Digital Commons Network^™

Drug Repurposing: New Mechanisms And Applications Of Existing Compounds, Biyun Celia Cui

Theses and Dissertations

HIV infection remains a significant global health challenge. Despite the widespread use of combination antiretroviral therapy, people living with HIV (PLWH) still face a disproportionate burden of major health problems. One of these problems is HIV-associated neurocognitive disorders (HAND), which includes a spectrum of cognitive, motor, and behavioral impairments. Although severe forms of HAND have decreased, milder forms are on the rise, posing a significant obstacle for PLWH.

The persistence of HIV in the central nervous system (CNS) is a challenge of HAND treatment and involves a combination of factors, including neurotoxic HIV proteins, chronic neuroinflammation, and comorbidity with substance …

Cdk8 And Cdk19 Mediator Kinases As Novel Targets In Advanced Prostate Cancer, Jing Li

Theses and Dissertations

Following androgen deprivation therapy (ADT), prostate cancers (PCa) progress to castration resistant prostate cancer (CRPC) status, where their growth becomes independent of androgen signaling, through altered androgen receptor (AR) signaling or other genetic or transcriptional changes. Metastatic CRPC remains incurable, and the most potent new drugs prolong survival by only a few months. There is an urgent need for novel agents against advanced CRPC. Here we have investigated the roles of CDK8 and CDK19, two isoforms of Mediator kinase, which regulates transcriptional reprogramming, in regard to their biological activities and as potential novel targets for the treatment of CRPC.

To …

Becoming A Man: Concepts Of Writing Witness And Masculinity For Black Adolescent Males In Children’S And Young Adult Literature, Chelsea Danielle Rogers

Theses and Dissertations

Historically, the black male has had the world at his back, from the moment he stepped onto American soil, kidnapped and enslaved, the pressures to be a “good man” as a student or eventually as a father, to the need to “be somebody” as a proud American citizen, a human. In my dissertation, I evaluate further the position of the adolescent black male through the lens of young adult literature. The framework of a young adult novel is grounded in the experience of youth and adolescence rather than in adulthood and its nostalgic tendencies. The young black male experience and …

1, 2, 3: Counting On Problem Based Learning To Improve Mathematical Achievement In African American Students, Kelley P. Spahr

Theses and Dissertations

Mathematics is an important component of our everyday lives. It involves necessary skills, such as computation, problem solving, and critical thinking. In spite of this, a significant portion of our students are unable to demonstrate proficiency. These students are typically the underserved, marginalized students who are over represented in remedial classes and behavioral statistics (Gibson, 2022; Harper, 2010, 2021; Zilanawala, et al., 2018). This research study presented two instructional interventions, culturally relevant pedagogy and problem-based learning, to examine the impact of self-efficacy, critical thinking, and mathematical achievement. This study utilized a mixed-methods triangulation design. The participants of this study were …

Approaches To Detecting And Modeling Over-And Underdispersion In Alternative Count Data Distributions And An Application Of Logistic Regression And Random Forest Modeling To Improve Screening Tools For Tic Disorders In Children, Rebecca C. Wardrop

Theses and Dissertations

This dissertation focuses on theory and application of discrete data methods, particularly approaches to over- and underdispersion relative to the Poisson distribution and an application of random forest and logistic regression modeling. The first chapter derives a score test for over- and underdispersion in the heaped generalized Poisson distribution. Equi-, over-, and underdispersed heaped generalized Poisson and heaped negative binomial data are simulated to evaluate the performance of the score test by comparing the power it achieves to that of Wald and likelihood ratio tests. We find that the score test we derive performs comparably to both the Wald and …

A Study Of Computational Thinking Skills And Attitudes Towards Computer Science With Middle School Students, Lorien W. Cafarella

Theses and Dissertations

Many middle school students come to Computer Science (CS) classes without any previous CS instruction or any Computational Thinking (CT) skills that are needed to be successful. To overcome this, many curriculums and programming environments have been used to engage students and to instill a love of CS. Which curriculum should be used to develop CT skills that will also increase positive attitudes towards CS so students will continue in this field of study in higher grades? The purpose of this mixed method action research study was to evaluate how Code.org’s block-based programming curriculum affects middle school CS students’ CT …

