Digital Commons Network^™

Elastin-Like Polypeptide As A Model To Study Intrinsically Disordered Proteins, Sadegh Majdi

Theses and Dissertations

The elastin-like polypeptide (ELP) is a well-studied structural protein that is easily amenable to amino acid (AA) sequence modifications and has the potential to yield a wide variety of uses in bioengineering and biomedical applications. One unique property of ELP is the inclusion of intrinsically disordered domains (IDP) within the structure that allow for its diversity of physical properties. While it is generally understood that amino acid sequence dictates protein folding arrangements, the contributions of specific amino acid sequences to the intrinsic disorder of ELP has yet to be fully resolved. Therefore, identifying the contributions of specific amino acid sequences …

Unveiling The Unique Ras Isoform And Domain Specific Regulation Of Braf Kinase, Tarah Trebino

Theses and Dissertations

BRAF kinase is a key member of the MAPK pathway, important for cell growth and division. Upstream signals promote BRAF activation by interaction with the membrane bound GTPase, RAS, which leads to relief of autoinhibition and dimerization. The N-terminal regulatory domains of BRAF, including the BRAF specific region (BSR), the RAS binding domain (RBD), and the cysteine rich domain (CRD), govern the conformational state of the cytosolic, autoinhibited monomer and drive the RAS-RAF interaction. Active BRAF phosphorylates and activates its substrate MEK, which in turn phosphorylates and activates ERK. Mutations in RAS and BRAF are the cause of many cancers …

Behavioral Effects Of Novel Treatments For Pain Using Different Pathways, Danya M I Aldaghma

Theses and Dissertations

Pain is defined as an unpleasant sensation that is mostly caused by a stimulus from our surroundings. This sensation has the potential to become a significant concern, disrupting daily activities, and diminishing overall quality of life. However, it could also hold significant importance as it serves as a protective mechanism. Pain acts as an alarm system for the human body, alerting it to potentially harmful situations where tissues may be at risk of damage1. Despite the considerable advancements in pain treatment and the extensive knowledge scientists possess regarding the pathophysiology and pathways of pain, numerous medications aimed at alleviating pain …

Investigation Of Machine Learning Driven Adaptive Control Strategy For Heat Exchanger Under Varying Fouling Conditions, Reshma Madhu Pk

Theses and Dissertations

Fouling is an undesirable and inevitable phenomenon that affects Heat Exchanger (HE) dynamics, increases maintenance cost (>50%), and loss of production. Conventional fouling prediction and control techniques demand an in-depth understanding of the HE-specific fouling dynamics. Hence, machine learning emerges as an ideal tool for learning the fouling process from the available measurement dataset.

The proposed work aims to design a machine learning-driven adaptive control technique for an industrial HE, subjected to varying fouling conditions. Naphtha cooler, an industrial HE utilized in petroleum refineries, employs cooling water to lower Naphtha temperature, but the high impurities in the recycled cooling …

Deep Learning Model Compression On Edge Devices For Audio, Afsana Rahman Mou

Theses and Dissertations

Audio classification plays a crucial role in interpreting and understanding soundscapes, enabling applications like voice assistants, sound event detection, and music analysis. However, deploying deep learning models for audio classification on edge devices presents significant challenges. These models often require substantial computational resources and memory, which are limited on edge devices. Balancing performance, efficiency, and accuracy remains a key hurdle in this field. In this research, we explore various deep learning architectures, including Convolutional Neural Networks (CNN), Long Short-Term Memory (LSTM), and Audio Spectrogram Transformer (AST), for the purpose of audio classification on the ESC 50 and Audio Set datasets. …

Integrated Project Delivery (Ipd): A Contractual Framework For The Egyptian Construction Industry, Sarah Hussain

Theses and Dissertations

This abstract highlight the significant findings and contributions of the study, which aimed to develop model clauses specifically tailored to the Egyptian construction industry for multi-party construction contracts. The research methodology encompassed several key components. Firstly, a comprehensive literature review was conducted to explore the various construction delivery methods prevalent in Egypt. This review provided a solid foundation for understanding the existing practices and identifying areas for improvement. The study also delved into the concept of Integrated Project Delivery (IPD) and its potential benefits as well as an analysis of the commonly used standard forms of contract and successful case …

