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Investigating The Role Of Metallothioneins In Fungal Iron Homeostasis, David Eap Jul 2025

Investigating The Role Of Metallothioneins In Fungal Iron Homeostasis, David Eap

Theses and Dissertations

The pathogenic fungi Aspergillus fumigatus requires metals to survive and infect humans, but metal overload can be detrimental. Metallothioneins (MTs) are small, cysteine-rich proteins that alleviate metal toxicity by binding excess metals (typically Zn or Cu) for storage or delivery. A recent report indicates that the Fe-S cluster binding glutaredoxin GrxD and the putative Cu-MT CmtA were interacting under high iron conditions in A. fumigatus. We hypothesize that this MT may have a role in binding iron or Fe-S clusters under iron overload conditions to prevent iron toxicity. We also aim to characterize this new MT by determining its …


The Impact Of The Flipped Learning Approach On Student Engagement In A High School Chemistry Classroom, Alana Lyn Hicks Jul 2025

The Impact Of The Flipped Learning Approach On Student Engagement In A High School Chemistry Classroom, Alana Lyn Hicks

Theses and Dissertations

This mixed-methods action research study investigated the impact of the flipped classroom approach on student engagement and attitudes within a science classroom. Data was collected using student-reported responses on the Classroom Engagement Inventory, Motivated Strategies for Learning Questionnaire, student journal entries, teacher reflective journals, and an observation tracking chart kept by the classroom teacher. Findings revealed that the flipped classroom model significantly increased affective and cognitive engagement among students in a larger class size, as well as for medium-achieving students and girls. These results suggest that while the flipped classroom has the potential to enhance engagement, its effectiveness is influenced …


Relative Hazard Losses Along The Atlantic And Gulf Coasts, Erin Kemp Jul 2025

Relative Hazard Losses Along The Atlantic And Gulf Coasts, Erin Kemp

Theses and Dissertations

Coastal areas face a variety of natural hazards, many of which are increasing in frequency or severity due to climate change. Continued coastal development emphasizes the need for a better understanding of the impact of these hazards on coastal communities. This study aims to improve this understanding by investigating temporal, spatial, and causal patterns in county-level relative losses (RL) from hazards along the Atlantic and Gulf Coasts from 2001 to 2021. Three research questions are addressed: 1) Are relative losses increasing over time in coastal counties? 2) Where are the highest relative losses among coastal counties? and 3) Which hazards …


An Efficient Detection And Deep Clustering Based Pipeline For Reliable Rodent Ultrasonic Vocalization Analysis, Sabah S. Anis Jul 2025

An Efficient Detection And Deep Clustering Based Pipeline For Reliable Rodent Ultrasonic Vocalization Analysis, Sabah S. Anis

Theses and Dissertations

Ultrasonic vocalizations (USVs) are critical for understanding rodents' emotional states and social behaviors. However, manual analysis of USVs is time-consuming, subjective, and prone to errors. This thesis presents an automated pipeline that addresses these challenges by performing efficient USV detection and clustering. The proposed approach significantly reduces the time and effort needed to analyze USV data while improving accuracy and reproducibility.

To address this gap, we introduce ContourUSV, a five-step pipeline for USV detection. First, it begins with generating spectrograms from audio recordings, which are then pre-processed to enhance the contrast between USVs and background noise. Key steps include median …


Exploring Technology Use And Loneliness Among African American Older Adults, Sarah Pace Jul 2025

Exploring Technology Use And Loneliness Among African American Older Adults, Sarah Pace

Theses and Dissertations

Loneliness among African American older adults is a pressing public health concern, affecting more than one-quarter of this population and increasing the risk of premature death. This study explores the experiences of loneliness among African American older adults and examines the technologies they use, the purposes they serve, and their perceived role in mitigating loneliness. It also investigates barriers and facilitators to technology use for promoting social connection. Guided by the Social Support Theory and Technology Acceptance Model 3 (TAM3), the study centers the perspectives of an underrepresented population.