Words Evaporate, The Images Remain: Testing Visual Warnings In The Context Of Intentions To Vape Among U.S. Adults As An Expansion Of The Theory Of Planned Behavior (Tpb), Carl Arland Ciccarelli

Theses and Dissertations

This dissertation applied the Theory of Planned Behavior (TPB) model variables of attitudes, subjective norms, and perceived behavioral control, along with the variable of fear to explain individuals’ behavioral intentions to vape. Previous studies have explored the social appeal, intrigue, and potential consequences of vaping among adolescent and college student populations. However, these past studies have largely relied upon focus groups and self-reported data conducted among samples of teen, adolescent, and college student populations. Thus, the aims and designs of these previous vaping studies may have been lacking in construct validity and a theoretical approach from which to explain behavioral …

Widely Digitally Delicate Brier Primes And Irreducibility Results For Some Classes Of Polynomials, Thomas David Luckner

Theses and Dissertations

This dissertation considers three different sections of results. In the first part of the dissertation, a result on consecutive primes which are widely digitally delicate and Brier numbers is discussed. Making use of covering systems and a theorem of D. Shiu, M. Filaseta and J. Juillerat showed that for every positive integer k, there exist k consecutive widely digitally delicate primes. They also noted that for every positive integer k, there exist k consecutive primes which are Brier numbers. We show that for every positive integer k, there exist k consecutive primes that are both widely digitally …

Effects Of Parenting And Self-Efficacy On Diet, Family Mealtime And Weight-Related Outcomes In African American Adolescents, Haylee Michele Loncar

Theses and Dissertations

Despite substantial research and concern, adolescent overweight and obesity continues to be a significant public health problem. Theory based on developmental literature emphasizes the role of adolescent self-regulatory factors, like self-efficacy, in health behavior engagement and weight-related outcomes. There is also extensive literature that highlights parents’ role in promoting self-regulatory development through warm and responsive behaviors and practices. However, few studies have considered longitudinal associations and changes in weight-related outcomes over time, as well as moderated effects by parenting. This study assessed longitudinal associations between adolescent self-efficacy parenting factors and adolescent BMI, diet, and family mealtime to fill gaps in …

A Qualitative Study Examining And Comparing Families’ And Teachers’ Perceptions Of School Readiness, Shalonya Cerika Knotts

Theses and Dissertations

A child’s readiness for school can impact their trajectory in subsequent grades and later in life. Therefore, children must be prepared when transitioning to kindergarten. As a kindergarten teacher at a Title I elementary school, I noticed a lack of readiness and conducted this qualitative action research study to create a readiness plan for my school by examining and comparing families’ and teachers’ perceptions of school readiness. The participants included my students’ parents and caretakers and my fellow kindergarten teachers. The findings indicate similar perceptions of school readiness. The family and teacher samples both associated readiness with academics and peer …

Multimodal Digital Literacy Practices: Perspectives Of L2 Academic Writing Instructors, Priscila Jovazino Bastos Medrado Costa

Theses and Dissertations

The purpose of my dissertation study was to explore the experiences and perceptions of English language instructors about the use of multimodal digital technologies in the teaching of academic writing. Writing academically in English as a second language (L2) is complex and multilayered for international students, and multimodal digital literacy practices are essential in the writing process in the age of information technology. The literature on multimodal digital literacies applied to L2 English instruction and to academic writing and the literature on teachers’ impressions about instructional technologies are vast. However, there is a need for further studies that address the …

Analysis, Measurement, And Modeling Of Millimeter Wave Channels For Aviation Applications, Zeenat Afroze

Theses and Dissertations

Millimeter wave (mmWave) communication systems can employ a large amount of spectrum, and can consequently offer large data rates, e.g., multi-Gigabits-per-second. This technology can be used in many sectors: aviation, vehicles, public transportation, robotics, autonomous factories, etc. Yet mmWave communication systems suffer from some propagation challenges, including large free space path loss (PL), large penetration loss, and large diffraction loss. Hence, it is vital to quantify these and other channel effects to ensure link reliability. Most mmWave systems will employ directional antennas to enable acceptable link distances. In many settings this will require directional receiver antennas to rotate in azimuth …

Stem Educators’ Perceptions Of Gender Bias And The Contributing Factors That Persist For Women In Stem Education, Haleigh Nicole Kirkland

