Digital Commons Network^™

Integrating Data-Driven And Mechanism-Driven Modeling In Drug Discovery And Hepatotoxicity Evaluation, Xuelian Jia

Theses and Dissertations

The pharmacological activities and hepatotoxicity significantly influence the success or failure of new drugs during drug discovery and development. Traditional experimental methods, such as animal models, are costly and time-consuming for chemical testing. There is a great need to develop in vitro and computational modeling to help identify the pharmacological activities and hepatotoxicity potential in the early stage of drug discovery and safety evaluation. In this dissertation, new computational models and associated modeling frameworks were described for predicting the biological profile and hepatotoxicity of chemicals. Firstly, a novel data mining and Quantitative Structure-Activity Relationship (QSAR) workflow was developed to construct …

Development Of Electrically Conductive Asphalt Pavements For Deicing Applications In Cold Regions, Ashith Marath Padinhare Purakkal

Theses and Dissertations

Winter conditions often lead to significant traffic delays and safety risks due to ice or snow accumulation on pavement surfaces. This study evaluates the potential of electrically conductive asphalt (ECA) pavements to prevent such accumulations by melting ice and snow under real-world conditions. The study involved preparing ECA mixtures using graphite and carbon fibers, three carbon fiber lengths (3 mm, 6 mm, and 24 mm), and aggregates with two nominal maximum aggregate sizes (NMAS) (4.75 mm and 9.5 mm). Electrical resistivity, rutting susceptibility and cracking resistance of compacted ECA mixtures were evaluated. Results indicated that ECA mixtures with 15% graphite …

Mirror Mirror On The Screen Show The Me That I Want Seen: Navigating Digital Influences On Identity Construction: A Qualitative Case Study, Jaime Digirolamo Vona

Theses and Dissertations

This qualitative case study explores how information messages, on and offline, influence the identity construction of young adult learners using a self-authorship frame at County Community College (CCC). Self-authorship is the construction of beliefs, values, and identities based on a personally defined internal process rather than reliance on external formulas for meaning (Baxter Magolda, 2023). Data collection and analysis included semi-structured interview transcriptions from eighteen students aged 18-24. The findings revealed the dynamic interplay between traditional values and online ideals, highlighting the challenges of influence and dissonance in the identity journey. The study's findings call on educators and policymakers to …

"Remember Me": A Narrative Analysis On Latino Representation In Disney's Coco And Encanto, Angie Nicole Vega

Theses and Dissertations

This study explores the authenticity of Latino representation in Disney animated films by reviewing the visuals, symbols, and themes incorporated into the animations. Using a narrative analysis method, the study examines themes present in the films, including characters, setting, music, and language, to uncover deeper meanings and cultural references. Through this analysis, the study aims to identify commonalities in how Latino culture is represented in mainstream media and to uncover any underlying messages or biases that may be present. The findings of the study suggest that both films showcase Latino culture in a positive and celebratory manner, highlighting the importance …

Distracted Driving: Identification, Contributing Factors, And Safety Countermeasures, Ahmed Sajid Hasan

Theses and Dissertations

Distracted driving is a hazardous behavior responsible for 25% of all fatal traffic crashes in New Jersey. While traditional methods such as surveys, videos, and simulations have been used to identify and evaluate distracted driving events, these approaches primarily provide cross-sectional data that fails to capture the true rate of distraction on the road. This study addresses this limitation by collecting longitudinal data on distracted driving events across selected corridors in New Jersey. A data collection team continuously drove through these corridors, manually counting and video recording driver distraction events. The collected data was then analyzed to assess the significance …

Navigating The Maze: Women Experiences Transitioning From Faculty To High-Level Administration In Four-Year Postsecondary Institutions In The United States, Jonathan Miles Hubbell

Theses and Dissertations

This dissertation explores the experiences of women transitioning from faculty roles to high-level administrative positions within four-year postsecondary institutions in the United States. Utilizing a phenomenological approach, this study investigates the strategies, challenges, and successes of nine women who have navigated this career progression, highlighting the systemic barriers they faced and the resilience they developed along the way. Through the lens of resiliency theory and intersectionality, the research examines how women balance personal and professional obligations, overcome institutional barriers, and utilize mentorship networks to support their advancement. From the in-depth interviews, four themes emerged: (a) adaptability, (b) resilience, (c) mentoring, …

