Digital Commons Network^™

Targeting The Warburg And Q Effect: Novel Strategy To Disrupt Cancer Metabolism, Mahmoud Adel Mohamed

Theses and Dissertations

One of the hallmarks of cancer cells is their altered metabolism, which serves their need to grow and proliferate. Cancer cells exhibit a marked increase in glucose consumption (Warburg effect). In addition, cancer cells also exhibit excessive uptake of glutamine, for biomass synthesis and for energy production through mitochondrial substrate level phosphorylation (glutaminolysis pathway). Glutamine metabolism is enhanced upon inhibition of glycolysis, also interference of glutamic metabolism leads to upregulation of glucose metabolism. So, simultaneous inhibition of glycolysis and glutaminolysis presents promising metabolic intervention strategy. In this study, we investigated high dose Vitamin C mechanism of action through MTT assays …

The Relationship Between Teacher Efficacy, Leadership Support, And Professional Learning Communities: Implications Of A Pilot Study, Shana Spriggs-Loring

Theses and Dissertations

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Analyzing Blogs About Uyghur Discourse Using Topic Induced Hyperlink Network, Ifeanyichukwu Joshua Umoga

Theses and Dissertations

The Uyghurs are a Turkic ethnic group that descends from the general region of Central and East Asia. In recent years, the Chinese government has been accused of violating the human rights of Uyghur Muslims by imprisoning them in camps and subjecting them to forced labor, forced abortion, and other harmful treatments. Aside from western news outlets, lot of information is available on blogs regarding the Uyghur issue. The information found in these blogs provide an alternative lens to analyze the Uyghur discourse from non-traditional media outlets. However, it is difficult to show the connection between blogs and how information …

Detecting Gene-Gene Or Gene Environment Interactions In Association With Complex Disease Outcomes, Taiwo Adetunji Famuyiwa

Theses and Dissertations

Identifying gene–gene and gene–environment interaction is complicated and gainsaying most especially because of high multifactor dimensions involve in the analysis of such combination discrediting the functionality of parametric statistical method like Logistic Regression. [22] developed a multi-factor-dimensionality reduction (MDR) method for detecting and characterizing high-order gene-gene and gene-environment interactions in case-control and discordant-sib-pair studies with relatively small samples, which is inspired by the combinatorial partitioning method of [18]. [16] proposed Generalized MDR (GMDR) framework based on the score of a generalized linear model which allows adjustment of covariates, provides a unified framework for handling both dichotomous and quantitative phenotypes. However, …

The Effects That Spaces And Places Of Campus Have On Undergraduate Students, Ashley Davis

Theses and Dissertations

Student sense of belonging on campus is changing post COVID-19 pandemic, and this is because the way students utilize spaces on campus has evolved. Facilities on campus can impact the way students feel they belong based on how the spaces are set up and where students go in between classes (Samura, 2018). This study investigated the relationship between providing accessible, specific physical spaces and the participants' perception of student belonging. Undergraduate students enrolled full time at Rowan University were interviewed to collect data, and a qualitative research approach was used to analyze the data. Results conclude that there is a …

Aggregate Characteristics For Unpaved Highway Shoulders, Jessica V. Lewis

Theses and Dissertations

This thesis studied unpaved highway shoulders, and in particular shoulders of lower volume asphalt pavements being overlaid. The primary objective was to better understand how different shoulder aggregates perform on lower volume routes with asphalt surfaces and relatively narrow shoulders. A literature review and an evaluation of a full-scale test section containing five aggregate categories in nine test sections over a thirty-four-month period were the primary efforts performed to evaluate unpaved highway shoulders. The study concluded shoulder width measurements were not especially informative, and that California Bearing Ratio measurements were only modestly informative. Crushed concrete outperformed all other aggregates, though …

Endeavors Of Large Family Firms: A Property Rights Perspective Of Internationalization, Vitaliy Skorodziyevskiy

Theses and Dissertations

A large number of firms around the world are family firms. Many of these family firms are involved in internationalization strategies. Despite the breadth of knowledge on the internationalization of large family firms, not enough attention has been paid to some of the aspects of internationalization. Specifically, the literature is scarce with respect to understanding the mechanisms that may help or harm family firms in their internationalization strategies and the impact of these strategies on firm performance. In my dissertation, I use property rights theory to argue that family firms are able to minimize their negotiating and policing costs, allowing …

