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Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy Dec 2026

Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy

Theses and Dissertations

Physiological vital-sign forecasting estimates future measurements based on recent temporal patterns and can support analysis of continuously recorded monitoring data. This study comparatively evaluated deep feedforward, recurrent, bidirectional recurrent, long short-term memory, and bidirectional long short-term memory architectures for one-step-ahead forecasting of peripheral oxygen saturation, heart rate, and pulse rate. Each model received consecutive observations of peripheral oxygen saturation, heart rate, pulse rate, respiratory rate, and age, while separate single-output models predicted the next value of the selected target.

Random and patient-wise data splitting were compared using identical input definitions, preprocessing procedures, model architectures, and training hyperparameters. The strongest architecture …


A Fundamental Study Of Fatty Acid Ionic Liquids And Their Effects On Biomolecules, Achismita Dutta Sep 2026

A Fundamental Study Of Fatty Acid Ionic Liquids And Their Effects On Biomolecules, Achismita Dutta

Theses and Dissertations

Fatty acid ionic liquids (FAILs) are a class of ionic liquids (ILs) with relatively low toxicity and potential applications in biological systems. This study examined the interactions of tetramethylguanidinium decanoate, tetramethylguanidinium octanoate, choline decanoate, and choline octanoate with lipid membranes, proteins, and nucleic acids. Membrane leakage experiments using model lipid vesicles showed that decanoate-based FAILs produced greater membrane permeabilization than octanoate-based analogues, consistent with their higher membrane permeability. These effects were stronger for the ILs than for decanoate alone and occurred below the critical micelle concentration (CMC), suggesting that micelle formation may not be essential for membrane disruption. The ability …


A Hybrid Rule-Based And Large Language Model Framework For Extracting Acronym–Definition Pairs From Scientific Literature, Petro Skrypnyk Sep 2026

A Hybrid Rule-Based And Large Language Model Framework For Extracting Acronym–Definition Pairs From Scientific Literature, Petro Skrypnyk

Theses and Dissertations

Authors of scientific papers rely heavily on acronyms and often use them without defining them, making the literature harder to read and index. This thesis develops and evaluates a hybrid rule-based and large language model (LLM) framework that extracts acronym–definition pairs from scientific PDF documents. It extends an earlier Rowan University system that combined a regular-expression parser with a single LLM on 200 papers. That system showed that neither the parser nor the LLM alone is sufficient for accurate extraction of the pairs. The framework is a fully automated pipeline from PDF input to scored results. It compares four LLM …


Effects Of Social Comparison Instructions On Affect, Motivation For Healthy Behavior, And Health Behavior Selections: Guidance To Identify Or Contrast, Raj Harsora Sep 2026

Effects Of Social Comparison Instructions On Affect, Motivation For Healthy Behavior, And Health Behavior Selections: Guidance To Identify Or Contrast, Raj Harsora

Theses and Dissertations

Engaging in healthy behaviors early in life is crucial for preventing noncommunicable diseases such as type 2 diabetes, cancer, and heart disease. College is an optimal period to establish these habits, yet students often engage in poor dietary and physical activity practices; thus, identifying effective health behavior change techniques for this population is essential. Social comparisons are known to influence health behaviors, yet no research has tested comparison instructions as a behavior change technique, particularly identification versus contrast with upward and downward targets. Using a preregistered protocol (https://osf.io/z29en), we tested whether guiding college students (N=664) to identify with or contrast …


Problematic Technology Use And Quality Of Life In College Students With Varying Levels Of Schizotypy, Joseph P. Skinner Sep 2026

Problematic Technology Use And Quality Of Life In College Students With Varying Levels Of Schizotypy, Joseph P. Skinner

Theses and Dissertations

Problematic Technology Use (PTU) has emerged as a growing concern with technology’s continual integration into daily living. Individuals higher in schizotypy may be particularly vulnerable to the negative consequences of digital environments. The present study cross-sectionally examined associations among schizotypy, PTU, and quality of life (QOL) in 533 college students using structural equation modeling. Consistent with hypotheses, greater total schizotypy was associated with higher PTU and lower QOL. Additionally, positive, negative, and disorganized schizotypy all uniquely predicted poor QOL with the negative domain demonstrating the strongest standardized association. Contrary to hypotheses, PTU did not significantly moderate the relation between total …