Theses and Dissertations

Social influence from society holds the key to social norms that influence students and their future aspirations. Gender bias is considered one of the influencing factors that affects the decisions of female high school students on participating in STEM education. This descriptive study describes the key factors that STEM educators perceived as influential for female high school students' participation in STEM education. The research questions of the study included: (1) What are high school STEM educators’ perceptions regarding gender bias in the STEM School of Study cluster at Skyler High School and (2) What factors do high school STEM educators …

Insurance Status And Cancer Staging, Time To Treatment, And Mortality: Examining Cancers Of The Breast, Colon, And Lung, Gabriel A. Benavidez

Theses and Dissertations

Introduction: When examining cancer outcomes, timely detection and treatment are critical factors for favorable prognoses. Previous studies have shown that individuals with public health insurance, specifically Medicaid, have worse cancer outcomes than those with private insurance. While differences in socioeconomic status may account for this disparity, one potential area for further investigation is the effect of Medicaid enrollment timing on cancer outcomes. In some states, individuals may not be eligible for Medicaid until after their cancer diagnosis, potentially nullifying health insurance benefits. This analysis examines the impact of Medicaid enrollment timing on cancer outcomes by comparing patients not enrolled in …

The Moderating Role Of Patient-Centered Culturally Sensitive Health Care On The Relationship Between Health Self-Efficacy And Patient Engagement Among Black American Adults, Kaylyn Ann Garcia

Theses and Dissertations

Black Americans continue to embody strength and resilience in the face of systemic racism and oppression. However, as health disparities experienced by Black Americans continue to widen, it cannot be expected that they be solely responsible to leverage cultural strengths to improve health and well-being in the face of systemic injustice. Instead, it is equally as important to consider the wealth of opportunities that exist for systems, organizations, and policies to dismantle barriers to health and well-being experienced by Black Americans. Therefore, the present study examined the moderating role of patient-centered culturally sensitive health care (PC-CSHC) on the relationship between …

Measuring Social Vulnerability And Exposure To Potential Risks Induced By Spaceport Operations In South Texas: An Empirical Study Utilizing Gis Methods And Social Vulnerability Indicators, Evan D. Garcia

Theses and Dissertations

The commercialization of space has increased spaceport development and activity across the United States. The magnitude of growth can be witnessed through the spaceport expansion and spacecraft testing at the SpaceX “Starbase” Launch Facility, located along the Texas-Mexico border. Matching the pace of SpaceX’s growth while evaluating levels of risk, the Federal Aviation Administration (FAA) diligently conducted a comprehensive Programmatic Environmental Assessment (PEA). While this assessment provides significant environmental impact data and risk analysis, much is left to understand regarding hazards and risk exposure to local communities. More specifically, research is needed to understand hazards associated with operational- and anomaly- …

Evaluating The Use And Performance Of Marine Protected Areas To Conserve Reef Fish Biodiversity In The Caribbean, Mathias Tjarko Cramer

Theses and Dissertations

Reef fishes are an integral part of life in the Caribbean, fulfilling essential roles in their native marine ecosystems and the many human communities that neighbor them. Perhaps most directly to humans, reef fishes and their fisheries are an essential source of dietary protein, and further support local human communities through employment opportunities. More indirectly, reef fishes fulfill numerous ecological roles that help maintain their native reef ecosystems, which, in turn, confer benefits to humans. For example, a recent analysis estimated that every square kilometer of coral reef generates an average annual income of $473,000 (USD), which would represent 23 …

Stages Of Entrepreneurial Success: A Qualitative Study Of Post-Soviet Immigrant Entrepreneurs In The United States, Nathan Thor Rozea

Theses and Dissertations

The rate of immigrant entrepreneurship continues to grow, affecting economic development in many host country communities. Immigrant entrepreneurs are found in past research studies to be outpacing host natives in entrepreneurial activities, offering additional economic, social, and cultural benefits. This study examined a phenomenon at the individual immigrant entrepreneur level in the United States to provide increased insight into understanding the phenomena of surges in immigrant entrepreneurial startups for continued research on immigrant entrepreneurship to effect related policy formation and decisions. This research examined a cohort of eighteen post-Soviet immigrant entrepreneurs from 11 different Eastern European countries with successful businesses …

