Digital Commons Network^™

Portrait Of A"Gentlemanly"Profession: Whiteness And The Persistent Racial Imperviousness Of Accounting, Adam J. Saatkamp

Theses and Dissertations

While the accounting profession has employed numerous initiatives aimed at diversification and inclusion over the past 50 years, Black CPAs are still significantly underrepresented in the accounting profession, evidence of the profession’s persistent racial imperviousness. Black Americans who do successfully enter the accounting profession feel excluded from informal business-related networks and report finding it challenging to navigate the politics of the profession. Black accountants also report sensing a need to work extra hard to prove their knowledge and worth to their white colleagues and supervisors (Dey, Lim, Little, & Ross, 2019). The purpose of my study is to evidence and …

Investigating How Ecologically Relevant Thermal Conditions Affect Gonadal Development In A Turtle With Temperature-Dependent Sex Determination, Anthony Trey Breitenbach

Theses and Dissertations

In turtles and numerous other reptilian species, sex is determined by the environmental temperatures during embryonic development, which is referred to temperature-dependent sex determination (TSD). In the type of TSD common in turtles, cool temperatures (below 29 °C) during embryonic development produce mainly males while warm temperatures (above 29 °C) produce mainly females. Gonadal differentiation in TSD species involves numerous genes that are also necessary to produce a testis or ovary in species with genotypic sex determination. However, most of what we know about TSD comes from studies performed in the laboratory using constant temperature incubation conditions, which are not …

Animal Abuse In Egypt: An Assessment Of Attitudes, Behaviors And Protective Factors Among University Students And Graduates., Salma El Saedy

Theses and Dissertations

Animal abuse is an understudied problem in Egypt with possible ramifications on both non-human and human animals and links to interpersonal violence and conduct problems. This study aims to explore the attitudes and behaviors of Egyptian university students and graduates towards the treatment and use of animals in society and to test if exposure to animal abuse is associated with abusive behavior. The study also aims to identify possible protective factors against animal abuse among a group of positive deviants. A mixed-methods approach was used to study these questions; an online survey was disseminated over social media platforms, and 99 …

The Cynics' Understanding Of And Contribution To Philosophy, Yossra Hamouda

Theses and Dissertations

The Cynics are an understudied school in the history of philosophy especially, if we compare the amount of literature written on the Cynics to the amount of literature written on Socrates, Plato, Aristotle and other Greek schools like the Epicureans, the Neo-Platonists and even the Stoics. The lack of research interest in the Cynics, both from the side of philosophers and historians, is possibly grounded in a lack of interest in understanding the Cynical conception of philosophy. Unless we take a serious interest in understanding the Cynical conception of philosophy, we risk reducing the Cynics to the historical clowns of …

Communication Fatigue Among Egyptian School Teachers, Nahla El Gendy

Theses and Dissertations

Communication fatigue is a situation when a person is no longer able to engage in communication. This study, which is one of the very first in the field, determines the antecedents and consequences of communication fatigue among Egyptian school teachers to be used as a guide for decision makers in the educational sector. Communication between teachers and students is fundamental in the learning process and understanding the antecedents and consequences of communication fatigue is meant to improve the communication between teachers and students and positively reflect on the learning process.

This study answers three main research questions: What is communication …

Characterization Of Testis-Derived Mesenchymal Cells And The Hunt For Universal Stemness Markers, Myret Ghabriel

Theses and Dissertations

Mesenchymal stromal/stem cells (MSCs) are multipotent cells residing in multiple tissues with the capacity for self-renewal and differentiation into various cell types. Due to the myriad sources of MSCs the International Society for Cellular Therapy (ISCT) proposed certain criteria for their characterization. Here, we isolate adult MSCs from mouse testes and demonstrate that these testis-derived MSCs (tMSCs) follow some of the ISCT’s criteria. tMSCs expressed the MSCs surface markers CD44, CD73, and CD29 and lacked the expression of the hematopoietic cell marker CD45. Moreover, the cells displayed the capacity for self-renewal and in vitro differentiation into adipocytes. Since the isolation …

The Effect Of Pain Tolerance On Healthcare Utilization Among Patients With Chronic Pain, Callie Rose Teufert

