Digital Commons Network^™

Asymmetric Cuh-Catalyzed Reductive Coupling Of Allenamides With Carbonyl Electrophiles & Development Of Nanocatalysts For Heterogeneously Catalyzed Buchwald-Hartwig Amination, Raphael K. Klake

Theses and Dissertations

Many drugs and natural products contain multiple stereogenic carbons bearing heteroatoms throughout their carbon framework. Therefore, methods that can efficiently install multiple heteroatoms on a molecule are valuable. Reductive coupling reactions have been extensively studied, and the allylation of carbonyls via the reductive coupling approach has been a key method for generating chiral tertiary and secondary allylic alcohols. This work utilizes inexpensive Cu for the asymmetric reductive coupling of allenamides with carbonyls to simultaneously install two heteroatoms (oxygen and nitrogen) on the product. These molecules have a polarity profile that make them difficult to make using traditional methods. Herein, we …

Blockchain Security And Applications, Phuc D. Thai

Theses and Dissertations

Cryptocurrencies, such as Bitcoin and Ethereum, have proven to be highly successful. In a cryptocurrency system, transactions and ownership data are stored digitally in a ledger that uses blockchain technology. This technology has the potential to revolutionize the future of financial transactions and decentralized applications. Blockchains have a layered architecture that enables their unique method of authenticating transactions. In this research, we examine three layers, each with its own distinct functionality: the network layer, consensus layer, and application layer. The network layer is responsible for exchanging data via a peer-to-peer (P2P) network. In this work, we present a practical yet …

Quantitative Changes In Hippocampal Ccr5+ Microglia With The Administration Of Maraviroc (Mvc): Does Sex Matter?, Ama S. Boakye-Agyei

Theses and Dissertations

Human immunodeficiency virus type-1 (HIV-1) has been greatly studied in recent decades. Combined anti-retroviral therapy (cART), the development of drug treatments such as maraviroc, and the wider availability of support for those in resource-rich environments have been instrumental in improving the prospects of people living with HIV (PLWH). It is well- documented that PLWH can suffer from a host of cognitive deficits collectively known as HIV- associated neurocognitive disorders (HAND). Moreover, the role of biological sex in the development of HAND and other cognitive deficits is still being studied. C-C chemokine receptor type 5 (CCR5) is one of the two …

A Six-Month Comparison Of Orthodontic Pain Associated With Fixed Edgewise Appliances And Clear Aligners, Victor Chan

Theses and Dissertations

Title: A Six-Month Comparison of Orthodontic Pain Associated with Clear Aligners and Fixed Edgewise Appliances

Objective: To document and compare pain perception, intensity, and analgesic use over a sixmonth period between patients treated with fixed appliances (FA) and clear aligners (CA).

Methods: A prospective, parallel, two-arm, multi-center, longitudinal cohort study was conducted with 87 adults treated with CA (n=59) or FA (n=28). Subjects were selected according to inclusion and exclusion criteria. A seven-item, digital survey was sent at three timepoints (preappointment, 2-days post-appointment, and 7-days post-appointment) at each adjustment over a six-month period. The variables measured included pain experience, pain …

Biting Range, Effie Bowen

Theses and Dissertations

Biting Range is an essayic text about dogs, process, order, and memory. Structured as a conceptual material list, the writing addresses experiential textures and tensions gleaned from observation. Writing within and against the margins, I address the performativity of the page as its own form to be agitated.

Homeworld, Ilana Dodelson

Theses and Dissertations

This thesis explores the experience of being tied to many worlds at once, and how that can be represented through paint.