An Examination Of The Impacts Of Macroeconomic Indicators On Conventional And Islamic Equity Fund Returns: Perspectives From The Mena Region, Amr Elshabouny

Theses and Dissertations

This study examines the performance of conventional and Islamic equity mutual funds in the MENA region, and the influence of major macroeconomic determinants on the two types, by analyzing 503 conventional and 128 Shariah-compliant funds. It incorporates three major macroeconomic variables using Generalized Linear Models (GLM). The findings indicate no significant superiority of Islamic funds over conventional ones. The study also notes that while market performance and foreign exchange rates positively affect both fund types, GDP growth and inflation have a negative impact. Islamic funds are less influenced by excess market returns, GDP growth, and inflation compared to conventional funds, …

Synthesis And Characterization Of Bio Based Amphiphilic Molecules, Vandana Singh

Theses and Dissertations

Among various molecular self-assemblies, low molecular weight gelators (LMWGs), that can form gels in organic solvents/water/oils, have gained much research attention due to their huge potential applications. Generally, gels are soft nanomaterials formed by the self-assembly of amphiphilic molecules into a three-dimensional fibrous network entrapping the solvent.

As these gels are formed by self-assembly via non-covalent interactions they are reversible and differ from macromolecular gels. To synthesize LMWGs, biomolecules such as fats, oils, fatty acids, lignocelluloses, sugars, amino acids, and peptides are commonly used as their inherent property favors self-assembly. In the current scenario, interest in synthesizing bio-based gelators has …

Automated Management Of Time Extension Claims In Construction Projects, Mariam Elazhary

Theses and Dissertations

Disputes within the construction industry have caused parties to incur additional costs not accounted for. In fact, one of the notorious reasons for disputes can be attributed to Extension of Time (EOT) claim submissions. Such is due to its susceptibility to the human factor. Accordingly, there is a need to diminish reliance on the human factor in the EOT process and to bolster it with commodities of the industrial revolution 4.0. While research efforts have endeavored in tackling the drawbacks of the EOT claim process individually, no superior solution is provided to overcome all drawbacks at once. Initially, the literature …

An Analysis Of Fathers’ And Toddlers’ Behaviors During Shared Book Reading, Caitlin Marie Kelly

Theses and Dissertations

Shared book reading interactions between parents and their children have been studied to draw correlations to a child’s vocabulary growth, language development, mathematical scores, and socioemotional skills. However, there is a lack of research regarding fathers’ and toddlers’ engagement and behaviors during shared book reading interactions. The current study investigated and analyzed father and toddler interactions during shared book reading. The data was collected from a larger longitudinal study. Seven father-child dyads participated in the study (Mage = 35 years; range = 30-43 years). The children included four males and two females, and up to two videos were collected for …

Class-Wide Function-Related Intervention Teams In Middle School Classrooms With English Language Learners: Effects And Perceptions, Emily Joy Warburton

Theses and Dissertations

English language learners (ELL) and Latinx students are at an increased risk of difficulties that can lead to problem behaviors at school. Effective classroom management strategies may help these students remain on task despite these challenges, but teachers often feel they lack training in classroom management strategies. Class-wide Function-related Intervention Teams in Middle School (CW-FIT MS) is a research-based classroom management intervention that has helped teachers increase their students' on-task behavior through group contingency, reward, and praise. We investigated the efficacy of CW-FIT MS in classrooms with high proportions of Latinx ELL students. One middle school English teacher and her …

Foreign-Born Black Males: An Interpretative Phenomenological Analysis Of Their Persistence In Higher Education, Eliezer Marcellus

Theses and Dissertations

The purpose of this study is to explore the academic and social integration experiences of foreign-born Black male students who persist at a four-year research institution. Research has shown that foreign-born Black males do not self-identify, and, as a result, their experiences in higher education have been grouped in with the persistent experiences of native-born Black males (Nesbett, 2002; Williams, 2005). This phenomenological study examines the lived experience of foreign-born Black males in higher education. Ten face-to-face interviews were conducted in order to describe the essence of this phenomenon. The findings from this study revealed five themes that explained the …

Reparative Description: Suggested Revisions Of Library Of Congress Subject Headings For Indigenous Peoples In The Sequoyah National Research Center Online Library Catalog, Mikaela Nicole Bailey

