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Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat Jan 2026

Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat

Theses and Dissertations

This research investigates how social media shaped political participation during the 2024 July Uprising in Bangladesh, focusing on the production and negotiation of political truth, legitimacy, and resistance through everyday digital practices. Rather than conceptualizing social media solely as a communication tool, the study analyzes digital platforms as contested spaces where activists, state-aligned actors, and other participants constructed, circulated, and challenged competing political narratives throughout the uprising.

Drawing on digital ethnography, this study integrates netnographic observation of Facebook groups, pages, hashtags, memes, and protest-related visual content with content analysis, reflexive participant observation, and semi-structured interviews with Generation Z participants. The …


Cultivating Culturally Responsive Special Educators: A Qualitative Study Of Self-Efficacy Journeys Across Preservice Preparation And Inservice Professional Development, Ashley R. Norton Jan 2026

Cultivating Culturally Responsive Special Educators: A Qualitative Study Of Self-Efficacy Journeys Across Preservice Preparation And Inservice Professional Development, Ashley R. Norton

Theses and Dissertations

In an increasingly diverse society, educators must be prepared to effectively instruct students from a wide range of cultural, linguistic, and ability backgrounds. Teacher self-efficacy in culturally responsive practices (CRP) is critical to achieving equitable educational outcomes, particularly in special education, where students often experience multiple forms of marginalization. Despite the importance of culturally responsive teaching, limited research has examined how special educators develop culturally responsive teaching self-efficacy (CRTSE) over the course of their professional careers, particularly in urban school districts serving culturally and linguistically diverse (CLD) populations.

This qualitative study explored the self-efficacy journeys of special educators and their …


Role Conflict And Role Ambiguity Amongst U.S. Black Women In Executive Leadership: A Qualitative Phenomenological Study, Alyssa D. Claybrooks Jan 2026

Role Conflict And Role Ambiguity Amongst U.S. Black Women In Executive Leadership: A Qualitative Phenomenological Study, Alyssa D. Claybrooks

Theses and Dissertations

Many Black women in executive leadership roles in corporate and/or business settings are being undermined, underpaid, overworked, and excluded despite their tenure or executive-level positions. This qualitative phenomenological study explored role conflict and role ambiguity experienced by Black women serving in executive leadership roles in corporate or business settings in the United States. The lived experiences, as described in narrative accounts, provided a platform for Black women to voice their stories, struggles, triumphs, and aspirations and offer insights into the broader context of role conflict and role ambiguity for Black women in executive leadership. The theoretical underpinnings of role theory, …


Ottoman Wikālas In Cairo: Islamic Architecture Beyond The Mosque, Yumna Moussa Jan 2026

Ottoman Wikālas In Cairo: Islamic Architecture Beyond The Mosque, Yumna Moussa

Theses and Dissertations

This thesis traces one of the largest architectural typologies in Cairo: the wikāla, a type of urban caravanserai unique to Egypt. Estimated to have reached more than five hundred buildings by the 18th century, the wikāla was the building of choice for most patrons in Ottoman Cairo. This study initially investigates the evolution of commercial architecture within the Islamic city. It then explores the defining architectural features of Cairene wikālas built between the 16th and 18th centuries—their plans, decorative/iconographic programs, and urban distribution—based on waqfiyyas, chronicles, travelers’ accounts, and photographic archives. Since many of …


On The Reasonableness Of Religious Belief According To W. James' "The Will To Believe" With Reference To Alvin Plantinga's “The Nature Of Necessity”, Maria Gadelrad Shenouda Nakhla Jan 2026

On The Reasonableness Of Religious Belief According To W. James' "The Will To Believe" With Reference To Alvin Plantinga's “The Nature Of Necessity”, Maria Gadelrad Shenouda Nakhla

Theses and Dissertations

Analytically, I follow William James's approach in his paper "The Will to Believe" to demonstrate that holding a religious belief is reasonable and it is not incompatible with being a philosophy scholar. I do this through explaining the way James addressed the main obstacle that Clifford puts against belief (in general) which is ‘the lack of sufficient evidence’. Clifford claims that belief cannot be accepted without evidence on it.