Development Of A Haptic System For Robot-Assisted Femur Fracture Surgery, Fayez H. Alruwaili

Theses and Dissertations

Robot-assisted surgery has emerged within the field of surgical technology, driven by the need for greater accuracy and speed in the ongoing evolution of healthcare. This advancement has influenced numerous areas requiring enhancements to achieve optimal surgical results. However, surgical robotics tends to lack the surgeon’s connection to the operation, creating a gap in the intuitive skill set required for successful operations. The gap is seen through the lack of sense of touch, which may result in tissue damage and additional injury when the robot interacts with the patient. Furthermore, challenges faced during femur fracture surgery have positioned robot-assisted surgery …

Injectable Hydrogels That Can Measure Radiation At Body Temperature, Daniel Joseph Ball

Theses and Dissertations

Hydrogel-based radiation dosimeters are used to calibrate and validate radiation delivered by linear accelerators used in radiotherapy. Specifically, Fricke hydrogel-based dosimeters containing ferrous ion complexes oxidize upon exposure to radiation, leading to a change in optical density that can be measured via a color change in a photometric reagent. While gelatin-based Fricke hydrogels are routinely used to measure radiation, these hydrogels are unstable at body temperature, and it is currently not possible to noninvasively measure radiation dose inside a patient. This study reports the synthesis and characterization of self-forming hydrogels containing Fricke components that are stable at body temperature. The …

Use Of Pulsed Electric Fields And Hydrogen Peroxide For Pre And Postharvest Strategies To Reduce Microbial Loads On Fresh Produce, Zachary Rosenzweig

Theses and Dissertations

Several issues exist within the agricultural industry surrounding failure to prevent pathogen transfer to plants preharvest and failure to decontaminate foods postharvest. Fresh produce, like leafy greens, pose a large threat to public safety if contaminated because they are minimally processed and often eaten raw. Numerous outbreaks have been linked to fresh produce in recent decades, with irrigation water emerging as a potential source. These outbreaks have severe economic repercussions and can contribute to millions of hospitalizations and deaths each year, worldwide. This thesis focuses on the usage of pulsed electric fields (PEF) and hydrogen peroxide (H2O2) as a means …

Experimental Investigations On Mechanical Wear And Corrosion Behaviour Of Sintered Atomet 4601 Based Hybrid Alloys, Palaksha Reddy K

Theses and Dissertations

Powder metallurgy enables the development of new materials to manufacture products for applications requiring unique properties. The present research initially investigates the mechanical and tribological behaviour of powder metallurgy alloys made from ATOMET 4601 prealloyed powder and varying amounts of elemental carbon (0, 0.5, and 1.0 wt%) as reinforcement. ATOMET 4601 is a high-strength, water-atomized prealloyed powder capable of being compressed to higher densities, with applications in producing near-net or net-shaped parts for the industrial field.

Mechanical behaviour studies on sinter-forged ATOMET 4601, ATOMET 4601+0.5C, and ATOMET 4601+1.0C alloy steels revealed increased hardness, tensile strength, and impact strength, with ATOMET …

Identifying School-Wide Inequities: Action Research Conducted Using An Equity Audit To Inform Annual School Planning For A Pre-K–8 School, Janine Casella

Theses and Dissertations

This action research study aims to identify and address equity gaps within a PK-8 New Jersey school by leading a professional learning community (PLC). The study will use action research methods to conduct an educational equity audit, which will inform the annual school plan and create a leadership action plan to stimulate organizational change. Traditionally, teachers at the research site have used Data-Driven Decision Making (DDDM) cycles, but this study will integrate Critical Data-Driven Decision Making (CDDDM) cycles, including an equity audit analyzed in PLCs. The audit will identify patterns of inequity and identify strategies to address them. The study …

Deciphering Evolutionary Co-Option By Studying The Origin Of Self-Fertility In Caenorhabditis Nematodes, Jonathan P. Harbin