Fifteen African American women aged 67–82 participated in semi-structured interviews between …


Post-Selection Inference In Regression Models, Qinyan Shen Jul 2025

Post-Selection Inference In Regression Models, Qinyan Shen

Theses and Dissertations

This dissertation develops new methodology for valid statistical inference following model selection in various regression settings. We first consider the logistic regression model for a binary response that can only be observed at the group level, as in group testing, and is subject to testing error. With the true responses only partially observed, we employ the expectation-maximization (EM) algorithm to account for missing information in the response data and simultaneously conduct variable selection using the LASSO-penalized log-likelihood function. After variable selection, we extend an existing post-selection inference method based on the polyhedral lemma \parencite{lee2016exact} to make inferences on selected covariates, …


Methods And Applications For Bayesian Semiparametric Survival Analysis, Zile Zhao Jul 2025

Methods And Applications For Bayesian Semiparametric Survival Analysis, Zile Zhao

Theses and Dissertations

Survival analysis is a cornerstone of biomedical and clinical research and plays an important role in fields as diverse as engineering, actuarial science, and sociology. In this dissertation, we develop new semiparametric Bayesian methodology for three problems from survival analysis: 1) adjustment for treatment crossover in randomized controlled trials (RCTs), 2) multilevel modeling of clustered survival outcomes when the cluster size is also informative, and 3) divide-and-conquer Bayesian inference for massive survival data. Our methods are semiparametric in the sense that we assume the covariates have a linear effect with regard to the log-hazard or the log- survival time; however, …


Enhancing Self-Efficacy In Ap Psychology Through Targeted Intervention Strategies, Felicia Jennifer Butler Jul 2025

Enhancing Self-Efficacy In Ap Psychology Through Targeted Intervention Strategies, Felicia Jennifer Butler

Theses and Dissertations

The purpose of this mixed-method action research case study was to measure the effects of an individualized intervention on academic self-efficacy and academic achievement in an Advanced Placement (AP) psychology class. The study focused on four students who received a failing grade on the first unit test and took place over an eight-week period. Quantitative data was collected in the form of assessment data (both formative and summative), survey questions modeled after the General Academic Self-Efficacy Scale (GASE), and assignment completion. Qualitative data was collected in the form of semi-structured interviews and open-ended reflection questions. The findings suggest that psychology …


Quinone-Mediated Extracellular Electron Transfer In Escherichia Coli During Glucose Oxidation Metabolism, Megan Danielle Whisonant Jul 2025

Quinone-Mediated Extracellular Electron Transfer In Escherichia Coli During Glucose Oxidation Metabolism, Megan Danielle Whisonant

Theses and Dissertations

The growing global demand for energy, ongoing reliance on fossil fuels, and increasing water pollution from industrial and anthropogenic sources present significant environmental challenges. In response to these issues, renewable and sustainable energy sources offer substantial potential for reducing dependence on fossil fuels and ensuring access to clean water. Microbial electrochemical systems (MESs) have emerged as promising, eco-friendly solutions for energy-efficient wastewater treatment and bioremediation. A key challenge in MESs development is facilitating effective electron transfer between microorganisms and electrode surfaces. The first chapter of this thesis discusses the fundamentals of MES types, explains mechanisms of extracellular electron transfer, and …


Educational Technology In Peer-Led Academic Support In Higher Education: The Impact Of Technology-Focused Training On Peer Educators’ Session Plans, Christopher Gulino Jul 2025

Educational Technology In Peer-Led Academic Support In Higher Education: The Impact Of Technology-Focused Training On Peer Educators’ Session Plans, Christopher Gulino

Theses and Dissertations

Students interact with technology daily; whether that is in the classroom, engaging with classmates, or studying material. Although technology has been widely adopted across the field of higher education, it has not been widely utilized to engage with students through the peer-to-peer support model. The purpose of this action research was to evaluate the implementation of educational technology training and its effect on undergraduate peer educators’ confidence to utilize technology in their plans for their peer-to-peer support sessions at a university in the southeast of the United States of America. The research will address the following research questions: How confident …


Lessons In Game Use: Examining Engagement And Content Knowledge With The Use Of Digital Game-Based Learning Lessons In Biology, Rebecca Anne Valencia Jul 2025

Lessons In Game Use: Examining Engagement And Content Knowledge With The Use Of Digital Game-Based Learning Lessons In Biology, Rebecca Anne Valencia

