Digital Commons Network^™

Characterizing Patterns Of Adherence To Physical Activity Goals In Behavioral Weight Control, Melissa Lee Stansbury

Theses and Dissertations

Introduction: Many individuals fall short of the physical activity (PA) goals provided during lifestyle programs, and there is considerable variability in weight loss response and adherence to recommendations for behavior change. Weight loss response within the early weeks of program initiation predicts future weight loss success; however, little is known about what distinguishes those who respond well to treatment from those who fail to respond. Exposing the behavioral patterns which underlie weight loss response may point towards targets for treatment optimization. The purpose of this study was to (1) characterize individuals with distinct patterns of adherence to PA goals during …

The Utility Of Multiple Structure Torsion Angle Alignment In Protein Active Site Description (Asd), Devaun L. Mcfarland

Theses and Dissertations

Proteins are responsible for various functions throughout organisms, or within the systems, they operate. Active-sites or functional/ binding sites are regions responsible for activity in a protein; they serve as a catalyst for reactions, attach or bind to other molecules (ligands), and maintain function. With the profusion of protein sequence and structure data, it's increasingly relevant to develop automated methods of identifying and investigating active-sites for proteins. Active-sites identification will have a direct impact: in better understanding molecular basis for diseases, assisting in drug design, the study of targeting mutants, and for functional annotation of unknown proteins. The proper knowledge …

A Novel Analytical Method For Studying Pharmacological Treatments For Affective Disorders In Neuroscience, Shane N. Berger

Theses and Dissertations

Histamine and serotonin are important neurochemicals that maintain crucial brain functions. Both are thought to be altered in affective and neurodegenerative disorders such as depression and Parkinson’s disease. Histamine and serotonin are thought to modulate one another but the exact relationship remains unknown and this gap in knowledge makes diagnosing and treating disorders involving the transmitters difficult. The Hashemi lab studies serotonin neurochemistry to understand serotonin’s role in psychiatric disorders. However, histamine has remained an understudied neurotransmitter due to a lack of analytical tools. In 2015 and 2016, the Hashemi lab pioneered a novel detection method utilizing fast-scan cyclic voltammetry …

Incorporation And Measurement Of Uncertainty In Clustered And Spatial Data, Yuan Hong

Theses and Dissertations

Analyzing population representative datasets for local estimation and predictions over time is important for monitoring related public health issues, however, there are many statistical challenges associated with such analyses. Mixed effect models are one of the common options which can incorporate time and spatial effect in the model and related inference is well established.

In the first part of this dissertation, to estimate area-level prevalence using individuallevel data, small area estimation (SAE) with post-stratified mixed effect models were used where sampling weights were also incorporated into it. However, if poststratification which requires more computation effort can improve estimation accuracy is …

The Experiences Of Black Women In Diversity Roles At 4-Year Predominantly White Institutions, Tristen Brena� Johnson

Theses and Dissertations

Many Black women professionals at predominantly White colleges and universities share similar experiences regarding racism, sexism, and classism at their institutions. However, there is a dearth of research regarding the experiences of Black women who specifically work in diversity related positions at four-year predominantly White institutions (PWI). The purpose of this study was to explore the lived experiences of Black women who hold diversity related roles at PWIs. For the purpose of this study, diversity positions were defined as roles held in housing and residence life as well as in multicultural affairs departments and centers. Using a qualitative research approach …

Aqueous Kinetics Of Α-Hydroxyhippuric Acid Derivatives Bearing Electron-Withdrawing Groups As A Function Of Ph And Buffer Catalysts, Mohamad Imad Rafie

Theses and Dissertations

It has been shown that carbinolamides are intermediates in the enzyme-catalyzed synthesis of -amidated peptides. Although carbinolamides are important intermediates in the production of these hormones and have roles in other biological venues, little attention has been given to their mechanisms of reaction in water, and, thus, it is difficult to speculate how their reaction would be enzymatically catalyzed. The purpose of the work presented here was to synthesize structural analogs of the biological intermediates and study their mechanism of breakdown in water. -Hydroxyhippuric acid, a substrate for the enzymatic system, provides an easily modified template for the study of …

