Digital Commons Network^™

Gardenia Jasminoides Extract As A Potential Neuroprotective Agent In An In Vitro Tauopathy Model, Inas Birekdar

Theses and Dissertations

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder marked by the selective loss of neurons in various brain regions, leading to cognitive dysfunction. Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau protein accumulate within neuronal cells leading to cell death. The development of effective treatments for neurodegenerative diseases (NDs) remains a significant challenge, with neuroprotection emerging as a promising therapeutic strategy to slow disease progression and preserve cognitive function.

Objective: This study aims to investigate the potential neuroprotective effect of Gardenia jasminoides fruit extract, which contains geniposide, a biologically active compound known for its neuroprotective properties, in mitigating Tau hyperphosphorylation in …

Characterization Of Ultra-High-Speed Friction Stir Welds Made In Thin Sheet Aa6061-T4 Material, Todd Grant Lainhart

Theses and Dissertations

Friction stir lap welding (FSLW) of thin aluminum sheets in industry and in research has faced challenges in weld quality that limit welding speeds. Interfacial defects such as hooking and thinning are common defects that appear at the interface of FSLW, and researchers and process operators have traditionally reduced process parameters such as feed rate and spindle rotation to fully eliminate the defects. While such measures are successful in creating fully consolidated FSLW, feed rates for FSLW have stagnated around 1 mpm with the fastest feed rates recorded at 3 mpm, making it difficult for manufacturers to implement FSLW in …

Computational Advances For Single-Cell Proteomics, Hannah Boekweg

Theses and Dissertations

The overarching goal of biologists is to characterize biological systems. When the workings of a system are understood, they can be fixed, broken, preserved, mimicked, and even replicated. The field of proteomics seeks to characterize systems through the lens of proteins. Proteins are referred to as the 'workhorse' of the cell to illustrate that they perform most functional tasks within the cell. These tasks are highly varied, including enzymatic activity, structural support, transport, storage, cell signaling, gene regulation, immune response, and more. Proteomics has been instrumental in new biological discoveries by characterizing the functional state of cells. A new area …

The Cellular Mechanisms Of Alzheimer's Disease Protection By The Pilra G78r Variant, Wenhan Cheng

Theses and Dissertations

Microglial dysfunction is increasingly linked to Alzheimer’s Disease (AD). Immune receptors like TREM2 and CD33 play opposing roles in microglial activity. TREM2 activation triggers immunoreceptor tyrosine-based activation motif (ITAM) signaling to promote microglial activities, including amyloid-β clearance, but variants in TREM2 such as R47H that impair its function increase AD risk. In contrast, CD33 is an inhibitory receptor that contains an immunoreceptor tyrosine-based inhibitory motif (ITIM) which transmits signals that suppress microglial function. An AD-protective variant in CD33 alters CD33 activity, potentially enhancing TREM2 function. PILRA is another inhibitory immune receptor expressed by microglia that contains an ITIM. A naturally …

Implications Of The Mind’S Active Participation In The Formation Of Perception, Maikel Adel Samy Michael

Theses and Dissertations

The mind-body problem, particularly the issue of qualia, remains a fundamental challenge in understanding the nature of the mind and its relation to the body. In this thesis I argue that the problem is epistemic, stemming from how we perceive and know ourselves as physical and mental beings. This argument will be explored through the respective of idealisms proposed by George Berkeley and Immanuel Kant. Berkeley's idealism suggests that reality is rooted in perception, offering a major steppingstone by demonstrating the major role perception plays in understanding and acquiring knowledge. Kant contributes by asserting that the "thing-in-itself" is beyond our …

Future Of Work: Implication Of Green Economy On Employment Dynamics In Egypt, Sarah Adel Elgohary

Theses and Dissertations

Is Egypt's green economy a reality or just a policy-level aspiration? This thesis explores the tangible impact of the green economy on Egypt's labor market by examining key sectors—automotive, agriculture, and renewable energy. Through qualitative interviews and focus group discussions with private sector representatives, the study assesses the true implications of the green transition from a business-level perspective, beyond the propaganda and hype surrounding climate policies. What is the current scale of the green economy in Egypt's labor market? What existing policies and regulatory frameworks are in place to support the green economy transition? how urgent is the transition to …

The Social Standing Versus The Mind Standing Of Older Adults In Egypt: Cross-Sectional Analysis Of The Relationship Between Social Capital And Cognitive Functions, Shaza H. Shinaishen Dr

Theses and Dissertations

Introduction: Egypt's population, much like that of other countries, is expected to age considerably over the course of the coming decades. Although biological and socioeconomic predictors of cognitive function have been studied widely, personal level social capital remains unexplored, especially in LMICs.

