Digital Commons Network^™

Educational Technology In Peer-Led Academic Support In Higher Education: The Impact Of Technology-Focused Training On Peer Educators’ Session Plans, Christopher Gulino

Theses and Dissertations

Students interact with technology daily; whether that is in the classroom, engaging with classmates, or studying material. Although technology has been widely adopted across the field of higher education, it has not been widely utilized to engage with students through the peer-to-peer support model. The purpose of this action research was to evaluate the implementation of educational technology training and its effect on undergraduate peer educators’ confidence to utilize technology in their plans for their peer-to-peer support sessions at a university in the southeast of the United States of America. The research will address the following research questions: How confident …

Statistical Power To Detect Simultaneous Violation Of Proportionality In Hazards And Additive Assumption In Cox Regression Model, Lawrence Mensah Agbota

Theses and Dissertations

The Cox proportional hazards regression model is a widely employed semi-parametric tool in epidemiological and medical research for analyzing time-to-event data and assessing the relationship between patient survival times and one or more predictors. This method involves regression analyses necessitating a meticulous approach to careful examination of the covariates and the relationship among covariates included in the model through a series of critical decisions and steps. Violation of the additivity of the effects and the proportionality in hazards (PH) assumption can lead to biased results and misleading scientific findings. We conducted a Monte Carlo simulation study to assess the performance …

Cytidine Triphosphate Specifically Modulates Parb-Mediated Dna Compaction: Insights From Single-Molecule Analysis And Parb C-Terminal Lysine Mutagenesis, Lois Akosua Serwaa

Theses and Dissertations

ParB is a central player in bacterial chromosome segregation, and cytidine triphosphate (CTP) is known to modulate its DNA compaction activity. This study explored whether CTP’s regulatory effect is due to specific molecular interactions beyond its known CTP-binding pocket. Using single-molecule flow-stretching and TIRF microscopy, we showed that CTP significantly reduces DNA compaction by wild-type Bacillus subtilis ParB, while ATP has no effect, supporting the hypothesis that CTP acts through specific recognition rather than general charge. CTP’s modulatory effect persisted across C-terminal domain (CTD) lysine mutants. Compaction was reduced in wild-type and K255A but abolished in K252A and K259A. The …

Electrocatalytic Degradation Of Methylene Blue Using Graphene Oxide, Antimony Oxide, And Graphene Oxide-Supported Antimony Oxide Ink-Based Electrodes, Maria Irene Myers Armas

Theses and Dissertations

This study investigates the electrocatalytic degradation of methylene blue (MB) using copper mesh electrodes coated with graphene oxide (GO), antimony oxide (Sb₂O₃), and their composite (GO/Sb₂O₃). These materials were evaluated across a pH range of 2 to 8 using sodium sulfate as the supporting electrolyte. UV-Vis spectroscopy at 665 nm confirmed dye degradation, with removal efficiencies reaching up to 95% at pH 2. However, degradation decreased at higher pH, with 40 – 60% removal at pH 8, depending on the electrode. Kinetic analyses revealed optimum performance under acidic conditions. GO/Sb₂O₃ electrodes demonstrated the most consistent and effective performance across all …

Investigating The Threshold Of Opa1-Mediated Mitochondrial Fusion In Shsy5y Cells, Jorge Alberto Elizondo

Theses and Dissertations

Mitochondrial dynamics occurring under stress-induced conditions in SHSY5Y neuroblastoma cells provide insight into the OPA1-mediated mitochondrial fusion threshold in cells of varying energetic demands. Mitochondria are dynamic structures that are continuously balancing fusion and fission, depending on cellular needs. The ability to fuse and divide relies on the maintenance of the mitochondrial transmembrane potential. Stress-induced conditions in SHSY5Y cells were induced via utilization of carbonyl cyanide m-chlorophenylhydrazone (CCCP), a protonophore that disrupts the transmembrane potential. OMA1 protein reacts to the loss of transmembrane potential and subsequently cleaves the fusion-active isoforms of OPA1, L-OPA1. This causes an accumulation of S-OPA1, the …

Foxo Factors’ Ability In Binding To And Inducing Tcf7 In Glioblastoma Cells, Stephanie Oyervides