Struggling Readers Collaborate On Reading Interventions For Fifteen Minutes A Day, Jordan Dobzanski Sep 2026

Struggling Readers Collaborate On Reading Interventions For Fifteen Minutes A Day, Jordan Dobzanski

Theses and Dissertations

This thesis examines what happens when struggling readers collaborate on reading intervention practices for fifteen minutes a day. Relevant theories that guided this research included Bandura’s Social Learning Theory, Vygotsky’s Social Constructivist Theory, and Lankshear and Knobel’s New Literacies Theory. Throughout the six-week study, four third-grade students identified as below grade level participated in a collaborative reading intervention that focused on vocabulary development, fiction and informational text comprehension, student-led discussions, digital literacy activities, and reflective journaling. Students worked together in structured literature circles while engaging in literacy activities connected to their classroom curriculum. Data were analyzed through triangulation in order …


Polymer Nanocomposite Dielectrics For High-Temperature Superconducting Cables: Cryogenic Characterization And Testing Environment Development, Jared R. Ericksen Sep 2026

Polymer Nanocomposite Dielectrics For High-Temperature Superconducting Cables: Cryogenic Characterization And Testing Environment Development, Jared R. Ericksen

Theses and Dissertations

High-temperature superconducting (HTS) cables require dielectric insulation materials that can withstand cryogenic operating environments while maintaining electrical reliability, mechanical stability, and manufacturing compatibility. This thesis investigates polyamide-based polymer nanocomposites as candidate HTS cable insulation materials and develops cryogenic testing platforms for evaluating thin-film dielectrics at reduced temperatures. Two silicon-based filler systems are studied: sol-gel-derived silicon dioxide (SiO 2 ) nanoparticles and polyhedral oligomeric silsesquioxane (POSS). Dielectric breakdown behavior is evaluated under DC and AC high-potential testing, while mechanical behavior is assessed through tensile testing. The results show that PA/SiO 2 nanocomposites provide the strongest overall balance of mechanical reinforcement and …


“Voices Of Tomorrow”: A Youth Participatory Action Research Study Of A Middle School Advisory In An Urban Public Charter School, Seth Hull Sep 2026

“Voices Of Tomorrow”: A Youth Participatory Action Research Study Of A Middle School Advisory In An Urban Public Charter School, Seth Hull

Theses and Dissertations

Urban middle schools often grapple with how to create spaces that affirm students’ identities and foster authentic engagement within a broader landscape shaped by standardized testing and accountability pressures. This dissertation examines Youth Participatory Action Research (YPAR) and advisory as two relationally grounded practices that can address these challenges. Grounded in critical hope (Zembylas, 2013), culturally sustaining pedagogy (Paris & Alim, 2017), and community responsive education (Duncan-Andrade, 2022), the study explores the experiences of 12 middle school students who spent seven months investigating their school’s advisory program as student-researchers, as well as the findings that emerged about advisory. Data sources …


A Framework For Automated Quantity Extraction From .Ifc Models And Normalized Bid Comparison, Asmaa Mohamed Farouk Sep 2026

A Framework For Automated Quantity Extraction From .Ifc Models And Normalized Bid Comparison, Asmaa Mohamed Farouk

Theses and Dissertations

Accurate bid comparison remains a major challenge in construction tendering due to

differences in Bill of Quantities formats, item naming conventions, and pricing methods across

contractor submissions. These variations require time-consuming manual work and often lead to

subjective decisions. This research presents a computational framework that uses Building

Information Modeling through the .ifc file format, combined with text analysis techniques for

automated bid normalization.

The developed system uses a dual-component approach. Phase 1 extracts quantities from .ifc

model files using 3D geometric calculations, automated element classification. Phase 2 uses text

mining with a domain-specific dictionary of construction terms to interpret …


The Game Within: An Anthropological Approach To Games And Play, Nehal Maged Mohamed Sep 2026

The Game Within: An Anthropological Approach To Games And Play, Nehal Maged Mohamed

Theses and Dissertations

This thesis is based on an eighteen-month ethnography of El Ghawasa, an Egyptian play-based organization that designs educational games, tools, and services. Claiming that El Ghawasa, with its ethos of play, seeks to create an alternative to the capitalist corporate structure. Through tracking how this organization navigates ruptures, negotiates constraints, and experiments with different practices and internal restructuring, I explore the possibilities and limitations of El Ghawasa, while attempting to resist absorption by the very system it opposes. I ask: when the rules keep changing (while the logic of the capitalist corporate structure remains the same), and the boundaries of …