Theses and Dissertations

According to both national and local data, students in high school biology classes are disengaged in content learning and do not demonstrate sufficient understanding of the content taught during units focused on the mechanisms of heredity and gene expression. Traditional teaching methods do not hold their interest which leads to disengagement and missed learning opportunities. The purpose of this action research was to evaluate the effect of digital game-based learning lessons on biology 1 students’ engagement and content knowledge application regarding the mechanisms of heredity and gene expression, as well as on the students’ perceptions of their digital game-based learning …


Reduced Order Model-Based Framework For Microsecond Model Updating Of Two-Dimensional Structural Systems Using The Local Eigenvalue Modification Procedure, Emmanuel Abiodun Ogunniyi Jul 2025

Reduced Order Model-Based Framework For Microsecond Model Updating Of Two-Dimensional Structural Systems Using The Local Eigenvalue Modification Procedure, Emmanuel Abiodun Ogunniyi

Theses and Dissertations

Real-time model updating is crucial for active structures and electronic assemblies subjected to high-rate dynamic events. High-rate dynamic events refer to events that occur at high speeds and with rapid changes in the forces and energy involved. These events can include explosions, impacts, and crashes. These systems are characterized by a high dynamic response with a high rate (< 100 ms), high amplitude (> 100 gn), highly nonlinear, meaning that the response is not proportional to the applied force, and involve complex interactions between multiple objects or materials. A system exposed to high-rate dynamic environments is frequently prone to rapid plastic deformation, involving violent and …


Sensing Others, Alissa Reed Jul 2025

Sensing Others, Alissa Reed

Theses and Dissertations

In this project, I notice how we listen and respond to animals, both through marine bioacoustics studies and rhetorical theory, and consider how we might develop new ways of noticing and interacting with animals. I hold together rhetorical theory, marine bioacoustics studies, and my observations nest sitting sea turtles to see what kind of multispecies ethic emerges from messy encounters with nonhuman others – specifically, with sea turtles nesting on the beaches of the Outer Banks in the Summer of 2020. By confronting the unavoidable moments of indecision, and even possible violence, inherent to encounters with nonhumans others, even and …


Cultivating Smiles On The Frontier: The Making Of Brazil’S Soybean Capital And Community Building In Sorriso, 1980-2020, Nathalia Francio Cocenza Jul 2025

Cultivating Smiles On The Frontier: The Making Of Brazil’S Soybean Capital And Community Building In Sorriso, 1980-2020, Nathalia Francio Cocenza

Theses and Dissertations

This dissertation explores the transformation of Sorriso, a small municipality in Mato Grosso, Brazil, into one of the world's leading soybean producers, placing its local history within the broader context of global agricultural and economic shifts from 1980 to 2020. Sorriso represents the unique convergence of local, regional, and international forces that reshaped Brazil's agricultural landscape. This study critically examines the political, environmental, and social dynamics that positioned Sorriso at the forefront of soybean production, illuminating the town's transition from a remote frontier settlement to a global agribusiness hub.

Through a detailed analysis of previously unstudied archival sources, interviews with …


Development Of Teacher Leader Identities In Stem Teacher Leader Programs: Key Experiences From The Perspectives Of Program Developers And Program Completers, Paula Adams Jul 2025

Development Of Teacher Leader Identities In Stem Teacher Leader Programs: Key Experiences From The Perspectives Of Program Developers And Program Completers, Paula Adams

Theses and Dissertations

The purpose of this qualitative case study was to add to the understanding of attributes of a STEM teacher leader project that contribute to the growth of STEM teacher leader identity. Single case study design was employed to explore key experiences in a collaborative Science Technology Engineering and Math teacher leader project and to explore how those experiences enhanced the teacher leader identity of participants. This research includes seven programs from six universities across the United States. The perceptions of two subunits, program developers and program completers, were considered. Data collection began with a document review which included initial university …


The Digital Forum: A Pedagogical Approach To Teaching College English Composition, Thomas Edward Plichta Jul 2025

The Digital Forum: A Pedagogical Approach To Teaching College English Composition, Thomas Edward Plichta