Theses and Dissertations

Glioblastoma Multiforme (GBM) is an aggressive astrocytoma tumor type with a poor prognosis and limited immunotherapeutic options for those inflicted. Stem gene expression of this cancer indicates a direct relationship with the transcription factors, Forkhead box subfamily O (FOXO-1, -3 and - 4). These transcription factors are evolutionarily conserved, partially redundant. They are involved in diverse and fundamental biological processes such as cell survival, stem cell homeostasis, cell fate determination, cell cycle maintenance, metabolism, and apoptosis. Increasing evidence suggests interconnectivity between the WNT Pathway and FOXO transcription factors; however, the mechanism and full extent to which these interactions play a …

Predicting Enzyme-Substrate Association Using Heterogeneous Knowledge Graph, Jannatul Ferdaus

Theses and Dissertations

Phosphorylation and dephosphorylation are dynamic processes that control many aspects of cellular activity, such as metabolic pathways, cell cycle progression, and signal transduction. Protein activity and interactions are modulated by the reversible addition or removal of phosphate groups, which allows cells to react abruptly to evolving conditions. Although kinase-specific phosphorylation site prediction has advanced, phosphatase-specific dephosphorylation site computational prediction is still a major obstacle that prevents us from fully comprehending the extent of cellular regulation. In this study, we constructed a knowledge graph for the prediction of enzymes (kinases and phosphatases) and their associated substrates with specific phosphosites. As part …

Contributions Of Citizen Science Data To Butterflies Of The Lower Rio Grande Valley, Akane Jazmyn Benitez

Theses and Dissertations

Citizen science-provided insect data inherently exhibits variability in accuracy. In the Lower Rio Grande Valley (LRGV), butterfly occurrence reporting is predominantly reliant on citizen science contributions. My research compared fieldwork conducted monthly over a year to occurrence records submitted by visitors at the National Butterfly Center and in Mission, Hidalgo County, Texas. I hypothesized that butterfly occurrences at the Center would be maximized during the fall and minimized during winter and summer months. My research findings revealed that butterfly taxa richness is contingent upon the following factors: 1) the impact of citizen science submitting reports, and 2) monthly butterfly activity …

Oxytocin As A Possible Vegf Inhibitor For Treatment Of Diabetic Retinopathy, Daira Yepez

Theses and Dissertations

Diabetic retinopathy (DR) is a major complication of diabetes and a leading cause of vision loss largely driven by the overexpression of vascular endothelial growth factor (VEGF), which promotes neovascularization and vascular permeability in the retina. Current treatments, primarily anti-VEGF injections, inhibit the effects of VEGF once it has been secreted but can be ineffective in a certain subset of patients. Recent studies suggest that oxytocin (OXT), a neuropeptide mainly known for its roles in reproduction and social bonding, may downregulate VEGF expression. This study aimed to investigate whether OXT influences VEGF secretion in the human retinal pigment epithelial (RPE) …

Autoregressive Modeling Of Dna Molecule Shapes Accompanied By An Empirical Assessment Of The Ljung-Box Test, David William Custer

Theses and Dissertations

The assumption of independence rarely holds in real-world data. Correlated observations are ubiquitous, especially in sequential contexts where time series models are essential for capturing temporal dependence. This study analyzed six groups of damaged and undamaged DNA sequences, where an "F" in the middle of a sequence indicates damage. One biological aim is to understand how DNA regenerates with the assistance of proteins that recognize damaged regions. Motivated by empirical support for AR(2) modeling, we fit autoregressive models to the first three principal component scores of each DNA group, capturing the dominant structure in the data. We conducted model diagnostics, …

Queer Inclusion In Libba Bray's Beauty Queens: The Case For Lgbtq Ya Literature, Kayla Michelle Crumbley

Theses and Dissertations

This thesis is a time sensitive case study on the nature of Libba Bray's novel Beauty Queensand it's placement as both a metacognitive novel and discourse in the nature of queer acceptance in the publishing and media landscape of the 2010s and 2020s. This includes focusing on contextualizing the book in the changing landscape of queer acceptance and visibility in the media over the last 20 years through the lens of the inclusion in YA and how that manifest in the 2010 and 2020s book bans on LGBTQ YA fiction. The novel highlights the wider need for LGBTQ YA …

First Detrital Zircon Provenance Data From Oligocene-Pleistocene Sediment In The Beaufort-Mackenzie Basin, Arctic Ocean, Joseph Martina