Workers Authoring Assessment: Play And Power In Early Childhood Education, Phoebe M. Gilpin Aug 2026

Workers Authoring Assessment: Play And Power In Early Childhood Education, Phoebe M. Gilpin

Theses and Dissertations

Researchers assert that play-based pedagogy is an effective approach to teaching young children, but there is less consensus on the specific methods of play-based teaching. This mixed-methodology exploratory case study investigated early childhood (EC) educators’ conceptualizations of play-based pedagogy in three phases: Phase 1’s quantitative measure testing found a mismatch between researchers’ conceptualization of play-based pedagogy and EC educators’ (n=183) understandings. In Phase 2, EC educators (n=3) articulated their perspectives about teaching through play and co-authored a new tool, the Teacher-Authored Play and Teaching Scale (TAPTS). Within Phase 3, EC educators (n=60) completed the TAPTS, which I interpreted through a …


Dual-Polymer Concrete With Recycled Pet And Hdpe Aggregates: Mechanical And Durability Performance Assessment, Omar Abd El Mageed Hammouda Aug 2026

Dual-Polymer Concrete With Recycled Pet And Hdpe Aggregates: Mechanical And Durability Performance Assessment, Omar Abd El Mageed Hammouda

Theses and Dissertations

This study investigates the fresh, mechanical, durability, thermal, performance as well as preliminary financial aspects of dual-polymer concrete incorporating recycled polyethylene terephthalate (PET) as a partial replacement for fine aggregate and recycled high-density polyethylene (HDPE) as a partial replacement for coarse aggregate, with silica fume as a supplementary cementitious material held constant at 10% by weight of cement. The study responds to the convergence of two pressing challenges in the Egyptian context: the scale of plastic waste mismanagement, which results in widespread informal open burning and environmental contamination, and the high operational energy demand of residential buildings in Egypt's hot …


Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair Aug 2026

Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair

Theses and Dissertations

Solving right-triangle problems as well as integrating right-triangle and circular trigonometry into a coherent understanding are documented challenges for students. Prior research has deeply investigated students constructing ratio meanings for sine and cosine using a circle-first approach, which then can be extended to right triangles. Also, past work has separately documented distinct meanings that are useful for sine and cosine, in addition to the ratio meaning, including as lengths in a unit circle and coordinate points. This study took these existing ideas and put them together into one possible developmental progression, based on APOS theory, where students can learn length, …


Actionable Hydrologic Data To Information With National Water Model-Based Derived Dataset, Cutting-Edge Data Services, And Agentic Ai System, Sujan Chandra Mondol Aug 2026

Actionable Hydrologic Data To Information With National Water Model-Based Derived Dataset, Cutting-Edge Data Services, And Agentic Ai System, Sujan Chandra Mondol

Theses and Dissertations

Hydrologic data are the cornerstone of many complex hydrologic research and operational workflows that produce useful hydrologic information for water resources decision-making, flood risk communication, and water availability implications. The National Water Model (NWM) is a valuable source of hydrologic data, particularly for its extended coverage of unmonitored streams and the large-scale continuity of hydrologic processes. Precomputed secondary datasets derived from this simulated data, such as streamflow indices, can improve operational efficiency through thresholding. Disseminating the data through modern technologies, such as application programming interfaces, is required for ready integration into applications. However, if extraction requires an intermediate service, there …


"Tithing Is An Insurance Premium": A Framing Analysis Of Speaker Innovation And Diachronic Trends In Latter-Day Saint Religious Discourse, Reid Empey Aug 2026

"Tithing Is An Insurance Premium": A Framing Analysis Of Speaker Innovation And Diachronic Trends In Latter-Day Saint Religious Discourse, Reid Empey

Theses and Dissertations

Religious language relies on shared metaphor and frames that contextualize religious experience and practice. Current approaches to frame semantics (Fillmore 1982) and cognitive metaphor (Lakoff & Johnson 1980) lend important insight into religious language, particularly in describing the role that figurative language serves in a religious speech community. However, a vital component of many religious speech communities is the presence of and engagement with a scriptural canon, which often contains metaphorical and framing language that religious speakers can directly reference. Yet, past conceptualizations of speech communities have not accounted for this engagement with a shared canon. To illustrate the role …


Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin Aug 2026

Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin

Theses and Dissertations

In Alzheimer's disease (AD), a brain protein called "tau" abnormally clumps and forms neurofibrillary tangles (NFTs), causing damage to brain cells. Ac-PHF6-NH2 is a hexapeptide segment of tau protein that plays a dominant role in tau aggregation and is used as a model to design tau protein aggregation inhibitors. In this research we synthesized four dehydroamino acid (□AA) containing PHF6 analogues with △Abu (derived from L-threonine) and △Val (derived from □-OH-Valine) at position 2 or 3 via dehydrations or azlactone ring-openings as key reactions. We evaluated their proteolytic resistance, ability to inhibit aggregation of PHF6, and impact on the morphology …


Measuring Proteostasis Changes In Apolipoprotein E Mouse Models Using Quantitative And Kinetic Proteomic Methods, Ariel E.A. Denos Aug 2026

Measuring Proteostasis Changes In Apolipoprotein E Mouse Models Using Quantitative And Kinetic Proteomic Methods, Ariel E.A. Denos

Theses and Dissertations

Alzheimer's Disease (AD) is a neurological disorder associated with brain mass loss and cognitive decline. It affects millions of elderly people and is currently uncurable. Since 1906, when the disease was first described, researchers have uncovered many components of AD pathology. However, it is now evident that curing Alzheimer's Disease will require intervention before the pathological onset of amyloid beta plaque deposition, tau neurofibrillary tangles, and associated neuronal loss. Studying AD from the perspective of early intervention requires special attention to small changes that may disrupt the normal processing of cells. Cells undergo a natural cycle of creation and destruction …


Multi-Band Extinction Modeling In Early-Type Galaxies With Circumnuclear Disks, Nonnie Bash Aug 2026

Multi-Band Extinction Modeling In Early-Type Galaxies With Circumnuclear Disks, Nonnie Bash

Theses and Dissertations

In this thesis, we present a spatially resolved, multi-band dust-attenuation method for correcting the stellar luminosity models used in dynamical supermassive black hole (BH) mass measurements. If uncorrected, dust extinction effects may dominate over other systematic uncertainties when determining the BH mass ($M_\mathrm{BH}$). We expand on a simple dust-attenuation method that treats the circumnuclear disk as a thin dust layer embedded in the galaxy midplane. Using a Multi-Gaussian Expansion, we create a three-dimensional stellar luminosity model to calculate the fractions of stellar light originating in front of and behind the disk along each line of sight. We infer the pixel-by-pixel …


Family Religious Socialization Index: Development And Preliminary Validation, Kaelie Rene Crockett Aug 2026

Family Religious Socialization Index: Development And Preliminary Validation, Kaelie Rene Crockett

Theses and Dissertations

A key area of interest for religious scholars is how religious beliefs are passed across generations, or religious socialization. To expand this field of study, a theoretically grounded, validated measure of this construct is needed. This article describes the development and validation of the Family Religious Socialization Index (FRSI), a multi-informant, multidimensional assessment of the processes through which parents socialize religion and faith in their children. Based on Social Cognitive Theory and through a rigorous development and validation process, three subscales were developed to represent the primary processes of religious socialization. The FRSI consists of two parallel scales, a parent …


Identifying The Brain Circuits Involved In Religious Obsessive-Compulsive Disorder, Kiana Bunnell Aug 2026

Identifying The Brain Circuits Involved In Religious Obsessive-Compulsive Disorder, Kiana Bunnell

Theses and Dissertations

Obsessive-compulsive disorder (OCD) is an often-debilitating psychiatric disorder involving a pattern of obsessive thoughts and compensatory compulsions. Symptoms tend to be chronic, leading to substantial emotional burden and significant impairment across multiple domains of daily functioning. Previous research has identified some consistency in the brain regions implicated in OCD. In particular, cortico-striato-thalamo-cortical (CSTC) circuitry has been linked to behavioral features commonly observed in OCD. Moreover, some studies suggest that distinct patterns of brain activation and functional connectivity may be associated with different OCD symptom dimensions, though findings have not been consistent. One symptom dimension of OCD (scrupulosity) is characterized by …


Modifying Lta Zeolites For Reversible Hydrogen Sulfide Capture And Elucidating The Structure Of The Incorporated Metal And Sulfur Ions, Adeyemi D. Ojaide Aug 2026

