program. A four-part education module was provided using a one-group pretest posttest quasi-experimental design, which included education on occupational balance, barriers and supports to occupational balance, strategies to …
The Influence Of Dual Sources Cerebellar Transcranial Direct Current Stimulation On Muscle Fatigue, Janriek Asuncion Bognot
The Influence Of Dual Sources Cerebellar Transcranial Direct Current Stimulation On Muscle Fatigue, Janriek Asuncion Bognot
UNLV Theses, Dissertations, Professional Papers, and Capstones
Transcranial direct current stimulation (tDCS) applied unilaterally to the cerebellum (ctDCS) can improve several aspects of human motor performance. The purpose of the study was to examine the influence of dual source tDCS delivered bilaterally over the cerebellar cortices (dsc-tDCS) on the time to task failure (TTF) of a fatiguing contraction. The study utilized a double-blind, randomized, SHAM-controlled, within-subjects, crossover design and participants were given either dsc-tDCS or SHAM stimulation in two different experiments held 7 days apart. Every aspect of the two experiments was the same except the type of stimulation (dsc-tDCS or SHAM) delivered during the fatiguing contraction. …
Assessing The Potential For Magmatic Sulfides Within Southwestern Laurentia Large Igneous Province, Thomas J. Boes
Assessing The Potential For Magmatic Sulfides Within Southwestern Laurentia Large Igneous Province, Thomas J. Boes
UNLV Theses, Dissertations, Professional Papers, and Capstones
The ~1.1 Ga magmatism of the Southwestern Laurentia Large Igneous Province (SWLLIP) generated a series of mafic-ultramafic sheets, sills, and dikes emplaced within Mesoproterozoic sedimentary units and older crystalline basement rock throughout the southwest United States and northern Mexico. This large igneous province (LIP) event remains enigmatic in identifying the processes that generated this magmatism. In addition, potential links to the contemporaneous magmatism of North America's magmatic Ni-Cu-platinum group element (PGE) mineralized Mid-Continent Rift (MCR) LIP to the northeast of the SWLLIP remain unclear. The contemporaneous 1.1 Ga MCR LIP event hosts economically viable magmatic sulfide deposits in the Duluth …
Black Women Educational Leaders In Pk-12 Public Education: A Multiple Case Study On The Double Consciousness Of Black Women Educational Leadership In Southwestern United States, Malena Baizan
UNLV Theses, Dissertations, Professional Papers, and Capstones
This dissertation examined the stories of Black Women Educational Leaders (BWEL) in PK-12t public education and their double consciousness as expressed through their leadership. The focus of this study was BWEL’s counternarratives as leaders within a system built upon systemic racism and oppression. Their experiences as Black Women Educational Leaders in PK-12 in a school district in which most school administrators are white, but most of the student body is Black and Brown were highlighted and centered to shed light on how the double consciousness of Black women informs their leadership. Utilizing Critical Race Feminism as the theoretical framework with …
An Examination Of The Teaching And Learning Of Resonance In General Chemistry I And Organic Chemistry I Using Variation Theory, Sabrina Barakat
An Examination Of The Teaching And Learning Of Resonance In General Chemistry I And Organic Chemistry I Using Variation Theory, Sabrina Barakat
UNLV Theses, Dissertations, Professional Papers, and Capstones
Resonance is a fundamental chemistry concept first introduced to students in General Chemistry I, reintroduced in Organic Chemistry I, and then utilized throughout other higher-level chemistry courses. A molecule or ion can be said to exhibit resonance when it can be represented by two or more chemical structures (i.e., Lewis structures) that differ only in their arrangement of electrons. In other words, resonance represents the electronic structure of a molecule or ion when a single Lewis structure does not adequately depict the true distribution of electrons. The molecule or ion is best represented as a combination of all of the …
Racial Microaggressions Research: Intersectionality, Coping Strategies, And Groups Impacted, Aldo M. Barrita
Racial Microaggressions Research: Intersectionality, Coping Strategies, And Groups Impacted, Aldo M. Barrita
UNLV Theses, Dissertations, Professional Papers, and Capstones
Microaggressions, a term first coined to name everyday experiences with oppression five decades ago (Pierce et al., 1977), has evolved in the literature naming specific aggressions taking place in microsystems targeting minoritized groups (Sue et al., 2007). However, as this research area expands, a need for specificity about who is being impacted by racial microaggressions and how this impact takes place remains a gap in the literature that the research program of this dissertation aimed to address. Expanding from traditional racial microaggression approaches (Sue et al., 2019; Williams et al., 2021), this dissertation incorporates aspects of intersectionality, coping strategies, and …
Differential Expression Of Microrna Mir-145 And Mir-155 Downstream Targets In Oral Cancers Exhibiting Limited Chemotherapy Resistance, Conner Belnap
Differential Expression Of Microrna Mir-145 And Mir-155 Downstream Targets In Oral Cancers Exhibiting Limited Chemotherapy Resistance, Conner Belnap
UNLV Theses, Dissertations, Professional Papers, and Capstones
Background: New evidence has suggested that non-coding microRNAs play a significant role in mediating and modulating chemotherapy resistance, particularly among oral cancers. One recent study found that the expression of miR-145 and lack of miR-155 expression strongly correlated with a limited chemotherapy resistance to Cisplatin, 5-Fluorouracil and Paclitaxel , although the mechanism(s) responsible for these observations remain unidentified.
Methods: Using commercially available cell lines of oral squamous cell carcinoma (OSCC), RNA was isolated using phenol:chloroform extraction. The isolated RNA was converted into cDNA by reverse transcription and subsequently screened for the presence or absence of downstream targets of miR-145 and …