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Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey Dec 2023

Characterizing Stress Granule Regulation By Pas Kinase, Ataxin-2 And Ptc6 And Investigating The Lifespan Of Covid-19 Virus On Currency, Colleen R. Newey

Theses and Dissertations

The protein Ataxin-2 is a known positive regulator of stress granules in humans, mice and yeast (known as yeast PBP1). Due to the role that stress granules play in diseases including Amyotrophic Lateral Sclerosis (ALS) and cancer, this thesis investigates the role of Ataxin-2 and its protein binding partners in stress granule development and its effects on various metabolic phenotypes of the cell. PAS kinase is a sensory protein kinase, conserved from yeast to man, which regulates respiration and lipid biosynthesis. Our lab discovered that PAS kinase phosphorylates and activates Ataxin-2 in yeast, and that PAS kinase overexpression enhances localization …

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A Series Of Improved And Novel Methods In Computer Vision Estimation, James J. Adams Dec 2023

A Series Of Improved And Novel Methods In Computer Vision Estimation, James J. Adams

Theses and Dissertations

In this thesis, findings in three areas of computer vision estimation are presented. First, an improvement to the Kanade-Lucas-Tomasi (KLT) feature tracking algorithm is presented in which gyroscope data is incorporated to compensate for camera rotation. This improved algorithm is then compared with the original algorithm and shown to be more effective at tracking features in the presence of large rotational motion. Next, a deep neural network approach to depth estimation is presented. Equations are derived relating camera and feature motion to depth. The information necessary for depth estimation is given as inputs to a deep neural network, which is …

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Soil Health In American Sports Fields, Miria C. Barnes Dec 2023

Soil Health In American Sports Fields, Miria C. Barnes

Theses and Dissertations

Healthy soils are essential for sustaining the world's ecosystems and maintaining human lifestyles. The adoption of biological, chemical, and physical analyses to assess soil health is a relatively new concept with a paucity of scientific work assessing how these metrics are affected by field management in urban systems Soil samples (n = 110) were collected from a diverse range of sports fields and, for comparative purposes, golf courses, farm fields, non-sport urban, undisturbed forest, and non-vegetated sandy soils. The samples were then analyzed using biological, chemical, and physical metrics to determine if there were significant differences between sport/golf venues and …

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Interfacial Properties Of Hybrid Lipid-Polymer Bilayers: Applications In Drug Delivery And Biosensors, Keith L. Willes Dec 2023

Interfacial Properties Of Hybrid Lipid-Polymer Bilayers: Applications In Drug Delivery And Biosensors, Keith L. Willes

Theses and Dissertations

Amphiphilic block copolymers are unique macro-molecules capable of self-assembling into bilayers analogous to naturally occurring lipid membranes. When combined with lipids, these copolymers form hybrid membranes with unique and sometimes unpredictable properties, including increased chemical and mechanical stability. These synthetically enhanced biological structures represent a versatile platform suitable for a wide range of applications, from advanced biosensing devices to drug delivery systems. The realization of these advancements necessitates a deep understanding of material properties, including the ability to predict and control interfacial behaviors. It has been shown that in the case of pure lipid membranes, interfacial behaviors are dominated by …

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Effectiveness Of Intelligent Transportation Systems On Utah Roadways, Matthew Cline Davis Dec 2023

Effectiveness Of Intelligent Transportation Systems On Utah Roadways, Matthew Cline Davis

Theses and Dissertations

This thesis presents the findings of a comprehensive research study conducted for the Utah Department of Transportation (UDOT) to evaluate the effectiveness of commonly deployed Intelligent Transportation System (ITS) treatments in Utah, with a focus on Variable Message Signs (VMS), traffic cameras, and Road Weather Information System(s) (RWIS) sites. The study aimed to determine the impact of these ITS treatments on mobility and safety for Utah's unique road conditions and configurations. Three primary analyses were performed: a diversion rates analysis to assess the effectiveness of VMS on Utah freeways during incidents; a weather analysis to evaluate the effectiveness of VMS …

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Twitch Chat Advertising: How Live Chat Valence Affects Consumer Advertising Perceptions, Austin W. Camper Dec 2023