Modifying Lta Zeolites For Reversible Hydrogen Sulfide Capture And Elucidating The Structure Of The Incorporated Metal And Sulfur Ions, Adeyemi D. Ojaide

Theses and Dissertations

Hydrogen sulfide (H2S) is a highly toxic and corrosive gas that poses significant environmental and industrial challenges, particularly within the wastewater treatment and oil and gas sectors. H2S leakage is among the deadliest industrial hazards, highlighting the urgent need for the development of highly efficient, non-corrosive adsorbents. This dissertation provides an in-depth examination of the use of metal-zeolites for H2S capture. We carefully investigate the impact of multiple divalent and one monovalent transition metals on LTA zeolites to optimize H2S removal. While Linde Type A (LTA) zeolites offer a robust structural framework for gas separation, a comprehensive understanding of how …


Is “No Change” Really No Change?: A Qualitative Analysis Of Clients With “No Change” On Routine Outcome Monitoring Who Report Improving In Therapy, Audrey Louise Stewart Parker Aug 2026

Is “No Change” Really No Change?: A Qualitative Analysis Of Clients With “No Change” On Routine Outcome Monitoring Who Report Improving In Therapy, Audrey Louise Stewart Parker

Theses and Dissertations

Routine outcome monitoring (ROM), the practice of tracking client progress in therapy by administering regular questionnaires to assess functioning, has demonstrated a significant positive effect on psychotherapy outcomes, especially for clients are who not improving as expected. However, some researchers argue the symptom-based measures and outcome classification criteria commonly used in ROM may not represent a complete picture of client change. A recent body of mixed-methods research has investigated these ROM-determined outcome categories to gain insight into client experiences and whether the category and client perception of therapy outcome align. In this investigation, researchers have found significant variety within outcome …


Behavioral Effects Of Novel Treatments For Pain Management Using Combinatorial Methods, Rohit Rajeev Nambiar Aug 2026

Behavioral Effects Of Novel Treatments For Pain Management Using Combinatorial Methods, Rohit Rajeev Nambiar

Theses and Dissertations

Pain, despite being an uncomfortable feeling to experience, is a necessary protective mechanism for the body1. Understanding that pain results from several different mechanisms within the body is important to discovering the optimal way to treat and manage a person’s pain. Modern medicine has seen numerous advancements in treating or managing acute and chronic pain, particularly with opioid drugs. However, these treatments come with potential side effects, including opioid use disorder (OUD) and fatal overdose. Finding new treatment methods, or improving existing methods, is crucial for patients with pain. This thesis explores two projects looking to develop safer analgesia using …


A Graphical Approach To Isospectral Unfoldings, Dallin Seyfried Aug 2026

A Graphical Approach To Isospectral Unfoldings, Dallin Seyfried

Theses and Dissertations

Isospectral reductions are mathematical techniques used to shrink a matrix, or a graph, into a smaller, dimensionally reduced form while preserving its spectrum. Simple graphs that share isospectral reductions also share quantum walk properties. As such we further develop the inverse process, isospectral unfoldings, to find graphs that share isospectral reductions. We first prove many conditions relating to isospectral reductions and unfoldings. Afterwards, we define two new unfolding processes: general unfolding which unfolds the graph one vertex at a time, and equitable partition unfolding which excels at larger graph unfolding. In particular, through equitable partition unfolding, we discover many graphs …


Analyzing The Transition From Writing Center Tutor To Graduate Student Instructor, Luci Mackenzie Sullivan Aug 2026

Analyzing The Transition From Writing Center Tutor To Graduate Student Instructor, Luci Mackenzie Sullivan

Theses and Dissertations

Writing center tutoring is almost universally considered to be beneficial preparation for graduate student instructors (GSIs) of writing, so much so that many programs require writing center experience as part of their GSI training. Despite various similarities between the roles of tutor and teacher, the precise ways in which writing center experience influences GSIs as teachers remain unclear. This IRB-approved, mixed-methods study builds on previous empirical scholarship on transfer between tutoring and teaching to determine how new GSIs with previous writing center experience integrate practices, knowledge, and dispositions developed in the writing center. My findings echo those of previous studies …


Threads Across The Atlantic: A Dialogue Of Feminist Writings Between Portugal And Cape Verde, Elliana Shillig Venancio Aug 2026

