Digital Commons Network^™

Investigation Of Succinated Protein Turnover By Autophagy, Lydia Proctor

Theses and Dissertations

Background. Diabetes is a widespread public health concern that alters the metabolism of adipocytes through high glucose stress and hormonal dysregulation. Under diabetic conditions there are excess nutrients available and subsequently an accumulation of tricarboxylic acid cycle intermediates such as fumarate. Fumarate can irreversibly react with protein cysteine residues to form S-2-succinocysteine (2SC, protein succination). Succinated proteins can be turned over by autophagy, a mechanism of removing damaged proteins and organelles that have accumulated due to metabolic stress.

Purpose. The basal flux through autophagy in adipocytes matured in non-diabetic and diabetic conditions was examined to determine the turnover of succinated …

From Near And Far: Utilization Of In-Situ And Remotely Sensed Satellite Data From Nasa And Noaa, Jessica Rochelle Price Sutton

Theses and Dissertations

Satellite remote sensing observations have been used for numerous studies to better understand physical and biological properties over varying spatial and temporal scales. Depending on the satellite and sensor, the satellite-derived observations can provide high spatial and temporal resolution for many important physical and biological variables. While there are many limitations in utilizing satellite remote sensing products, there are also many advantages. This dissertation investigates three different applications for satellite remote sensing products to address climatological and ecological concerns. This dissertation is motivated by two overall research questions: (1) How can satellite remote sensing products be used to address important …

Novel Methods For Analyzing Longitudinal Data With Measurement Error In The Time Variable, Caroline Munindi Mulatya

Theses and Dissertations

In some longitudinal studies, the observed time points are often confounded with measurement error due to the sampling conditions, resulting into data with measurement error in the time variable. This type of data occurs mainly in observational studies when the onset of a longitudinal process is unknown or in clinical trials when individual visits do not take place as specified by the study protocol, but are often rounded to coincide with the study protocol. Methodological and inferential implications of error in time varying covariates for both linear and nonlinear models have been studied widely. In this dissertation, we shift attention …

Patient Agency, Terministic Screens, And The Role Of The Public In The Cases Of Karen Ann Quinlan And Terri Schiavo, Ashley Marie Moore

Theses and Dissertations

Humanity has always been fascinated with death, and in recent history, has attempted to delay or suspend death through life-preserving technologies. These advancements in artificial life support, such as ventilators and feeding tubes, have contributed to tenuous and controversial situations in which the dividing line between life and death is unclear. In this thesis, I interrogate two case studies in order to analyze how the various medical, legal, and public discourses have grappled with the ambiguous space between life and death regarding patients in persistent vegetative states. The case of Karen Ann Quinlan from 1975 and the case of Terri …

Textile As Intercessor: Understanding Margery Kempe's Sartorial Body, Hannah Lynn Davis

Theses and Dissertations

In this thesis, I will explore Margery Kempe’s late fourteenth, early fifteenth century mystical text. Previously, Margery Kempe has been discussed in reference to her highly erotized language with Christ and her maternal themes that appear throughout her Book. However, I urge other medieval scholars to also look at her usage of textiles and clothing as a means of gaining authority with both Christ and the medieval church. First, I discuss Margery’s gendered situation within the male-centered church and community. Margery uses her position as a woman to build her agency and, as such, uses gendered specific clothing to introduce …

Decorative Turkey Callmakers: Artists Or Craftsmen, Lauren E. Virgo

Theses and Dissertations

This thesis explores the history of the wild turkey call and the role of decorative callmakers in the world of art and craft. Is a turkey callmaker an artist or a craftsman? Are their decorative turkey calls works of art or works of craft? This debate is explored via the decorative turkey calls that have won the Decorative Turkey Call Best of Show portion of the National Wild Turkey Federation’s Grand National Callmaking Competition. These winning turkey calls are currently on display at the NWTF’s Winchester Museum in Edgefield, South Carolina.