Actions Speak Louder Than Words: The Role Of Organization Segmentation Norms On Work-Family Enrichment, Engagement & Burnout, Sarah Jensen

Theses and Dissertations

Increased frequency of virtual work environments has changed the dynamics of boundary management decisions for employees and underscored the importance of organizations being aware and purposeful of how their norms will impact their employees. The goal of this study was to a) understand how organizations norms towards segmentation impact employee burnout, engagement, and enrichment, and b) how segmentation preferences, job demands, and job crafting strengthen these relationships. Two samples of participants were recruited from a mental health organization (N = 73) and mTurk (N = 80) to complete surveys on the variables for the study. Organizations with a norm for …

Affiliative And Challenging Prosocial Behavior: Exploring Why And When Through The Lens Of Self-Construal, Vanessa Melendez

Theses and Dissertations

Prosocial behavior yields important benefits for both employees and organizations. This research was designed to extend our understanding of the antecedents of prosocial behavior by focusing on self-construal. Specifically, this study investigates (a) the distinction between affiliative and challenging forms of prosocial behavior and how these relate to self-concept orientations (SCOs), (b) workplace affective commitment variables (workgroup commitment and organizational commitment) and motives (prosocial values and organizational concern) as potential mediators, and (c) independent self-construal as a potential moderator of the link between interdependent SCOs and affective and motivational mediators. The study involved 205 full-time workers completing two Qualtrics surveys …

Obscuration Analysis Of Camera Imagery For Aviation Applications, Patrick James Roelant

Theses and Dissertations

Image feature detection is a potent tool with many applications, such as fog identification, roadway conditions, etc. As part of the recent surge in machine learning applications, cloud detection has also become an increasingly engaged area of research. Identifying low clouds is especially useful with respect to aviation, particularly in regions of complex topography prone to visibility-related hazards such as haze or fog. To address this issue, a threshold-based semi-automated algorithm was developed and tested to determine whether or not an image is obscured by fog or haze. Images were obtained from a ground-based camera network in Southern California, the …

Comparative Analysis Of Soil Properties, Microbial Community Composition, And Yield Responses To Cover Crops In Different Ecoregions Of South Texas, Daphne Zapsas

Theses and Dissertations

Comprehensive understanding of soil properties, their interdependencies, and the effects of management practices is crucial for designing sustainable agricultural strategies. By adopting site-specific and need-based practices that enhance soil health, farmers can optimize crop growth, increase yield, and contribute to long-term environmental sustainability. Cover crops have been recognized for enhancing soil fertility, promoting microbial activity, and increasing organic matter content. However, while their effectiveness is well documented in temperate regions with readily available water, their impact in water limited systems in subtropical regions remains mixed. The aim of this study is to assess soil conditions in four different farms across …

A Convolutional Neural Network Based Approach To Study The Gravitational Waves From Core-Collapse Supernovae In Ligo's Third Observation Run: Detection Efficiency And Parameter Estimation, Bhawana Sedhai

Theses and Dissertations

Core-Collapse Supernova (CCSN) is one of the most anticipated sources of Gravitational Waves (GW) arriving at the advanced LIGO detectors during the fourth observation run (O4). CCSN are rare, weak and unmodeled having a very low rate of occurrence in our galaxy (estimated 2 per century). Thus, detection of GW from CCSN is a challenging problem. An analysis pipeline used in this study is Multi-Layer Signal Enhancement with cWB and CNN or MuLaSEcC that combines Machine Learning methods with a network of Gravitational Wave detectors to identify and reconstruct signals from core collapse supernovae, while minimizing false alarms through the …

A Girl And Her Knife: A Feature-Length Screenplay, Alyssa C. Sandoval

Theses and Dissertations

A Girl and Her Knife is a dramatic screenplay written to promote inclusivity and empowerment of U.S. Chicanas in mainstream Hollywood. Once her grandmother dies, the protagonist, Luisa Fregoso, learns about her family’s history through her grandmother’s journal entries. Luisa’s grandmother, Ana, ensured Luisa became successful as an independent woman who understood she didn’t need love from a man. Luisa learned self-autonomy and self-liberation at a young age, but always struggled with love. Ultimately, her deceased grandmother continues to guide Luisa, but in a dangerous and dark way. The screenplay defies Hollywood’s traditional gender and cultural standards through distinctly written …

Cover Crops Influence Arthropod Community Dynamics Through Seasonal Variation And Cascading Effects, Adegboyega Fajemisin

Theses and Dissertations

Chapter 1: This chapter gives an overview of how cover crops influence soil’s physical, chemical, and biological properties, and their role on mediating arthropod community dynamics with implications for pest management in the subsequent cash crop.