Marxist Analysis Of Social And Economic Narratives In Childrens' Cartoons, Shane Mcgregor

Theses and Dissertations

Using a Marxist framework with a grounding in critical literacy, this study employs a content analysis methodology to analyze 25 episodes of five of the most popular children’s television cartoons in order to understand how these cartoons portray economic and social systems, as well as how the messages these cartoons express would tend to support these systems. In so doing, this research hopes to provide a conceptual framework that educators and parents can use as a guide for demonstration of a critical approach to understanding the curriculum of children’s media inside or outside of the classroom. Educators can modify this …

Analysis Of Weather-Related Flight Delays At 13 United States Airports From 2004-2019 Using A Time Series And Support Vector Regression, Caroline E. Sleeper

Theses and Dissertations

This study seeks to investigate weather-related flight delay trends at 13 United States airports. Flight delay data were collected from 2004-2019 and normalized by airport operations data. Using Support Vector Regression (SVR), visual trends were identified. Further analysis was conducted by comparing all four meteorological seasons through computing 95% bootstrap confidence intervals on their means. Finally, precipitation and snowfall data were correlated with normalized delays to investigate how they are related. This study found that the season with the highest normalized delay values is heavily dependent upon location. Most airports saw a decrease in the SVR line at some point …

The Neuroprotective Role Of Vitamin D In Humans With A Traumatic Brain Injury: A Systematic Review, Hailey Jarr

Theses and Dissertations

Traumatic brain injuries (TBI) are a leading cause of death worldwide. Previous research supports a relationship between vitamin D and TBI outcomes; however, they rely on animal studies. This review aimed to examine the neuroprotective role of vitamin D in humans with TBIs. A search was completed (PubMed and Scopus) following PRISMA guidelines to review publications investigating the relationship between vitamin D deficiency (VDD) and TBI or the effect of vitamin D supplementation on TBI outcomes; 8 studies were identified. Patients had the
/="/">following ranges: 26-88% deficiency and 62-88% insufficiency compared to 24% and 49% of the general population. …

Physiology Of Human-Equine Interaction During Substance Withdrawal, Molly Marie Friend

Theses and Dissertations

Psychotherapy incorporating equine interaction (PIE) is emerging as an effective treatment for substance use disorder (SUD), but research is limited concerning physiological impacts during substance withdrawal. This study investigated impacts of PIE on salivary cortisol concentrations, heart rate, anxiety, and depression during SUD withdrawal. Heart rate and cortisol concentrations were measured in horses to determine potential human-horse coupling. Saliva samples and heart rates were collected pre and post PIE from residential SUD patients (n=18) and their therapy horses (n=4) during and following the withdrawal period. Participants (n=10) also completed a survey measuring anxiety and depression (P = 0.05). A …

Inline Real Time Moisture Sensing For Gin Cotton, Lucas Gay

Theses and Dissertations

The objective of this study was to assess the performance of a capacitive sensor in measuring moisture content of cotton within the moisture range of 6-13%. The assessment was conducted in two phases: static and dynamic. During the static phase, models to predict moisture content were created and a 95% Confidence Interval of [-0.619,0.619], Percent Residual Accuracy of 97.586%, and a mean error of 4.396% were achieved. The Bland-Altman plot yielded a curve with a slight positive trend, suggesting the data could be modeled more appropriately by multiple models. The dynamic phase saw similar results as the static tests in …

Monolithic Multiphysics Simulation Of Hypersonic Aerothermoelasticity Using A Hybridized Discontinuous Galerkin Method, William Paul England

Theses and Dissertations

This work presents implementation of a hybridized discontinuous Galerkin (DG) method for robust simulation of the hypersonic aerothermoelastic multiphysics system. Simulation of hypersonic vehicles requires accurate resolution of complex multiphysics interactions including the effects of high-speed turbulent flow, extreme heating, and vehicle deformation due to considerable pressure loads and thermal stresses. However, the state-of-the-art procedures for hypersonic aerothermoelasticity are comprised of low-fidelity approaches and partitioned coupling schemes. These approaches preclude robust design and analysis of hypersonic vehicles for a number of reasons. First, low-fidelity approaches limit their application to simple geometries and lack the ability to capture small scale flow …