Thrive: Empowering Women's Health Through Healing Design, Tawny Chamberlain

Theses and Dissertations

MOTIVATION Despite the immense focus on patient-centered care over the past two decades, a lack of knowledge exists regarding how to apply these guidelines to women, which contributes to gender disparities in healthcare (Filler et al, 2020). For example, one in eight American women will have breast cancer in her lifetime, yet one third do not complete regular screenings (NCI, 2020), perhaps because mammograms and gynecological exams often cause significant anxiety and fear in women. Decreased engagement with providers, coupled with disjointed healthcare, leaves women in a vulnerable position. ISSUE There is ample evidence that well-designed spaces can help patients …

Cone Beam Computed Tomographic Analysis Of Outcomes In Ridge Augmentation Using Titanium Mesh And Titanium Reinforced Ptfe Membranes, Lina Elnakka

Theses and Dissertations

Objective: The primary goal of this study is to evaluate and compare the average vertical and horizontal bone gain between titanium reinforced polytetrafluoroethylene (Ti-PTFE) and titanium mesh (Ti-mesh) using superimposition of preoperative and postoperative (CBCT). The secondary goal is to evaluate and compare the surgical outcomes between the two techniques.

Methods: A retrospective chart review was completed to assess the clinical and radiographic outcomes of patients who underwent ridge augmentation therapy using either Ti-PTFE or Ti-mesh. Preoperative and postoperative CBCT scans were superimposed using InVivo 3D imaging software. Vertical component of the augmented site (L1) was assessed along a vertical …

A Constructed Memoir: The History And Heritage Of The Baloch Community In Qatar, Somaia Nahang Dorzadeh

Theses and Dissertations

In the 1960s, when my father was only thirteen years old, he took a perilous journey on a boat alone from Sistan va Baluchestan, Iran, to Qatar, in the hopes of a better life. Like many long-term residents from Balochistan, my father has lived in Qatar for decades, predating the establishment of the modern state of Qatar itself in 1971. His legal position in the country today remains subject to the Kafala system, and his residency is subject to his employment status, which must be renewed each year. In other words, permanency is never guaranteed, nor is future planning.

In …

How Stromal Interactions Play A Role In The Quest For Human Papillomavirus Specific Cancer Therapeutics, Alexis-Leigh A. Fakunmoju

Theses and Dissertations

High-risk human papillomaviruses (HPV), like HPV16 and HPV18, are associated with malignant cancer growth within the oropharynx and cervix. Globally, HPV-induced cancers, including oropharyngeal and cervical cancers, contribute 5% to the overwhelming burden of all cancers. HPV is highly transmissible by sexual contact via micro abrasions to the mucosa. Once exposure occurs, the virus begins replication and creates an intimate relationship with the host’s cellular proteins. While most HPV is cleared quickly by our immune system, persistent infections, or infections in immune compromised individuals, are susceptible to transformation and tumor progression. Early detection measures like PAP smears and preventable measures …

Incorporating Noh Training Into Contemporary Western Theatre: An Examination Of The Benefits To Implementing Noh Theatre And Suzuki Training Into Western Performance Pedagogy, Baylee A. Holloran

Theses and Dissertations

Noh theatre is a traditional Japanese theatre practice that focuses on isolated and intentional physicality and separating actor personality from character. It is an imaginative and heightened performance that differs greatly from Western theatrical realism. This thesis examines Noh theatre, its origins, and why it should be more implemented into Western acting pedagogy. I start by describing what Noh is as an art form, from the ritualistic aspects to how it is staged and performed. Then I outline the religious and historical significance of Noh and how they are showcased in its storytelling and performance. I analyze the pedagogies of …

Innovations In Drop Shape Analysis Using Deep Learning And Solving The Young-Laplace Equation For An Axisymmetric Pendant Drop, Andres P. Hyer

Theses and Dissertations

Axisymmetric Drop Shape Analysis (ADSA) is a technique commonly used to determine surface or interfacial tension. Applications of traditional ASDA methods to process analytical technologies are limited by computational speed and image quality. Here, we address these limitations using a novel machine learning approach to analysis. With a convolutional neural network (CNN), we were able to achieve an experimental fit precision of (+/-) 0.122 mN/m in predicting the surface tension of drop images at a rate of 1.5 ms^-1 versus 7.7 s^-1, which is more than 5,000 times faster than the traditional method. The results are validated on real images …