Twitch Chat Advertising: How Live Chat Valence Affects Consumer Advertising Perceptions, Austin W. Camper

Theses and Dissertations

The streaming platform Twitch.tv, is a popular video streaming website where users can watch, communicate, and chat with streamers and other viewers live. Twitch and other live streaming websites typically offer viewers a chat window where the viewer can chat (in real-time) with the streamer and other viewers who are currently watching the stream. Research in live streaming platforms like Twitch and the effects of their various features are novel. The purpose of this study is to analyze how the sentiment of a live chat (positive or negative) and the stated or not stated disclosure of an advertisement posted in …

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Advancements In Levitated Optomechanics: Exploring Plasmon-Enhanced Light-Matter Interactions In Optical Trapping, Siavash Mirzaei Ghormish Dec 2023

Advancements In Levitated Optomechanics: Exploring Plasmon-Enhanced Light-Matter Interactions In Optical Trapping, Siavash Mirzaei Ghormish

Theses and Dissertations

Optical trapping of metallic nanoparticles investigates phenomena at the interface of plasmonics and optical micromanipulation. This thesis combines ideas from the optical properties of metals, originating in solid-state physics, with the force mechanisms resulting from optical trapping. I explore the influence of enhanced light-matter interaction due to the plasmon resonances of gold particles on their trapping properties. I present theories for trapping mechanisms of gold metallic particles and then verify these theories through experiments. Optical trapping of metallic nanoparticles is considered challenging, especially in air, as they are highly absorbing and reflecting at optical wavelengths. Yet the optical levitation of …

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Analysis And Simulation Of Nuclear Thermal Energy Storage Systems For Increasing Grid Stability, Jaron Wallace Dec 2023

Analysis And Simulation Of Nuclear Thermal Energy Storage Systems For Increasing Grid Stability, Jaron Wallace

Theses and Dissertations

With the growing capacity of renewable energy production sources, nuclear energy, once a mainstay of power generation, faces challenges due to its limited adaptability to fluctuating energy demands. This inherent rigidity makes it less desirable than the more flexible renewable sources. However, integrating thermal energy storage (TES) systems offers a promising avenue, enabling nuclear power plants (NPPs) to enhance their operational flexibility and remain competitive in an evolving renewable market. A comprehensive ranking methodology has been introduced, delineating the criteria and processes to determine the most synergistic TES/NPP design couplings. This methodology considers the unique characteristics of both current and …

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Investigating The Effects Of Unfused Powder Damping In Laser Powder Bed Fusion, Samuel Hao Teng Dec 2023

Investigating The Effects Of Unfused Powder Damping In Laser Powder Bed Fusion, Samuel Hao Teng

Theses and Dissertations

This study uses Additive Manufacturing (AM) processes to fabricate 316L stainless steel beams with pockets of unfused powder for increased damping. Modal testing was completed to compare damping factors of beams with varying pocket geometries as well as number of pockets and pocket location. For the first three bending modes that were tested, an initial damping increase was observed when pocket height is greater than powder diameter. Following the initial increase there is a height threshold, which is mode dependent, that is required to achieve a statistically significant increase in damping.

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Use Of Microcalorimetry To Evaluate Hardening Reactions In Protein Bars During Accelerated Storage, Tiffany Rose Spackman Dec 2023

Use Of Microcalorimetry To Evaluate Hardening Reactions In Protein Bars During Accelerated Storage, Tiffany Rose Spackman

Theses and Dissertations

Protein bars have become a popular option among consumers to increase protein content in their diets. Since there is a large market for protein bars, many factors must be considered when creating a protein bar that both satisfies consumers and has a long shelf-life. Hardening and textural changes in protein bars are some of the most common modes of shelf-life failure in this product category. When the typical product creation timeline from formulation to launch can be as short as 3-6 months and with added pressure from executives to quickly launch another new product afterwards, product development scientists simply do …

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Economy Of Scale Of Energy Intensity In Aquifer Storage And Recovery (Asr), Alyson Haley Rapp Dec 2023

Economy Of Scale Of Energy Intensity In Aquifer Storage And Recovery (Asr), Alyson Haley Rapp