Are We Prepared?: A Quantitative Study Of Elementary School Counselors' Knowledge, Skills, And Dispositions To Working With Lgbtq Youth, Kristina D. Weiss

Theses and Dissertations

It is estimated that there are over three million lesbian, gay, bisexual, transgender, and questioning (LGBTQ) youth in the United States. Based on their perceived or real sexual orientation and gender identity, these youth face multiple accounts of bias and discrimination in schools. As a source of solace, many LGBTQ students seek out adult supports in school, namely the school counselor. While extensive research exists about the interactions and capabilities of secondary school counselors to work with LGBTQ youth, there is a limited research surrounding elementary school counselor's competencies with this population. The purpose of this quantitative research was to …

Investigation Of The Sequence-Structure-Activity Relationship In Ponericin L1 From Neoponera Goeldii & Synergistic Interactions Of Ionic Liquids And Antimicrobials To Improve Efficacy, Alexandria S. Senetra

Theses and Dissertations

Non-traditional antimicrobials have been an area of great interest due to the increasing prevalence of antimicrobial resistance (AMR) in bacteria. Antimicrobial peptides (AMPs) & ionic liquids (ILs) are two examples that have been investigated as a potential solution. Most AMPs are naturally derived & exhibit high selectivity against bacterial targets over host cells. The venom-derived peptide, ponericin L1 from Neoponera goeldii, was used to investigate the role of cationic residues & net charge on peptide activity. Using both in vitro & microbiological methods, L1 peptide & derivatives exhibited an alpha-helical conformation with enhanced binding to lipid vesicles containing anionic lipids …

Development Of Functional Metal Organic Frameworks For Wastewater Treatment, George Morcos

Theses and Dissertations

Novel amine-functionalized zirconium-based metal organic frameworks (MOFs) were solvothermally synthesized for the efficient and selective removal of Pb (II) in concentrated multi-component heavy metal ions systems. Pristine UiO-66 and UiO-67 MOFs were grafted with thiourea and amidinothiourea via a facile one-step post synthetic modification. Successful grafting was confirmed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The microporous amidinothiourea modified MOFs demonstrated excellent performance in their high maximum adsorption capacities of 246 and 367 mg.g-1, respectively, as well as their remarkable selectivity for Pb (II) ions in highly concentrated multi-ion solutions. This is, in …

Enhancement Of Abiotic Stress Tolerance In Rice And Soybean By Biotechnological And Nanotechnological Approaches, Sudha Shanmugam

Theses and Dissertations

Abiotic stress is one of the major factors which affects plant productivity. The generation of stress-tolerant crops is a pressing need and a major challenge in the field of plant biology. Rice and soybean are the major crops in Arkansas that significantly contribute to state’s economy. Arkansas is one of the hardest-hit states during the drought season. Several approaches have been used for the regulation of abiotic stress tolerance in crops. Here, we have used two different approaches: the classical genetic engineering approach and the nanotechnological approach for improving plant growth as well as enhancing abiotic stress tolerance in the …

Role Of Ataxia Telangiectasia Mutated In The Repair Of Magnetite Nanoparticles Induced Double Strand Breaks Associated With Heterochromatin, Mie Mohamed Mounir

Theses and Dissertations

Magnetite nanoparticles particulate matter pollution is escalating in large cities like New Mexico, Manchester city, Cairo, and New Delhi. Combustion derived Magnetite nanoparticles was found deposited in internal vital organs of deceased residents of urban areas. A great deal of research focused on the genotoxic and cytotoxic effects of Magnetite Nanoparticles (MNPs). In our work we focus on the mechanisms employed in DNA repair of higher chromatin structures. We employed the sensitive analysis of anti γ-H2AX to detect and monitor the repair of DSBs following exposure to MNPs. A 2- fold delay in the repair of heterochromatin associated DSBs in …

Novel Dna Ligases From The Red Sea Brine Pools: Cloning, Expression, In Silico Characterization And Comparative Thermostability, Iyanu Mumeen Oduwole