The National Wild Turkey Federation (NWTF) is a non-profit …

Frequency Of Colonoscopy Surveillance In Average-Risk Adults Relative To Guideline Recommendations, Meng-Han Tsai

Theses and Dissertations

Colorectal cancer (CRC) is the third leading cancer in the United States with an estimated 132,700 new cases and 49,700 deaths in 2015. Well-performed screening colonoscopies prevent cancer by allowing visualization of the entire colon and removal of precancerous polyps (adenomas). Persons with high-risk polyps at screening are therefore advised to undergo periodic surveillance colonoscopy. Screening and surveillance colonoscopy guidelines were updated by the U.S. Multi-society Task Force (USMSTF) in 2006, which emphasized risk stratification by polyp features at screening colonoscopy.

This is a retrospective cohort study of patients with screening colonoscopy at an endoscopy center in South Carolina between …

Assessing The Effects Of The Mud Snail, Ilyanassa Obsoleta, On The Benthic Microalgal Community In A Pristine Saltmarsh, Miranda Gore

Theses and Dissertations

Saltmarshes are among the most productive ecosystems globally. At North Inlet estuary, South Carolina, about one third of the primary production comes from benthic microalgae. During the tidal cycle, mobile microalgae vertically migrate through the upper 3 mm of sediment. At low tide, algae are vulnerable to a variety of grazers, including the mud snail, Ilyanassa obsoleta, which is abundant in tidal creeks. Many species of intertidal snails have been shown to significantly alter the community structure and density of microalgae within the sediment. The purpose of this study was to determine how I. obsoleta affects the benthic microalgae community …

Divine Ideas For Metaphysical Realism, Michelle Lynn Panchuk

Theses and Dissertations

In recent years more and more theist philosophers have turned their attention to an apparent tension between the existence of abstract universals and the God of classical monotheisms. In this project I argue that this tension can be relieved by adopting a Neo-Augustinian account of universals. When the doctrine of creation ex nihilo is given sufficient place within one’s theory, divine concepts can do all of the work for which abstract universals are usually posited. Over the course of 5 chapters, I argue that the problem of universals, at base, requires a theory of properties as its solution; that my …

North American Butterfly Association Counts At Congaree National Park: A Case Study For Connecting Citizen Science To Management, Austin Clarridge

Theses and Dissertations

Citizen science is becoming an ever more popular way for scientists and resource managers to deal with needs for large temporal and spatial scale datasets. It provides a free or low cost means for collection of extensive amounts of data across time and space while acting as a public education and outreach tool, empowering communities to be involved in the management decisions being made in their back yard. Though large, well-known citizen science programs such as the Christmas Bird Counts are being used extensively for peer reviewed literature and management decisions, there are numerous smaller, local counts that have the …

Defensive Roles And Factors That Affect The Production Of Monoterpenes In Morella Cerifera, Florence C. Anoruo

Theses and Dissertations

Plants as sessile organisms encounter myriad biotic and abiotic challenges in their habitats. Pathogen and herbivore attack are among the prominent biotic challenges that plants face in their environment. Plants respond to these attacks by using chemical compounds including monoterpenes that are constitutively and inductively produced in some plants, and stored inside glands on their leaves. Among the abiotic factors that influence the production of defense compounds, especially monoterpenes are light intensity and nutrient availability.

The objectives of this dissertation are to 1) comprehend the defensive role of monoterpenes, specifically investigating the associational defense of a non-odorous species (Ilex vomitoria) …

Like I Said, Matthew Mossman

Theses and Dissertations

Like I Said is a collection of memoir essays spanning the author’s life from his earliest memories to the present day. Topics touched on include but are not limited to: the struggle of being raised as an undiagnosed sufferer of ADHD, the cultural/familial dynamics at work in rural southeast Missouri, the author’s trial with hitting puberty and finding religion in the same year, and the ongoing shifts in the Mossman family’s relational dynamics in the years since the author’s mother was first diagnosed with breast cancer.