Theses and Dissertations

The Library of Congress (LOC) presents thousands of items in its online catalog and uses subject headings to link and relate items of the same subject matter, origins, or creator. Smaller libraries,archives, and other institutions use the subject headings provided by the LOC to easily link related materials within their own online catalogs. The Library of Congress Subject Headings are not inclusive and do not represent all Peoples. Subject Headings used by the Library of Congress may correctly represent a community, misrepresent by using other names than what the People choose to call themselves, or may not represent a People …

Open System Neural Networks, Bradley Hatch

Theses and Dissertations

Recent advances in self-supervised learning have made it possible to reuse information-rich models that have been generally pre-trained on massive amounts of data for other downstream tasks. But the pre-training process can be drastically different from the fine-tuning training process, which can lead to inefficient learning. We address this disconnect in training dynamics by structuring the learning process like an open system in thermodynamics. Open systems can achieve a steady state when low-entropy inputs are converted to high-entropy outputs. We modify the the model and the learning process to mimic this behavior, and attend more to elements of the input …

Cancer Treatment By Targeting Hdac4 Translocation Induced By Microsecond Pulsed Electric Field Exposure: Mechanistic Insights Through Kinases And Phosphatases, Zahra Safaei

Theses and Dissertations

Epigenetic modifications, arising from sub-cellular shifts in histone deacetylase (HDAC) activity and localization, present promising strategies for diverse cancer treatments. HDACs, enzymes responsible for post-translational histone modifications, induce these epigenetic changes by removing acetyl groups from ε-N-acetyl-lysine residues on histones, thereby suppressing gene transcription. Within the HDAC group, class IIa HDACs are notable for their responsiveness to extracellular signals, bridging the gap between external stimuli, plasma membrane, and genome through nuclear-cytoplasmic translocation. This localization offers two significant mechanisms for cancer treatment: nuclear accumulation of HDACs represses oncogenic transcription factors, such as myocyte-specific enhancer factor 2C (MEF2C), triggering various cell death …

A Case Study Of The Implementation Of The New Clery Act Guidelines, Eunice Adigun

Theses and Dissertations

The Clery Act requires all higher education institutions participating in federal financial aid programs to keep and disclose campus crimes by submitting an Annual Security Report by October 1st of every year. In October 2020, the U.S. Department of Education replaced the 265-page Clery Act guidelines for administrators with a 13-page Appendix with specific changes to geographical locations to include in the report, eliminated the definition of crimes, and limited individuals designated as Campus Security Authority to those with direct responsibilities over student affairs. This case study examined how campus security officers implement the new Clery Act guidelines in crime …

Development Of A Xenograft For Annular Repair Using Pulsed Electric Field Exposures For Enhanced Decellularization, Prince Mensah Kwaku Atsu

Theses and Dissertations

Severe back injuries and chronic pain necessitate surgical replacement of damaged intervertebral disc (IVD) cartilage in advanced disease stages. Bovine IVD tissue has been exposed to an upper threshold pulsed electric field (PEF) dose, causing cell death without thermal damage to the tissue. Subsequent PEF exposures at lower magnitudes have accelerated the removal of immunogenic biomolecules though electrokinetic extraction using optimized aqueous solutions. This approach yields a natural scaffold, ready for biocompatibility and mechanical strength assessment. The effects of microsecond pulsed electric fields (µsPEF) on primary bovine AF fibroblast-like cells have been characterized in vitro. PEFs of 10 and 100 …

Integrated Computer-Aided Design, Experimentation, And Optimization Approach For Perovskites And Petroleum Packaging Processes, Swapana Subbarao Jerpoth

Theses and Dissertations

According to the World Economic Forum report, the U.S. currently has an energy efficiency of just 30%, thus illustrating the potential scope and need for efficiency enhancement and waste minimization. In the U.S. energy sector, petroleum and solar energy are the two key pillars that have the potential to create research opportunities for transition to a cleaner, greener, and sustainable future. In this research endeavor, the focus is on two pivotal areas: (i) Computer-aided perovskite solar cell synthesis; and (ii) Optimization of flow processes through multiproduct petroleum pipelines. In the area of perovskite synthesis, the emphasis is on the enhancement …

Repeat After Me, Bonnie Morano

Theses and Dissertations

Bonnie Morano’s devotional abstract oil paintings are an offering of conviction reconciled with joy. Balancing spiritual zeal with geometric space, she creates mirrored compositions filled with gravitas and play. The sacred and domestic join together in maximal harmony, examining alternative arrangements of transcendental experience.

