Digital Commons Network^™

De Novo Protein Binding To Zinc Oxide Through Biomineralization Pathways, Jean-Mark A. Francis

Theses and Dissertations

De novo proteins are structurally distinct from proteins found in nature and thus capable of having their amino acid sequence modified to accomplish tasks such as increasing protein-nanoparticle binding without unfolding or decomposing. Zinc Oxide nanoparticles are functionally distinct from their bulk counterparts and are widely used as semiconductors in a variety of fields such as medicine and agriculture. With demand for these nanoparticles increasing, environmentally sustainable methods of Zinc Oxide nanoparticle synthesis are being investigated as an eco-friendly alternative to currently utilized but environmentally hazardous chemical and physical techniques. This research investigates the binding characteristics between Zinc Oxide nanoparticles …

Commissioning & Daily Qa Of Converted Linac For Electron Flash, Tomaj Javidtash

Theses and Dissertations

Ultra-high dose rate (FLASH) radiotherapy has demonstrated promising normal tissue sparing in preclinical studies; however, the lack of standardized dosimetry, commissioning, and quality assurance (QA) methodologies remains a major barrier to its reproducible and safe implementation. In particular, conventional clinical commissioning and QA protocols are not directly applicable at FLASH dose rates due to challenges associated with detector response, dose-per-pulse effects, and beam control limitations.

This thesis presents the commissioning of a converted Varian 21EX linear accelerator for electron FLASH operation within the Division of Medical Physics at the Virginia Commonwealth University (VCU) Department of Radiation Oncology. Comprehensive beam characterization …

Follow The Cyclists: Everyday Navigation Of Richmond's Bike Infrastructure, Emily E. Schreer

Theses and Dissertations

This thesis explores the embodied experience of cycling in Richmond, emphasizing the importance of centering firsthand, lived experience in cycling research and urban planning. While traditional transportation planning can often myopically prioritize efficiency and safety metrics to evaluate infrastructure, this project argues that such approaches overlook essential experiential, sensory, and emotional dimensions of cycling that determine how infrastructure is perceived, used, and ultimately succeeds or fails.

Through an ethnographic approach combining field observation of cyclist behavior and mental mapping sessions with Richmond cyclists, this study positions people who bike in Richmond as expert knowledge holders. Participant contributions, combined with observations …

Between The Veins: Materializing Memory In The Age Of Digital Storage, Alice Mohammed Aslem

Theses and Dissertations

What happens to a childhood stored behind a password? This thesis began with a simple moment of scrolling through my son’s photographs on my phone. As the images multiplied, they began to lose clarity, turning into an overwhelming digital archive. This made me ask: What kind of memories am I preserving for him?

Having grown up between analog and digital worlds, Between the Veins explores how I navigate memory through material objects and digital archives. Using weaving, images are transferred onto screw pine and palm leaves. In this process, digital files of his childhood are translated into organic fibers of …

Munajat: Design As A Dialogue With The Divine, Shawky Abdalla

Theses and Dissertations

Contemporary design discourse remains grounded in functional, seemingly user-centered paradigms, often neglecting what lies beyond the tangible within a human experience. This research challenges such frameworks by positioning design as a dialogue with what exceeds the physical, moving toward the experiential, where meaning precedes and informs form. Drawing on Islamic philosophy, particularly the relationship between zahir and batin (outward form and inward meaning), the study repositions design as a medium for remembrance (dhikr) rather than mere utility.

Through a critique of modernist and postmodernist principles, the research proposes a series of objects that engage with memory, introspection, and transcendence in …

Contours Of Duration: Movement Authored Through Form—A Behavior Archive, Jood Senussi Elbeshti

Theses and Dissertations

Insect anatomy offers an elegant example of motion derived from structure. Inspired by insect movement, Contours of Duration employs a cam-and-follower system consisting of moving, leg-like parts, designed to engage a series of rotating cams, such that the shape of each cam’s surface activates the legs in unique ways, generating repetitive movement, and demonstrating how geometry produces distinct motion behaviors over time. Through iterative experimentation and controlled variation, trace emerges as a central methodology, whereby movement, over time, creates a distinct pattern of marks, making motion legible and reflecting how subtle changes to surface and form generate different behavioral outcomes. …

Fused Filament Fabrication Additive Manufacturing Of 17-4 Ph Stainless Steel: Process–Structure–Property Relationships In Magnetic Materials, Maanav Patel