Structurally, the text takes inspiration from the “lyric essay,” a subgenre of creative nonfiction …

Remembering Salinger's Franny And Zooey Through Pari And The Royal Tenenbaums, Taraneh Zohadi

Theses and Dissertations

This paper explores the ways in which Mehrjui’s Pari and Anderson’s The Royal Tenenbaums borrow from Salinger’s Franny and Zooey. My argument is that Salinger and the concepts he introduced in the book are remembered through both films. Being a product of their historical/cultural contexts, The Royal Tenenbaums embraces the aesthetics of the text and Pari converses with the spiritual aspect of the main text. Anderson’s film captures the United States’ preoccupation consumerism and the hollowness at turn of the twenty-first century, while Pari explores the angst and despair in the post Iran-Iraq war context of the film’s release, feelings …

Bayesian Nonparametric Approaches To Multiple Testing, Density Estimation, And Supervised Learning, William Cipolli Iii

Theses and Dissertations

This dissertation presents methods for several applications of Polya tree models. These novel nonparametric approaches to the problems of multiple testing, density estimation and supervised learning provide an alternative to other parametric and nonparametric models. In Chapter 2, the proposed approximate finite Polya tree multiple testing procedure is very successful in correctly classifying the observations with non-zero mean in a computationally efficient manner; this holds even when the non-zero means are simulated from a mean-zero distribution. Further, the model is capable of this for “interestingly different” observations in the cases where that is of interest. Chapter 3 proposes discrete, and …

Toward A Multidimensional Framework: Exploring The Constructed Identities And Pedagogical Styles Of Black Male Kindergarten Teachers In The South, Nathenial Bryan

Theses and Dissertations

Given the one-dimensional, essentialist view of Black male teachers as social change agents (i.e., role models and father figures) (Brown, 2012b; Rezai-Rashti, 2008), the purpose of this study was to examine the identities, the ability to support Black male students’ success, and pedagogical styles of Black male kindergarten teachers in the South. Using a multidimensional conceptual framework including Black masculinity, Fictive Kinship Network, Culturally Relevant Pedagogy, and Critical Race Theory, this study captured counterstories of culturally relevant Black male kindergarten teachers. The counterstories were used as a methodological tool to convey major themes which demonstrated Black male kindergarten teachers’ ability …

Enhancing The Efficacy Of Thymidylate Synthase Inhibitors By Genetic Modulation Or Pharmacological Inhibition Of Bone Marrow Derived Cells In The Tumor Stroma, Nikeya Lashanna Tisdale

Theses and Dissertations

The impact of tumor associated stromal cells in tumor formation, progression, and response to therapy has led to a paradigm shift in cancer therapy. For many years, tumors were considered as a mass consisting only of actively proliferating cancer cells and therapies were design to target these cells. However, research in the last two decades has shown that tumors are not only comprised of a heterogeneous population of neoplastic cells, but they are also comprised of and infiltrated by a heterogeneous population of non-tumor cells that contribute to tumor progression and potentially affect the efficacy of tumor-directed chemotherapies. Tumors are …

Sleep Disruption And Cancer Incidence In A Southeastern Veteran Population, Alexandria F. Delage

Theses and Dissertations

Sleep disruption influences biological processes that can facilitate carcinogenesis. However, studies examining the relationship between sleep disruption and cancer risk have been inconclusive. This retrospective cohort study used de-identified data from the Veterans Administration (VA) electronic medical record to test the hypothesis that sleep disorder diagnoses among Veterans seeking care in the Southeast United States Service Network are associated with increased risk for cancer of the prostate, breast, colorectum, or total cancer (1999-2010, N=663,869). Sleep disorders were defined as patients with an in- or out-patient diagnosis as specified by the International Classification of Sleep Disorders. Cancer cases were defined as …

Multiscale Modeling Of Water Transport And The Influence Of Water Quality Parameters On Membrane Processes, Linkel Kwabena Boateng

Theses and Dissertations

Membrane-based desalination processes have become a viable means of producing potable water to meet water resource needs in both industrialized and developing nations. Extensive experimental investigation, in conjunction with computational modeling is critical in the development of sustainable and cost-effective desalination technologies. The overall goal of this dissertation is to develop a multiscale modeling framework to elucidate water and salt transport mechanisms and the influence of water quality parameters on membrane processes. The key tasks involved in this study are: establish a criterion for estimating water flux using Bayesian inference; develop a multiscale framework to connect molecular dynamics (MD) simulations …

Ultra-High Temperature Full Field Deformation Measurements Of Materials Subjected To Thermo-Mechanical Loading: A Dic Based Study, Guillemo A. Valeri Paoli

