Digital Commons Network^™

Hybrid Lipid-Gold Nanoparticles Designed For Simultaneous Gene Therapy And Photothermal Therapy Against Cancer, Navya Sree Devaguptapu

Theses and Dissertations

Traditional cancer treatments such as chemotherapy and surgery include adverse side effects and acquire resistance. Here, I developed a novel hybrid lipid-gold nanoparticle technology (LGNP) to achieve simultaneous gene regulation and photothermal therapy, specifically targeting pediatric acute myeloid leukemia (AML) and ovarian cancer. This core material consists of slice core/gold nanoshells, which are efficient heat transducers where NIR light activates nanoshells embedded in tumors, generating localized heat for tumor ablation. The ionizable lipid coating facilitates intracellular delivery of nucleic acids, such as mRNA or siRNA, to modulate gene expression effectively. Lipid-gold hybrid nanoparticles (LGNPs) are synthesized via a controlled self-assembly …

Leveraging Oxaziridines In Transition Metal Catalysis And As Reactive Intermediates, Jenna Marie Doran

Theses and Dissertations

Oxaziridines are versatile three-membered nitrogen–oxygen heterocycles that can function both as reactive intermediates and as components of transition-metal catalysts, enabling selective and diverse organic transformations. This work explores the dual role of oxaziridines in facilitating alkene functionalization and amide synthesis. We discovered that vanadooxaziridines catalyze intermolecular allylic amination with high regio- and chemoselectivity, providing a mild route to allylic amines, whereas molybdooxaziridine complexes display an unexpected preference for vinyl sulfonation, revealing a divergent pathway from the typical nitrogen-transfer reactions and offering access to synthetically valuable sulfur-containing motifs. In parallel, oxaziridine intermediates derived from imines mediate efficient formation of amides from …

Analytic Solutions To Oceanographic Kinematic Property Equations, James Turbett

Theses and Dissertations

With the recent advent of large submesoscale drifter deployments, interpreting the timeseries of kinematic properties (KP) - divergence, vorticity, shear, and normal strain rates observed therein is a pressing issue. The evolution equations for the four KP are derived from the two-dimensional momentum conservation equations. The resulting equations, a nonlinear coupled system of ordinary differential equations, capture the submesoscale motion of drifters along fixed ocean surfaces, with time and space scales on the order of days and kilometers. This thesis builds theory around KP timeseries behavior by solving for the analytic solutions in the particular cases that one KP is …

Vibro-Seismic Approach For Remediation Of Near-Wellbore Damage, Mounira Ahmed Abdallah

Theses and Dissertations

The research highlights the importance of vibro-seismic technology in the oil and gas industry. The primary objective of this study is to demonstrate how the vibro-seismic method enhances formation properties which are porosity, and permeability. Ultimately, this will lead to improved productivity and its application to remove the wellbore damage.

The research discusses whether or not the formation properties will be enhanced by the optimized acoustic vibration formation parameters. The thesis details laboratory experiments on core plugs, and four key findings are presented. The experimental work first showed that the use of the proper and optimum parameters enhanced the porosity …

The Role Of Complexity In Structural Transfer: A Corpus Study From Turkish And Bulgarian, Sarah Joy Russell

Theses and Dissertations

This study the explores the need to examine the increasingly varied methods of quantifying morphological complexity in regards to their ability to influence structural borrowing across languages, with particular attention to the distinction between enumerative complexity (enumeration of all of the morphemes and distinctions in a system) and integrative complexity (entropy-based calculation of the class distinctions of the system). While existing models in contact linguistics often assume that structurally simpler languages are more likely to serve as sources of grammatical transfer, such accounts typically rely on enumerative measures of complexity alone and do not fully account for the role of …

Multidisciplinary Inverse Robust Co-Design Of Materials, Products, And Manufacturing Processes, H M Dilshad Alam Digonta

Theses and Dissertations

Realizing the design for Integrated Computational Materials Engineering (ICME) requires the materials, product, and manufacturing-process disciplines to be designed together. Because these disciplines interact and influence one another's decisions, coordination is needed among their distributed decision-makers. Their interactions are captured through the processing-structure-property-performance (PSPP) linkages, which must be established from limited, costly data. Moreover, each discipline introduces its own sources of uncertainty, and these propagate through the process chain to influence final product performance. The effective realization of the product-material-manufacturing system, therefore, calls for a co-design approach that enables the concurrent coordination of the interacting disciplines while quantifying and managing …