Theses and Dissertations

Sediment, runoff, and nutrient input to the Arctic Ocean plays a critical role in both physical and biological processes that impact regional and global systems. The Beaufort-Mackenzie Basin, situated in the Arctic Ocean offshore northwestern Canada, contains more than 14 km of clastic strata and provides a record of erosion and sediment transport from the Cretaceous to present. Pliocene sedimentation rates within the basin jump nearly 2000% relative to underlying units, but the cause of this shift remains unknown. We used cuttings from the N. Issungnak L-86 well, focusing on the Oligocene-lower Miocene Kugmallit and Mackenzie Bay sequences and the …

Investigating Mechanisms And Day-Level Factors That Influence Children’S 24-Hour Movement Behaviors, Hannah Parker

Theses and Dissertations

Twenty-four hour movement behaviors (i.e., physical activity (PA), screen time (ST), and sleep) are associated with health outcomes, chronic disease (obesity, type 2 diabetes), and mortality. Most literature evaluating children’s 24-hour movement behaviors has focused on static person-level demographic information such as age or biological sex. Relatively less work has examined the variable factors that change day to day, such as environment or context. The Structured Days Hypothesis (SDH) suggests that when children are in structured environments, they have healthier movement behaviors compared to less structured environments where children have more discretionary time to engage in obesogenic behaviors. Besides school/childcare, …

Understanding Community College Students’ Thoughts And Motivations Regarding Tutoring In An Undergraduate Mathematics Course, Whitney Paige Cherekos

Theses and Dissertations

This mixed-methods study examines community college students’ thoughts and motivations regarding tutoring, with the aim of identifying disparities in tutoring utilization and engagement at a community college in North Carolina. The purpose of the dissertation is to evaluate tutoring effectiveness and explore students’ perceptions of tutoring. The findings of this study led to proposed solutions to reduce or eliminate the barriers that today’s community college students encounter when needing academic support.

To evaluate tutoring effectiveness, I collected quantitative data from institution registration reports, transcripts, tutoring logs, and an anonymous student survey for students enrolled in multiple sections of a single …

In Their Own Words: How Standardization Shapes Student Learning Experiences, Jessica Cantley

Theses and Dissertations

This qualitative action research study explores how students perceive and experience standardized and elective educational environments in a rural, Title I high school in the U.S. South. Through semi-structured interviews and focus group discussions with seven diverse participants, the study investigates student-defined learning objectives, motivation and engagement across different classes, and youth perceptions of valuable learning experiences. The research is grounded in constructivism, applying feminist theory and critical race theory as lenses to challenge power dynamics and promote equality in education.

Findings confirm the problem of practice that inspired the study by revealing a contrast between students’ experiences in standardized …

Awareness And Practice Methods For Musicians With Invisible Disabilities: Insights Gained From Playing The Flute With Ehlers-Danlos Syndrome, Jessica Pelltier

Theses and Dissertations

Ehlers-Danlos Syndrome (EDS) is a connective tissue disorder that presents significant physical and mental challenges for musicians, particularly in instrumental performance. These challenges may include chronic pain, joint instability, fatigue, anxiety, and depression. While such symptoms are associated with EDS, they are not exclusive to it and are also common among individuals with other invisible disabilities, such as fibromyalgia, postural orthostatic tachycardia syndrome (POTS), celiac disease, attention-deficit/hyperactivity disorder (ADHD), generalized anxiety disorder (GAD), and chronic fatigue syndrome (ME/CFS). This study explores the experiences of flutists with EDS and other invisible disabilities, focusing on the coping strategies and adaptations they use …

Examining Coping, Individual Resilience, And Family Resilience As Strengths-Based Factors For Lgbtq+ Individuals, Elizabeth Moriarty Combs

Theses and Dissertations

Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, and More (LGBTQ+) individuals are part of a diverse and complex community that has unique considerations regarding physical and mental health. While there is ongoing health equity research regarding LGBTQ+ individuals, the focus is often on health disparities. A strengths-based approach to helping LGBTQ+ individuals through research and other avenues may be beneficial. This multi-manuscript dissertation includes two studies that explored the current literature on strengths-based factors such as coping, individual resilience, and family resilience within LGBTQ+ individuals, as well as determined the feasibility of utilizing these factors to assist LGBTQ+ individuals with health and …

Camp In The Kitchen: Feminism And Craft In Liza Lou's Beaded Worlds, Aurora X. Bell