Pan Shot!, Samuel Robert Gaston Mattax

Theses and Dissertations

Sam Mattax's practice is aimed at working through what he has lived and what he is living. They are self-involved diaristic building blocks of marking time and release. The layered drawings negotiate Sam's history and his day to day, distorting one another into a place of unrecognizable space and condensed energy. It is a process of attaining a loose understanding of his life and forgetting it all at once. Sam's work is survival.

Affectionate Facsimiles, Julio C. Williams

Theses and Dissertations

The paintings in Affectionate Facsimiles are journeys into the expansiveness of color and memory via the accumulation of gestural action. Sporadic freneticism is used to archive desire and time and their relationship to identity. Thin and translucent layers are built up in bursts of intensity as palimpsests of intentioned labor.

Ripe Spoils, Yan Cynthia Chen

Theses and Dissertations

Chen’s practice primarily focus on sculptures and installation. She explores the interplay between the idea of nature and the constructed environment, by examining how language informs what we know. The central thesis, "Ripe Spoils", employs citrus fruits as symbols for bodily experiences and personal identity, investigating their cultural and historical significance. Her sculptures summon the qualities and embedded meanings in materials like paper pulp and clay, wax and citrus fruits, often resulting in abstracted forms evocative of the human body. This thesis paper and exhibition reflect on themes like mortality and the essence of self.

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Place-Conscious Vs. Place-Bound, Julie Avetisyan

Theses and Dissertations

Julie Avetisyan’s installation of sculptures, paintings and printmaking works are driven by an exploration of constructed identity that is not place-bound, but place-conscious. In this paper, she explores how her art practice generates world building under the context of the Armenian Diaspora – considering histories of indigeneity, migration, and assimilation.

Where The Under And The Over Meet And Disappear, Louisa Owen

Theses and Dissertations

Vignettes of light: light disappearing, light contrasting, light directing, light wandering, and light uncovering.

This Life Is A Constant Rehearsal, Alex Schmidt

Theses and Dissertations

Alex Schmidt’s conceptual practice explores the artist’s precarious condition as an affective freelance worker; a utopian parasite. Schmidt employs paintings as props, performance as muse, and writing on transactional care as a metaphor for this cobbled life.

Art In The Age Of Algorithmic Automation And Artificial Intelligence, Milly Skellington

Theses and Dissertations

The 21st century is examined in order to understand how the artists tools have gained unprecedented autonomy.

Recuerdos Efímeros, Karewith A. Casas

Theses and Dissertations

The following 12 poems were written in 2023 leading up to my MFA thesis exhibition at Hunter College. Each relate and were inspired by or inspired the visual works in the exhibition. My writing, the music I make, and the visual works I create are all intertwined and feed off of each other. The relationship between my works of art and poetry are not in the tradition of ekphrasis, but are instead extensions of each other. Each mark, material, color, or image are words, sounds, sentences, movements, and pauses. And vice versa as well. Moments on a picture plane or …

Barley As A Human Companion Species - Exploring The Relationship Between Barley And North Atlantic Peoples: 4000 Bc – Ad 1200, Chloe Combs

Theses and Dissertations

Barley (Hordeum vulgare) is an ancient cereal crop originating in the Fertile Crescent approximately 12,000 years ago and is presently one of the most important cereal crops globally. Barley has a long and complex history. This thesis aims to explore one dimension of this history through the lens of human companion species using archaeobotanical data collected from the islands of the North Atlantic from the Neolithic (4,000 BC) to the Norse period (AD 1200).

The Black Arts And Black Power Movements In The Artwork Of John T. Riddle, Jr., Isabella Vitti

Theses and Dissertations

This thesis examines the under-studied work of the Black sculptor John T. Riddle, Jr. and how he was influenced by the politics of Los Angeles in the 1960s and 1970s. Police brutality, the Vietnam War, the Black Power Movement, and the Watts uprising had a major impact on Riddle’s work.

Crucifixion Can Happen To Anyone: Embodying Christ Through The Queer Artist, Xander Guyer

Theses and Dissertations

In the late 20th century, queer artists incorporated the Crucifixion into their artworks, embodying a crucified Christ in the process. This thesis seats these contemporary works within traditional Christian art history, a position long denied to these transgressively queer artists.