Fraud And Focus: Examining Self-Control Strategies In Students Experiencing Impostor Phenomenon, Francesca Angela Catalano

Theses and Dissertations

Impostor phenomenon (IP) is a common experience among individuals in achievement contexts characterized largely by feelings of self-doubt, attributions of success that focus on external factors, and beliefs that one is “fooling” others about their competence. Current research suggests the effects of IP are complex (e.g., IP is associated with higher grade point average and productivity but also self-handicapping, psychological distress, and difficulties adjusting to college). To better understand these complex effects, this study proposes a self-control perspective for IP, where this phenomenon is seen as involving additional self-control burdens. Specifically, the study examines whether IP is associated with grade …

The Effects Of Functional Coaching On Increasing Functional Play Behaviors In Adults, Abby L. Pattengale

Theses and Dissertations

Play is a critical developmental context for children with autism spectrum disorder (ASD), supporting cognitive, social, communication, and adaptive skill development. However, many adults, specifically registered behavior technicians (RBTs), demonstrate limited engagement in developmentally appropriate play behaviors, which can restrict the quality of play-based interventions, which are essential for effective treatment. However, little research has examined interventions designed to improve adult play behaviors. The purpose of this study was to evaluate the effects of functional coaching on increasing adult functional play behaviors during therapy sessions with children diagnosed with ASD. Two RBTs participated in the study, and two children receiving …

On The True Interstellar Anisotropy Of Tev Cosmic Rays And Its Implications For The Local Interstellar Medium, Noufel D. Maalal

Theses and Dissertations

Several ground-based cosmic ray (CR) air shower experiments have produced sky maps of intensity anisotropy in the energy range from 1 TeV to a few hundred TeVs with very high statistics and angular resolution. These measurements provide opportunities to study CR sources and propagation in the interstellar medium (ISM). Such studies present two major difficulties. Firstly, CRs are deflected by the heliospheric magnetic field on the last stretch of their journey to Earth. Secondly, measurements at different latitudes are difficult to compare, leading to uncertainties in latitudinal variations on the order of the observed anisotropy. Experiments usually assume latitudinal variations …

How Esl/Efl Textbooks Are Created: A Description Of The Publishing Processes For Elt Coursebooks, Timothy P. Arnold

Theses and Dissertations

The purpose of this study was to describe the current ELT textbook publishing processes and evaluate a descriptive model of the publishing processes. While criticisms of ELT textbooks abound (Akbari, 2008; Bell & Gower, 2011; Jordan & Gray, 2019; Tomlinson & Masuhara, 2008; Long, 2016; etc.), little previous research has focused on describing the ELT textbook publishing. This is despite most criticisms appearing to focus on aspects of ELT textbooks that come about during the publishing processes. The work of Littlejohn (1992), McGrath (2013), and Yildiz and Harwood (2023) are exceptions to this. To provide additional descriptive information on the …

Neural Processing Of Japanese And Korean Phonological Items In Romanized Versus Native Writing Systems, Kyle Thayne Chipman

Theses and Dissertations

Romanization is a common, yet sometimes controversial, tool used to make Korean and Japanese more accessible to beginning learners, but its effects on orthographic processing and phoneme discrimination ability are not well understood. The participants consisted of 34 university students (21 female, 13 male; mean age = 20.97) enrolled in 100- and 200-level Korean and Japanese courses at Brigham Young University. Using a quasi-experimental, counterbalanced design, participants completed phonological judgement tasks in three orthographies per language while accuracy, reaction time, and cortical activation were measured using functional near-infrared spectroscopy (fNIRS); post-task surveys contextualized learner responses. Orthography significantly affected accuracy in …

Grit, Self-Assessment, And Second Language Proficiency: A Large-Scale Examination Using Data From The Language Ability Self-Evaluation Resource, Andrew T. Skoy