Purpose: This study primarily investigates the relationship between individual social capital and cognitive functioning among older adults aged 65 years and older in Egypt using the structural and cognitive components of social capital, including group membership, civic engagements, and caregiving roles.

Methods: A cross-sectional survey on 363 older individuals in different geographical and demographic segments of Egypt using …

Assessing The Impact Of Digital Transformation On Regulatory Processes And Systems Compared To Traditional Paper-Based Processes At The Egyptian Drug Authority, Rania Aa Soliman

Theses and Dissertations

In the past several decades, the rate of scientific and technological advancements in drug development and digital fields have been extraordinary. Internet of Things and block chain technologies are currently viable in the mature cloud computing industry, these transformative examples contrast starkly with the current pharmaceutical regulatory submission, review, and approval process of the EDA. However, with the emergence of initiatives that aim to improve and expedite regulatory decision-making, there is a promising future ahead. These initiatives, if successful, will not only transform the current transactional structure but also leverage scientific and technological advances to deliver patient-centric therapies. This radical …

Comparative Analysis Of Water Management Practices In Denmark, Egypt And Uganda: Implications For Sustainable Water Management In Uganda, Junior Twehamye Ashaba

Theses and Dissertations

Water scarcity and mismanagement are escalating global challenges, with over two billion people lacking access to safe drinking water and projections indicating that nearly two thirds of the world’s population could face water shortages by 2050 (Jones et al., 2024). This thesis presents an analysis of water governance and management practices in Denmark, Egypt, and Uganda-three countries that exemplify diverse hydro-climatic conditions, socioeconomic realities, and institutional frameworks. The study explains how governance structures, technological innovation, stakeholder participation, and policy design shape water resource outcomes, and how lessons from Denmark and Egypt can inform more resilient and sustainable water management in …

5d Framework To Maximize Revit's Potential In Bim For Commercial Projects, Mohamed Swailim

Theses and Dissertations

This research investigates the integration of a 5D framework within Building Information Modeling (BIM) using software to optimize efficiency in the design and construction of commercial projects, specifically within the hospitality, retail, and residential sectors. While the advantages of BIM are well documented, its full potential remains underutilized, particularly in large-scale commercial developments that significantly impact national economies. A structured methodology was employed to address this gap, beginning with a systematic literature review (SLR) to explore existing applications of 5D-BIM in commercial projects, focusing on trends, challenges, and implementation strategies. Expert interviews were conducted to gain insights from professionals experienced …

Practicality Of Implementing Sub-Clause 8.4 [Advance Warning] Of The Fidic 2017 Red Book In Egypt, Gehad Ibrahim

Theses and Dissertations

Disputes in construction projects can cause cost and time overruns that can be detrimental to the parties involved and to the project. Several measures have been advocated by the industry’s practitioners in an attempt to avoid disputes and their adverse impacts. One of these measures is the introduction of advance warning sub-clauses in construction contracts, where the contracting parties play a proactive and collaborative role in warning each other of potential adverse impacts to the project. Such clauses have been in the NEC suite of standard construction contracts for decades and have recently found their way to the 2017 edition …

Opportunistic Networks On The Move: A Context-Aware Framework For Opportunistic Networking Under Heterogeneous Mobility Settings, Sara Elsingergy

Theses and Dissertations

Most computer networks require continuous end-to-end connectivity between sending and destination nodes for data transfer. However, in certain scenarios—such as disaster zones, geographically remote areas with intermittent or no connectivity, or regions facing peak network loads—such continuous communication paths may be unavailable. A notable example of this challenge occurred during Hurricane Milton in 2024 and the Los Angeles wildfires in 2025, where Starlink provided free satellite internet to support disaster relief efforts and enable communication in affected areas. However, while offering satellite services at no cost can be effective in emergencies, it may not always be feasible on a global …