Theses and Dissertations

More water utilities are adopting Aquifer Storage and Recovery (ASR) to balance long-term water supply and demand. Due to large implementation and operation costs, ASR projects need to be optimized, particularly for energy use, which is a major operating expense. This study examines the relationships among energy use, recharge, and recovery at two ASR projects in the western United States. The major finding is an economy of scale for recovery processes, but not for gravity-fed recharge processes. The economy of scale found is as follows: the energy intensity recovered decreases with volume. This suggests it is more energy-efficient to recover …

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Using Jtag For External Scrubbing On The Amd Versal Acap, Michael L. Bjerregaard Dec 2023

Using Jtag For External Scrubbing On The Amd Versal Acap, Michael L. Bjerregaard

Theses and Dissertations

The Versal Adaptive Compute Acceleration Platform (Versal ACAP) is a system-on-chip (SoC) developed by AMD Xilinx. To help protect the programmable logic from soft errors, the configuration needs to be constantly checked and repaired through a process called scrubbing. This thesis provides a methodology for scrubbing the configuration over JTAG. The scrubber uses two platform device image (PDI) files, one to read the configuration and one to send corrected frames. The methodology is characterized to determine the time it takes to completely scrub the configuration. The designed scrubber was able to scrub the VM1802 in 11.5 seconds, or 41.6 Mbits/second, …

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A Framework For Implementing Data Integrity Program Enabling Mid-Size Financial Institutions To Meet United States Federal Reserve Data Quality Requirements For Model Risk Management, Divya Yadav Dec 2023

A Framework For Implementing Data Integrity Program Enabling Mid-Size Financial Institutions To Meet United States Federal Reserve Data Quality Requirements For Model Risk Management, Divya Yadav

Theses and Dissertations

The purpose of this mixed-methods, action research study was to help financial institutions build and implement controls for data quality and integrity for model data input, allowing financial institution models to offer quality output or reports for quality business decisions by upper management. This mixed-methods study addressed three research questions. The quantitative question that was addressed was: To what extent does implementing a Data Integrity Program (DIP) influence the quality and integrity of model data input at different stages of Model Risk Management (MRM) in mid-size financial institutions? The qualitative portion of the study addressed two research questions which included: …

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An Inexpensive, 3d Printable, Arduino And Bluray-Based, Confocal Laser And Fluorescent Scanning Thermal Microscope, Justin Loose Dec 2023

An Inexpensive, 3d Printable, Arduino And Bluray-Based, Confocal Laser And Fluorescent Scanning Thermal Microscope, Justin Loose

Theses and Dissertations

The Fluorescence Scanning Thermal Microscope (FSTM v3.0), was designed to create an inexpensive, and easily manufactured, device for measuring the diffusivity of samples with microscopic locational precision. This was accomplished by using a Blu-ray device known as a PHR-803T, referred to in this work as a PHR. The optics in the PHR are nearly identical in function to conventional devices used in thermoreflectance microscopy, making the PHR extremely useful to integrate into the FSTM design. The focus of this thesis is the application of the FSTM as a confocal microscope using 3D printed components and various low-cost devices to operate …

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Modeling The Influence Of Vibration On Flow Through Embedded Microchannels, Joseph S. Seamons Dec 2023

Modeling The Influence Of Vibration On Flow Through Embedded Microchannels, Joseph S. Seamons

Theses and Dissertations

The influence of vocal fold (VF) vibration on perfused flow through VF vasculature is an area of research that has previously received limited attention. The aim of the research presented in this thesis was to contribute towards an improved understanding of the effects vibration on perfusion through vasculature within the VFs. This was done using a series of computational simulations of geometric changes to, and perfusion through, microchannels embedded in VF models. A computational structural model based on synthetic VF models used in previous experimental studies was first developed. The model and its embedded microchannel were initially studied under static …

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Using Quantitative And Kinetic Proteomics To Explore Proteostasis, Nathan Raul Zuniga Pina Dec 2023

Using Quantitative And Kinetic Proteomics To Explore Proteostasis, Nathan Raul Zuniga Pina