Theses and Dissertations

In my research, I examined the characteristics of male and female sex-determination mutants in C. nigoni and investigated the regulatory pathway they define. This work tested whether flexibility in the sex-determination pathway was a preexisting condition that favored the origin of self-fertility in Caenorhabditis. Furthermore, I developed an approach for using interspecies hybrid mutants to assess the robustness of the C. nigoni pathway. My findings showed that the C. nigoni pathway is highly robust and canalized, suggesting that changes leading to self-fertility must have involved the impairment of this canalization in the germ line, to allow eventual alteration of germ …

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods For Peripheral Nerve Regeneration, Jacob Lee Carter

Theses and Dissertations

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A …

School Administrators Making Sense Of Wellness Issues And Technology Policy: A Qualitative Instrumental Case Study, Allyson Michelle Rose

Theses and Dissertations

Technology use has been identified as a key contributor to the decrease in youth mental health (Children’s Bureau, 2019; Lebrun-Harris et al., 2022; Dwyer, 2022; Mojtabai et al., 2016; Yasakci, 2019; Odgers & Jensen, 2020). The purpose of this qualitative instrumental case study was to investigate how school district administrators are addressing wellness issues that are developing in elementary aged students due to technology use. The intent of this study was to use the theory of sensemaking (Weick, 1995) to investigate how administrators create policies that respond to the current wellness crisis arising from technology usage in public elementary school …

Exploring Islamic School Teacher Adaptations To Reduce Cultural Mismatch For Muslim Middle Eastern American Students: A Grounded Theory Study, Zenab Eldreny

Theses and Dissertations

Culturally responsive practices are imperative in American classrooms due to the increasing diversity of the student population. These practices prioritize contextualizing materials, building relationships with students, and leveraging students’ cultural experiences and capital to improve their overall experience in the educational process. However, there is little understanding of the intersection between culturally responsive practices and social-emotional learning frameworks, particularly in contexts beyond the traditional public school environment. This qualitative study employs grounded theory to explore how Islamic school teachers adapt the social-emotional learning curricula to accommodate better Middle Eastern American (MMEA) students' cultural values. Focus groups were conducted to augment …

Elements, Andres L. Sanchez

Theses and Dissertations

Elements is a dissertation that presents my work as an out-of-the-Academy conceptual writer that loves teaching even though I won’t ever teach again. The dissertation includes a critical introduction, “Do You Actually Want to See This?” that seeks to examine conceptual poetry in the light of Sianne Ngai’s stuplimity and Antonin Artaud and Bertolt Brecht’s performance theories so that we may rethink conceptual poetry’s effect on the audience when it is performed. The creative manuscript, “Elements,” is the result of a process stolen from Raymond Queneau to be used on David Hilbert’s The Foundations of Geometry but is instead redirected …

Role Of Customized Visual And Multifactorial Interventions In Preventing Falls Among Individuals With Visual Impairment In South India, Ramya S

Theses and Dissertations

Falls are the second leading cause of unintentional injuries and extensively studied among the elderly. Hence, intervention studies for falls prevention are restricted to the elderly with or without visual impairment (VI). Even among studies with VI, strategies for treatable VI are widely explored. Hence this study aimed to understand falls and interventions that may reduce falls in all the age groups especially among those with untreatable VI.

This mixed methods study included identification of subjects aged ≥ 18 years with VI from clinical records of Medical Research Foundation, Chennai and details of previous history of falls were enquired over …

Discovery Of Small Molecules To Alleviate Heart Disease-Induced Proteinopathy And Proteotoxicity Characteristic Of Alzheimer’S Disease, Nirjal Mainali

Theses and Dissertations

Cardiovascular disease (CVD) is the leading cause of death in the world and in the United States. Reduced cardiac output due to CVD has been previously associated with decreases in systemic and cerebral perfusion. Cerebral hypoperfusion increases the risk of Alzheimer’s disease (AD), accompanied by accumulation of aggregates that feature Aβ amyloid and hyperphosphorylated tau. Protein aggregation is a shared hallmark of aging and neurodegenerative diseases. We previously reported elevated aggregation in hearts of hypertensive and aged mice and now find that aggregation is induced in hearts and brains of male C57BL/6 mice after transient ligation of the left coronary …