Theses and Dissertations

Chronic pain patients are more likely to use healthcare services and have greater expenditures related to health needs, which has led to studies on different aspects of pain that may lead to greater use, disability, functional impairment, and other outcomes. Factors that have been researched for their potential relationships with healthcare utilization (HCU) in various populations include function loss, pain catastrophizing, anxiety, fear, pain severity, and pain duration. Pain tolerance has not been extensively studied for its impact on healthcare utilization among patients with chronic pain. This study examined the relationship between perceived pain tolerance in chronic pain patients and …

Effects Of Cumulative Trauma, Discrimination, And Racial Trauma Among African Americans, Brittany Renee Clayton

Theses and Dissertations

In the current study, we examined the impact of cumulative trauma, racial trauma, and everyday discrimination experiences within the African American community on psychological outcomes. One hundred and nineteen participants completed a series of self-report measures that analyzed their experiences of lifetime stressors, racial trauma, frequency of everyday discrimination, current posttraumatic stress disorder, depressive symptoms, and experiential avoidance levels. It was hypothesized that increased exposure to lifetime stressors, racial trauma events or experiences, and everyday discrimination would be associated with increased psychological distress. Correlations were conducted to identify and examine these relationships. This hypothesis was supported for lifetime stressor exposure …

A Predictive Model For Geographical Location Using Microbiome Composition And Covid-19 Based Analysis, Ahmed Adel Aboushanab

Theses and Dissertations

The human microbiome is a main contributor for the health and welfare of the human body. It is affected by many factors like diet and hygiene. These factors differ between different populations. Testing the population-microbiome differences using healthy samples from different countries is the first objective of this study. This data was then used in training and testing machine learning models (Random Forest and L2-logistic Regression Classifiers) for the prediction of the geographical location based on the microbiome data. Random Forest Classifier had the highest accuracy. Feature importance analysis showed that the data for Proteobacteria, Actinobacteria, and Bacteroidetes improved the …

Selective Gsk3Β Inhibition Mediates An Nrf2-Independent Anti-Inflammatory Microglial Response, Mohamed H. Yousef

Theses and Dissertations

Glycogen Synthase Kinase 3 (GSK3) is associated with the proinflammatory phenotype of microglia and has been shown to act in concert with Nuclear factor kappa B (NF-κB). . GSK3 is also a suppressor of Nuclear factor erythroid 2-related factor 2 (Nrf2), the principal regulator of redox homeostasis. Agreeing with the oxidative paradigm of aging, Nrf2 is often deregulated in parainflammatory and neurodegenerative diseases. In this study, we aimed to explore a multimodal disease-modifying utility of GSK3 inhibition, beyond neuronal proteopathologies, Furthermore, we aimed to underscore the difference in therapeutic value between the two GSK3 paralogs by isoform-selective chemical inhibition.

The …

Rework Prediction On A Construction Site Through Bim & Ann Integration, Raghda Attia

Theses and Dissertations

Construction Rework is a common and widespread issue in the construction industry that has a detrimental impact on the project performance, whether in terms of schedule delay or cost overrun. Developments in Building Information Modelling (BIM) have aided in the resolution of coordination issues, which are thought to be one of the leading sources of rework particularly during the construction stage. Nevertheless, the majority of research has focused on resolving coordination issues during the design stage with minimum regard to the coordination issues that occur during the construction stage. In a BIM environment, the goal of this research is to …

Repurposing Metformin And Antifolates For The Treatment Of Hepatocellular Carcinoma, Sherouk Mohamed Tawfik

Theses and Dissertations

Hepatocellular carcinoma (HCC), one of the most prevalent types of cancers worldwide, continues to maintain high levels of resistance to standard therapy. As clinical data revealed poor response rates, the need for developing new methods has increased to improve the overall wellbeing of patients with HCC. Due to its safety, wide availability and previously reported anti-cancer effects, metformin (MET) serves to be a possible therapeutic agent when combined with other well-known anti-cancer agents. The aim of this study was to investigate the potential anti-cancer effects of MET, an anti-diabetic agent, when combined with two antifolate drugs: trimethoprim (TMP) or methotrexate …

