Digital Commons Network^™

Targeting Als: A Multi-Cellular Study On The Potential Therapeutic Role Of Azole-Based Compounds, Alisha R. Kennedy

Theses and Dissertations

Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that leads to the degeneration of motor neurons, which control voluntary muscle movements such as eating, speaking, and breathing. As these neurons are damaged, voluntary movement ceases, leading to a fatal outcome. The survival time of ALS patients varies, ranging from a few months to up to 10 years. Chapter 1 of this thesis provides an overview of ALS, highlighting the role of transactive response DNA-binding protein 43 (TDP-43), a key feature in ALS and other neurodegenerative diseases. The aggregation of TDP-43, particularly due to …

Purification Of Recombinant His6-Gfp-Preptin Fusion Protiens, Apoorva Kollaram

Theses and Dissertations

Preptin, a 34-amino-acid peptide derived from proinsulin-like growth factor II, has emerged as a promising therapeutic candidate for both Type 2 diabetes mellitus and osteoporosis. Its dual functionality—stimulating insulin secretion without inducing hypoglycemia and promoting osteoblast proliferation—positions it as a unique alternative to traditional sulfonylureas and osteogenic agents. In this study, we developed a purification protocol for green fluorescent-preptin fusion proteins. These fusion proteins will be used to investigate the functional significance of residues Pro17, Val18, Gly19, Trp27, Lys28, and Gln29 in rat preptin, which shares high sequence similarity with the human form. Site-directed mutagenesis was performed using NEB Q5 …

To Be Loved Is To Be Seen: Gazing As A Form Of Interpretation In The Turn Of The Screw, Yasmin Mezayek

Theses and Dissertations

The heated discourse that would follow Henry James’s novella “The Turn of the Screw” centered on whether the ghosts were real or not. With Shoshana Felman’s groundbreaking article “Turning the Screw of Interpretation” a new-found focus on the ambiguities, as opposed to finding a singular, definitive meaning of the novella would usurp the Freudian and anti-Freudian arguments. With the governess’s sight being the main source of debate, reading the novella through the Lacanian lens of the Gaze, the Imaginary, and the Symbolic offer unprecedented explanations and arguments for the governess’s behavior. Given the contemporary shift to discussing the ambiguities of …

Riverside Readings: Audio Drama Development And Implementation Plan, Trent P. Mylie

Theses and Dissertations

The current state of media includes broadcasting, podcasting, and a new yet familiar form of accessible media through streaming. Numerous examples illustrate the significance of broadcasting and counter the notion that it is a niche or outdated form of media. Younger generations, including mine, have grown up in an era rich in media, witnessing the dawn and resurgence of formats that once seemed lost. As we transition into a collegiate environment, we seek to channel our creativity through a medium; for us, that medium is radio and podcasting. Riverside Readings allows individuals to explore their creative passions and engage in …

Qlorax: Heuristic-Guided Fine-Tuning Of Llama-2 For Domain Adaptation In Entrepreneurship, Gaurob Saha

Theses and Dissertations

This thesis presents a study on the fine-tuning of large language models (LLMs) for domain-specific applications using limited data. We fine-tuned the LLaMA-2 (7B) model on a curated entrepreneurial dataset containing 3,545 human-written question-answer pairs, of which 3,095 were used for training and 450 were reserved for evaluation. A complete fine-tuning and evaluation pipeline was developed, which included clustering human-written answers, generating centroid-based summaries for each cluster, and evaluating the model's generated responses through cosine similarity.

Training was carried out over five epochs, with model performance evaluated after each epoch. The fine-tuned model demonstrated strong semantic alignment with human-written content, …

Understanding Women’S Attitudes Toward Midwifery Practices For Maternal Care In Middle Georgia, Kristen M. Simpson

Theses and Dissertations

Compared to other high-income countries, women in the United States are more likely to die from problems related to pregnancy and childbirth. In Georgia, maternal mortality is particularly acute. Midwifery models of maternal care have been shown to produce positive pregnancy and childbirth outcomes for patients, but these services are underutilized in Georgia. This study sought to identify women’s attitudes toward midwifery, what contributed to those attitudes, and what influenced women in Middle Georgia to seek midwifery services using a qualitative, Grounded Theory approach. Three participants who self-identified as having used a midwife before were interviewed using a semi-structured protocol. …