Theses and Dissertations

This action research study focused on the identification of ways to improve the curriculum of freshman Writing Intensive Seminars using an innovative multimodal pedagogical methodology, the Digital Forum, in addition to formal papers and in-class writing. The research examined a Writing Intensive Seminar with approximately 20 students; There were two Research Questions for the present study. RQ1: How does the incorporation of the Digital Forum as a pedagogical approach in college freshman writing classes influence students' levels of behavioral, cognitive, and emotional engagement? RQ2: How does the incorporation of Digital Forums in freshman English Composition courses affect the quality of …


Multi-Dimensional Strategies Impacting Beginning Readers’ Word Solving And Engagement, Brooke Clayton Jul 2025

Multi-Dimensional Strategies Impacting Beginning Readers’ Word Solving And Engagement, Brooke Clayton

Theses and Dissertations

This dissertation studied the impact of reading instruction on beginner-level readers’ decoding skills and engagement among four first-grade students in Lexington, South Carolina. The following research question directed the study:

Will an instructional strategy foregrounded on direct, systematic phonics instruction in conjunction with multi-dimensional reading strategies improve beginner readers’ decoding skills and engagement?

The study is grounded in several theoretical frameworks, including Scarborough’s Reading Rope (Appendix A), the Simple View of Reading, the Active View of Reading (Appendix C), Onset-Rime phonics instruction, and Self-Determination Theory. Interventions included the LETRS Science of Reading Phonics Small Group Plan (Moats & Tolman, 2019) …


Determination Of Structure-Function Relationships In Hybrid Catalysts On Metal Oxide Supports, Joseph John Kuchta Jul 2025

Determination Of Structure-Function Relationships In Hybrid Catalysts On Metal Oxide Supports, Joseph John Kuchta

Theses and Dissertations

Transition metal catalysis has revolutionized chemical synthesis, enabling efficient and selective transformations critical to the pharmaceutical, agricultural, and materials industries. However, traditional methods often rely on expensive, non-sustainable metals and harsh reaction conditions that generate significant waste. This dissertation explores a series of innovations aimed at bridging the gap between homogeneous and heterogeneous catalysis through the development of hybrid catalysts. These systems combine the molecular precision of homogeneous catalysts with the stability and practicality of heterogeneous supports, offering a pathway to more sustainable and scalable catalytic processes.

The first area of focus investigates nickel-based hybrid catalysts as a cost-effective and …


Generalized Dynamic Pole Placement Control For Voltage Source Converters With Inductive-Capacitive Output Filters, Byunghee Moon Jul 2025

Generalized Dynamic Pole Placement Control For Voltage Source Converters With Inductive-Capacitive Output Filters, Byunghee Moon

Theses and Dissertations

Voltage Source Converters (VSCs) with inductive-capacitive (LC) filters are prevalent in power electronics applications. There are many control techniques utilized for that category of power converter topology. However, as converter applications continue to increase their switching frequency, faster control methods are desirable to take advantage of the higher bandwidth that increased switching frequency allows for

Dynamic pole placement (DPP) controls are very promising methods for achieving high-speed control of VSCs with LC filters. However, the conventional DPP controls have very high sensitivity to disturbances and noise. In order to address this, two novel DPP current control methods are proposed and …


Impact Of Simulation On Project Management Knowledge, Self-Efficacy, And Student Perceptions: An Action Research Study With Non-Traditional Undergraduate Students In A Project Management Capstone Course, Deborah Marindin Jul 2025

Impact Of Simulation On Project Management Knowledge, Self-Efficacy, And Student Perceptions: An Action Research Study With Non-Traditional Undergraduate Students In A Project Management Capstone Course, Deborah Marindin

Theses and Dissertations

This study investigated the effectiveness of a project management simulation in enhancing non-traditional undergraduate students' project management knowledge, self-efficacy, and perceptions in a project management capstone course. The simulation tool, SimulTrain®, provided an authentic, real-world context to bridge the gap between theoretical knowledge and practical application. Utilizing mixed-methods action research, the study comprehensively evaluated the simulation’s impact on students’ learning. The research was guided by three questions: (1) How does a simulation activity affect non-traditional students’ project management knowledge in a capstone course? (2) To what extent does the simulation impact their self-efficacy? (3) What are students’ perceptions of learning …


Inorganic Nanoparticle And Nanoplastic Transformations And The Impact On Biouptake By Freshwater Algal Cells Using Single Cell And Single Particle Inductively Coupled Plasma Mass Spectrometry, Elizabeth Carey Bair Jul 2025