Theses and Dissertations

Every cell consists of carefully orchestrated biomolecules such as lipids, carbohydrates, and proteins. To maintain internal stability (homeostasis), cells maintain the right amount of these molecules at the right time and at the right place. This process is especially true for proteins since they are the foundation functional units within the cell. Proteins form structures and perform chemistry that bestows cells overarching functional roles. Cells maintain protein homeostasis (proteostasis) by modulating synthesis, folding, and degradation processes (turnover) to maintain the abundance levels for all proteins. This is the foundational kinetic model of proteostasis that is covered in this work, and …

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Novel Fire And Herbivory Regime Impacts On Forest Regeneration And Plant Community Assembly, Devri A. Tanner Dec 2023

Novel Fire And Herbivory Regime Impacts On Forest Regeneration And Plant Community Assembly, Devri A. Tanner

Theses and Dissertations

Human activities are increasing the occurrence of megafires that have the potential to alter the ecology of forest ecosystems. The objective of this study was to understand the impact of a 610 km2 megafire on patterns of forest regeneration and herbivory of three forest types (aspen/fir, oak/maple, and pinyon/juniper) within the burn scar. Sapling density, meristem removal, and height were measured across a transect network spanning the area of the burn scar over three years from 2019-2021. The network consisted of 17 burned/unburned transect pairs in adjacent burned/unburned forest stands (6 aspen/fir, 5 oak/maple, and 6 pinyon/juniper). Species that regenerated …

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Understanding The Experiences And Perceptions Of Subject Librarians And Faculty At Brigham Young University, Duane E. Wilson Dec 2023

Understanding The Experiences And Perceptions Of Subject Librarians And Faculty At Brigham Young University, Duane E. Wilson

Theses and Dissertations

This study used a qualitative case study method to explore the position of a subject librarian in a large academic library in the United States using the subject librarians at Brigham Young University as the case. In the first phase of the study, all Brigham Young University subject librarians were given the opportunity to participate in a semi-structured interview. Subject librarians considered their main purpose to be connecting the people at the university with library resources. Their duties of collection development, reference, instruction, liaison, citizenship, professional development, and scholarship are interrelated and work together in important ways. Subject librarians are …

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Shifting The Academic Leadership Paradigm: Culturally Responsive Associate Deans In Illinois Community Colleges, Cathy Y. Taylor Dec 2023

Shifting The Academic Leadership Paradigm: Culturally Responsive Associate Deans In Illinois Community Colleges, Cathy Y. Taylor

Theses and Dissertations

This study explored how associate deans in Illinois community colleges understand and practice culturally responsive leadership (CRL) in their institutions. The conceptual framework for this study is composed of the Culturally Responsive School Leadership (CRSL) model in the K-12 system first proposed by Khalifa et al. (2016) and the Applied Critical Leadership (ACL) model for higher education leaders by Santamaria et al. (2016). The study used the convergent parallel mixed-methods approach to simultaneously collect quantitative and qualitative data from associate deans in Illinois community colleges to measure how they understood and practiced culturally responsive leadership in their institutions. The study …

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Uniquely Tailored Ionic Materials For Implementation In Energy, Imagining, And Antibacterial Applications, Amanda Jalihal Dec 2023

Uniquely Tailored Ionic Materials For Implementation In Energy, Imagining, And Antibacterial Applications, Amanda Jalihal

Theses and Dissertations

In this dissertation, the novel class of ionic materials is explored. Ionic materials are easily tuned and tailored to fit a wide variety of applications. The synthesis of ionic materials is extremely simple and prompt. Briefly, two ionic moieties are joined electrostatically through a double displacement resulting in a new compound without complicated synthesis. This process leads to a close proximity of the ions which allows for enhancement of the FRET mechanism between a fluorophore and chromophore. A potential application of a FRET active ionic material is explored as a photosensitizer using IR820 and Nile Blue A. The ionic material, …

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On The Duty Of Uncivil Disobedience: Thoreau's Action From Principle, Alan F. Garcia Dec 2023

On The Duty Of Uncivil Disobedience: Thoreau's Action From Principle, Alan F. Garcia

