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Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Utilization Of Biotechnological Drugs In Rare Diseases Requiring The Use Of Off-Label Drugsin Children In Turkey, Neri̇man İpek Kirmizi, Volkan Aydin, Nari̇n Akici, Banu Bayar, Ahmet Akici
Turkish Journal of Medical Sciences
Background/aim: Pediatric patients, especially those with rare diseases, represent a population that has a high tendency towards offlabel drug use (OLDU) and needs a more careful practice of pharmacotherapy than in adults. We aimed to investigate biotechnological drug use in children with rare diseases requiring OLDU. Materials and methods: This retrospective study examined all single-diagnosed OLDU applications (n = 5792) for 4992 children (
Does Fludrocortisone Treatment Cause Hypomagnesemia In Children With Primaryadrenal Insufficiency?, İbrahi̇m Mert Erbaş, Selda Ayça Altincik, Gönül Çatli, Tolga Ünüvar, Bayram Özhan, Ayhan Abaci, Ahmet Anik
Does Fludrocortisone Treatment Cause Hypomagnesemia In Children With Primaryadrenal Insufficiency?, İbrahi̇m Mert Erbaş, Selda Ayça Altincik, Gönül Çatli, Tolga Ünüvar, Bayram Özhan, Ayhan Abaci, Ahmet Anik
Turkish Journal of Medical Sciences
Background/aim: Aldosterone is a mineralocorticoid that secreted from adrenal glands and a known factor to increase magnesium excretion by direct and indirect effects on renal tubular cells. Although the frequency of hypomagnesemia was found to be approximately 5% in adult studies, there is no study in the literature investigating the frequency of hypomagnesemia in children by using fludrocortisone, which has a mineralocorticoid activity. Materials and methods: A multi-center retrospective study was conducted, including children who were under fludrocortisone treatment for primary adrenal insufficiency and applied to participant pediatric endocrinology outpatient clinics. Results: Forty-three patients (58.1% male, 41.9% prepubertal) included in …
Evaluation Of The Learning Curve Of Pediatric Kidney Transplantation Anesthesia, Tümay Uludağ Yanaral, Peli̇n Karaaslan
Evaluation Of The Learning Curve Of Pediatric Kidney Transplantation Anesthesia, Tümay Uludağ Yanaral, Peli̇n Karaaslan
Turkish Journal of Medical Sciences
Background/aim: Pediatric kidney transplantation (PKT) anesthesia brings some different challenges than adult kidney transplantation (KT) anesthesia and there are still no studies analyzing the role of experience on PKT outcomes. In this study, we aimed to evaluate the anesthesia learning curve in pediatric kidney transplants performed in our institution and the effect of increasing experience on renal transplantation-related data. Materials and methods: Patients age ≤ 18 years who underwent KT were included in the study, while patients age >18 years were excluded. Patients were divided into 3 groups according to the date of transplant, as the first 10 patients in …