Theses and Dissertations

Kitchen (1991–96) was the first major work of art by American artist Liza Lou. It is an installation of a life-size kitchen in which every surface and object is covered in glass beads. Kitchen, which Lou refers to as a monument to women’s unsung domestic labor, received considerable critical attention and drew the artist into ongoing conversations around the relationship between “fine art” and “craft” and about the role of feminism in the art of the 1990s. In contemporary interviews, however, Lou expressed discomfort with the label of “craft” as well as with feminist art that she considered “didactic.” …

Quantifying Biomass Burning Impacts On Soil Nox Emissions And Reactive Nitrogen Cycling, Olivia Rae Steinbeck

Theses and Dissertations

Nitrogen oxides (NOx = NO + NO₂) are trace gases that play a critical role in the atmosphere by influencing air quality, oxidation chemistry, and the deposition of fixed nitrogen. Historically, NOx emissions have been primarily linked to anthropogenic sources such as fossil fuel combustion, industrial activities, and agriculture. However, as successful legislation has significantly reduced these emissions, the relative importance of natural NOx sources has become an increasing concern. Soil NOx emissions are of particular interest due to their strong temperature dependence and their connection to global climate change. Rising global temperatures are expected to accelerate soil NOx emissions …

Inorganic Nanoparticle And Nanoplastic Transformations And The Impact On Biouptake By Freshwater Algal Cells Using Single Cell And Single Particle Inductively Coupled Plasma Mass Spectrometry, Elizabeth Carey Bair

Theses and Dissertations

The ubiquitous presence of nanoparticles (NPs) and nanoplastics (NPPs) and their effects on environmental and human health is a significant concern. They are used in every aspect of our lives, and while they offer many benefits, there are concerns about their impacts on ecosystems and human health. The primary aim of this dissertation is to quantify NP and NPP transformations in the presence of algae and determine how those transformations influence bioavailability. The methodology involves two complementary analytical techniques: single particle (SP) and single cell (SC) inductively coupled plasma mass spectrometry (ICP-MS). These techniques are tested and applied to two …

Seeding Science: Exploring Impacts From Interdisciplinary Project-Based Learning Experiences On Preservice Teachers Science Teaching Self-Efficacy, Kathryn Ruth Madden

Theses and Dissertations

Early childhood and elementary education preservice teachers often report having limited firsthand experiences in constructivist, inquiry-based science instruction. This can be a factor in contributing to nervous or anxious feelings about teaching science to young learners. To address this critical problem, this study explored the impact of interdisciplinary project-based learning (PBL) experiences on preservice teachers' selfefficacy. The study extended over six weeks of the preservice teachers' science methods courses. The early childhood participants engaged in interdisciplinary PBL by designing and exploring schoolyard gardens. The elementary participants investigated the local saltmarsh ecosystem focusing on the plants and animals. The PBL experiences …

The Impact Of Teachers’ Cultural Competence On Curriculum Development In Advanced English Courses, Rhine D. Kirkland

Theses and Dissertations

As student demographics become increasingly more diverse, it is imperative that classroom teachers are responsive to the needs of learners from varied backgrounds. The purpose of this study was to examine the impact of teachers’ cultural competence on their curriculum development in advanced English courses. This case study provided insight on the use of administrative instructional coaching as a professional learning approach to aid in teachers’ creation and implementation of culturally responsive curriculums based on the tenets of Culturally Relevant Pedagogy. The analysis and triangulation of survey, interview, document, and observation data yielded key themes regarding the considerations and conditions …

Impact Of Simulation On Project Management Knowledge, Self-Efficacy, And Student Perceptions: An Action Research Study With Non-Traditional Undergraduate Students In A Project Management Capstone Course, Deborah Marindin

Theses and Dissertations

This study investigated the effectiveness of a project management simulation in enhancing non-traditional undergraduate students' project management knowledge, self-efficacy, and perceptions in a project management capstone course. The simulation tool, SimulTrain®, provided an authentic, real-world context to bridge the gap between theoretical knowledge and practical application. Utilizing mixed-methods action research, the study comprehensively evaluated the simulation’s impact on students’ learning. The research was guided by three questions: (1) How does a simulation activity affect non-traditional students’ project management knowledge in a capstone course? (2) To what extent does the simulation impact their self-efficacy? (3) What are students’ perceptions of learning …

Exploring Professional Development Of Expatriate Teachers In Kuwait Through Mentoring, Taji Abdul-Raheem