James breaks apart this obstacle through many steps. First, analyzing the nature of belief itself, showing that belief cannot be attained based on intellectual grounds alone (which needs sufficient evidence), but …


Trajectories Of Egyptian Women In The Us, Sageda A. Tagen Jan 2026

Trajectories Of Egyptian Women In The Us, Sageda A. Tagen

Theses and Dissertations

This thesis aimed at studying and analyzing the experiences of highly skilled Egyptian migrant women living in the US both who migrated as adults and those who migrated as children with their families. It analyzed their backgrounds prior to the migration decision, the migration decision and their legal status, the role of the family in their journey and their challenges within the social context of their workplaces. The study utilized a qualitative ethnographic lens. The study is based on ethnographic interviews with 15 highly skilled women living in the US, most of whom are concentrated in Indiana and Michigan. The …


(Post-)Colonial Shakespeares: Macbeth In South Africa, Mahmoud T. Kholeif Dec 2025

(Post-)Colonial Shakespeares: Macbeth In South Africa, Mahmoud T. Kholeif

Theses and Dissertations

The history of Shakespeare in South Africa is that of an often contested cultural battleground, with meanings fought over across a colonial boundary. In Chapter One, we examine some of the many cultural intersections between Shakespeare and South African rewriters. In the process, we can see how Shakespeare came to the region as a tool for colonial domination, but would eventually be used to rebuke the colonial narrative that was conservatively ascribed to him. He was used to enforce racial and political hierarchies, particularly through missionary education and institutions like the “Kaffir Institution.” The anxieties surrounding the ‘overproduction’ of Western-educated …


Three Case Studies Of Transformative Learning In A Service-Learning Anthropology Course, Elizabeth S. Schulte Dec 2025

Three Case Studies Of Transformative Learning In A Service-Learning Anthropology Course, Elizabeth S. Schulte

Theses and Dissertations

This study investigates the processes of personal transformation of three students enrolled in a service-learning based course that I taught at Brigham Young University. Informed by my observations as instructor of the course, in the analysis below I draw upon these students' weekly personal reflection essays to describe the process of individual transformation of these three students across the semester. This accounting provides insight into aspects of and contributing factors to that growth. I propose that a service-learning based course design with a framework of anthropological theory is a good way to facilitate transformational educational experiences. Aspects of service-learning such …


Cybernest: A Step Forward For Training Cybersecurity Professionals, Justin Mott Dec 2025

Cybernest: A Step Forward For Training Cybersecurity Professionals, Justin Mott

Theses and Dissertations

The growing complexity of cyber threats has exposed a critical gap between academic cybersecurity education and the operational demands of the workforce. This thesis presents a pilot study for a use-case of CyberNEST, a simulation-based training platform that integrates adversary emulation and threat-informed learning to create realistic, hands-on experiences for cybersecurity students.(17) The system was designed to replicate Security Operations Center (SOC) environments and incident response workflows, allowing participants to investigate, analyze, and respond to simulated attacks under authentic conditions. This pilot-study performed training simulations using the CyberNEST platform, developed by Brigham Young University, with students, collecting data from pre- …


Kuleana Mākua: Native Hawaiian Parents' Exercise Of Agency In K-12 School Selection, Joseph Piikeha Kahaka`Ulamaikalaniki`Eki`E Hao Dec 2025

Kuleana Mākua: Native Hawaiian Parents' Exercise Of Agency In K-12 School Selection, Joseph Piikeha Kahaka`Ulamaikalaniki`Eki`E Hao

Theses and Dissertations

In this qualitative study the author investigates how Native Hawaiian parents on Hawai`i Island navigate educational choices for their children amidst a history of centralized, Western-dominated schooling and systemic cultural suppression. Grounded in Bandura’s Social Cognitive Theory (SCT), the research explores parent perceptions of different K–12 school types and the complex factors that drive their selection. Through semi-structured interviews and a card sort activity with sixteen Native Hawaiian parents (n = 16), the study confirms that parental choice is fundamentally an act of indigenous self-determination defined by Kuleana Mākua (parental responsibility, authority, and privilege). The findings reveal that parents’ choices …


An Analysis Of Ukrainians' Language Attitudes And Ideology: A Conflict-Catalyzed Language And Identity Shift, Kateryna Kravchenko Dec 2025

An Analysis Of Ukrainians' Language Attitudes And Ideology: A Conflict-Catalyzed Language And Identity Shift, Kateryna Kravchenko