The Sealed Palace: How Direct Access To The Supreme Constitutional Court Can Bridge The Gaps In Constitutional Review In Egypt, Ahmed Sameh Fahmi

Theses and Dissertations

This thesis examines the limitations of Egypt’s current constitutional review system and argues for the introduction of a direct access mechanism to the Supreme Constitutional Court (SCC). Under Egypt’s centralized model of judicial review, individuals are restricted to indirect access through ordinary courts, which has resulted in significant procedural and substantive inefficiencies. The referral-based mechanism of judicial review of legislation has caused delays in adjudicating constitutional claims, the insulation of certain laws from review, legislative omissions, and excessive gatekeeping by lower courts. Through a comparative analysis of direct access models in Colombia, Germany, Turkey, and South Africa, the thesis identifies …

Predicting Secondary Mathematics-For-Teaching Knowledge Using Beliefs, Experience, And School Culture: A Hierarchical Regression Analysis, Adam R. Brulhardt

Theses and Dissertations

Research in recent decades has supported the notion that practice-based mathematical knowledge is crucial for effective teaching, playing an important role in enacting reform-oriented instruction required for improving student achievement. Despite its importance, teachers—especially novices—require more support in acquiring such knowledge, an ongoing challenge exacerbated by teacher shortages. The purpose of this quantitative study was to determine whether collaborative school culture (CSC) explained variance in knowledge of algebra for teaching (KAT) beyond variance explained by mathematics-related beliefs and years of teaching experience for U.S. secondary teachers. Measures within an online Qualtrics survey included the Beliefs About Mathematics and Teaching Scale …

Rapid Beamformer Weight Calibration Update Method For The Advanced L-Band Phased Array Camera For Astronomy (Alpaca), Kayla Lyman Ward

Theses and Dissertations

The Advanced L-Band Phased Array Camera for Astronomy (ALPACA) is a phased array feed instrument designed for the Green Bank Telescope. It is capable of producing 40 real-time beams on the sky, widening the telescope's field of view and significantly increasing survey speed. ALPACA employs an RF-over-fiber (RFoF) signal transport system from the phased array feed front end to the digital backend. This RFoF link is expected to introduce phase delays and changes in gain through out the course of an observation, invalidating the beamformer weights previously calculated. This work presents rapid beamformer weight calibration updates for ALPACA, a method …

Development And Pilot Evaluation Of A Math Intervention Program To Increase Number Sense Proficiency Of Second Grade Students, Susan Galloza

Theses and Dissertations

Students continue to function below grade level proficiency in math and thus, the need for effective intervention. The purpose of this study was to develop and examine the efficacy of a targeted number sense intervention for second grade students. Specifically, the study examined the benefits of an intervention, analyzed number sense as an essential foundational skill, and determined if proficiency in number sense leads to math proficiency. Employing a quasi-experimental design, an intervention was implemented in 14 weeks for students who demonstrated a deficit in number sense and outcomes were assessed using multiple measures. Primary findings indicated that students who …

Leading The Way For Better Stem Education: Perceived Leadership, Self-Efficacy, And Commitment Among Stem Teachers, Celina Fayez Fanik Bray

Theses and Dissertations

This study investigated the relationships among leadership, self-efficacy, and commitment in STEM high school teachers. Grounded in social cognitive theory (Bandura, 1986) and self-determination Theory (Deci & Ryan, 1985), the study was guided by three hypotheses: (1) STEM teachers perceived leadership is significantly related to self-efficacy; (2) STEM teachers perceived leadership is significantly related to commitment to teaching; and (3) self-efficacy mediates the relationship between STEM teachers perceived leadership and commitment. This study employed a quantitative cross-sectional research approach that specifically used descriptive correlational design to examine possible relationships among perceived leadership, self-efficacy, and commitment in STEM high school teachers …

Wireless Bus Interconnects For Enhanced Small Satellite System Integration And Reliability, Adam Fifth