Theses and Dissertations

Professional growth as a teacher is fundamental for teacher retention and an overall determinant of favorable student outcomes. Academic research underscores professional development as an indicator of success for a school’s success as well. Expatriate teachers in Kuwait, who comprise a significant portion of the workforce, come from various backgrounds and levels of readiness for teaching in a contextually and culturally unfamiliar setting. Due to how teachers are hired and approved for teaching without induction, an implementation for continuous professional development has yet to be materialized for teachers in the private sector. This qualitative study leverages Improvement Science to diagnose …

Investigating The Role Of Metallothioneins In Fungal Iron Homeostasis, David Eap

Theses and Dissertations

The pathogenic fungi Aspergillus fumigatus requires metals to survive and infect humans, but metal overload can be detrimental. Metallothioneins (MTs) are small, cysteine-rich proteins that alleviate metal toxicity by binding excess metals (typically Zn or Cu) for storage or delivery. A recent report indicates that the Fe-S cluster binding glutaredoxin GrxD and the putative Cu-MT CmtA were interacting under high iron conditions in A. fumigatus. We hypothesize that this MT may have a role in binding iron or Fe-S clusters under iron overload conditions to prevent iron toxicity. We also aim to characterize this new MT by determining its …

The Moderating Effects Of Religious Support And Family Support Between Racial Discrimination And Psychological Health Outcomes Among Black Adolescents, Tiera Cleveland

Theses and Dissertations

Racial discrimination is a common experience for Black adolescents. This study aimed to examine family support and religious support as a moderating variable between discrimination and mental health among Black adolescents. This study utilized data from an existing data set, the National Survey of American Life-Adolescent (NSAL-A). The NSAL-A included 1170 adolescents: 810 African American¹ and 360 Black Caribbean². The sample contained an equal amount of female (n = 608) and male (n = 562) Black adolescents³, who range in age from 13 to 17 years. Significant findings suggest that family support moderates the impact …

Quinone-Mediated Extracellular Electron Transfer In Escherichia Coli During Glucose Oxidation Metabolism, Megan Danielle Whisonant

Theses and Dissertations

The growing global demand for energy, ongoing reliance on fossil fuels, and increasing water pollution from industrial and anthropogenic sources present significant environmental challenges. In response to these issues, renewable and sustainable energy sources offer substantial potential for reducing dependence on fossil fuels and ensuring access to clean water. Microbial electrochemical systems (MESs) have emerged as promising, eco-friendly solutions for energy-efficient wastewater treatment and bioremediation. A key challenge in MESs development is facilitating effective electron transfer between microorganisms and electrode surfaces. The first chapter of this thesis discusses the fundamentals of MES types, explains mechanisms of extracellular electron transfer, and …

The Potential Importance Of Microenvironment On Polymer Bound Chemical Reagents, Nathan Joseph Halsteter

Theses and Dissertations

In this thesis will provide a brief history of polymer bound reagents, their uses, and advancements. The importance of polymer microenvironments will be explored using a model kinetic resolution reaction utilizing polymer bound reagents to observe how changes in a polymer’s microenvironment effects the yield and selectivity of a reaction. It was found that there are copious factors that affect polymer bound reagents, and no direct conclusion could be drawn from the study.

Impact Of Participation In Extracurricular Activities On Female Students’ Motivation, Noha Ibrahim

Theses and Dissertations

This study investigated the impact of extracurricular activities (ECAs) on academic motivation among female high school students at a semi-governmental international school in the UAE. It addressed three research questions: (1) the effect of ECA participation on academic motivation, (2) students’ perceptions of how these activities influence their motivation, and (3) teachers’ perspectives on their impact. I conducted this action research in a school of 4,500 K-12 students predominantly local and from high-income backgrounds with an international teaching staff. Participants included grade 11 and 12 female students (ages 16–18) enrolled in one of four clubs (Reading, International, Sports, and Art) …

Sensing Others, Alissa Reed

Theses and Dissertations

In this project, I notice how we listen and respond to animals, both through marine bioacoustics studies and rhetorical theory, and consider how we might develop new ways of noticing and interacting with animals. I hold together rhetorical theory, marine bioacoustics studies, and my observations nest sitting sea turtles to see what kind of multispecies ethic emerges from messy encounters with nonhuman others – specifically, with sea turtles nesting on the beaches of the Outer Banks in the Summer of 2020. By confronting the unavoidable moments of indecision, and even possible violence, inherent to encounters with nonhumans others, even and …