Theses and Dissertations

On February 24, 2022, the Russian Federation invaded Ukraine. According to Vladimir Putin's speech, the main goal of the war was to protect the Russian-speaking population of the Donbas region in eastern Ukraine. Many Ukrainians indeed speak Russian on a daily basis, largely due to the long and complicated history between the two countries. Recently, there has been an increase in pro-Ukrainian ideologies (Kulyk 2016); however, as the full-scale invasion began, people started advocating for Ukrainian usage in all public domains, and many even vowed to never speak Russian again. Since then, there has been a profound change in language …


Evaluating The Performance Of The Primary Heat Exchanger In A Sco2 Brayton Cycle While Firing Solid Fuels, Brian Jeffrey Schooff Dec 2025

Evaluating The Performance Of The Primary Heat Exchanger In A Sco2 Brayton Cycle While Firing Solid Fuels, Brian Jeffrey Schooff

Theses and Dissertations

The sCO2 closed-loop Brayton cycle is an alternative to the standard steam-Rankine cycle for generating electrical power from a heat source. The sCO2 Brayton cycle is advantageous because it can be more efficient, use less water, and have smaller turbomachinery than the steam-Rankine cycle. While there are several research groups advancing the technology necessary to utilize the sCO2 Brayton cycle on an industrial scale, none of these groups use solid fuel combustion as the heat source. A Brigham Young University-led project developed and tested a pilot-scale sCO2 Brayton cycle unit (1.6 MWth) using natural gas, pulverized coal, and pulverized biomass …


Rab32c Mediates Osmoregulation And Calcium Homeoastasis In Dictyostelium Discoideum, Ashley Esparza Dec 2025

Rab32c Mediates Osmoregulation And Calcium Homeoastasis In Dictyostelium Discoideum, Ashley Esparza

Theses and Dissertations

Vesicular trafficking is a fundamental process essential to cell viability and dictates roles in both cellular and tissue function in multicellular organisms. To further understand various vesicular trafficking processes, our lab focuses on the moderators of these processes, Rab GTPases, using the model organism Dictyostelium discoideum. This dissertation focuses explicitly on the uncharacterized protein Rab32C, a homolog of human Rab32. While several Rab family members have been well defined, the functionality of Rab32C remains poorly understood. This project investigated both the subcellular localization and functional role of Rab32C with biochemical, imaging, and molecular assays. Results from this study provide evidence …


Inelastic Behavior Of Three-Story Buildings With Concrete-Filled Composite Plate Shear Walls Subjected To Wind Loads, Joshua John Blom Dec 2025

Inelastic Behavior Of Three-Story Buildings With Concrete-Filled Composite Plate Shear Walls Subjected To Wind Loads, Joshua John Blom

Theses and Dissertations

Although elastic design of the main wind force resisting system in a building is the conventional approach it is not always desirable. In this study, nonlinear static and dynamic analyses are used to predict the inelastic behavior of a three-story building with concrete-filled composite plate shear walls subjected to wind loads. To explore the potential for inelastic design, two types of planar composite shear wall buildings are examined: individual shear walls designed using an elastic approach, and coupled shear wall pairs designed using an inelastic approach adopted from seismic design provisions. Nonlinear static "pushover" analyses are run using an assumed …


Measuring And Modeling Nonlinear Vibrations In Structures With Mechanical Joints, Suzanna Gilbert Dec 2025

Measuring And Modeling Nonlinear Vibrations In Structures With Mechanical Joints, Suzanna Gilbert

Theses and Dissertations

Many assembled structures have bolted or riveted joints. Aside from providing a convenient method of assembly, mechanical joints have an important effect on the structure's dynamic response to its environment. Friction and microslip within the joints help to damp out unwanted vibration. However, the joints also introduce nonlinearity into the response. Most notably, the natural vibrational modes of the structure no longer have constant natural frequencies and damping ratios. Rather, they shift as a function of vibration amplitude. Several methods exist to characterize the dynamics of nonlinear systems, yet they are generally validated on simple benchmark structures, and many still …


Netflix And Kill: The Role Of True Crime Consumption In The Development Of Acquired Capability For Suicide, Chandler Jayne Mcdaniel Dec 2025

Netflix And Kill: The Role Of True Crime Consumption In The Development Of Acquired Capability For Suicide, Chandler Jayne Mcdaniel