Theses and Dissertations

In small satellite engineering systems, managing numerous subsystem interconnections presents a significant design challenge directly impacting mission success. Traditional CubeSat subsystems rely on the PC/104 header system for integration, which consumes substantial board area and adds considerable vertical spacing between subsystems. This rigid wired architecture severely restricts subsystem density, complicates assembly and testing procedures, and prevents reconfiguration of interconnections after deployment. This dissertation presents a transformative approach to satellite subsystem integration by developing and validating a Bluetooth Low Energy (BLE) wireless interconnect system replacing traditional wired connections. This research addresses wireless implementation challenges. Through iterative prototype development, I demonstrate a …

Development And Miniaturization Of Pad-Printed Carbon Electrodes For Antibody-Type Biosensing, Elizabeth Danielle Clark

Theses and Dissertations

Miniaturized, pad-printed carbon electrodes (PPCEs) offer a promising platform for antibody-type biosensors, enabling rapid and cost-effective point-of-care diagnostics. This study investigates the development, fabrication, and electrochemical performance of large and miniaturized PPCEs functionalized for antibody-type detection, with the eventual goal of detecting pancreatic cancer specific biomarkers. The PPCEs were made of silver- and carbon- based inks that were formulated to be pad printable and conductive and printed on polycarbonate film so they can be easily disposed of after use. Each PPCE was thoroughly cleaned with ethanol several times to ensure a clean base on which to adsorb antibodies and antigens. …

From Assistance To Impact: The Expanding Role Of Undergraduate Teaching Assistants In Higher Education, Erin Measom

Theses and Dissertations

This dissertation is presented in a three-article format. It explores the evolving role of undergraduate teaching assistants (UTAs) in higher education, with a particular focus on how they facilitate interaction, engagement, and student success in online courses. As higher education institutions expand online learning and seek innovative ways to enhance student support, UTAs have emerged as key players in bridging the gap between students and instructors. The first article provides a scoping review of the literature on UTAs, tracing their historical evolution and examining their expanding role. While traditionally viewed as logistical or grading assistants, UTAs are increasingly taking on …

Multi-Parameter Optimization Of Brine Desalination Using Machine Learning, Elaf Mman Seif

Theses and Dissertations

Air Gap Membrane Distillation (AGMD) is a promising desalination technology with significant potential for addressing global water scarcity. However, the interplay of operational parameters significantly impacts its performance, making optimization a challenging task. This research focuses on brine desalination as a means to mitigate the negative environmental impacts of brine disposal which will eventually help in provide a sustainable solution for handling brine while producing freshwater. The study seeks to develop a predictive model and optimize the AGMD process for efficient brine desalination. To achieve this, Response Surface Methodology (RSM) and Artificial Neural Networks (ANNs) were utilized to develop predictive …

Deep Neural Networks For Particle Identification In Simulated Proton-Proton Collisions At Lhc And Rhic, Omar Mazhar Khalaf

Theses and Dissertations

Particle identification is an essential part of experimental high-energy physics, which allows the study of the most fundamental constituents of matter. This thesis explores the use of deep neural networks for identifying particles in simulated proton-proton collisions at the Large Hadron Collider (LHC) and the Relativistic Heavy Ion Collider (RHIC). The deep neural networks were trained on LHC datasets which have various momentum ranges including regions of high transverse momentum above 3 GeV/c. The key findings of thesis include achieving an accuracy of 99.99%, 98.3%, and 90.14% for 3-5 pt, 5-7 pt and above 7 pt regions respectively for the …

Optimization Of Pile Construction Sequence Using Cfa Machines, Omar Wael Ammar

Theses and Dissertations

In most construction projects with deep foundations, piling activities are critical to the project schedule and often fall on the critical path. The piling construction process requires a diverse range of resources, including equipment, materials, and skilful labour. Without carefully planning the construction process according to installation standards, there is a significant risk of time and cost overruns. These overruns are caused by inefficiencies such as equipment idle or lost time due to required lags between closely spaced piles. Therefore, it is essential to develop an optimized construction sequence to minimize these risks and enhance overall project efficiency. The primary …

An Llm Approach For Automating The Analysis Of Bim (Ifc) Data, Miral Selim

Theses and Dissertations

This thesis introduces a novel methodology for automating the analysis of Building Information Modeling (BIM) data using LangGraph, an advanced extension of the LangChain framework, and integrating Google’s Gemini Large Language Model (LLM) with IfcOpenShell. BIM, and specifically Industry Foundation Class (IFC) files, are widely used in the construction industry for representing and managing building data. However, analyzing this data effectively remains a significant challenge due to its volume and complexity. Additionally, analyzing BIM data typically requires knowledge of different BIM software depending on the application. This research addresses this challenge by creating a workflow that utilizes LangGraph’s ability to …