Development Of Bio-Based Organogels For The Replacement Of Silicone Elastomers In Cosmetic & Personal Care Applications, Courtney A. Lemasney

Theses and Dissertations

Silicone elastomers (SE) are a major component in many cosmetic and personal care products, providing excellent spreading properties, leaving a dry, silky feel on the skin. Unfortunately, the manufacturing of silicone is a high energy consuming process, and these products are not biodegradable. Capryloyl/glycerin/sebacic acid (CGS) copolymers are an economical, nontoxic platform for synthesizing bio-based materials with tailored properties. These polyester networks are formed through esterification with water as its only side product. By altering feed ratios and reaction conditions, final products can vary from branched fluids to highly crosslinked elastomers. This thesis investigated controlling the crosslink density of the …

Effective Integration Of Waste Plastics In Hot Mix Asphalt Mixtures: Towards Sustainable Infrastructure, Venkatsushanth Revelli

Theses and Dissertations

The study investigated the potential of waste plastics such as low density polyethylene(LDPE), high density polyethylene(HDPE), polyethylene terephthalate(PET) and polystyrene (PS) for designing superior performing asphalt mixtures. Both wet mixing and dry mixing methods were adopted for designing plastic modified asphalt mixtures. Initially LDPE and HDPE were selected for developing plastic modified binders, based on melting characterization, determined from differential scanning calorimeter(DSC). In wet mixing process, the influence of dosage, size of plastic, blending duration and interaction between plastic and asphalt were assessed. Plastics were found to exhibit phase separation with asphalt, while finer particles take only longer to segregate …

Incorporating Culturally Relevant Practices To Improve Self-Efficacy And Engagement For Students With Disability Labels, Jennifer Chestnut Zingaro

Theses and Dissertations

The purpose of this study was to explore the lived experience of middle school students with disability labels in the pull-out resource ELA setting when their teacher included culturally relevant practices. This study utilized qualitative teacher research inquiry methods, and data collection methods included student surveys, teacher journaling of class discussions and observations, and examination of student work samples. This study came about through the lack of culturally relevant pedagogy in the segregated, special education middle school ELA program. Students with disability labels who test below grade level on standardized assessments are placed in a small group, homogeneous classroom with …

Dissecting The Interplay Of Protein Synthesis And Degradation Pathways In Cellular Adaptation To Stress, Brittany Friedson

Theses and Dissertations

Adaptation to stress requires cells to reprogram transcription, translation, and proteolytic pathways. Although much is known about the response of each program, it remains unclear how they coordinate following stress. My studies in S. cerevisiae identified the Cdk8 kinase module (CKM) of the Mediator complex as a new player in coordinating these processes. It is well established that the CKM consists of four highly conserved proteins (cyclin C, its cognate kinase Cdk8, and two structural proteins Med12 and Med13) and predominantly represses a subset of stress responsive genes in yeast. We demonstrated for the first time that the CKM also …

Computational And Experimental Advances In Nuclear Magnetic Resonance For High Resolution Structures, Ryan Toomey

Theses and Dissertations

Since its inception, nuclear magnetic resonance (NMR) has been a valuable tool for determining chemical structure. In recent years, the field of NMR has been advanced forward by the ability to calculate theoretical parameters with increasing accuracy and efficiency. These calculations are compared to experimental data to produce high resolution structures. The progression of these applications has been made possible by improved instrumentation, data processing methods, probe and experiment design, better quality functionals and basis sets, as well as increased computational power. This research is especially relevant with the emergence of artificial intelligence, which has great potential to expedite steps …

Locating Diversity In Reservoir Computing Using Bayesian Hyperparameter Optimization, Whitney Lunceford

Theses and Dissertations

Reservoir computers rely on an internal network to predict the future state(s) of dynamical processes. To understand how a reservoir's accuracy depends on this network, we study how varying the networ's topology and scaling affects the reservoir's ability to predict the chaotic dynamics on the Lorenz attractor. We define a metric for diversity, the property describing the variety of the responses of the nodes that make up reservoir's internal network. We use Bayesian hyperparameter optimization to find optimal hyperparameters and explore the relationships between diversity, accuracy of model predictions, and model hyperparameters. The content regarding the VPT metric, the effects …