Theses and Dissertations

Determining the mechanical response of materials at elevated temperatures is a subject of great interest in metal forming, aerospace and aero-engine industries. For example, measurement of the deformation response under tensile loading at high temperatures is crucial for establishing thermomechanical and thermo-physical properties of materials, consequently, determining the reliability of a component or structure exposed to elevated temperatures. In order to predict the behavior of materials at ultra-high temperatures, a novel experimental approach based on Digital Image Correlation (DIC) is proposed and successfully applied to different materials at temperatures ranging from room temperature to 1100˚C. In these studies, a portable …

Ecohydrology And Groundwater Dynamics In A Salt Marsh Island, Andrea L. H. Hughes

Theses and Dissertations

Tidal salt marshes are extraordinarily productive and valuable ecosystems that provide via groundwater a not insignificant portion of coastal solute and nutrient budgets. Among the many goods and services they provide are habitat for diverse wildlife, protection for coastal communities during storms, and protection for coastal surface waters by filtering anthropogenic pollutants. One threat to the health of tidal salt marshes along the East Coast have been episodes of Acute Marsh Dieback (AMD) from 1999 to 2001. Dieback was observed at North Inlet salt marsh from 2000 to 2001. Since salt marsh hydrology is dominated by the local tidal regime, …

Satellite-Assisted Assessment Of The Effects Of Human Development On Coral Reefs, Roatan Honduras, Clayton A. Helm

Theses and Dissertations

Human intervention is degrading coastal marine environments on a global scale. Coral reefs are one of the most valuable ecosystems occupying coastal areas that provide a vast majority of consumable fish, recreational activities, and protection from extreme events, such as tropical cyclones. Unfortunately, as human development activities such as the construction of buildings, road infrastructure, and agriculture increase in coastal areas, so do the detrimental impacts on the health of coral reefs. Consequences of coastal development such as pollution, sedimentation, eutrophication, overfishing, and recreational activities have been linked to diminished coral health. A degraded coral ecosystem can often be identified …

The Cranial Morphology Of The Black-Footed Ferret: A Comparison Of Wild And Captive Specimens, Tyler Antonelli

Theses and Dissertations

The black-footed ferret (Mustela nigripes), a North American mustelid species, was once found abundantly throughout the Midwest until extreme decline in prairie dogs, the black-footed ferrets primary food source, brought the species to near-extinction. This resulted in the development of the Black-Footed Ferret Recovery Program which included bringing the entire species into captivity with the intention of breeding the species back to sufficient numbers to allow for successful reintroduction. While in captivity, many components of the ferrets’ health were accounted for, but the current study aims to address the effects that captivity may have had on the cranial morphology of …

Cut Purses And Poisoned Paintings: Resisting Gender Objectification, Meredith N. Will

Theses and Dissertations

The early modern English stage often portrays gender as polarized, creating an unwelcoming atmosphere toward characters who act exhibit characteristics from both male and female genders. Moll Cutpurse from Thomas Dekker and Thomas Middleton’s The Roaring Girl and Alice of Arden of Faversham resist early modern gender boundaries, conflating masculine and feminine attributes as they use objects to navigate their respective social spaces. Critics often describe Moll as a transvestite due to her fashion choice to wear a codpiece, along with her exaggerated, boisterous masculine behavior; however, she consistently defends her biological sex, implicating herself within her arguments concerning female …

Enslaved Labor In The Gang And Task Systems: A Case Study In Comparative Bioarchaeology Of Commingled Remains, William D. Stevens

Theses and Dissertations

This study designs and tests an approach intended to confront one of the major problems faced within biological anthropology, the commingling or mixing of human skeletal remains. The first goal of the study is to implement an approach to sorting mixed human remains in order that they can be made amenable to comparative study. Bioarchaeologists depend on an array of measures, preserved in the human skeleton, to assess the lifestyles and identity of past human groups. As many of these measures are preserved within the morphology of different bones, it is imperative that the association and context of remains are …

Emodin Regulates Macrophage Polarization: Application In Breast Cancer Treatment, Stephen Iwanowycz