Activity Level Of Helicoverpa Armigera Nucleopolyhedrovirus (Hearnpv) And Feeding Habits Of Helicoverpa Zea Larvae After Ingestion Of Hearnpv In Mississippi Soybean, Judge Tyler Fortenberry

Theses and Dissertations

HearNPV was applied to a soybean field and evaluated for residual efficacy at different time intervals (0, 12, 24, 36, 48, and 72 hours) after application in laboratory bioassays with treated leaves. Larval mortality was rated at five, seven and twelve days after larval infestation. Larval mortality increased as the number of days after infestation increased. To evaluate the feeding habits of Helicoverpa zea at the 2^nd and 3^rd instar, HearNPV exposed larvae and untreated larvae were weighed at zero (before diet exposure), four, and seven days. At four days after exposure, larval weight gain of …

Mitigating Adverse Impacts Of Increased Electric Vehicle Charging On Distribution Transformers, Akansha Jain

Theses and Dissertations

There is a growing interest in electric transportation, and the number of electric vehicles (EVs) is increasing. The resulting increase in EV charging power demand has an adverse impact on the existing power grids, especially the distribution transformers. The repeated and continued overloading caused by EV charging can significantly reduce their operational life. This dissertation aims to comprehensively study the adverse impacts of EV charging on distribution transformers and provide robust and practical solutions to mitigate it. A typical North American secondary distribution system with different EV penetration levels and four realistic residential EV charging scenarios are used for the …

Understanding Dietary And Thermal Influences On Invasive Cichlids In Puerto Rico Reservoir Systems, Jacob A. Moreland

Theses and Dissertations

Jaguar Guapote (Parachromis managuensis) and Amphilophus spp. were assessed for effects of temperature on standard metabolic rate (SMR) and lower dissolved oxygen tolerance (LDOT), efficacy of gastric lavage for diet analysis, and diet in Puerto Rico reservoirs. Fish were acclimated to 22°C, 28°C, and 34°C and SMR and LDOT were measured using intermittent respirometers. Jaguar Guapote acclimated to 34°C had the greatest SMR, with 22°C and 28°C having similar SMR values. Amphilophus spp. acclimated to 28°C were similar to fish acclimated at 22°C and 34°C. Fish were resilient to high temperatures, losing equilibrium more rapidly at the coldest temperature, 22°C. …

Natural Amino Acid Derived Iron (Iii) Catalysts For Green Oxidation Chemistry Applications, Karie Sanford

Theses and Dissertations

Tetraamido macrocyclic ligand activators are a group of catalysts that have been developed to perform green oxidation chemistries. In this thesis, the traditional synthesis of these catalysts was successfully altered to begin with natural amino acids, rather than the conventionally used synthetic derivatives of amino acids, which has never been shown in previous research. This was confirmed using a variety of characterization techniques including electrospray ionization-mass spectrometry. One of these catalysts was utilized in several dye degradation studies, where it was determined that the catalyst can remove about 98% of methylene blue and indigo carmine pollutants from water within 45 …

Examining Food Insecurity Among Mississippi Community College Students, Laura Jean Kerr

Theses and Dissertations

Food insecurity among postsecondary students and especially community colleges is a persistent social problem, but the prevalence continues despite much research. Postsecondary students experience food insecurity slightly differently from the general population and they are held to different rules to qualify for food support such as the supplemental nutrition assistance program (SNAP). In this research I examine the prevalence, frequency, and duration of food insecurity experiences among Mississippi community college students. I begin with a discussion of the literature of food insecurity and policy used to address food insecurity. I draw upon Bourdieu’s theory of social fields, capital, and habitus …

Halide Substitution Of Ternary Bismuth Chalcogenides For Photovoltaic Applications, Thomas Boggess