Low-Power Sensor Design And Fusion To Edge Devices For High-Speed Object Detection And Enhanced Soldier Situational Awareness, Scott Patrick Wood

Theses and Dissertations

Threat detection and physiological monitoring of soldiers from fused sensor data collected in real time is currently limited to running deep neural networks with substantial computing needs. The lack of data acquisition from sensor readings and efficient detection of novel enemy signatures motivates the need for a low-power, low-cost, wireless multisensor fusion computing system. We propose the current trends in Internet of Things to deploy a chargeable, wireless multi-channel acquisition system that can be interfaced to a high speed, Single Board Computer (SBC) such as the NVIDIA Jetson Orin capable of running object detection models, such as YOLOv7-tiny to enable …

Improving Ligand Pharmacokinetics Via Bioisosteric Substitution Of Amides With 1, 2, 3-Triazoles While Maintaining Dopamine D4 Receptor Selectivity And Potency, Mohammad Alkhatib

Theses and Dissertations

Several neurophysiological functions, such as attention, cognition, and emotional regulation, are regulated by the binding of dopamine on G-Protein coupled receptors. D4Rs are mainly located in the prefrontal cortex and the hippocampus and are known to have a key role in decision-making, memory formation, cognition, and attention. Administration of D4Rs- selective ligands during the preclinical studies enhance the outcomes and the results in animal models suffering from neuropsychiatric disorders, including ADHD, substance use disorders (SUD), and Alzheimer's disease. Recently, we reported a group of D4R-selective ligands with different efficacies depending on their phenylpiperazine ring scaffold to illustrate D4R function during …

Structural And Functional Correlates Of The Sleep-Suicidal Ideation Association, Jolynn Jones

Theses and Dissertations

Each year, about 800,000 individuals die by suicide globally, affecting millions more. Mitigating suicide risks by targeting modifiable factors such as the sleep disturbances of insomnia and nightmares, which are prevalent and linked to suicidality is important. This study investigated the structural and functional brain differences related to sleep disturbances and suicidality, with the anterior cingulate (caudal and rostral), insula, middle frontal gyrus, posterior cingulate, thalamus, amygdala, and orbitofrontal cortex as seed regions. Participants had no history of suicidal ideation (NSI; n=43) or suicidal ideation within the past two weeks (SI; n=25). Measures for analyses included the Insomnia Severity Index …

Identifying The Challenges That Hinder Research Productivity In Academia: Evidence From Somaliland And The Way Forward., Khalid Jama

Theses and Dissertations

In any nation, research is the primary force behind innovation and progress. It contributes to the Economic growth, global competence, and social progress. Research productivity is highly valued in the scientific community. Scientific community research is regarded as the key factor determining academic recognition, financial support, and academic recognition. Nonetheless, the output of research faces difficulties in many sub-Saharan African nations. This study aims to understand what limits the research publication in Somaliland. The study adopt a mixed methods approach to understand and analyze the main reason behind the research and publication limitations in Somaliland’s higher education. Individuals from various …

A Study To Explore How People Evaluate The Quality Of Their Medical Information From The Social Media For Celiac Disease, Phillip Arnold

Theses and Dissertations

Every day, millions of people visit various social media platforms to post updates on their daily lives, to search for information, and to repost and/or potentially like posts on social media. This has led to scores of pieces of misinformation appearing on these social media posts. While some misinformation can be harmless and disregarded by the general public, there are various subject matters, including medical treatments and diseases, where misinformation on the treatment and other various subjects involving the disease can lead to dire consequences. This research proposes to investigate how social media users vet their data on two different …

Developing Coexpression Systems To Introduce Hydroxyproline Into Protein Engineered Collagen Peptides Utilizing Hydroxylase From Acanthamoeba Polyphaga Mimivirus, Jennifer Soldatich

Theses and Dissertations

A major challenge of developing collagen mimetic peptides (CMPs) by bacterial expression is to include hydroxyproline for biomedical applications. Coexpression of Prolyl-4-hydroxylase from A.mimivirus with CMPs was investigated. Additionally, four expression designs were created for potential applications in mammalian cells to utilize their natural ability of proline-hydroxylation by post-translational modification.