Theses and Dissertations

Grit has been defined as being "perseverance and passion for long-term goals" (Duckworth et al., 2007). Research has tied grit to success in the discipline of second language acquisition (SLA), where researchers have adapted Duckworth's general grit self-assessment instrument to capture measurements of grit within second language learners (Teimouri et al., 2022). Such a scale appears on the Language Ability Self-Evaluation Resource (LASER), a standardized language proficiency test developed by researcher at Brigham Young University. With the aim of replicating the studies that were done to validate the design of the LASER, responses to the grit-measuring section of the test …

Friction Stir Processing Of Cobalt-Chromium-Molybdenum For Improvements In Biomedical Applications, Kaleb Kiyoshi Bates

Theses and Dissertations

Friction Stir Processing (FSP) has been investigated as a means of microstructural modification aimed at improving mechanical properties such as corrosion resistance and wear resistance of biomedical-grade cobalt-chromium-molybdenum (CoCrMo) alloy. FSP was successfully completed on high-carbon ASTM F1537 CoCrMo plates with operating temperatures ranging from 630°C to 850°C by adjusting spindle speed, traverse speed, and forge force. Hardness, wear resistance, and corrosion resistance testing were performed, along with Electron Backscatter Diffraction (EBSD) to analyze grain refinement and phase structure. FSP produced grain refinement up to 97% relative to the untreated baseline across the investigated temperature range, with lower processing temperatures …

Receiving Isaac Again: Joy And Return To The Finite In Fear And Trembling, Jeffrey M. Matheson

Theses and Dissertations

This thesis argues that joy is a constitutive but underexamined feature of faith in Søren Kierkegaard’s Fear and Trembling. While the text is often interpreted through sacrifice, silence, dread, paradox, and the teleological suspension of the ethical, these categories do not exhaust Johannes de Silentio’s account of Abraham. By foregrounding Abraham’s joy, this thesis shows that faith is not merely the willingness to surrender the finite, but the capacity to receive the finite again after it has been given up. Isaac is not only Abraham’s beloved son, but the child of promise, the visible form of God’s covenant, and the …

A Mathematical Model Of The Interactions Between A Collagen Lattice, Fibroblasts, And Fixed Surfaces With Varying Topographies, Mary Jenkins

Theses and Dissertations

Collagen is an important structural protein in the body, which plays a role in wound healing, particularly the contraction process. Collagen lattices have been studied for nearly 50 years to provide insight into wound contraction. In some cases, collagen interacts with surfaces that have fixed shapes, such as medical implants. Our model focuses on the interactions of a collagen lattice with such a fixed surface. We mathematically model a collagen lattice as a network of nodes connected by springs. We also model fixed surfaces that have various topographies. Our model includes fibroblast cells that connect to both surfaces and remodel …

An Analysis Of Heat Spread Through Smoldering Pine Needles, Timothy Keith

Theses and Dissertations

The goal of this thesis is to calculate the average speed of flame spread through smoldering pine needles. We present two different models for doing this: the first is a very large system of ODEs meant to represent the spread of flame through individual needles, the second is a macroscopic model based on the porous medium PDE. Simulations are run for each of these models and compared to each other as well as to existing models and experimental results.

A Holistic Framework For Enhancing Machine Learning Reliability: From Model Architecture And Algorithm Design To Human Interpretability, Kyle Naddeo

Theses and Dissertations

Modern machine learning systems can perform well on benchmarks yet fail in ways that are difficult for users to anticipate, interpret, or manage. This dissertation treats reliability as more than accuracy: a reliable system performs when it can, signals when it should not be trusted, and supports abstention, fallback, escalation, or human review. Unlike robustness, which emphasizes performance under shift, corruption, adversarial perturbation, or drift, reliability also requires recognizing limited competence, preserving useful semantic structure when fine-grained certainty is unjustified, and exposing mechanisms that make failures understandable. The dissertation develops this view through four contributions. Uncertainty-aware decision heads provide portable …

Learning Trajectories Of Online Batch Selection Methods, Luke Green

Theses and Dissertations

Modern deep neural networks achieve strong performance on large-scale datasets, but often require substantial training time. Online batch selection methods seek to reduce this cost by updating models on informative subsets of each batch rather than on all available examples. Recently introduced methods leverage teacher models and report substantial speedups, particularly in noisy-label settings. However, comparisons are often based on the number of epochs required to reach a target test accuracy, a coarse metric that is sensitive to implementation details and may obscure important differences in learning dynamics. In this thesis, we implement several online batch selection methods in a …