Design And Fabrication Of Nanostructured Electrodes For Complementary Electrochemical And Photoelectrochemical Water Splitting, Kholoud El Sayed Abousalem

Theses and Dissertations

Designing highly active, durable, and nonprecious electrodes for overall water splitting is of urgent scientific importance to realize sustainable hydrogen production. Accordingly, the need to search efficient energy production systems is of crucial necessity. In this thesis, two various systems for sustainable hydrogen production have been reported using electrochemical and photoelectrochemical pathways. In the first part of the thesis, electrochemical water splitting involving both hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) has been established. To this end, an innovative approach is demonstrated to synthesize flower-like 3D homogenous trimetallic Mn, Ni, Co phosphide catalysts directly on nickel foam via …

Knockdown Of Mdm2 In Hepg2 Cell Line: A Step Towards Understanding The Relation Between Mirna590-3p And Its Downstream Target Gene, Mdm2, In Hepatocellular Carcinoma, Jihad Mahmoud

Theses and Dissertations

Background: miRNA 590-3p is a small non-coding RNA that has previously been associated with the occurrence and progression of several cancer types. Its expression pattern and biological role in Hepatocellular carcinoma (HCC), however, remain controversial. Interestingly, a previous study in our lab revealed a tumor suppressing activity of miR-590-3p in HCC and identified the MDM2 gene as the miR-590-3p target gene.

Aim: The current study aimed to knock down the expression of MDM2 in HepG2 cells to understand how the inhibition of MDM2, as a validated downstream target of miR-590-3p, would affect different functional pathways in HCC. In …

Mathematical Modeling And Optimization Of Water Efficiency In Residential Buildings, Mahmoud Amin

Theses and Dissertations

Water scarcity is a global issue that is rapidly worsening. The domestic sector is one of the fastest-growing segments of world water usage. Many researchers have explored various approaches to promote sustainable uses of water, with Greywater (GW) recycling and utilization of innovative plumbing fixtures among the methods presented to reduce freshwater consumption for domestic usage. Nonetheless, previous studies have dealt with both means independently, with limited analysis of the integrated effect of utilizing GW recycling with innovative plumbing fixtures, both on quality of supplied water, as well as on cost of the integrated system. Accordingly, this research aims at …

Final Bid Price Estimation For Negotiated Contracts: Bargaining Game Theory Approach, Amr El Mahallaoui

Theses and Dissertations

The wide use of the low bid method by employers for awarding construction contracts has created an aggressively competitive environment among contractors in the construction industry. As a result, a contractor may resort to use a low mark-up percentage for his bid to increase his chances of winning, which may lead to losses and conflicts in case he is awarded the project. Additionally, a contractor who reaches the final negotiations stage for a certain project is faced by the dilemma of the minimum discount percentage he may need to offer to the employer that maximizes his chance to win the …

A Comprehensive Evaluation Of Wastewater Grit Characteristics And Its Application In The Design Of A Facility-Specific Grit Removal Solution, Tetiana Kolsovska

Theses and Dissertations

Tailored solutions for wastewater treatment plants (WWTPs) are becoming more prevalent for optimization of treatment process, based on the unique quality of the influent received by each facility. In-depth evaluation of the influent properties is necessary for design of the most appropriate treatment system. In this study, wastewater grit was evaluated in terms of its quantity, particle size distribution, total organic carbon (TOC) content, including fats, oils, and grease (FOG), and settling velocity of the particles, over the course of one year at the headworks, collection network, and through the treatment stages of the Atlantic County Utilities Authority (ACUA) WWTP, …

Optimization Of A Smart Sensor Wearable Knee Sleeve For Measuring Skin Strain To Determine Joint Biomechanics, David Steven Wood

Theses and Dissertations

This work addresses three objectives related to the design and modeling of an instrumented knee sleeve and its high deflection strain gauges for at-home knee rehabilitation. First, a multi-objective Bayesian approach was developed to economically optimize a high deflection strain gauge's mechanical and electrical behavior. Four objective functions were simultaneously optimized with two design variables in seven iterations; 90% faster than a grid search approach. The presented algorithm adjusts variables in the manufacturing process of high deflection strain gauges and produces a sensor with optimized properties for a predetermined purpose. Second, an algorithm was created to accurately approximate the dynamic …