Theses and Dissertations

Macrophages are pleiotropic cells capable of performing a broad spectrum of functions. Their phenotypes are classified along a continuum between the extremes of pro-inflammatory M1 macrophages and anti-inflammatory M2 macrophages. The seemingly opposing functions of M1 and M2 macrophages must be tightly regulated for an effective inflammatory response to foreign molecules or damaged tissue. Excessive activation of either M1 or M2 macrophages contributes to the pathology of many diseases. Infiltration of macrophages into breast tumors correlates with increased metastasis and decreased patient survival. Tumors recruit macrophages to the primary site as well as pre-metastatic niches, and educate them to adopt …

Iron Uptake And Accumulation Is A Target Of Nickel Toxicity During The Lag Phase In Escherichia Coli, Geoffrey Tuttle Ford

Theses and Dissertations

Various transition metals are essential to all forms of life, and are only required in trace amounts. But this dependence comes as a double-edged sword. All organisms must maintain a careful intracellular quota that does not traverse outside an acceptable range. One transition metal in particular is nickel. The importance of this transition metal has been debated widely and its function varies greatly between organisms, including bacteria. However, the adverse effects caused by over exposure to this metal have been the center of much experimentation in recent years. Still, the mechanisms of nickel toxicity and the subsequent effects on cellular …

Tumor Suppressor P53 Response To Uv Light In Normal Human Keratinocyte Strains From Different Individuals, Fadi Farooq Abboodi

Theses and Dissertations

Human Papillomavirus (HPV) is a causative factor in variety of diseases ranging from simple pathologic conditions to malignant ones like cervical cancer in which HPV is the primary cause in more than 90% of cases. HPV is also associated with other tumors like head and neck squamous cell carcinoma (HNSCC) and the percentage of association varies according to the anatomical site, reaching its highest level (65%) in the oropharyngeal region. HPV proteins E6 and E7 are responsible for the transforming potential of the virus. The principal action of E6 is targeting the tumor suppressor protein p53 for degradation, while E7 …

The Effect Of Depression And Antidepressants On Cost, Survival And Adherence To Hormone Therapy In Breast Cancer, Virginia Noxon

Theses and Dissertations

Introduction: Breast cancer patients with a depression diagnosis before or after cancer diagnosis have increased cost, shorter survival time and reduced adherence to hormone therapy. Treating depression in these patients should improve these outcomes; however, there is scarce literature on this topic. Currently, no study has determined the association of concurrent depression while adjusting for a history of depression or treating depression with antidepressants with cost, survival and adherence to hormone therapy. This study has two objectives: 1) to determine the association of concurrent depression with cost, survival and adherence to hormone therapy adjusting for a history of depression 2) …

Assessment Of The Probability Of Loggerhead Sea Turtle (Caretta Caretta) Recovery In The Northwest Atlantic Ocean Within 50 Years Of Federal And State Protection In The Us, Michael D. Arendt

Theses and Dissertations

Systematic implementation of sea turtle conservation measures have occurred in the U.S. since the 1970’s. As such, this dissertation assessed the probability that loggerhead sea turtles (Caretta caretta) in the NW Atlantic will meet or exceed recovery criteria in the minimum timeframe (i.e., 50 years) specified by the Recovery Plan. Mathematical modeling (Chapter 1) of a theoretical population resembling an important nesting assemblage in a stochastic environment for 200 years revealed broad (<20k to >106k) fluctuation in annual nest counts without extinction, as well as strong contemporary environmental influence on annual nest counts. Modeling also substantiated the importance of monitoring the …

Selective Behavioral Alterations In The Hiv-1 Transgenic Rat: Implications For Diagnosis Of Pediatric Hiv-1, Kristen A. Mclaurin

Theses and Dissertations

Since the advent of combination antiretroviral therapy (cART), pediatric HIV-1 (PHIV) has evolved from a fatal disease to a chronic disease with children perinatally infected with HIV-1 surviving into adulthood. The HIV-1 transgenic (Tg) rat, which expresses 7 of the 9 HIV-1 genes constitutively throughout development, was used to investigate the early development of chronic neurological impairment in PHIV. Male and female Fischer HIV-1 Tg and F344N control rats, sampled from 35 litters, were repeatedly assessed during early development using multiple experimental paradigms, including somatic growth, locomotor activity, cross-modal prepulse inhibition (PPI) and gap-prepulse inhibition (gap-PPI). A rightward shift towards …