Theses and Dissertations

Extreme physicochemical conditions such as high temperature, salinity, and the presence of heavy metal are characteristics of some of the Red Sea brine pools environment. We screened two Red Sea Brine pools (Atlantis II(AT-II), and Discovery Deeps (DD), and one interface layer (Kebrit Deep) to identify novel DNA ligases with potential extreme biochemical properties. Furthermore, we did an in silico comparative thermostability study by examining the stability role of proline and arginine residues at the loop conformations and exposed regions of ligase sequences from metagenomic assemblies of different extreme environments, including the Red Sea metagenomes. A sequence-based metagenomics approach was …

Not All Factors Are The Same: Examining Institutions Among Sex Offenders Throughout The Life-Course, Brooke Cooley

Theses and Dissertations

This dissertation focused on the quality of institutions relative to theories of life-course and desistance. Specifically, this study focused on the quality of marriage, parenthood, and employment and whether the quality of these institutions inhibited or encouraged sexual offending/reoffending and how these factors influenced individuals’ offending behavior over time. While there is an abundance of literature relative to institutions and general offending, little is known about how these institutions impact sexual offending. The purpose of this dissertation was to fill this gap in the extant literature by qualitatively examining how the institutions of marriage, parenthood, and employment influenced sexual offending/reoffending …

Development And Implementation Of A Coarse-Grained Markov State Model, Brian Chen

Theses and Dissertations

Markov State Models (MSMs) are constructed from Molecular Dynamics (MD) simulation data, high-resolution spatial and temporal information stored in the form of trajectories, of biological processes, such as ligand-receptor bonding, as a model to understand detailed kinetic information. Traditional MSM implementations involve a clustering step that clusters the MD trajectories into thousands of experimentally unverifiable clusters known as "microstates" before lumping them together into "macrostates". This work details a novel software implementation, using a combination of R, Python, and Tcl, that I have created for the purpose of creating a coarse-grained MSM that directly clusters the MD trajectories into a …

Hulumtimi I Ekuilibrave Vitaminkë Tek Konsumatorët E Preparateve Vitaminke, Erëblina Hajdini

Theses and Dissertations

Aktualisht konsumatorët në Kosovë po përballen me një ndryshim në shpresit e përdorimit të produkteve ushqimore, vitaminave, suplementeve (shtesave ushqimore) dhe produkteve të tjera dietike. Kohën e fundit mjedisi farmaceutik u pasurua me produkte të ndryshme, jo vetëm nga kompani të ndryshme por edhe të ndryshëm për përdorim, grupet e synuara, statusin fiziologjik të konsumatorit etj.Për shkak të përvojës dhe zhvillimit të teknologjive të prodhimit, diapazoni i shtesave ushqimore dhe produkteve të tjera dietike ka ndryshuar gjatë viteve me qëllim të sigurimit të produkteve që janë gjithmonë të sigurta. Ndonjëherë, konsumatorët përveç që janë më të ndjeshëm ndaj rolit dhe …

Survey Of Airflow Around A Heated Manikin As A Simulated Aeromedical Evacuation Patient On A Litter With Computational Fluid Dynamics Models, George P. Lemmer

Theses and Dissertations

Aeromedical Evacuations remain the predominant method used to transport patients from forward deployed areas of operations to secure locations with more robust medical infrastructure. Transportation of chemical warfare casualties and infectious patients require additional attention to prevent cross contamination. Specific airflow characteristics paired with environmental control system settings are a gap in scholarly literature. Based on the available literature computational fluid dynamics models were created to simulate the airflow around a patient represented by human geometry using commercially available software. In order to compare simulated and experimental results a heated manikin was placed in the MURPHEE aerosol exposure chamber and …

Development Of A Semi-Quantitative Methodology For Evaluation Of Whole-Body Chemical, Biological, Radiological, And Nuclear Decontamination Using An Ultraviolet Fluorescent Aerosol, Emily M. Titus

Theses and Dissertations

This work describes a literature review which was conducted on publicly available literature on chemical, biological, radiological, and nuclear (CBRN) decontamination to understand the body of knowledge and gaps in this body of knowledge, including the assumption that disrobing after a CBRN incident will remove 90% of contamination. Also included is a description of the design and characterization of an aerosol test chamber which was constructed for use in this research. Finally, the bulk of this work describes the development of a semi-quantitative methodology for visualizing contamination. This method uses an ultraviolet fluorescent aerosol (to simulate contamination by a chemical …