Lights, Camera, Action: A Student's Perspective On Reimagining Film Production Opportunities, Ma'lon I. Lane

Theses and Dissertations

The pursuit of a crew job in the film industry is a multifaceted endeavor, offering various pathways that cater to diverse aspirations and circumstances. Central to this exploration is the question of whether attending a university and obtaining a degree in film is essential for success. I was determined to answer the following: What is the likelihood that a higher education in Film Production leads to more efficient job acquisition in the film industry? The project is considered narrative, originating from the personal quality of the research questions. I used my resources to gather qualitative data through interviews of film …

Exploratory Data Analysis (Eda) And Predictive Machine Learning (Ml) For Buildings’ Energy Fault Detection, Akshith Nukala

Theses and Dissertations

Building energy load fault detection is a critical challenge in energy usage analysis. It helps uncover energy wastage, machinery/appliance degradation or inefficiency, and failures or faults in buildings’ HVAC (heating, ventilation, and air conditioning) systems. Early identification of machinery failure and energy wastages due to operational maintenance negligence in large sites such as campus buildings is indispensable for achieving energy efficiency. This is crucial for saving patrol and minimizing the response time to restore the building appliances or systems to their optimal state.

Advancements in state-of-the-art AI/ML data-driven algorithms and techniques enabled us to build accurate, efficient and scalable fault …

Leadership Traits Which Improve School Climate Star Ratings And Ccrpi Single Scores In Georgia K-12 Urban Schools: A Mixed-Methods Study, Rodney D. Jordan

Theses and Dissertations

The purpose of this mixed methods study was to investigate the relationship between the self prescribed leadership styles of principals with the teacher perceptions of those leadership styles and how that difference may impact school climate ratings and College and Career Readiness Performance Index (CCRPI) single scores in Georgia urban K-12 schools. The quantitative method was used to examine quantitative differences related to these two components of Georgia’s state accountability model. The qualitative method was used to explore teachers’ perceptions of the influence of leadership style on climate star ratings and CCRPI single scores. Quantitative data was collected through the …

The Impact Of Pre-Kindergarten Programs On Literacy Achievement In Primary Grades In Rural Southeast Alabama Title I Schools, Courtney Sonntonya Thorton

Theses and Dissertations

The purpose of this study was to examine how pre-kindergarten impacts the literacy achievement of students in Alabama Title I schools. This quantitative study employed a causal-comparative (ex post facto) research design to examine the impact of Alabama’s First-Class Pre-K (FCPK) program on early literacy and school readiness, as measured by the Dynamic Indicators of Basic Early Literacy Skills (DIBELS) and the Alabama Early Learning Inventory (AL ELI). The design was selected due to its appropriateness for studying naturally occurring groups and its capacity to explore potential cause-and-effect relationships without researcher-controlled intervention.

The independent variable was Pre-K attendance (attendee vs. …

Flavorful Foes: Assessing Students’ Perceptions Of Processed And Fast Food And Its Health Implications., Soumi Roy Banerjee

Theses and Dissertations

High fast-food consumption is a common public health concern due to its link to a number of non-communicable diseases and mental health, but increased consumption of processed food, rapid urbanization, and changing lifestyles have led to a shift in dietary patterns. People are consuming more foods high in energy fats and free sugars. This mixed methods study was conducted at a college campus in Georgia, to assess knowledge and understanding of the students between the ages of 18 and 22 years about highly processed Fast Food, and its effects on health. Forty student participants were chosen through convenience sampling and …

Why A Healthy Diet Is Important For Women's Health, Halley Doster

Theses and Dissertations

Nutrition plays a critical role in women’s reproductive health, yet many women face barriers to maintaining a balanced diet. This study aimed to examine the relationship between nutritional intake and reproductive health outcomes among women of reproductive age, as well as to assess their knowledge and challenges related to healthy eating. Using a cross-sectional survey design, data were collected from 50 women at a community health center and analyzed using SPSS to generate descriptive statistics and explore patterns through chi-square and regression analyses. Findings revealed that most participants had moderate to low fruit and vegetable intake, and fewer than half …