Theses and Dissertations

Additive manufacturing (AM) enables the fabrication of complex metallic components through layer-by-layer processing directly from digital models. Among AM techniques, material extrusion–based processes such as fused filament fabrication (FFF) provide an accessible method for producing metal parts using filament feedstocks composed of metal powders and polymer binders. When applied to precipitation-hardening stainless steels such as 17-4 PH, the processing route and heat treatments can influence the resulting microstructure and functional properties. This work investigates the magnetic behavior of 17-4 PH stainless steel fabricated using FFF and evaluates how heat treatment conditions influence measured magnetic properties. Samples were produced and analyzed …

Tms Phantoms For Investigating Multimodal Neuromodulation Procedures, Wesley H. Lohr

Theses and Dissertations

Evidence suggests that combining deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) is potentially unsafe for certain TMS target locations, though TMS can alleviate several DBS-resistant PD symptoms such as speech impairment, freezing of gait, and dysphagia. Addressing this issue, head phantoms designed for TMS with embedded electric field (E-field) triaxial dipole probes (TDPs) are used to investigate a tunable magnetic shield that can protect implants from periphery E-fields and focalize magnetic fields. Through segmentation of MRI files, 3D printing, and injection molding of CNT-PDMS conductive composites, anatomical head phantoms are created. Anchoring TDPs to clinically relevant regions in …

Characterization Of Growth, Motility And C-Di-Gmp In Selenomonas Sputigena Atcc 35185, Margaret E J Stiker

Theses and Dissertations

Selenomonas sputigena is an obligate anaerobic, Gram-negative pathobiont that transitions from a low-abundance commensal bacteria to a structural component in dysbiotic oral biofilms associated with early childhood caries and periodontitis. Analysis of S. sputigena ATCC 35185 cultures optimized in TYGVS media revealed robust growth, characteristic crescent morphology with flagellar tuft motility, and strong monospecies biofilm formation comparable to Streptococcus mutans via crystal violet assays.

ELISA quantification demonstrated significantly elevated c-di-GMP levels in sessile biofilm fractions relative to motile planktonic cells (p=0.0009), establishing the secondary messenger’s correlation with the motile-sessile lifestyle switch. Recombinant expression and purification yielded PilZ-domain effector proteins, Selsp_1666 …

Class-Aware Early-Exit Networks For Efficient And Secure Edge Deployment, Mohammed Ayyat

Theses and Dissertations

Edge devices increasingly run high-stakes machine learning workloads under strict latency, power, memory, and communication constraints. Deep neural networks provide the accuracy needed for tasks such as network intrusion detection, health monitoring, autonomous sensing, and human activity recognition, but conventional inference executes the same computational path for every input. Early-exit neural networks reduce average inference cost by allowing confident samples to terminate before the final layer. However, existing early-exit systems are largely class-agnostic: they allocate computation according to confidence or uncertainty, without considering that different output classes may carry different operational urgency. This dissertation develops class-aware early-exit inference, a framework …

Nanomagnet Based Straintronic Devices For Unconventional Computing: Simulation And Performance Analysis, Rahnuma Rahman

Theses and Dissertations

Nanomagnetic devices are of great interest in digital hardware because of their non-volatility and dynamic ability to change magnetization but suffer from high switching error rates and temperature sensitivity. Magnetostrictive nanomagnets that utilize strain to switch between stable magnetization states encoding bit information are of interest since they are extremely energy efficient as piezoelectric layers can be used to rotate magnetization that have switching energies in the range of attojoules. Their stochasticity can also be useful in probabilistic, analog, neuromorphic, and collective computing systems, where occasional switching errors are not devastating. The dissertation extends spintronics beyond conventional computing schemes by …

Ontological Runtime Monitoring For Mission Engineering, Alexander R. Will

Theses and Dissertations

The advent of the Urban Air Mobility (UAM) concept will bring low-altitude aviation to civilians through passenger and cargo transport. However, the prospective vehicles in UAM studies are predominantly autonomous, raising questions about their efficacy and stability in densely populated urban areas. At the same time, extensive work has been performed to define a new branch of systems engineering that focuses on runtime behavior, synchronization, communication, and task allocation.This field is known as "mission engineering". Mission engineering has been deployed in military scenarios to model human-autonomy cooperation. By applying the concepts from this field to UAM, full systems-of-systems can be …

Foreign-National Families, Education, And Parenting: Unpacking The Influence Of Cultural Transitions On Child-Rearing And Expectations, Yuqi Zhang