Selective Small Molecule Targeting Of Mcl-1 In Multiple Myeloma, Omar S. Al Odat

Theses and Dissertations

Multiple Myeloma (MM) is a deadly blood malignancy, characterized by the uncontrolled proliferation of aberrantly differentiated plasma cells. MM is challenging to diagnose and treat, accounting for approximately 12% of hematologic malignancies. The overexpression of anti-apoptotic group of Bcl-2 family proteins, particularly Myeloid cell leukemia 1 (Mcl-1), play a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis. Thus, inhibition of the Mcl-1 protein is an attractive therapeutic strategy against myeloma cells. Over the last decade, the development of selective Mcl-1 inhibitors has seen remarkable advancement. In this project, …

The Measurement Of College Athletes' Knowledge And Behavior On Pre-And Post-Workout Nutrition Utilizing A Text-Message Intervention, Hannah Christine Young

Theses and Dissertations

The purpose of this study was to measure athlete’s knowledge on pre- and post-workout nutrition, specifically assessing their macronutrient intake. Nutrition education for collegiate athletes has been a popular topic of discussion for years. Illinois State University athletes participated in the study by completing a pre- and post- sports nutrition survey which consisted of 29 questions. This survey regarding nutrition knowledge specifically included questions based off their pre-workout intake, recovery, as well as behavior-related questions based off a 1-7 Likert Scale (one being disagree and seven being agree).

A total of 40 participants completed both the pre- and post-assessment surveys. …

Understanding The Regulation Of Innate Immune Mechanisms And Its Relevance In Diseases Using Drosophila Melanogaster, Pooja Kadaba Ranganath

Theses and Dissertations

Drosophila melanogaster is an excellent model organism to study conserved innate immune mechanisms. D. melanogaster utilizes both humoral and cellular immune responses to combat fungal, bacterial and parasitic pathogens; The cellular immune response targets parasites and parasitoid wasps are a major parasite of D. melanogaster. Fly larvae are commonly infected by parasitoid wasps and in response, mount a robust cellular immune response against the parasitoid egg. Numerous signaling pathways like JNK and JAK-STAT have been shown to play a role in the immune response against parasitoid wasps and have a conserved role in human immunity. However, the regulation of the …

A Systematic Approach For Developing Feed-Forward/Back-Propagating Neural Network Models For Predicting Bulk Chemical And Physical Properties Of Transition Metals, Neil Clifton Mitchell

Theses and Dissertations

Bulk materials made from transition elements and their alloys are substances used in many industrial applications and are composed of elements contained in the d- and f-blocks of the periodic table. Many of the useful properties of these materials are related to their unfilled d- and f-orbitals. It is supposed that computational models of orbitals describing two-atom homogeneous clusters of transition elements provide enough information to predict bulk chemical and physical properties of transition materials. This thesis reports the use of a simple (one hidden node) three layer feed-forward/back-propagating artificial neural network and orbital energies obtained from DFT-SCF/MO approximations to …

Advanced Materials For Skin Regeneration, Ingrid Safina

Theses and Dissertations

Massive skin loss, over 20% of the total body surface area, is challenging to heal (Rowan et al. 2015). Ideally, autologous skin grafts have the ability to support complete skin reconstruction. However, skin grafting faces major limitations, such as shortage of donor sites and secondary injury. Alternatively, advanced materials can be used to produce skin constructs that could potentially serve as skin substitutes (Stanton and Billmire 2002). Herein, we used two polymeric materials: graphene and polyurethane (PU) to produce films that support skin cells in their growth and maturation. The surface properties of these materials were modified to enhance their …

White Faculty Responses To Implicit Racial Bias And Racially Responsive Pedagogy In The Community College Classroom, Julie Anne Clemens