Image Processing And Classification Of Remotely-Sensed Satellite Imagery: An Application Towards Cloud Detection, Oluwamuyiwa Adesola Adeegbe

Theses and Dissertations

Atmospheric studies have been carried out for decades to forecast weather and climate trends such as tropical storms, etc. Of recent concern is the level of greenhouse gases in the atmosphere, which has a relative influence on the weather and climate trends. Over the years, large weather satellites like the GOES series have been used to monitor these GHGs. However, an in-depth understanding of the movement of these gases requires consistent monitoring, which has given rise to the need for miniaturized satellites. Since the miniaturized satellites are novel, they require a ground-truth like the GOES-16 satellite to validate these observations. …

Bioprinted In Vitro Model Of Human Glioblastoma, Rachel Lauren Schwartz

Theses and Dissertations

Glioblastoma multiform (GBM) is one of the most aggressive forms of primary brain tumors. GBM is fast progressing and resistant to treatment, resulting in a low survival rate. Conventional 2-dimensional tissue culture models cannot fully replicate the complexities of cancer lesions that contain multiple cell types and structures (e.g. vessels composed of endothelial cells, cancer cells, normal cells, etc.) as well as an intricate scaffold of proteins comprising the extracellular matrix (ECM). In addition, animal models cannot translate into the clinical disease in patients. Thus, this study has developed a bioprintable organ-on-a-chip (OOAC) model that mimics the important ECM factors …

A Grounded Theory Of The Impact Of Teachnj On The Instructional Leadership Of Superintendents, Russell Matthew Lazovick

Theses and Dissertations

The purpose of this grounded theory study was to develop a theory, grounded in data obtained by interviewing current superintendents on how TEACHNJ has impacted their ability to improve student performance. TEACHNJ is a law enacted by the state of New Jersey to improve teacher quality and raise student performance by changing evaluation and tenure processes in order to create greater transparency, equity, consistency, and accountability across districts. This study examined the law's impact on five specific actions superintendents can take that have been found to enhance student performance. The study found that TEACHNJ served as a punctuating event, sending …

Novel Material For Advanced Tissue Regeneration, Karrer Mahdi Kadum Alghazali

Theses and Dissertations

Nerve tissue damage or failure can occur for various reasons, including infection, disease, aging, and trauma. The tissue microenvironment (extracellular matrix-ECM) plays a key role in regulating the self-renewal and recovery of damaged tissue. ECM-cell interactions govern cell migration and physiology, with biochemical and biophysical boundaries being the main factors that control ECM-cell interaction. Optimizing these boundaries for the recovering tissue will create a healthy microenvironment to support and enhance the recovery rate (1, 2). We have developed a novel, multidimensional nanocomposite system that incorporates gold nanorods (AuNRs) (aspect ratio of around 3) as an artificial ECM for cell adhesion, …

Predictors Of Paternal Postpartum Depression: A Meta-Analysis, Zachary Joseph Blackhurst

Theses and Dissertations

While major depression is a well-defined mental health condition, it's presentation can be vastly different across individuals and groups, and many factors impact one's vulnerability. A critical period of vulnerability to depression is the postpartum period. Despite the frequent assumption that postpartum conditions solely affect women, prevalence estimates of paternal postpartum depression (PPPD) are comparable with those of women. Similar to mothers, men experience significant biological and psychosocial changes following the birth of a child that contribute to the onset of postpartum depression. A growing body of research has identified many potential variables related to PPPD, yet there is no …

Dynamics Of Interal Phosporus Cycling In A Highly Eutrophic, Shallow, Fresh Water Lake In Utah Lake State Park, Utah, Usa, Sheena Marie Smithson

Theses and Dissertations

Eutrophication is an increasing global concern as human effluent saturates lakes with an over abundance of nutrients. Phosphorus, generally being the limiting nutrient, is often the most impactful, allowing cyanobacteria populations to grow out of control leading to harmful blooms that can produce cyanotoxins, anoxic lake conditions, and mass fish kills. Utah Lake, a shallow highly eutrophic fresh water lake located in central Utah Valley, has experienced these harmful algal blooms for the last several years. The internal phosphorus cycle is a significant driver in Utah Lake's eutrophication, as the sediments act as both a sink and a source for …