Chapter 2: This chapter examines the effects of cover-cash crop rotation on arthropod community dynamics on four growers fields in the Lower Rio Grande Valley, Texas. We assessed the impact of cover crops planted in the summer months on the subsequent cash crops planted in the winter. Our results showed that cover crops had a differential effect on the population of beneficials and herbivores …

Implementation Of Dual Language Programs For Emergent Bilinguals: Understanding Instructional Decisions Of Elementary Principals, Susana Marlet Arredondo

Theses and Dissertations

According to the United States Department of Education (2017), the number of K-12 Emergent Bilingual students (EBs) has been increasing over the years; in the year 2014 – 2015, there were over 4.8 million English Learners in our country. Therefore, a new norm for many school districts has been to incorporate Dual Language Programs to close the learning gaps between this subgroup and non-English Learners. There are different models used under Dual Language Program models such as the 90:10 and 50:50 model approach. Moreover, other districts provide a Dual Language Program for all students, not just English Learners. The purpose …

Empowering Teachers To Support Mtss Students: An Action Research Study, Sahalija Dentico

Theses and Dissertations

In 2018, the elementary school where I serve as an instructional interventionist adopted a data-based multi-tiered system of supports (MTSS). Although our process has evolved over the years, I saw room for improvement. Therefore, the purpose of this action research study was to improve the MTSS process at my school, specifically by addressing teachers’ lack of awareness of their role. Framing the study with a combination of social cognitive theory and curriculum ideologies, I explored 12 English language arts teachers’ perceptions of the MTSS model, curricular views, and sense of self-efficacy. Through a two-phase, mixed-method approach, I investigated how sharing …

The Impact Of A Literacy Program On Summer Reading Setback: Providing Access To Books And Project-Based Learning, Tiffany Gayle Robles

Theses and Dissertations

This action research study examined the impact of a summer literacy program on summer reading setback. Gaining Ground is a summer intervention program designed primarily for economically disadvantaged students in Grades K–5. By granting access to self-selected books and implementing project-based curriculum, Gaining Ground aims to improve reading proficiency during the summer break. Faucet theory illuminated the challenge of reaching and maintaining proficiency over break, and constructivism and self-determination theory framed the program’s efforts to resolve this problem.

As the curriculum director, I used mixed methods to assess Gaining Ground’s impact. Quantitative methods revealed maintenance, improvement, or decline in student …

Development Of Intensity Duration Frequency Curve Of The Lower Rio Grande Valley, Binaya Poudel

Theses and Dissertations

Section 1: This chapter incorporates extensive information about the concept of Intensity-Duration-Frequency (IDF) curves, their historical development and usage, specific focus on the Lower Rio Grande Valley, and the importance of using a comprehensive 32-year data set from 1990-2022 to develop these curves.

Section 2: This chapter provides detailed information about the rigorous comparison of the developed IDF curves with previous ones, where past IDF curves were developed using an empirical formula method. The research presented here employs the Gumbel distribution method, providing a fresh perspective and potentially more accurate predictions of future weather extremes.

Section 3: This chapter outlines …

Long-Chain Fatty Acid Sensing And Catabolism In Commensal Escherichia Coli Impact Murine Gut Colonization, Tessa Carolina Cox

Theses and Dissertations

The gastrointestinal tract is home to trillions of microbes that collectively influence host physiology, immunity, nutrient metabolism, and infectious disease. The overgrowth of naturally-occurring Escherichia coli in the gut is a common signifier of microbiome dysfunction and occurs in many chronic diseases including obesity. Recent studies have shown that higher fat intake is associated with increased gut E. coli growth. However, it remains unknown whether gut E. coli utilize lipids such as long chain fatty acids (LCFAs) as carbon sources to colonize the mammalian gut. Therefore, the central objective of my dissertation was to utilize bacterial genetics and various mouse …