Theses and Dissertations

Semiconductors play an integral part in modern society. From computing to LEDs their use is ubiquitous, and no field is more reliant on them than that of power generation. Current political movements have seen a push to decrease reliance on traditional forms of power generation, which relies on fossil fuels, to renewable sources such as solar power. However, current commercial solar panels, based on silicon, are lacking in efficiency, only reaching between 18% and 22% efficiency.¹ In recent years, materials called perovskites have been garnering significant attention as possible replacements for silicon cells due to their favorable optoelectronic properties. …

Identification And Quantification Of Allelochemicals Associated With Weed Suppression In Sweetpotato, Varsha Varsha

Theses and Dissertations

Mississippi ranks among the leading states in sweetpotato production in the US. However, managing weeds in sweetpotato fields presents a significant challenge, and the limited availability of herbicides labeled for use in sweetpotato makes it even more challenging. The widespread and repeated use of herbicides has led to the development of weed resistance. In addition, herbicides are incompatible with the organic production system. Finding sustainable weed management strategies to provide weed control options for organic cultivation and detain the development of herbicide-resistant weeds under conventional crop production is imperative. The natural chemicals released by the plants, also called allelochemicals, can …

Role Of Fungal Arv-1 Protein In Sterol Metabolism And Pathogenicity Of The Chestnut Blight Fungus Cryphonectria Parasitica, Soumyadip Kundu

Theses and Dissertations

Intracellular sterol redistribution is an important step in the lipid homeostasis of organisms, a process directly linked to the organizational arrangement in the plasma membrane (PM) of cells. Previous studies in the budding yeast Saccharomyces cerevisiae have demonstrated that the ARV1 (ACAT-related enzyme-2 required for viability 1) protein is a major regulator of sterol transport from the endoplasmic reticulum to the plasma membrane, contributing to the structural organization of the PM, rendering it resistant to anti-fungal compounds as well as maintaining ER integrity. This study assessed the significance of ARV1 in the plant pathogenic fungus Cryphonectria parasitica (Cparv1) …

An Investigation Into Perceptions, Expectations, And Development Of Professional Skills In Engineering Students, Morgan Kathryn Green

Theses and Dissertations

Upon graduation from an undergraduate institution, engineering graduates are expected to have a baselevel skill in technical skills related to their discipline. Teaching technical skills comes naturally to engineering programs as the conceptual understanding of the material form the foundation of engineering ability. However, engineering graduates also are expected to have a baselevel of professional skills, which are more subjective in nature and do not have a standardized approach for teaching or assessing them at the undergraduate level. An investigation into current perceptions of professional skills by relevant parties is an initial step in providing more structure to professional skills …

Variational And Adaptive Non-Local Image Denoising Using Edge Detection And K − Means Clustering, Shiraz Mujahid

Theses and Dissertations

With the increased presence of image-based data in modern applications, the need for robust methods of image denoising grows greater. The work presented herein considers two of the most ubiquitous approaches towards image denoising: variational and non-local methods. The effectiveness of these methods is assessed using quantitatively using peak signal-to-noise ratio and structural similarity index measure metrics. This study employs ��−means clustering, an unsupervised machine learning algorithm, to isolate the most dominant cluster centroids within the incoming data and propose the introduction of a new adaptive parameter into the non-local means framework. Motivated by the fact that a majority of …

Comet Nuclei Activity Simulation Using Percolation Theory On Comet 67p/Churyumov– Gerasimenko, Ahmad Sohani

Theses and Dissertations

Comets, remnants of the solar system's formation, exhibits partially unexplained outbursts that are closely tied to the physical structure of the nucleus. To investigate outbursts, we employed pore network modeling techniques, such as the Bower-Watson algorithm and Voronoi diagrams, to better represent the nucleus' complex porous structure and simulate gas transfer processes. We examined heat diffusion in the comet's subsurface and its influence on crystallization. The extra heat generated by crystallization can shift the crystalline front deeper into the nucleus, accelerating subsurface evaporation rates. This process results in the formation of a thicker ice mantle with reduced porosity on the …

Where Did They Come From? Why Did They Go? How Engineering Students’ Perceptions Cultivate Experiences And Influence Behaviors, Sara Campbell Vick

Theses and Dissertations

Engineering undergraduate students have opinions and perceptions of engineering disciplines and engineering undergraduate students do not always matriculate and graduate in precisely the same discipline. Understanding how these two characteristics of engineering undergraduate students interact to inform behaviors is important for engineering educators and administrators to increase and improve recruitment and retention among their students.