Theses and Dissertations

This qualitative study examines how highly skilled foreign-national parents navigate parenting and educational decision-making within the context of cultural transition in the United States. While existing research on foreign-national parenting has largely focused on socioeconomically disadvantaged populations, less is known about families who possess substantial educational and professional capital. Despite these advantages, these parents encounter unique challenges related to institutional navigation, identity negotiation, and social constraints. Guided by Bronfenbrenner’s bioecological theory, Coleman’s social capital theory, Berry’s acculturation framework, and Yosso’s community cultural wealth model, this study explores how cultural background and migration experiences shape highly skilled foreign-national families’ parenting beliefs …

Towards Sample-Efficient Deep Reinforcement Learning, Guang Yang

Theses and Dissertations

Deep reinforcement learning (DRL), combining reinforcement learning and high-performance function approximations such as deep neural networks (DNN), is a powerful approach to solving complex sequential decision-making problems. However, due to the complex solution space of the sequential decision-making problems and the inefficient design of the DRL algorithms, DRL algorithms usually require a prohibitively large number of data samples to train effective strategies. Consequently, it is difficult to apply these DRL algorithms to complex real-world problems that require high costs to collect a large volume of data samples. This dissertation proposes new mechanisms to address this sample inefficiency issue, realizing sample-efficient …

An Integrated Data-Driven Framework For Arctic Shipping: Analyzing Vessel Speed, Environmental And Ecological Factors Through Innovative Statistical Spatio-Temporal Methods, Inverse Optimization And Machine Learning, Mauli Pant

Theses and Dissertations

This dissertation develops an integrated data-driven framework to analyze vessel navigation and ecological risk in the United States Arctic from 2010 to 2019. As environmental change and maritime activity increase in the region, understanding how vessels respond to dynamic conditions and how those responses interact with marine ecosystems has become increasingly important. A central theme of this dissertation is the treatment of vessel speed as both an observed outcome and a decision variable reflecting trade- offs among operational, environmental, and ecological factors. The first chapter develops a predictive framework for vessel speed over ground (SOG) using Gaussian Process Boosting (GPBoost), …

Pingbongbilladingdong: Abjection And Comedy In Art, Leroy A. Winter

Theses and Dissertations

As of late, my work has dealt with themes of collapse and comedy, pertaining specifically to faded ideals of individualism in art. My thesis installation, titled Pingbongbilladingdong, is a testament to this tension, portraying a reconstruction of the disheveled chaos of the artist’s studio. In this paper, I use this installation as a means to further explore the ways that abjection and comedy intersect in art, and how myself and others repurpose the faded glamor of Ab-Ex as a means to probe this overlap. Serving as an allegory for my experience with the studio, Pingbongbilladingdong presents an image of the …

Magnetic Resonance Only Planning Validation Using Synthetic Ct By Mvision, Eric D. Brass Sr

Theses and Dissertations

Problems: Adaptive radiotherapy requires clinically practical methods for responding to patient-anatomy changes that occur between the original planning images and the day of treatment delivery. Registering a previously acquired computed tomography scan to a newly acquired magnetic resonance image can introduce cross-modality uncertainty and may delay replanning. This thesis evaluates whether synthetic computed tomography generated from same-day magnetic resonance imaging can reduce registration-related uncertainty while supporting rapid dose recalculation for fraction-level adaptation.

Procedure: Magnetic resonance imaging DICOM data were exported from the ViewRay MRIdian treatment planning system and uploaded to MVision for synthetic computed tomography generation. The synthetic computed tomography …

Regulation Of Tgf-Β1–Induced Epithelial–Mesenchymal Transition By Integrin Inhibition, Wesam Elhawabri

Theses and Dissertations

Epithelial–mesenchymal transition (EMT) is a critical process underlying cancer progression, fibrosis, and tissue remodeling, characterized by coordinated changes in cell morphology, nuclear structure, and extracellular matrix (ECM) organization. Transforming growth factor beta 1 (TGF-β1) is a primary inducer of EMT; however, the extent to which integrin-mediated signaling and ECM remodeling regulate these structural changes remains incompletely understood. In this study, we quantitatively investigated EMT-associated remodeling in A549 lung carcinoma cells and MCF10A epithelial cells following TGF-β1 stimulation. Cells were cultured on ECM-coated substrates and treated with TGF-β1 in the presence or absence of integrin-targeting inhibitors (ATN-161, 28-G11, and STX-100). Im …