Theses and Dissertations

This study focuses on the experiences and perceptions of White faculty in the community college classroom with implicit racial bias and racially responsive pedagogies. Through collaborative qualitative inquiry of interviews and subsequent focus groups, three questions are answered. First this study explores racial interactions in the classroom for White faculty and how these experiences have informed their teaching. Second, White faculty identify the ways they have made changes or would like to make changes to their teaching because of racial interactions in the classroom. And lastly, these faculty shared their perceptions of current faculty development programs offered by the college …

Why Do Street-Level Bureaucrats Risk Themselves For Others? The Case Of Public Health Care Workers In Egypt, Mohamed Adel Ahmed Eraky Moussa

Theses and Dissertations

The COVID-19 pandemic has shown how street-level bureaucrats play an essential role in working under tremendous psychological and physical pressure with limited resources. Healthcare workers are at the front lines to fight against the COVID-19 pandemic worldwide, and they are most vulnerable to infection and illness. Therefore, it is essential to identify the factors that enhance health care workers’ motivation at the time of pandemics and determine their willingness to risk their lives for others. The current study covers a sample of public health care workers working in two central quarantine public hospitals in Egypt. It considers a range of …

Molecular Characterization Of Antibiotic Resistant Shiga Toxin-Producing Escherichia Coli From Clinical And Food Samples, Khulud Alotaibi

Theses and Dissertations

Antimicrobial resistance (AMR) in foodborne pathogens can be a consequence of using antimicrobial drugs in food-producing animals. The emergence of antimicrobial resistance in foodborne pathogens is of great concern due to adverse patient health outcomes and the possibility of transferring genes encoding AMR to other clinically relevant pathogens. One of these bacteria is Shiga toxin-producing Escherichia coli (STEC), which can cause serious illness in humans for a haemolytic uremic syndrome (HUS). This study characterized and determined the mechanism of antibiotic resistance in 46 Shiga toxin-producing Escherichia coli strains collected by the U.S. Food and Drug Administration from food and clinical …

Heterologous Production Of Plant Secondary Metabolites Resveratrol And Caffeic Acid In E.Coli And Synechocystis Sp. Pcc 6803, Yong Xue

Theses and Dissertations

Caffeic acid and resveratrol are polyphenol compounds produced by plants as secondary metabolites to protect against biotic and abiotic stresses. In the last decades, numerous studies have demonstrated the beneficial effects of these compounds on human health as anticancer, antioxidant, anti-virus and anti-inflammatory agents. In plants, both caffeic acid and resveratrol are synthesized either from phenylalanine or tyrosine. Recently, heterologous production of phenylpropanoids using genetically engineered bacteria is gaining more and more attentions from industry because it can dramatically improve the yield with reduced costs. The major aim of the work is to explore the possibility of using Synechocystis or …

"Nothing ‘Personal’ To Lose": Alice Notley’S “I” And The Poetics Of Encounter In Disobedience, Christina T. Baulch

Theses and Dissertations

Though the lyric-I has often been perceived as an isolated ego, Alice Notley's "I" in her long poem Disobedience (2001) necessitates plurality through what I call a "poetics of encounter." In response to the 1978 Language poetry manifesto "Aesthetic Tendency and the Politics of Poetry," and to the larger well-rehearsed debate about vocal homogeneity and persona centrism in poetry, this paper argues that Notley's poetics of encounter brings the "I" of Disobedience into continual and complex conversation with material history, politics, and mass culture, thus situating it within, and not sequestered from, the world and its mediation.

Opportunities For Wonder In A Public Park, Alexander Butler

Theses and Dissertations

Research suggests unstructured play is important to a child's mental and physical development, and the natural world provides excellent opportunities for formative experiences. Urban environments, however, present challenges to finding and enjoying wild spaces. The potential role of public parks, supported by a small survey of college students, is discussed.

Afropolitan Manifestations In Contemporary African Art: Mobilizing Achille Mbembe, Petra Frank-Witt

Theses and Dissertations

This thesis explores Afropolitanism's conceptual-philosophical grounds and how its principles are mirrored in the arts. Achille Mbembe’s conceptualization is presented as a form of cultural cosmopolitanism, as shared by the artists presented, further distilled as a dynamic, forward-looking, emancipatory ideology that favors Africanness as open-ended signifier rather than overdetermined sign.