This dissertation approached each characteristic of engineering students, first separately and then together. A nationwide survey of undergraduate engineering students found significant differences in how students perceive various engineering disciplines along several paired-term anchored scales. These differences were equally significant when scores were considered in …

Development And Evaluation Of An Automated Tactical Tillage Tool To Control Weeds In Row-Crop Production Systems, Grace Mccormick Friday

Theses and Dissertations

Weed control is an integral part of a successful overall production strategy in row- cropping systems and has the potential to reduce or eliminate yield losses that negatively affect profitability. Timely and correctly selected herbicide applications are the major keys for effective weed control in a majority of instances. However, there are negative factors that contribute to ineffectiveness and weed escape issues that currently lack viable options for management. Sparsely populated late-season weeds that emerge after lay-by herbicide applications and weeds that have become tolerant and resistant to traditional herbicide chemistries are of greatest concern. Historically, these weeds would have …

Interactive Effects Of Bark Beetles, Ophiostomatoid Fungi, And Subterranean Termites On Wood Decomposition And The Biogeochemical Cycling Of Pine Forests, Kimberlyn Pace

Theses and Dissertations

A frequent source of pine tree mortality in recent years can be attributed to pine bark beetles and their vectored Ophiostomatoid fungi, an organism that has been observed to attract subterranean termites that preferentially recruit to this downed woody debris. This interaction may significantly modify biogeochemical fluxes in bark beetle mass mortality events, but studies are often limited to singular regions or single pine-dominated ecosystems. Two studies were designed to test the interactive effects of these associations on terrestrial biogeochemical cycles and decomposition processes, the first using replicated field trials in Mississippi, Arizona, and Honduras across two years and the …

Robotic Cotton Harvesting With A Multi-Finger End-Effector: Research, Design, Development, Testing, And Evaluation, Hussein Gharakhani

Theses and Dissertations

Cotton is harvested with large and heavy machines that are very efficient but have some disadvantages. They can harvest the crop only once at the end of the growing season. Since cotton bolls do not mature uniformly, the early opened bolls expose their fiber to weather for extended periods, reducing lint quality. In addition, the machines can also compact the soil, reducing water and fertilizer usage efficiencies and crop yields in the following years. Robotic cotton harvesting offers a promising solution to these issues. Smaller robotic harvesters could go to the field multiple times during the season to pick cotton …

Exact Solutions For Schrodinger And Gross-Pitaevskii Equations And Their Experimental Applications., Bhavika Bhalgamiya

Theses and Dissertations

A prescription is given to obtain some exact results for certain external potentials �� (r) of the time-independent Gross-Pitaevskii and Schrodinger equations. The study motivation is the ability to program �� (r) experimentally in cold atom Bose-Einstein condensates. Rather than derive wavefunctions that are solutions for a given �� (r), we ask which �� (r) will have a given pdf (probability density function) �� (r). Several examples in 1 dimension (1D), 2 dimensions (2D), and 3 dimensions (3D) are presented for well-known pdfs in the position space. Exact potentials with …

Determining The Impact Of Post-Harvest Water Management On Chironomid Abundance, Agrochemical Biomass And Potential Trophic Biomagnification, Mason Thomas

Theses and Dissertations

Agriculture has diminished shorebirds’ natural habitat in the Mississippi Alluvial Valley. Remaining natural stopover sites are supplemented with agricultural fields during the fall and winter. This study evaluates the impact of 4 different post-harvest water management strategies on shorebird food abundance and potential agrochemical biomagnification. Chironomid samples estimated abundance, biomass, and chironomid agrochemical concentration in each field. A risk assessment of agrochemical biomagnification to shorebirds was made across all treatments. Of treatments represented on all study sites, winter treatment had greatest chironomid abundance and biomass. Models indicated that days since flood initiation, start date, and temperature are significant predictors of …