Attacking Diabetes One Day At A Time, Kyla Duncan

Theses and Dissertations

The "Attacking Diabetes One Day at a Time" initiative targets the growing concern of public health, type 2 diabetes, among under-reserved communities. This comprehensive care program emphasizes the importance of prevention through education, improving lifestyles, and access to care. Based on insights from the Self-Care Management Theory, this initiative seeks to provide individuals with sound, culturally tailored strategies that reduce disease risk and help them manage healthy lifestyles. Major components include educational workshops, and resource navigation. The success of this program, from community engagement through evaluation on a phased implementation plan, is guaranteed. The expected outcomes of this work will …

Online Parameter Adaptation Of Lqr Controllers Via Rls For Prosthetic Joint Control: Experimental Validation On A Quanser Qube-Servo 2 Platform, Cynthia Lopez-Jordan

Theses and Dissertations

This thesis develops and experimentally validates an online adaptive Linear Quadratic Regulator (LQR) control method for prosthetic joint systems using Recursive Least Squares (RLS)-based real-time parameter estimation on the Quanser QUBE-Servo 2 platform. Traditional LQR controllers assume a fxed system model, which limits adaptability and results in reduced tracking accuracy, poor robustness, and loss of optimal performance when applied to dynamically changing prosthetic joints, infuenced by load variations, user gait changes, and mechanical wear. Limited experimental validation exists for combining RLS with online LQR adaptation in prosthetic-like systems.

To address these limitations, an RLS-driven Adaptive LQR framework was implemented to …

An Analysis Of Coal Ash Pollution In The State Of Georgia, Mick W. Etchison

Theses and Dissertations

This social science paper will explore the factors contributing to the prevalence of coal ash in specific regions of Georgia and its impact on local ecosystems and human health. It provides an analysis of the current environmental and political issues surrounding the containment and spread of coal ash throughout the State. Coal ash is primarily found in the central, southwestern, and northeastern regions where coal-fired power plants and coal ash storage sites are located. The paper will then discuss the political, economic, and legal reasons behind the lack of effective regulation and mitigation of coal ash spread. Coal ash illustrates …

Analysis Of Technology Skill Requirements For Entry-Level Accountants, Jiane Louella Tolentino Rabara

Theses and Dissertations

This study examines the evolving impact of emerging technologies on skill requirements for entry-level accountants. Using a mixed-method approach that combines literature review and quantitative analysis of 2,257,082 job postings from 2021 to 2024 provided by the Butler Center for Research and Economic Development, the study evaluates trends in employer expectations across firm sizes and time. Chi-square tests revealed significant changes in the proportion of postings requiring technological skills (χ² = 117,672, df = 3, p < .001), indicating a shift in how technology-related competencies are presented in job ads. Specifically, while previous job postings often included general technical skills alongside traditional accounting tasks, recent job postings increasingly emphasize advanced or specialized technologies—such as ERP systems, cloud accounting platforms, and automation tools. This shift suggests that employers are moving away from broad technical expectations toward more targeted skill sets, reflecting the evolving technological demands of the profession. A separate chi-square test found a significant relationship between technological skill requirements and job ad duration (χ² = 2,309.57, df = 4, p < .001). However, no consistent pattern of longer posting duration was observed for technology-oriented roles. Literature-based synthesis further showed that large accounting firms continue to demand more advanced technological competencies than smaller firms. Overall, while traditional accounting skills remain predominant, the findings indicate a transition toward more specialized technological expectations in the entry-level accounting role.

From Curiosity To Controversy: American Perception Of Japanese Immigrants, 1853-1924, Chloe Elizabeth Curbelo

Theses and Dissertations

In the mid-nineteenth century, as the United States reached the Pacific through westward expansion, Asia emerged as a new stage for commerce and power. Japan, long isolated under the Tokugawa shogunate, became an object of American fascination when forced into relations. While early depictions cast Japan as an exotic yet uncivilized nation in need of Western guidance, Japan’s rapid modernization and the growing number of Japanese immigrants on the West Coast transformed curiosity into anxiety. My paper traces this evolution of perception from 1850 to 1924, arguing that shifting views of Japan and its people reflected America’s ethnocentric notions of …

Correlations Between Parasocial Tendencies And Self-Esteem Among Romance Readers, Evelyn Smith