Advancing Data Usability, Activity Modeling, And Stability Optimization In Computational Enzyme Design, Spencer Gardiner

Theses and Dissertations

A grand challenge of computational biology is to computationally design, in a single pass, a protein sequence that catalyzes an arbitrary chemical reaction at a high rate under specified conditions [1]. This work details advances in three essential areas on the path to that goal: data quality, activity prediction and modeling, and stability optimization. The structure and implementation of the Allotrope Simple Model (a FAIR data format for many scientific instruments) was examined in [2], setting the stage for training deep learning models on high-quality experimental datasets from diverse sources. In [3], the limits of physics-based and deep learning tools …

Beyond Single Images: A Comprehensive Benchmark For Album-Level Vision-Language Understanding, Shawn Huang

Theses and Dissertations

Automatic album organization has been studied extensively over the past decades due to significant progress in digital photography. Recent Vision-Language Models (VLMs) have shown strong performance on multi-image understanding, making them natural candidates for automating album organization workflows. While VLMs’ abilities in multi-image understanding have been widely studied, their performance on album organization remains underexplored. To bridge this gap, we introduce AlbumBench, the first comprehensive benchmark for automatic album organization. Specifically, we (1) define album organization tasks as photo selection for album-specific user objectives, photo rating according to how well user intents are fulfilled, and album-specific photo grouping given a …

Split Alliance And Relationship Satisfaction In Couples Therapy: Examining Split Alliance As A Process Variable, Kyla Yetter

Theses and Dissertations

The present study examined how different patterns of alliance development impact couples' relationship satisfaction, with a particular emphasis on split alliances. The retrospective sample of 1149 couples was taken from the IRB approved Marriage and Family Therapy Practice Research Network. Alliance was measured at each session with the Intersession Alliance Measure- Couples version (IAM-C). The outcome variable, relationship satisfaction, was measured before the first and last sessions of therapy with the Couple Relationship Scale (CRS). Split alliance was operationalized using standard deviation differences in partners' alliance scores, and couples were divided into three groups: 1) Never had a split alliance, …

Enhancing Emotional Support For Advanced Placement Students, Laine Mckay Nesbitt

Theses and Dissertations

Although they may struggle with their emotional well-being, academically accelerated students are underrepresented in the research literature. Teachers are in a position to influence students' emotional well-being. Minimal qualitative research with student voices has been conducted. This study highlights the perspectives of students who have participated in an academically accelerated program. Students were interviewed about what their teachers do to help or hinder their emotional well-being and what they wish that teachers could do to support their emotional well-being. A total of 14 high school students were interviewed using the critical incident technique (CIT). The participants emphasized the importance of …

Maternal Perspectives On Support Needs: Insights From The Fonofale Model, Sara Lani Ditto

Theses and Dissertations

This interpretative phenomenological analysis (IPA) explored the lived experiences of parents raising children with disabilities in American Samoa. Five participants across two focus groups shared their perspectives on navigating educational, healthcare, and community systems while supporting their children with disabilities. Using the fonofale model as a cultural framework, the study incorporated culturally responsive methodology including card sort activities to facilitate dialogue on potentially sensitive topics. Analysis followed the Nizza et al. (2021) IPA approach, progressing from exploratory notes to experiential statements, clustered themes, and finally overarching themes. Findings revealed four major themes: systemic burden on parents, structural and service gaps, …

Respect And Aggression In Intimate Relationships: A Grounded Theory Of Relational Responsiveness, Aaron T. Fife

Theses and Dissertations

The negative effects of aggression in intimate relationships have been well documented through research and clinical literature (Lawrence & Bradbury, 2001; Shortt et al., 2006). Conversely, the positive effects of respectful behavior are well-known (Gottman, 1994; Dew & Wilcox, 2013). This important dimension of relationships is crucial to understanding what makes up healthy and unhealthy relationships. However, little is known about how couples understand the varying types of respect and aggression within intimate relationships, nor how they are lived and experienced relationally. The purpose of this study is to explore the dyadic processes behind respect and aggression as well as …