Threads Across The Atlantic: A Dialogue Of Feminist Writings Between Portugal And Cape Verde, Elliana Shillig Venancio

Theses and Dissertations

This thesis examines the feminist literary traditions of Portugal and Cape Verde through a comparative analysis of Ana de Castro Osório’s Infelizes and Dina Salústio’s Mornas eram as noites. Separated by nearly nine decades and an ocean, these two works nonetheless converge in their insistence on women’s autonomy, bodily sovereignty, and resistance to patriarchal structures. Drawing on Hélène Cixous’s theory of écriture féminine and Kimberlé Crenshaw’s framework of intersectionality, this thesis argues that despite the significant differences in time, geography, and socio-political context that separate these authors, powerful threads of feminist consciousness bind their writing together. At the same time, …


Automated Classification, Measurement, And Semantic Segmentation Of Open-Web Joists From Point Cloud Data, Justin Raymond Dworacek Aug 2026

Automated Classification, Measurement, And Semantic Segmentation Of Open-Web Joists From Point Cloud Data, Justin Raymond Dworacek

Theses and Dissertations

This thesis presents a BIM-oriented methodology for the automated classification, measurement, and segmentation of structural trusses from point cloud data. A real truss point cloud and a complementary synthetic dataset derived from CADBIM Revit families were used to develop and evaluate the workflow. Classification was performed using a rule-based Python algorithm based on principal component analysis, side-view feature extraction, and family-specific geometric decision logic, while a separate family-aware script was used to extract key truss dimensions. Semantic segmentation was evaluated using a PointTransformerV3 model to separate truss and non-truss points in mixed point cloud scenes. The results demonstrated strong performance …


Learning, Abstraction, And Creative Search For Interactive Agents, Jonathan Demke Aug 2026

Learning, Abstraction, And Creative Search For Interactive Agents, Jonathan Demke

Theses and Dissertations

Artificial intelligence systems are increasingly deployed as autonomous agents that interact directly with complex environments. Ensuring these agents remain reliable, adaptable, and useful presents an ongoing practical challenge. This dissertation studies agent-environment interactions through a progressive lens, examining behavior from foundational training stability and abstraction discovery to adaptation in unpredictable settings and open-ended creative search. The investigation begins by analyzing how hyperparameter settings affect early-stage Deep Q-Network performance, yielding practical guidelines for debugging reinforcement learning implementations. To address the challenge of long-horizon planning, the discovery of temporally extended options is formalized as the Minimum Shortcut Problem, demonstrating how agents can …


Online Parent Group Intervention For Executive Function Skills For Autistic Children And Adolescents, Kathleen Clark Aug 2026

Online Parent Group Intervention For Executive Function Skills For Autistic Children And Adolescents, Kathleen Clark

Theses and Dissertations

Executive functioning (EF) skills deficits are prevalent among children and adolescents with autism spectrum disorder (autism) that impacts their academic functioning, social relationships, and families' quality of life. This study aimed to explore an online parent group intervention, to test effectiveness of a 6-week parenting intervention on parenting stress and child's executive functioning (EF) among autism families in rural Utah with limited access to traditional intervention resources. The participants were eight parents from six families of children and adolescents (8-15 years) with clinical diagnosis of autism spectrum disorder and appropriate language abilities for their age. The parents participated in weekly …


A Coupled Reaction-Diffusion Model Of Promoting And Suppressing Interactions Among Cancer Hallmarks In Endometrial Cancer, Jeddy Bennett Aug 2026

A Coupled Reaction-Diffusion Model Of Promoting And Suppressing Interactions Among Cancer Hallmarks In Endometrial Cancer, Jeddy Bennett

Theses and Dissertations

Spatial transcriptomics enables the scoring of Cancer Hallmarks at a high resolution across a tissue biopsy, yet current analyses of these data remain largely descriptive, treating each spot as a static, independent observation. This thesis develops a coupled system of advection-diffusion-reaction partial differential equations to model the hallmark landscape as the steady-state solution of an underlying spatial process, and casts the recovery of its physical parameters as a PDE-constrained inverse problem. The framework is implemented in FEniCSx on tissue-specific finite element meshes derived from two endometrial cancer biopsies provided by the Huntsman Cancer Institute, with subdomains, boundary interfaces, and an …