Theses and Dissertations

The present study evaluated the correlations between romance readership and paralove strength, as well as paralove strength with self-esteem. With the popularization of the romance genre, previous qualitative studies have shown that readers of romance books receive mood benefits from consuming these novels, as well as social benefits that they apply to their real-life relationships. Additionally, low self-esteem has been shown to have a major effect on relationship satisfaction and the perception of rejection with real-life relationships, but not parasocial relationships. The researcher hypothesized that as romance readership increased, so too would paralove scores, and that as paralove scores increased, …

Exploring Career Advancement Experiences Of Black Women In The National Used Car Industry, Christina Anderson

Theses and Dissertations

Black women’s workplace experiences in the national used car industry affect their career advancement opportunities. How can we account for these experiences and outcomes? Using intersectionality as a theoretical framework, this thesis examines how overlapping identities, such as race and gender, intersect to create unique experiences of oppression or privilege. Intersectionality as a theoretical framework can also explain the double marginalization that Black women often experience in specific industries, as the stereotypes associated with their race and gender combine and contribute to fewer opportunities for career advancement. As a result, Black women must be diligent when confronted with the stereotypes …

How Do School Counselors And School Social Workers Support High School Bullying Victims: A Qualitative Exploratory Case Study, Dalentina N. Robertson

Theses and Dissertations

Bullying and student aggression are increasing in public high schools. Bullying and cyberbullying are a safety concern, and victims of bullying have shown a decline academically and emotionally. Additionally, high schools need increased support with bullying behaviors. The purpose of this exploratory case study was to explore school counselors’ and school social workers’ insights and perspectives regarding the support they provided to bullying victims in two school districts in rural Georgia. Bronfenbrenner’s Ecological Systems Theory was the framework used to focus research on understanding how environmental systems influence an individual’s development. Semi-structured interviews were conducted from a purposeful sample of …

Cultivating Mindsets And Transformative Practices Of Beginning Alternative Certified Teachers: A Teacher Perception Study, Rodney Keith Wilkerson

Theses and Dissertations

The shortage of qualified teachers in the United States has been a persistent issue for decades. The number of qualified candidates to fill teaching vacancies has fallen short as the number of teachers needed to educate today continues to increase (Carothers et al., 2019). Traditionally, teacher preparation programs were the primary source of certified teachers. However, these programs have been decimated by declining student enrollment and by criticisms that they do not meet the needs of prospective teaching candidates today (Darling-Hammond, 2020). In recent years, the shortage has become even more acute, with some regions facing severe teacher shortages (Carothers …

She Works Hard For The Money: Black Women Entrepreneurs, Business Networks, And Entrepreneurial Success, Dejuan Erica Price

Theses and Dissertations

Although Black women launched an estimated 2.08 million businesses in 2023 (accounting for 14.8% of all women-owned firms), they remain significantly underrepresented among high-growth, well-capitalized enterprises. This paradox highlights the need for deeper examination of the structural and social factors that shape their entrepreneurial experiences and outcomes. Using an exploratory sequential mixed-methods approach, this study examined how network structure, networking behaviors, personal motivations, and social contexts influence entrepreneurial success among Black women founders. The qualitative phase revealed how faith, emotional labor, social isolation, and cultural values shaped participants’ definitions of success and approaches to entrepreneurship. Founders emphasized purpose, healing, and …

African American Vernacular English: A Qualitative Study On Its Use In American Foreign Language Classrooms, Rickkay L. T. King

Theses and Dissertations

This qualitative research study examines how foreign language (FL) instructors perceive Black students' use of African American Vernacular English (AAVE) in the classroom. Historically, negative connotations of AAVE have colored the perspectives of the general public and educators alike. This collective case study of FL instructors gathered in-depth data through semi-structured interview questions. These research findings have the potential to impact world language curriculums in America positively, particularly those tailored to students with home language backgrounds different from Standard American English (SAE). Despite increasing overall college enrollment and bachelor’s degree attainment, Black students continue to have some of the lowest …

Critical Success Factors For U.S. Fintech Startups In The Post-Covid-19 Era: Applying The Entrepreneurial Ecosystem Framework, Wen Hua

Theses and Dissertations

The extradentary surge of financial technology (fintech) enterprises has fundamentally transformed contemporary financial markets, yet extant scholarly literature exhibits a notable absence of a unified and theoretically grounded framework for explicating fintech startups’ success (Hamza et al., 2025). This dissertation addresses this theoretical lacuna by synthesizing an integrative entrepreneurial ecosystem framework to illustrate the critical success factors (CSFs) that catalyze fintech venture performance (Conley, 2014). Drawing upon established theoretical foundations, this research employs a multi-method research design, and develops a comprehensive framework for fintech startup companies’ success. The methodological approach commenced with a systematic meta-analysis of theoretical paradigms, establishing a …