Inorganic Nanoparticle And Nanoplastic Transformations And The Impact On Biouptake By Freshwater Algal Cells Using Single Cell And Single Particle Inductively Coupled Plasma Mass Spectrometry, Elizabeth Carey Bair

Theses and Dissertations

The ubiquitous presence of nanoparticles (NPs) and nanoplastics (NPPs) and their effects on environmental and human health is a significant concern. They are used in every aspect of our lives, and while they offer many benefits, there are concerns about their impacts on ecosystems and human health. The primary aim of this dissertation is to quantify NP and NPP transformations in the presence of algae and determine how those transformations influence bioavailability. The methodology involves two complementary analytical techniques: single particle (SP) and single cell (SC) inductively coupled plasma mass spectrometry (ICP-MS). These techniques are tested and applied to two …


Editing Japan: Pornography Commentary As Postcolonial Revenge In China's Digital Sphere, Yichi Zhang Jul 2025

Editing Japan: Pornography Commentary As Postcolonial Revenge In China's Digital Sphere, Yichi Zhang

Theses and Dissertations

This study examines how Chinese male audiences reconstruct postcolonial masculinity through the consumption and reinterpretation of Japanese pornography. By analyzing commentary videos produced by "Team Strawberry," I argue that this phenomenon constitutes a symbolic revenge against Japan's historical dominance. Through degrading Japanese female performers and mocking Japanese culture and male actors, Chinese viewers invert colonial hierarchies, transforming sexual consumption into a nationalist project. However, this mimicry of colonial violence ultimately reinforces patriarchal structures rather than subverting them, while also framing nationalism through sexual conquest that mimics collective historical trauma. The re-editing and mocking of Japanese pornography by Chinese content creators …


The Return Journey: Migration, Reintegration, And Postcolonial Identity In Contemporary African Literature, Babila Bengala Samuel Jul 2025

The Return Journey: Migration, Reintegration, And Postcolonial Identity In Contemporary African Literature, Babila Bengala Samuel

Theses and Dissertations

Migration is a human practice as old as human society. It is primarily triggered by a human urge for self-preservation or the quest for better standards of living. Various periods of human history have known great flows of voluntary, semi-voluntary, and forced migrations. In contemporary days, people move more than ever before, mostly from countries of the Global South to countries of the Global North, mainly from African countries. These migrants flee from poverty, armed conflicts, unemployment, and repression from despotic leaders. While the question of migration has consistently and extensively been addressed, the focus in the mainstream migration studies …


Utilizing Culturally Responsive Teaching Practices In The Classroom, Lindsey Nicole Finley Jul 2025

Utilizing Culturally Responsive Teaching Practices In The Classroom, Lindsey Nicole Finley

Theses and Dissertations

This research study aimed to address the impact of teaching concepts of culturally responsive pedagogy on teachers’ understanding of their implicit biases. Additionally, it examined the impact that professional development training utilizing culturally responsive teaching (CRT) methods have on teachers working with multilingual learners (MLs). The research questions were: (1) What is the impact of teaching concepts of culturally responsive pedagogy on teachers' understanding of their implicit biases? and (2) What is the impact of intentional, ongoing professional development utilizing CRT methods for teachers working with multilingual learners? This study used a theoretical framework of culture centered pedagogies such as …


Exploring The Sense Of Community And Perceived Professional Learning Of Multigrade Teachers In Cohort-Based Online Community Of Practice Sessions: An Action Research, Paola Franco-Oudri Jul 2025

Exploring The Sense Of Community And Perceived Professional Learning Of Multigrade Teachers In Cohort-Based Online Community Of Practice Sessions: An Action Research, Paola Franco-Oudri

Theses and Dissertations

The purpose of this action research was to explore the influence of cohort-based, online Community of Practice sessions on the sense of community and perceived professional learning of multigrade teachers in a faith-based, private school system in North America. Approximately 25% of teachers in the Seventh-day Adventist school system are multigrade elementary teachers and teach three or more grade levels in the same classroom. Multigrade teachers often have limited access to traditional professional development (PD) options because of distance, cost, and staffing limitations, but furthermore, traditional PD programs do not address the needs and realities of small, multigrade schools. Additionally, …