Algorhythm: Commodification Of Hobbies On Social Media Platforms, Fariha Ahmed

Theses and Dissertations

Forcing the world online, the COVID-19 pandemic appeared to turn social-media-based hobbies into income-generating cash cows. Digital creative spaces became sites of capitalist logic where hobbyists came to operate as both laborers and commodities. Profit-focused algorithms operate imperceptibly, shaping creative behavior and decision-making in ways that are difficult to recognize, and even harder to resist. This thesis asks how algorithmic participation on platforms such as Instagram conditions a hobbyist, and how that conditioning can be made legible to audiences who inhabit such platforms without always seeing them. Using autoethnography, I position myself as both researcher and subject to document the …

Advancing Cybersecurity Through Userland Memory Forensics: From Runtime Analysis To Security Applications, Hala Ali

Theses and Dissertations

Memory forensics has become a crucial component of digital investigations, particularly for detecting malware operating solely in system memory. As operating system vendors implemented kernel access restrictions, malware authors shifted to userland malware. However, existing memory forensics techniques have largely focused on kernel-level analysis, leaving userland runtimes insufficiently covered. This dissertation addresses this gap by expanding memory analysis capabilities across two distinct paradigms: interpreted and compiled runtimes. The first phase targets the Python runtime, developing automated recovery techniques that enable several security applications. For malware detection, these techniques extract critical forensic artifacts such as encryption keys and command-and-control configurations. For …

Proof Of Recovery: A Model To Enhance Data Integrity In Data Management Systems, Gustaf Barkstrom

Theses and Dissertations

Businesses lose millions of dollars every year when they can’t restore data from backups. Research shows that Disaster Recovery Plan (DRP) testing is not conducted frequently enough, nor are records maintained that demonstrate full data recovery from backups. This work introduces a design science artifact called PRTOK that aims to increase DRP testing. The design science artifact is a software solution that integrates with Data Management Systems (DMS)

such as iRODS and DSpace, and can work with formats such as HDF5 and BagIt. Proof-of- recovery records, or tokens, are recorded in a replicated, resilient, and indelible proof-of- authority blockchain data …

Nanomagnet Based Reservoir Computing And Quantum Control, Fahim F. Chowdhury

Theses and Dissertations

Conventional CMOS scaling has driven remarkable advances in computing but faces increasing physical and energy constraints, motivating alternative computing paradigms that integrate memory and computation while improving energy efficiency. Nanoscale magnetic systems offer a promising platform for such approaches because their intrinsic nonlinear dynamics and localized magnetic fields can support both classical and quantum information processing. This thesis investigates nanomagnetic systems for physical reservoir computing and, with primary emphasis, for localized quantum control of spin qubits.

The first part explores dipole-coupled nanomagnet arrays as physical reservoirs. Micromagnetic simulations demonstrate nonlinear dynamical behavior with high short-term memory and parity-check capacity, enabling …

Empirical Dynamical Modeling Of Cortico-Hippocampal Information Transfer During Memory Encoding, Sam Y. Cole

Theses and Dissertations

Understanding how brain dynamics support successful memory formation remains a central challenge in neuroscience. This dissertation applies tools from empirical dynamical systems theory to investigate the neural mechanisms underlying episodic encoding, with a focus on cortico-hippocampal interactions. Using stereoelectroencephalography (sEEG) data recorded during a delayed free recall of word lists task, this work reveals nonlinear, state-dependent shifts in directed information flow between cortex and hippocampus that distinguish successful from unsuccessful encoding. To further characterize these dynamics, state-space trajectories are reconstructed using time-delay embedding and recurrence-based methods, and features derived from these trajectories are used to classify memory outcomes. By integrating …

Modeling Of Laser-Produced Plasma Plumes: Expansion, Chemistry, And Thin-Film Deposition, Edmund Tsiri Semaha, Edmund Tsiri Semaha

Theses and Dissertations

Abstract

Laser-assisted material processing involves coupled plasma expansion, chemical reactions, and particle transport that govern the quality of thin-film deposition. This dissertation presents a comprehensive computational investigation of these processes using the OpenFOAM framework. First, the performance of the twoPhaseEulerFoam (tPEF), rhoCentralFoam (rCF), and sonicFoam (sF) solvers is evaluated for modeling laser-produced plasma plume expansion under atmospheric conditions, demonstrating that tPEF accurately captures shock-wave propagation, hydrodynamic behavior, and multispecies interactions. Building on this validation, the reactingFoam (rF) solver is employed to investigate the chemistry of aluminum plasma expanding into an air environment (Al–N₂–O₂). The model incorporates appropriate thermodynamic, transport, and …