Theses and Dissertations

This thesis explores the uncivil disobedience evident in some of Henry D. Thoreau’s work, which is often regarded as the birth and foundation of what is today known as “civil disobedience.” Using the nature of Thoreau’s subtle language and his philosophy of action from principle in his writings, including “Resistance to Civil Government” (1849), Walden (1854), “Life Without Principle” (1863), “A Plea for Captain John Brown" (1859), and some of his real life actions, this thesis will examine the antagonistic and, perhaps, uncivil nature of Thoreau’s so-called “civil disobedience.” This thesis will also incorporate Sophocles’ play Antigone (441 BBC), Candice …

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Political Rhetoric And Latino Public Opinion: A Study Of Abortion In The U.S., Fernanda Valdez Dec 2023

Political Rhetoric And Latino Public Opinion: A Study Of Abortion In The U.S., Fernanda Valdez

Theses and Dissertations

This thesis studies political rhetoric and Latino public opinion on abortion in the United States. Mainly, this thesis asks: Is political rhetoric on abortion shaping the Latino vote? This thesis conducted a content analysis of political rhetoric through speeches, interviews, debates, political advertisements, and social media accounts from Democratic and Republican gubernatorial candidates. The gubernatorial races studied in this thesis are those from California and Texas from 2010 to 2022. In the content analysis, this research accounted for words and phrases that referenced abortion and the type of arguments (reproductive rights-based and moral-based arguments) made in those references. Then, this …

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Economic Governance And Violence: A Cross-National Analysis, Steven Mccain Dec 2023

Economic Governance And Violence: A Cross-National Analysis, Steven Mccain

Theses and Dissertations

Understanding how economic governance influences routine activities is crucial within the field of criminology to better understand how grounds for violence emerge. Literature of cross-national studies concerning the effects of economic governance has recently developed to study its relationship with violence, specifically homicide. However, there is a deficit of frameworks related to criminological theory in this literature. Using a routine activity framework, the current dissertation seeks understand how different degrees of economic governance in general and, more specifically, the five areas of economic governance – size of government, legal system and property rights, sound money, freedom to international trade, and …

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"When The Spring Flowers Bloom": Dorothy Fuldheim, The Kent State Killings, And Vietnam War Foreign Policy, Pablo Rangel Jr. Dec 2023

"When The Spring Flowers Bloom": Dorothy Fuldheim, The Kent State Killings, And Vietnam War Foreign Policy, Pablo Rangel Jr.

Theses and Dissertations

Dorothy Fuldheim is a significant figure in American history. A local legend of news broadcasting in Cleveland, Ohio, Fuldheim wrote and broadcasted exceptional commentaries that demanded the attention of her audience. Her evolving style caught the attention of many across the United States, eventually making her a nationally recognized journalist. Little scholarship has been written on Fuldheim and her contributions to the fields of history, allowing this thesis to lead the way in analyzing her life and work. The primary purpose of this thesis is to use Dorothy Fuldheim as a window to contextualize the events at Kent State University …

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Waterbody Size Influences Chemical And Community Characteristics Of North Dakota Prairie Wetlands And Lakes, Julia Renee Hampton Dec 2023

Waterbody Size Influences Chemical And Community Characteristics Of North Dakota Prairie Wetlands And Lakes, Julia Renee Hampton

Theses and Dissertations

The Prairie Pothole Region (PPR) of North America is home to dynamic glacier-formed lakes and wetlands that range in size from small intermittent wetlands to large permanently filled basins. Predicting water-related shifts in environmental conditions and biological community responses within these systems has been challenging due to non-linear, scale-specific changes. Furthermore, landscape-level changes in the quantity and distribution of surface water are becoming more frequent. This thesis contributes to our understanding of how waterbody size, and potential size fluctuations, influence chemical and community dynamics of complex PPR glacial lakes and wetlands. We paired remote sensing and discontinuity methods with US …

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"Maybe I Shouldn't Have Worn Such High Heels" Examining Self-Presentation Expectations For Corporate Women Using Communication Theory Of Identity, Taylor E. Mack Dec 2023

"Maybe I Shouldn't Have Worn Such High Heels" Examining Self-Presentation Expectations For Corporate Women Using Communication Theory Of Identity, Taylor E. Mack