Toward Passwordless Document Encryption, Isaac Henry Teuscher

Theses and Dissertations

Document files with sensitive information are used across nearly every industry. In recent years, cyberattacks targeting cloud-based file transfer applications have resulted in millions of sensitive documents being exposed. Although document encryption methods exist, they are often limited in usability, security, or deployability. Password-based encryption, the most widely available option, remains vulnerable to brute-force attacks, unauthorized sharing, and human error. We address these gaps in three phases. First, we present a structured comparative framework adapted from the usability-deployability-security model to evaluate nine document encryption methods across 15 design properties, identifying the benefits and limitations of current approaches. Second, we design …

A Lesson In Class: How Parents' Class Identity Changes Relate To Children's Exposure To Social Classes -- A Latent Profile Analysis, L. Caroline Moore

Theses and Dissertations

Class inequality in the United States has reached levels not seen since the late 1920s. This inequality has been linked to numerous harmful societal outcomes and may be particularly detrimental for children, who often experience limited intergroup contact with individuals from different social class backgrounds. Drawing on Social Identity Theory and the significant role parents play in shaping children's social environments, this study examined how White and Black parents' changes in perceived social class from childhood to adulthood relate to the ways they prioritize exposing their children to different social class environments (N = 702, U.S. sample). Latent Profile Analysis …

Hierarchical Parcel Swapping: A Novel Model In Turbulence, Masoomeh Behrang

Theses and Dissertations

Turbulent mixing plays a central role in a wide range of engineering and natural systems, particularly in reactive flows where turbulence--chemistry interactions strongly influence reaction rates, flame structure, and emissions. Accurately modeling these interactions remains a major challenge due to the multiscale and stochastic nature of turbulence, as well as the nonlinear coupling between transport and chemical kinetics. This dissertation develops and evaluates the Hierarchical Parcel Swapping (HiPS) model, a fully stochastic framework designed to represent turbulence-driven transport and scalar mixing without relying on traditional gradient-based closures. HiPS is investigated both as a standalone turbulence model and as a subgrid …

Likes, Lies, And Body Esteem: The Moderating Effects Of Age, Concealment, And Gender Between Social Media And Body Esteem For Utah Adolescents, Talise Hirschi

Theses and Dissertations

Social media use has become common among adolescents and contains many messages about one's body such as the thin and muscular ideal. Many parents are learning how to help their adolescent learn how to use social media, and some adolescents may conceal their social media use for various reasons. 588 adolescents (ages 11-18; 77% White; 55% female) from Utah filled out surveys about their social media use and body esteem each school year. In a two-wave cross lag panel model, specific aspects of social media use such as time spent on social media, problematic media use (PMU), and social media …

I Will Defend My Self, Emily Ward Hawkins

Theses and Dissertations

This thesis examines caregiving and motherhood as forms of load-bearing infrastructure. Cultural narratives often portray motherhood through sentimental images of joy, tenderness, and devotion, obscuring the structural labor that sustains family life. This project examines maternal labor as a largely unseen system of support that organizes family life while often remaining backgrounded. Caregiving reorganizes time, space, ambition, embodiment, and future orientation within maternal life. Through sculptural works using architectural materials and construction systems, such as oriented strand board, blueprint racks, metal armatures, and graph paper, the project visualizes caregiving as a structural condition. These materials reference the language of architecture …

Service Providers' Descriptions Of Survivors' Experiences With Mental Health Treatment, Melanie Gonzales Puente

Theses and Dissertations

Human trafficking survivors experience significant mental health challenges and barriers that limit their engagement towards treatment. A qualitative study was conducted that included semi-structured interviews of 33 professionals working with survivors of human trafficking in the United States. Findings indicate that survivors' engagement in treatment is limited by mistrust of providers, stigma, and a lack of access to services. Providers emphasize that addressing basic needs (e.g., safety and housing) must occur before engaging in trauma-focused therapy. Positive outcomes are associated with strong therapeutic relationships, autonomy, trauma-informed, individualized care, and offering comprehensive services. Furthermore, mental health providers should have certain abilities …