Theses and Dissertations

The Interpersonal-Psychological Theory of Suicide (IPTS) identifies acquired capability as a key factor contributing to suicidal behavior. Previous research has shown that violent media exposure can increase suicidal risk through desensitization, imitation, and trauma activation. However, little is known about the role of true crime consumption (TCC), a popular form of violent media engagement, in relation to IPTS constructs. This study examined whether TCC predicts acquired capability for suicide, perceived burdensomeness, and thwarted belongingness. A total of 215 participants were retained after data cleaning. Hypotheses predicted that higher TCC would be associated with higher acquired capability (H1), that TCC would …


Spectral Methods And Wavelets In Quantitative Finance Problems, Davood Damircheli Dec 2025

Spectral Methods And Wavelets In Quantitative Finance Problems, Davood Damircheli

Theses and Dissertations

This dissertation leverages advanced spectral methods and wavelet techniques to address complex quantitative finance models, enhancing the computation of financial derivatives and risk assessments. Building on foundational studies, this research extends these methods to broader, intricate financial contexts. The first section explores fractional-order generalized Chebyshev wavelets (FOCW) applied to fractional advection equations, relevant in both mathematics and physics. Using a regularized beta function to compute the Riemann-Liouville fractional integral operator, this study introduces a novel numerical scheme with robust accuracy, confirmed through error analysis and empirical tests. The second part examines the fractional Black-Scholes equations for option pricing under subdiffusive …


Responding To The Urban Canvas: Murals, Preservation, And Placemaking In Meridian, Ms, Katy Kemalyan Dec 2025

Responding To The Urban Canvas: Murals, Preservation, And Placemaking In Meridian, Ms, Katy Kemalyan

Theses and Dissertations

Public murals that depict elements of local culture and history are a creative placemaking tool increasingly used by preservationists invested in the revitalization of their historic districts. As this trend rises, it becomes necessary for preservationists to ask what should be painted, restored, or left alone? Research on public murals neglects Southern mid-sized towns, considerations of existing murals, and historic architecture used as substrates. Rectifying this omission and employing geographic surveys and stakeholder interviews, this study seeks to expand which genres of murals are considered for their creative placemaking value. Normally distinguished primarily by source in literature, community murals, ghost …


Small Area Estimation Methods For County-Level Forest Biomass Estimation, Pratyush Dhungana Dec 2025

Small Area Estimation Methods For County-Level Forest Biomass Estimation, Pratyush Dhungana

Theses and Dissertations

We evaluated small area estimation (SAE) methods for county-level forest biomass across four Forest Inventory and Analysis (FIA) regions in the contiguous United States using the coefficient of variation and relative root mean squared error. The Standard Fay–Herriot (FH) model was compared with multivariate, spatial, and measurement-error extensions, while the unit-level Battese–Harter–Fuller (BHF) model was compared with mixed-effects random forests (MERF) with auxiliary data from remote sensing. Spatial FH improved precision when spatial dependence was strong; otherwise, Standard FH was more reliable. All FH models were effective with fewer than 100 plots. Measurement-Error FH produced more accurate estimates than FIA …


Toward A Unified Network Flow Framework: From Conservation Principles To Fluid Dynamics Models, Zonghan Zhang Dec 2025

Toward A Unified Network Flow Framework: From Conservation Principles To Fluid Dynamics Models, Zonghan Zhang

Theses and Dissertations

Network flows govern a wide range of critical systems, from tangible infrastructures like transportation and power grids to replicable processes such as information spread and epidemics. While tangible flows obey conservation laws and physical constraints, replicable flows, like rumors or viruses, can grow, decay, or vanish unpredictably. Despite their increasing interaction in real-world settings, these flow types are typically modeled in isolation, using disconnected mathematical frameworks. This dissertation presents a unified modeling approach that bridges the gap between conserved and replicable flows by embedding principles from fluid dynamics into graph-based propagation models. I introduce physically informed extensions to classical models, …


The Effects Of Bullying Victimization And Bullying Perpetration On Academic, Social, And Emotional Self-Efficacy Among Adolescents, Amber Crenshaw Dec 2025

The Effects Of Bullying Victimization And Bullying Perpetration On Academic, Social, And Emotional Self-Efficacy Among Adolescents, Amber Crenshaw