Image-Based Models For Left Heart Flow Morphodynamics In Hypertrophic Obstructive Cardiomyopathy, Abdelrahman A. Sultan

Theses and Dissertations

Relieving flow obstruction in hypertrophic obstructive cardiomyopathy is highly effective in reducing symptoms and promoting left ventricular remodeling. However, existing characteristics in the disease, such as the systolic anterior motion of the mitral, mitral regurgitation, and papillary muscle motion, and their effect on ventricular flow and vortex formation, have not been thoroughly addressed. This study aims to develop image-based computational fluid dynamics models to evaluate flow morphodynamics in hypertrophic obstructive cardiomyopathy. A computational fluid dynamics model is constructed to investigate the interaction between inflow and outflow in hypertrophic obstructive cardiomyopathy, with a focus on how the motion of the left …

Removal Of Fluoroquinolones From Water Systems Employing Rice Husk Composited Sponges Via Nanoadsorption, Dalia Kanaa

Theses and Dissertations

A novel nanocomposite of polyvinyl alcohol formaldehyde (PVF) sponge loaded with green zinc oxide nanoparticles (ZnONP) and referred to as (NP-PVF) was fabricated as a potential adsorbent of ciprofloxacin from water. A simple mechanical foaming process was used to synthesize the adsorbent. Rice husk extract was used to synthesize zinc oxide nanoparticles (ZnONP) for its phytochemicals as reducing agents. A facile and low-energy-dependent extraction method was used that did not require the use of high-temperature annealing. The synthesized nanoparticles showed a maximum UV absorption at 347 nm, which corresponds to a 3.58 eV band gap energy. FTIR confirmed the successful …

The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher

Theses and Dissertations

Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …

Development Of Preventive Dental Guidelines In The Primary Healthcare Setting In Egypt: A Delphi Method, Basant Mehriz

Theses and Dissertations

This study addresses the critical need for standardized preventive dental care guidelines within Egypt's primary healthcare system amid the rising burden of oral diseases. Through a systematic two-phase methodology combining a comprehensive literature review and a Delphi consensus-building process engaging 35 dental professionals, the research established priorities for contextually appropriate preventive measures. The consensus framework revealed strong support for clinical interventions (mean of 83% agreement), particularly fluoride-based prevention; community initiatives (mean of 83%), especially school-based programs; policy measures (mean of 77%) such as workforce and educational development, though with variable support for taxation and social determinants approaches. Statistical analysis demonstrated …

Multi-Field Quantum Conference Key Agreement Using An Integrated Photonic Green Machine, Benjamin J. Fisher

Theses and Dissertations

Quantum Conference Key Agreement (QCKA) enables a group of users to generate a shared secret key, which reduces the latency and equipment overhead of establishing multiple Quantum Key Distribution (QKD) links. Conventional QCKA protocols send a multi-photon entangled state from one user to others and a key is generated only when all photons are detected, which is inefficient at high loss and opens side-channels at the receiver side. Here, we overcome this barrier through a multi-field QCKA protocol enabled by designing, fabricating, and testing an integrated photonic Green Machine that implements an eight-mode Hadamard unitary transformation through a beam-splitter network. …

Optimized Wireless Power Transmission For Low-Cost, Energy-Efficient Internet Of Things Devices In Residential Environments, Daniel Brook Hatch

Theses and Dissertations

Wireless power transmission (WPT) offers a promising solution for powering devices in locations where traditional electrical outlets are inaccessible, such as ceilings or outdoor environments. By utilizing electromagnetic waves, such as light, WPT enables power delivery without the need for physical connections. With line-of-sight (LoS) as its primary limitation, this technology offers significant flexibility and potential for a wide range of applications, making it a compelling focus for research and innovation. Despite the advancements in WPT technologies, their practical application for powering Internet of Things (IoT) devices in real-world scenarios remains underexplored. Many IoT devices are installed in locations where …