Theses and Dissertations

The present study examines how corporate women use self-presentation in the workplace to communicate professionalism. The study utilizes Communication Theory of Identity (CTI) to consider the self-presentation experiences of corporate women. CTI identifies four identity layers: personal, relational, enacted, and communal, which interact and influence each other as individuals attempt to define themselves. Through semi-structured, in-depth interviews with corporate women, the present study found the following results: women often receive communication regarding self-presentation standards from peers rather than formal policies, self-presentation expectations have become more casual and diverse, women still encounter challenges resulting in the need to (re)negotiate their identity, …

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Marss: Multi-Agent Reinforcement Learning For Satellite Swarms, Nicholas J. Yielding Dec 2023

Marss: Multi-Agent Reinforcement Learning For Satellite Swarms, Nicholas J. Yielding

Theses and Dissertations

Multi-agent systems and swarms in spacecraft formation flying are of ever-increasing importance in a contested space environment—use of multiple spacecraft to contribute to a cooperative mission potentially increases positive outcomes on orbit, while autonomy becomes an ever more important requirement to reduce reaction time in dynamic situations and lower the burden on space operators. This research explores difficult swarm Guidance Navigation and Control (GNC) scenarios using Deep Reinforcement Learning (DRL). DRL polices are trained to provide guidance inputs to agents in multi-agent swarm environments for completing complex, teamwork focused objectives in geosynchronous orbit. An example scenario is explored for a …

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An Improved Saliency Map With Trustworthiness For Localizing Abnormalities In Medical Imaging, Nolan C. Skelly Dec 2023

An Improved Saliency Map With Trustworthiness For Localizing Abnormalities In Medical Imaging, Nolan C. Skelly

Theses and Dissertations

Saliency maps are a widely used methodology to make deep learning models more interpretable. They provide post-hoc explanations through identification of the most pertinent areas of an input medical image. These techniques have been assessed based on 1) localization utility, 2) sensitivity to model weight randomization, 3) repeatability, and 4) reproducibility. Ten saliency map techniques will be tested, Grad, Smooth Grad, Integrated Gradients, Smooth Integrated Gradients, XRAI, Grad-CAM, Guided Backpropagation, Guided GradCAM, GradCAM++, and ScoreCAM. The neural networks used to predict and read medical information require a reliable solution to provide medical practitioners intelligible results. Using the information of two, …

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An Empirical Study Of The Relationship Between Board Chairperson Activism, Board Gender Diversity, Board Gender Inclusion, And Firm Performance, Phyu Phyu Aung Myint Dec 2023

An Empirical Study Of The Relationship Between Board Chairperson Activism, Board Gender Diversity, Board Gender Inclusion, And Firm Performance, Phyu Phyu Aung Myint

Theses and Dissertations

This dissertation empirically examined the effect of board chairperson activism and board chairperson power on board gender diversity, board gender inclusion, and firm performance using a sample of boards of Fortune 500 firms. Board chairperson activism, in this dissertation context, refers to board chairpersons taking actions such as speaking out on, advocating for, or actively supporting gender equality or women leadership in business. Board gender diversity refers to the gender heterogeneity of directors in the boards whereas board gender inclusion refers to the extent to which women directors are given opportunity to participate and contribute to …

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Process-Structure-Property Relationships Of Nanofibers For Biomedical Applications, Dipasree Bhowmick Dec 2023

Process-Structure-Property Relationships Of Nanofibers For Biomedical Applications, Dipasree Bhowmick

Theses and Dissertations

This thesis explores the fabrication, characterization, and applications of nanofiber membranes utilizing Forcespinning® technology. Two distinct nanofiber systems were developed and evaluated, one focusing on pH-responsive Eudragit-baicalin loaded nanofibrous membranes for wound healing and the second one on thermo-responsive nanofiber-hydrogel (PNIPAAm) systems for biosensing applications, specifically dopamine detection. In the first project, nanofiber membranes loaded with Eudragit and baicalin demonstrated superior antibacterial properties against both gram-negative (E. coli) and gram-positive (B. meg) bacteria. Additionally, these membranes exhibited antioxidant properties and enhanced cell proliferation of 3TT cells, making them promising candidates for wound healing dressings. In the second project, a …

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