From Silos To Synergy: A Multi-Case Study Of The Enablers And Inhibitors Of Successful Post-Acquisition Technology Platform Integration, Nasario Mejia

Theses and Dissertations

Mergers and acquisitions (M&A) have long been an important strategy for achieving growth. Levels of M&A have been increasing over the past 10 years. An enduring challenging problem post M&A is the effective integration of the technology platforms of the acquired and acquiring firms. This study investigates the enablers and inhibitors of successful post-acquisition technology platform integration (PATPI) through the lens of interdependent People, Process, Technology, and Data capabilities. Based on data collected from interviews with senior leaders combined with publicly available secondary data, a multi-site qualitative comparative case study analysis was used to identify enabling and inhibiting platform integration …

Psychotherapy And Changes In Adult Attachment: A Systematic Review, Meghan Kussman

Theses and Dissertations

Attachment insecurity is a transdiagnostic vulnerability factor linked to a wide range of emotional and relational difficulties. Although early attachment patterns tend to be relatively stable, research indicates that attachment orientations can change over time, particularly in response to significant relational or therapeutic experiences. This systematic review examined 39 empirical studies published between 2000 and 2024 to determine whether engagement in psychotherapy is associated with changes in adult attachment security. Eligible studies assessed attachment both pre- and post-treatment using validated self-report measures (e.g., Experiences in Close Relationships Scale; ECR) or interview-based measures (e.g., Adult Attachment Interview; AAI), and reported statistically …

Evidence-Based Treatments With Chileans, Caleb James Sheldrup

Theses and Dissertations

A dearth of research exists regarding evidence-based interventions for Chileans as well as research on barriers to mental health care services. In particular, there is a lack of research on adapting evidence-based practices in the Chilean context. This review examined the existing literature and succinctly discussed the existing interventions and adaptations. This review posed the following questions: (a) Which existing mental health interventions have evidence of effectiveness with Chilean populations? (a1) What are the core features of effective interventions for Chileans? (b) Which cultural adaptations are most effective at modifying mental health treatments for Chileans? (c) What adaptations are being …

Purpose-Driven Curriculum For 9th-12th Grades For Adulthood Careers & Life Gratification, Destiny Krystle Chioma Nnadozie

Theses and Dissertations

A purpose-driven or purpose-based curriculum is not the standard required for high schools in the United States. Students in grades 9th-12th are educated based on a curriculum that covers mathematics, English, science, and social studies (De Roux & Riehl, 2022; Xiao et al., 2018). The unique individual purpose of each student, realized while in high school, is not considered a priority, leaving students to enter their adult careers lacking true career fulfillment due to this misalignment (Baroudi et al., 2017; S. Lyons et al., 2015; H. Wu, 2024).  Using a qualitative systematic review research design, this study aimed to explore …

The Influence Of Fictional Storytelling On The Student Experience In A Gamified Classroom, Arrash Jaffarzadeh

Theses and Dissertations

This exploratory case study evaluated how the use of gamification and game-based learning (GBL) with the added element of storytelling affected engagement and attitudes of children ages 9 to 13 as they participated in quests to complete their learning objectives.  Archived artifacts of a computer technology class in a northern California private school using the Applied Computer Technology Education (ACTE) framework taught to grade 4-8 provided the data for the study.  Each quest was comprised of a fictional story that tied to the lesson. These stories involved the three archetypes of the warrior (herald), healer (ally), and mage (trickster) on …

Best Practices Of Vietnamese Catholic Priests Leading Vietnamese Community Parishes In Orange Diocese, Phuc Viet Nguyen

Theses and Dissertations

The Catholic Church is the largest church all over the world and is also the largest one in the United States (Pew Research Center, 2013). Over the past decades, great crises inside the Catholic Church have raised significant concerns for its leadership practices, especially for its governance and administration on the diocese and parish level. Moreover, the issue of immigrants also compounds the problem when there are different ethnic communities inside one single parish. In some dioceses like Orange County, which is one of the most culturally diverse dioceses in the United States (Diocese of Orange, 2018), the urgency of …