Characterization And Optimization Of An Image Charge Detector For The Measurement Of Martian Dust, Jace Rozsa

Theses and Dissertations

Image charge detector (ICD) technology has existed for decades. However, not until recently has an ICD been proposed for use in space exploration, specifically for studying the characteristics of the dust on Mars. Characterizing the dust on Mars is crucial for designing equipment to aid manned missions. It also improves our understanding of Mars' climate and weather systems. An ICD utilizing printed circuit board (PCB) electrodes, coupled with a custom differential amplifier, is best suited for this type of measurement because of its light weight, simplicity, and noise performance. The noise floor of our particular amplifier is measured to be …

Faulknerian Echoes And The Grotesque In Mccarthy’S The Orchard Keeper, William Haynes

Theses and Dissertations

ABSTRACT

Faulknerian Echoes and the Grotesque in McCarthy’s The Orchard Keeper (August 2020)

William Leland Haynes, B. A., Texas A&M International University

Chair of Committee: Dr. Manuel Broncano

This thesis is an exploration of Cormac McCarthy and William Faulkner’s craft through a focus on their works The Orchard Keeper and “Barn Burning.” This analysis charts the two dialoguing or conversing with each other across times through the art of their writings.

The basis of this project examines a key phrase from “Barn Burning,” where the problem of doing the right thing creates a conflict of identity within the story’s young …

Prediction Of Requirements Engineering Using A Multi Scale Probabilistic Approach: Case Study Ffg(X) Combat Ship, Mahdi Boucetta

Theses and Dissertations

Requirements engineering in a system-engineering project is a key factor in the success of a project. In the current state, stand-alone research has been conducted tackling this area, however, few studies addressed the requirements based on a probabilistic approach. In this thesis, a multi-scale probabilistic approach has been developed, named Bayesian Network, to evaluate the requirements engineering of a complex systems In order to pursue the aim of this paper, the FFG(X) navy ship is chosen to serve as a case study and to validate the proposed model. Results indicate the sub-requirements that highly affect the FFG capability/performance. These sub-requirements …

A Woman’S Portion: 5000 Years A Slave, Ann R. Glickman

Theses and Dissertations

Slavery has existed for all of recorded history. The evidence is conclusive that slave systems have almost always been majority female. I suggest that slavery originated as an attempt to control female reproductive capacity, and that this attempt to control was not limited to enslaved women.

Snow-Albedo Feedback In Northern Alaska: How Vegetation Influences Snowmelt, Lucas C. Reckhaus

Theses and Dissertations

This paper investigates how the snow-albedo feedback mechanism of the arctic is changing in response to rising climate temperatures. Specifically, the interplay of vegetation and snowmelt, and how these two variables can be correlated. This has the potential to refine climate modelling of the spring transition season. Research was conducted at the ecoregion scale in northern Alaska from 2000 to 2020. Each ecoregion is defined by distinct topographic and ecological conditions, allowing for meaningful contrast between the patterns of spring albedo transition across surface conditions and vegetation types. The five most northerly ecoregions of Alaska are chosen as they encompass …

Analysis Of Olfactory Mrna Cap Modifications Using Rnaseh And Lc-Ms, Ilinca M. Giosan

Theses and Dissertations

In the olfactory system, olfactory sensory neurons (OSNs) express odorant receptors (ORs) in a singular fashion through unknown mechanisms. Published data supports the notion that singularity is achieved, in part, through a modification the mRNA strand, perhaps in its 5’cap region. This theoretical study aims to test this 5’cap hypothesis.

Vegetation Phenology As A Function Of Plant Functional Type And Urbanization, Ryan Lennon

Theses and Dissertations

Urban land cover contributes to higher temperatures in urban areas compared to adjacent rural areas, which can cause an earlier start of the growing season for urban vegetation. Variations in plant community characteristics between urban and rural areas also produce intra-urban differences in vegetation phenophases, although few studies have investigated differences in phenology between plant functional types in multiple urban environments. In this study I used an exploratory analysis based on the Landsat Phenology Algorithm and weather station data to quantify differences in leaf-onset dates for different plant functional types in the New York City Metropolitan Area. The results demonstrate …