Instructional Systems Design In Lesson Planning For Substance Use Treatment Groups: A Mixed Methods Exploratory Study, Michelle Robin Gould

Theses and Dissertations

This study explored lesson planning for substance use disorder (SUD) treatment groups, investigating the presence of components from the ADDIE (Analysis, Design, Development, Implementation, Evaluation) instructional systems design (ISD) process in routine facilitator lesson planning practices. Using an exploratory mixed-methods convergent parallel design, data were collected via an online survey featuring closed- and open-ended questions regarding self-reported planning activities and perceived effectiveness. Quantitative analysis confirmed that SUD facilitators perform tasks associated with all five ADDIE phases. Qualitative findings showed that facilitators perceive themselves as effective planners despite logistical and organizational constraints. However, facilitators do not appear to conceptually link instructional …

To Put It Simply, Men Are Like Kites., Yangyang Zhang

Theses and Dissertations

This thesis explores the performative professionalization of So-called “emotional mentors” on mainstream Chinese social media platforms, specifically Douyin (the Chinese version of TikTok). and its impact on the contemporary Chinese emotional landscape. Through a series of undercover investigations in livestreams, I analyze the rhetorical tactics and professional jargon used by these “Gurus” to attract and monetize vulnerable audiences.

The research highlights a critical paradox: while promising emotional clarity, these methods from “Love Gurus” often corrupt the sincerity of intimate bonds, resulting in significant emotional labor and self-doubt for Female. The project aims to demystify this predatory industry and its role …

Loved Right: Encouraging The Responsible Adaptive Reuse Of Historic Buildings In The Information Age, Christie Chirinos

Theses and Dissertations

This research contributes to interior design scholarship by situating immersive virtual reality (VR) as an efficiency tool and an architectural visualization tool within adaptive reuse and historic preservation practice. Interior designers are increasingly tasked with mediating between cultural heritage, community stakeholders, regulatory constraints, and economic feasibility, in buildings that already exist. By positioning VR as a tool with utility across every stage of the design process, this study expands interior design research beyond material and spatial interventions to include storytelling and technological innovation as drivers for design decision-making. The work bridges interior design, preservation, and participatory planning, demonstrating how immersive …

Dodgeballs And Dragons: Gamified Live Theatre In The Service Of Community Betterment, Teddy Mcpherson

Theses and Dissertations

This thesis qualifies and documents a new genre of interdisciplinary, interactive theatre called Dodgeballs and Dragons. It covers a brief history of Dungeons and Dragons and Theatre of the Oppressed (the two foundational works for the new genre) as well as previous uses of D&D as a form of theatrical entertainment. After establishing the precedence used to create this product, the rest of the thesis breaks down how to write, lead, and play these shows on a regular basis. The document culminates in collected data providing concrete evidence for the future of the form and its many applications.

Culturally Responsive Pedagogy: Its Role In Maximizing Students’ Performance On Standardized Tests, Keisha Ricketts-Martin

Theses and Dissertations

This applied dissertation was designed to highlight the importance of pedagogy for cultural responsiveness, and to explore the relationship between such pedagogy and middle school students’ performance on state or standardized tests. Therefore, this study explores the educational or academic values that students will gain from being engaged in a learning environment that recognizes their culture and uses it as a tool to maximizing their educational outcomes.

This research employed convergent parallel mixed method design. Therefore, it implemented the qualitative and quantitative approach at the same time and placed equivalent worth to the information collected by each approach. Therefore, the …

From Bias To Bottleneck: A Quantitative Analysis Of Gender Preferences In Tech Hiring, Uma Chidambaram

Theses and Dissertations

This applied dissertation examined whether gender preferences influence hiring decisions in the information technology (IT) sector, and whether such preferences contribute to the ongoing labor shortage in the field. Despite national and international initiatives to close the gender gap, women continue to represent only 28% of the United States IT workforce and remain significantly underrepresented in technical and leadership roles. Grounded in the Eagly and Karau (2002) Role Congruity Theory of Prejudice, this study investigated whether evaluator gender and candidate gender alignment affect interview selection outcomes at the résumé screening stage for both leadership and non-leadership IT positions.

A quantitative, …