Practice Elements Delivered By Teachers To Support Children Who Display Challenging Behaviors In Business-As-Usual Early Childhood Settings, Navneet Kaur

Theses and Dissertations

Approximately 15-25% of children ages 3 to 5 years in early childhood settings display chronic challenging behaviors that increase their risk for developing an emotional and behavioral disorder. The early onset of emotional and behavioral disorders has long-term negative implications for these children. Therefore, it is vital to address these problems early on. One approach is through teacher-delivered practices (i.e., specific strategies, such as praise) and programs (i.e., manualized interventions that contain a collection of practices) in the classroom. Some practices and programs have shown positive outcomes for children. However, when practices and programs do not outperform business-as-usual group (BAU), …

The Hepatic Immunological Pattern Shaped By Dominant-Subdominant Cellular Interactions Creates A Collective Function Beyond The Function Of Each Cellular Constituent To Orchestrate Progression Of Hepatocellular Carcinoma, Nicholas J. Koelsch

Theses and Dissertations

Abundance of data on the role of inflammatory immune responses in the progression or inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for HCC. This is largely because of taking reductionist approaches and missing the collective function of the hepatic immune system by focusing on specific immune cell types. To this end, we propose that focusing on the dominant-subdominant patterns of the immune cells would allow understanding of the mechanism by which a collective immune function emerges. To identify the collective immune function through a systems immunology perspective, we performed high-throughput analysis of snRNAseq data collected …

Trans* Streamers On Twitch.Tv: The Intersections Of Gender And Digital Labor, R. Lawson

Theses and Dissertations

Twitch.tv is a live entertainment platform where individuals live stream events, including playing video games, playing board and tabletop games, creating art, and more. Twitch has a diverse base of streamers, but Twitch has just begun. The most common approach has focused on cisgender, heterosexual white men in the cases where it has been studied. Though these streamers should be studied in sociology, this focus leaves out the experiences of both cis women and Trans* streamers. This research proposal tries to situate the relationship of Trans* streamers with both the platform and their audience, seeing if these relationships affect their …

I'M Not Sure It Was A Hoopoe Or A Decanter, Ali Kaeini

Theses and Dissertations

“I’m not sure it was a Hoopoe or a Decanter” explores the experience of cultural displacement through the lens of an Iranian artist and immigrant. Drawing on ancient Iranian stories, Persian poetry, and cultural artifacts, my paintings and drawings reflect the uncertainty of the contemporary political and religious conditions in Iran, as well as the challenges faced by individuals forced to flee their homeland due to war, political instability, and social conditions. My work weaves references to ancient Iranian objects, Persian miniatures' structural forms and patterns, and Islamic architecture, using traditional and contemporary materials to create large, unconventional paintings. Through …

Half Of Two Hungers, Aida A. Lizalde Rios

Theses and Dissertations

Abstract

half of two hungers is an extension of my sculptural practice; a weaving of the ambiguous borders of memory, trauma, disease, identity, assimilation, survival, spirituality, love, erotics, and desire. It is a psychological and sensorial landscape, where I travel consciously and subconsciously to pull shapes and material experiences out into the world of bodies and objects.

Food Deserts And Pediatric Oral Health Status In An Under-Resourced Urban Community, Jessica T. Mcauliffe

Theses and Dissertations

Purpose: The aim of this analysis of survey data was to assess the influence of living within a food desert as a predictor of oral health problems among children of East Henrico County, Virginia.