Hardware Accelerated Simulation Of Buck Converters Using Physics-Informed Neural Networks, James Clayton Crews Jul 2025

Hardware Accelerated Simulation Of Buck Converters Using Physics-Informed Neural Networks, James Clayton Crews

Theses and Dissertations

Physics-informed neural networks (PINNs) are an emerging machine learning method for learning the behavior of physical systems described by governing differential equations. Dc-dc power-electronic converters are used in a variety of industry applications such as motor drives or power supplies where real-time simulation is critical for control and safety. This thesis investigates physics-informed machine learning as an approach to develop a real-time digital twin for dc-dc power converters. Traditional numerical integration methods are used to approximate discretized behavior, and the results are compared with a trained PINN model. Modern ML frameworks (such as PyTorch and TensorFlow/Keras) are used to quickly …


Strain And Redox Engineering For Enhanced Thermoelectric Performance In Transition Metal Oxide Thin Films, Mohammad Jamal El Loubani Jul 2025

Strain And Redox Engineering For Enhanced Thermoelectric Performance In Transition Metal Oxide Thin Films, Mohammad Jamal El Loubani

Theses and Dissertations

The discovery of highly efficient and cost-effective thermoelectric (TE) materials is essential to envision high-performance TE power generators that enable the direct conversion of waste heat into electricity. Transition metal oxides (TMOs) are considered promising candidates for high-temperature TE applications due to their excellent thermal stability and low cost. However, their maximum power output (power factor, PF = σ•S2) is constrained by the intrinsic trade-off between thermopower (S) and electrical conductivity (σ), both of which are inversely related to carrier concentration. This trade-off poses a significant barrier to improving the performance of TE devices. Among various strategies to overcome this …


The Impact Of Social Emotional Learning (Sel) Lessons On Students’ Mental Health Surrounding Standardized Testing, Margaret Denning Jul 2025

The Impact Of Social Emotional Learning (Sel) Lessons On Students’ Mental Health Surrounding Standardized Testing, Margaret Denning

Theses and Dissertations

This qualitative action research examined the emotional impacts of standardized testing on 4th and 5th graders and the effects of targeted social-emotional learning lessons in a Title 1 school. Pre- and post-intervention data were gathered through surveys (Children’s Test Anxiety Scale) and focus group interviews. By employing thematic and narrative analysis, findings revealed significant initial cognitive anxiety, physical symptoms, and difficulties in self-regulation. Following the SEL intervention, the data indicated that students exhibited improved emotional resilience, reduced anxiety symptoms, and enhanced coping skills. Although the SEL interventions enhanced overall emotional well-being, anxiety was not fully eliminated. This study highlights the …


Analyzing Factors Affecting Retention And Attrition Rates Of Teachers In The Pee Dee Region Of South Carolina, Jessica Allen Jul 2025

Analyzing Factors Affecting Retention And Attrition Rates Of Teachers In The Pee Dee Region Of South Carolina, Jessica Allen

Theses and Dissertations

The purpose of this qualitative action research study was to determine the factors and variables that affected the retention and attrition rates of novice and seasoned teachers in the Pee Dee region of South Carolina. Utilizing three frameworks, the Self-efficacy theory, the Social Identity theory, and the Multidimensional Theory of Burnout, the researcher conducted a virtual survey of 33 respondents and interviewed seven participants to collect data. Data was thematically coded to discover commonalities amongst the participant responses.

The data revealed administrative influence, teacher working conditions such as autonomy, time, and control, and workload were the most frequent elements of …


Reluctant Transitions: Place And Post-Extraction Politics In Southeastern Ohio, Jenna Lynn Haver Jul 2025

Reluctant Transitions: Place And Post-Extraction Politics In Southeastern Ohio, Jenna Lynn Haver

Theses and Dissertations

Based on a summer of ethnographic research in a subsection of Appalachian Ohio colloquially referred to as “The Valley,” this research challenges three narratives of this place that formulate a harmful Appalachian imaginary. The first narrative of industrycontrolled coal heritage is complicated by the way local people negotiate control over their own stories of coal and its existence outside of industry domain. The second narrative characterizes this as a space of extraction which is in tension with different social relations to varying types of energy – especially the discontinuity of the coal to fracking shift. The third narrative centers of …