Theses and Dissertations

Bullying remains a persistent challenge in schools and has been linked to diminished perceptions of capability across multiple domains. This quantitative, cross-sectional study examined how bullying victimization and bullying perpetration relate to domain-specific self-efficacy, academic, social, and emotional, among students in grades 4-12 in the southern United States. Students (N = 81) completed the Adolescent Peer Relations Instrument (APRI-BT) measuring victimization and perpetration across verbal, social, and physical behaviors. Students also completed the Self-Efficacy Questionnaire for Children (SEQ-C) measuring domain-specific self-efficacy. Analyses included descriptive statistics, internal consistency estimates, bivariate correlations, and hierarchical multiple regressions. Moderation by parental education and socioeconomic …


Effects Of Parenting And Differentiation Of Self On Career Identity Development In Emerging Adults, Benjamin Alexander Dec 2025

Effects Of Parenting And Differentiation Of Self On Career Identity Development In Emerging Adults, Benjamin Alexander

Theses and Dissertations

This work investigates how parenting styles relate to the development of career identity in emerging adults and whether differentiation of self helps explain those links. Using a two?manuscript format with a shared dataset of U.S. undergraduates (n =148), parenting behavior (i.e., warmth and control) was assessed alongside career identity constructs (career exploration and commitment); a second study added differentiation of self as a possible mediator of these relationships. Manuscript 1 examined whether parenting styles are associated with Marcia-based career identity outcomes. After deriving identity groupings consistent with achievement, foreclosure, moratorium, and diffusion, multinomial models indicated that more autonomy?supportive, high-warmth parenting …


Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota Dec 2025

Study Of Insect Frass-Associated Microbiome On Plant Growth And Their Potential Use As Biofertilizer, Jasmine Sahota

Theses and Dissertations

An increasing global food demand and the urgent need for sustainable agricultural practices have driven interest in insects as alternative feed and food sources. Insect frass, a by-product of insect rearing, represents a rich organic carbon source with diverse microbes that can enhance soil health and promote beneficial plant-microbe interactions. This study characterized the bacterial (16S-V4) and fungal (ITS2) microbiomes of frass from Black Soldier Fly (BSF) and Cricket species and evaluated their effects on maize (Zea mays) growth. Four frass variants were applied at rates of 56-280 kg ha⁻¹ in a pot experiment with untreated soil and mineral fertilizer …


Nanocarbons For Electrodes And Electrolytes Of Sustainable And Solid-State Energy Storage Systems: Materials, Electrochemical Characterization, And Lifecycle Analysis, Ridwan Tobi Ayinla Dec 2025

Nanocarbons For Electrodes And Electrolytes Of Sustainable And Solid-State Energy Storage Systems: Materials, Electrochemical Characterization, And Lifecycle Analysis, Ridwan Tobi Ayinla

Theses and Dissertations

The growing global demand for clean, efficient, and scalable energy storage technologies has intensified the search for sustainable alternatives to conventional battery and supercapacitor systems. Traditional electrochemical energy storage devices often rely on finite and environmentally harmful materials, toxic electrolytes, and rigid architectures that limit their applicability in emerging domains such as flexible electronics and wearable technologies. Additionally, the leakage of liquid electrolytes poses a persistent safety and reliability challenge, particularly for long-term and real-world applications. This research addresses these pressing challenges by developing a new class of green, flexible, and high-performance electrochemical energy storage systems using bio-derived materials. The …


How The Advisor-Advisee Relationship Contributes To Black Student Success At Pwis, Renata Denise Roberts Dec 2025

How The Advisor-Advisee Relationship Contributes To Black Student Success At Pwis, Renata Denise Roberts

Theses and Dissertations

This qualitative study explores how the advisor-advisee relationship contributes to Black student success at Predominantly White Institutions (PWIs). Black student enrollment and retention at PWIs continue to decline, especially with national efforts to cut DEI measures. Previous research highlights that engagement and institutional support are critical to persistence and graduation; however, limited literature exists on how academic advising relationships can impede or contribute to Black student outcomes in these environments. Viewing from the lens of Black students’ perceptions, this study examines how the academic advising experience can foster trust and contribute to academic achievement for Black students or impede their …


The Social In The Spiritual: Non-Theistic Spirituality In 12-Step Addiction Recovery, Steph Jacobs Dec 2025