Methods: Survey participants were recruited and questionnaires applied online. Residing in a food desert, using access to affordable produce as a proxy value, was the independent variable, while self- reported assessment of the child’s oral health status was the primary outcome variable. Analyses controlled for other indirect factors of pediatric oral health. Logistic regression was used to model the association between the self-reported access to healthy …

To, From: Of Time, Of Distance, Of Body And Mind, Fanxi Sun

Theses and Dissertations

This paper introduces the concepts, theories, and techniques associated with my thesis project “To, From.” The paper consists of three parts: Time as Structure, Distance as Premise, and Body and Mind. Each chapter is written in a mixture of personal narration and a general introduction to materials that are directly or implicatively relevant and important to the creation of my project. In this experimental narrative comprises film screening and live performance with multi-channel sound, I tell a story of non-story. Words and the exchange of words, movements and non- movements, objects that are being handled and subjects that are handling... …

Development Of A Qa Plan For A 3.0t Cannon Galan Mr-Sim, Nathaniel D. Teague

Theses and Dissertations

Purpose: To develop and incorporate a QA (quality assurance) program for a Canon Galan 3 tesla MR Simulator for applications in radiation therapy.

Methods and materials: The QA program was centered around tests performed with three separate levels of frequency. The daily QA procedure consisted of scanning a vendor provided daily QA cube phantom that measures basic performance parameters. Additionally, a series of basic safety check were performed. The monthly QA procedure consisted of several tests, including scanning the ACR MRI large accreditation phantom and manually performing its corresponding image quality tests. Scanning the MagPhan RT for its detailed geometric …

Through The Lens Of Glass, Paul J. Van Den Bijgaart

Theses and Dissertations

Glass is a key component of the development of the modern world and within this China has become the leading producer and consumer of the material. Through the dedication to my skilled craft as a glassblower I use my material understanding to explore eastern and western philosophical associations and artistic concepts through painting. As well as investigate the relevance of how craft contributes to the development of culture through consumables. An intuitive expressionist painting style is explored in relation to landscape painting with glass as a practice towards mindful engagement within an age of digitized globalization.

From Silence To Forte: Developing An Inclusive Space For Persian Musicians To Flourish, Sholeh Salimi

Theses and Dissertations

Music serves as a reflection of culture and conveys various emotional and intellectual states, such as a nation's perspective, social attitudes, and historical background. However, the Iranian revolution in 1979 led to the ban of music by the new regime, limiting the output and audience for Iranian music. In addition, the emergence of Western music accessibility through technology posed challenges for traditional Persian music, and the government's restrictions on music further compounded the problem. To support and advance the preservation and dissemination of Iranian music, this study aims to explore how an interior designer can create a space that enables …

“Trans Broken Arm Syndrome”: Examining Causal Antecedents Of Gender-Related Medical Misattribution And Invasive Questioning In An Analogous Healthcare Setting Through The Lens Of Person Perception, Catherine Wall

Theses and Dissertations

Transgender individuals face particular challenges when interacting with a cisgender focused medical system. Gender-related medical misattribution and invasive questioning (GRMMIQ), colloquially known by the tongue-in-cheek named “trans broken arm syndrome,” is a form of medical discrimination wherein a healthcare provider assumes that a transgender patient’s medical complaints, regardless of origin, result from their gender identity or medical transition. Previous research has suggested that this, and other forms of identity-related discrimination both in and outside of healthcare, might be understood either using a top-down approach focused on stereotypes founded in schema, or a bottom-up approach examining perceived typicality. One additional theory, …

一To二To三, Yameng Wang

Theses and Dissertations

This work relates to an animated film focusing on iteration, simulacrum, and artificial intelligence. It is based on the traditional Tao concept: “One life two, two beget three, three beget all things.”

Attitudes And Beliefs Of Cannabis Use During Pregnancy: Hashing Out The Impact Of Location And Legality, Anna Wiese

Theses and Dissertations

As more states authorize the use of cannabis for medical and recreational purposes, rates of prenatal cannabis use are on the rise. Yet research on perceptions of prenatal cannabis use has been limited, and the existing research lacks reliable, quantitative measures. In response, researchers in Denver developed the Perceptions of Prenatal Cannabis Use (PPCU) survey, a 16-item measure designed to assess perceived risks and benefits of prenatal cannabis use. The present study analyzed PPCU survey data administered at three different recruitment sites (Denver, CO; Pittsburgh, PA; and Richmond, VA). The present study examined women’s perceptions of the risks and benefits …

Prospective Investigation Of Insomnia Symptoms And Sleep Duration As Risk Factors For Stroke Incidence And All-Cause Mortality In U.S Adult, Wendemi Sawadogo

Theses and Dissertations

Background and Objectives: Stroke is the second leading cause of death in the world. In the United States, on average, someone has a stroke every 40 seconds and someone dies as a result of stroke every 3.5 minutes. Identifying modifiable risk factors of stroke is therefore a public health priority. The purpose of this study was to investigate the extent to which insomnia symptoms and sleep duration contribute to stroke incidence, all-cause mortality, and explore potential causal pathways.

Methods: The Health and Retirement Study (HRS) and the REasons for Geographic And Racial Differences in Stroke (REGARDS) study were …

Random Acts Of Stem: A Systematic Review Of Local K-12 School Division Stem Experiences In Virginia, Caro H. Medawar

Theses and Dissertations

The initial purpose of the study was to determine whether the school divisions in Virginia have definitions of STEM education. For the divisions that have described STEM education, the following valuation was based on the precise STEM education definition each has implemented. The population for the study included all 132 school divisions in This mixed-methods study investigated the implementation of STEM programs in Virginia K-12 schools. Data were collected through two avenues: publicly available online resources from school divisions and interviews with STEM leaders in the Virginia educational system. Data analysis on these two sources yielded five themes: (a) existence …

Examining Psychosocial Factors Of Chronic Disease Control To Improve Outcomes For Patients With Multiple Chronic Conditions, Kristen O'Loughlin

Theses and Dissertations

Psychosocial needs are associated with worse health outcomes for patients with multiple chronic conditions (MCC). The Biopsychosocial Model provides a framework for conceptualizing the influence that psychosocial factors have on the management of disease. To date, research has primarily focused on examining the relation between psychosocial factors and chronic disease onset. Therefore, the temporal relation between psychosocial factors and disease management remains poorly understood. The current study aimed to 1) describe patients’ psychosocial needs and their prioritization, 2) examine reciprocal relations between anxious symptoms, depressive symptoms, social needs, and MCC management, and 3) qualitatively explore patient definitions of health in …

Using Superatomic Clusters And Charge Transfer Ligands To Control Electronic Characteristics Of Phosphorene Nanoribbons And Phosphorene Monolayer, Ryan Lambert

Theses and Dissertations

Phosphorene is a two-dimensional electron poor p-type semiconductor with high carrier mobility and great promise for applications in electronics and optoelectronics. As the main theme in this dissertation, the following work represents different investigations of various electronic properties associated with phosphorene. Most notable are the findings on charge transfer doping with metal-chalcogenide superatoms which displays novel control of the two most important properties of a semiconductor – the band gap energy and the nature of carriers. By tuning the width of the gap and p-/n-type character of conduction, we gain control over a material’s capacity to play a certain role …

Early Termination In Phase Ii Clinical Trials: Admissible Designs Using Decreasingly Informative Priors, Chen Wang

Theses and Dissertations

In Phase II clinical trials, Thall and Simon’s Bayesian posterior probability design is commonly implemented to allow for an early termination to determine whether a new treatment warrants further investigation in a larger-scale Phase III trial; this in turn requires a pre-selected prior distribution based on known clinical opinion or historical information. Moreover, this Bayesian approach can result in an issue of inflating type I error rate by monitoring interim data to inform early termination decisions. Alternatively, a Bayesian approach with the decreasingly informative prior (DIP), which is an informative yet skeptical prior, can be implemented to overcome the contentious …