The Social In The Spiritual: Non-Theistic Spirituality In 12-Step Addiction Recovery, Steph Jacobs

Theses and Dissertations

To investigate whether Western-raised Narcotics Anonymous (NA) members engage in non-theistic spirituality and non-humanist modes of sociality with non-human beings, I conducted six qualitative interviews and a small-scale survey within a Vancouver NA community. The majority of participants practice non-theist spirituality, and three interviewees relate to non-humans in ways not accounted for by Western humanism. Findings suggest that connection and sociality are intrinsically woven into recovery and well-being. This research opens conversations about non-theistic spirituality in NA recovery, non-human sociality and healing, processes of ontological negotiation, and the entanglement of spirituality, sociality, and well-being. Through daily practices of exploration and …


Bridging The Gap: Enhancing Novice Teacher Retention Through Logistical And Administrative Support, Denise Fleurette Harrel Dec 2025

Bridging The Gap: Enhancing Novice Teacher Retention Through Logistical And Administrative Support, Denise Fleurette Harrel

Theses and Dissertations

This project examines the challenges novice teachers encounter and how structured support systems impact their job satisfaction, effectiveness, and retention. The review focuses on administrative and logistical support, highlighting gaps between teacher preparation and classroom realities that contribute to high attrition (Falk, 2017; Koca, 2016). Key challenges include insufficient time management training, inconsistent expectations, and limited district or school-level support (Fantilli & McDougall, 2009), all of which are intensified by the demands of navigating modern classroom technologies (Philipsen et al., 2019). The literature review centers on teacher perceptions to clarify what constitutes effective logistical and administrative support (Banerjee et al., …


Law As Performance: Sovereignty, Legal Indeterminacy, And The Chinese Private Security Industry, Alexandrya Pouliot Dec 2025

Law As Performance: Sovereignty, Legal Indeterminacy, And The Chinese Private Security Industry, Alexandrya Pouliot

Theses and Dissertations

This thesis examines how the legal indeterminacy of international law facilitates state evasion of accountability through the use of private military and security companies (PMSCs) as proxies in extraterritorial operations. Focusing on China’s deployment of PSCs to safeguard Belt and Road Initiative (BRI) projects, it argues that ambiguities within the doctrines of attribution and responsibility under the Articles on the Responsibility of States for Internationally Wrongful Acts (ARSIWA) create a permissive legal environment that enables states to outsource coercive functions without incurring formal liability. Drawing upon Hobbesian Realist theory, Carl Schmitt’s concept of the sovereign exception, and insights from Critical …


In Their Own Voice: A Grounded Theory On Overcoming Internet Gaming Disorder, Jayson Carmona Dec 2025

In Their Own Voice: A Grounded Theory On Overcoming Internet Gaming Disorder, Jayson Carmona

Theses and Dissertations

Internet Gaming Disorder (IGD) is highly comorbid with depression, anxiety, sleep loss, lower productivity, and social isolation. The DSM-5 TR designates IGD as a condition for further study, however the ICD-11 has designed Gaming Disorder as a codified illness. While most studies look at IGD via a medical model lens focusing almost exclusively on symptomology, very little research explores the process of recovery in IGD. In this grounded theory inquiry, a theory of recovery from IGD is generated. Secondary internet data consisted of 113 posts on the subreddit /r/StopGaming on reddit.com. This resulted in 196 pages of data. Researcher used …


Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal Dec 2025

Mitochondrial Insoluble Aggregates In Aging And Alzheimer’S Disease Models: Cross-Species Proteomic Integration, Identification Of Conserved Candidates, And Pharmacological Disruption Of Eef-2 Interactions, Sonu Pahal

Theses and Dissertations

Protein aggregation within mitochondria emerges early in both aging and Alzheimer’s disease (AD) and contributes to progressive loss of proteostasis. Insoluble mitochondrial aggregate fractions from Caenorhabditis elegans revealed extensive enrichment of metabolic and translational proteins that also appear in human Alzheimer hippocampal aggregates. Comparative analysis across age and genotype identified a conserved subset of aggregation-prone proteins, several of which cluster around elongation factor 2 (eEF-2), a regulator of ribosomal translocation and energy coupling. Cross-species integration defined a network in which eEF-2 links chaperones, metabolic enzymes, and RNA-binding proteins that co-aggregate in both human Alzheimer material and nematode models. Functional tests …