Digital Commons Network^™

Resilience In Early Second Career Stem Teachers Employed In Public Secondary Schools, Donald Selway

Theses and Dissertations

A troubling shortage of K-12 Science, Technology, Engineer and Mathematics (STEM) teachers exists in the United States. One solution to increase STEM teachers involves recruiting STEM professionals to transition from industry to K-12 teaching. Research indicates that fostering resilience is one way to help new STEM teachers’ retention and persistence in the field. This study explored individual and programmatic factors that increase early career and early second career K-12 STEM teachers’ resilience. Moreover, this research examined how strategic initiatives and programs assisted STEM professionals to build resilience as they transitioned into K-12 STEM educators.

This study utilized mixed-methods design to …

Development & Evaluation Of An Introductory Webinar Training For Mental Health Professionals Working With Perpetrators Of Child Sexual Abuse: A Strengths-Based Sociocultural Perspective, Angie Yvette Reyes

Theses and Dissertations

The purpose of this dissertation project was to develop an introductory webinar resource to provide training of mental health professionals (MHPs) to work with perpetrators of child sexual abuse (PCSA). The training utilizes a strengths-based approach with a focus on sociocultural considerations for working with this population. A literature review revealed a gap in resources, treatment, and clinical training pertaining to PCSA. The results of an initial training needs survey among MHPs indicated that MHPs do not receive education or training on PCSA and could benefit from training. Through this webinar training, MHPs acquire a basic understanding of PCSA and …

Survive And Thrive: An Exploration Of Methods Implemented By Small Businesses In The Construction Industry To Sustain Their Business Beyond 5 Years, Tamar Barsoumian

Theses and Dissertations

Small businesses represent an influential portion of the American economy yet retain a high rate of closure especially in their early years, therefore; this study sought to address a lack of available research regarding small businesses in the construction industry, by investigating the methods and strategies existing small business owners use to support business survivability, in the regionally specific area of Southern California. The purpose of this study was to investigate strategies used by existing construction industry small businesses, identify the challenges experienced as a construction industry small business organization in Southern California, and determine how the small business owners …

Generational Advancement In Sovereign Nations: A Qualitative Study Understanding The Significance Of Knowledge Infrastructure, George A. Vigil

Theses and Dissertations

Throughout history, socio-cultural and political movements have condemned indigenous peoples by advancing false rhetoric, half-truths, and equivocations championed as axiomatic principles. Foreign entities have massacred philosophies, traditions, and tribes while stealing ancestral lands that have yet to be recovered. This exploratory study examines the phenomenon of developing knowledge infrastructure within sovereign nations. A descriptive qualitative approach was used to answer the research question: To what extent, if at all, might knowledge infrastructure support generational advancement through learning and development programs within sovereign nations? Semi-structured interviews were conducted with 15 Tribal citizens, community members, and employees who currently or have worked …

Dating Violence In Latine Lgbtq+ Adolescent Relationships: Treatment Considerations, Tatiana Pinkley

Theses and Dissertations

According to the Centers for Disease Control and Prevention (CDC), violence-sexual and physical-within adolescent dating relationships has become a significant public health concern. This is especially true for sexual minority youth of color. As such, it is a prevalent and necessary topic in many therapeutic settings. However, many of the treatment protocols in place do not address or take into consideration various cultural identities of the clients in question. This study reviewed the scholarly literature regarding the prevalence of dating violence within the LGBTQ+ Latine community, the risk factors of intimate partner violence within this community, interventions that are available …

Did The Psychological Implications Of Covid-19 Influence Employees To Say, “I Quit”, Lori Fay

Theses and Dissertations

This qualitative study explored the forces that influenced employees to quit and how the employee-manager relationship mitigated this. The research centered on employees employed in the retail industry throughout the year 2020. This study aimed to investigate what factors motivated employees to remain committed to their organizations amidst the psychological impacts of COVID-19. The findings of this study suggest that the COVID-19 pandemic has had a significant impact on the mental well-being of individuals, as evidenced by their experiences of anxiety, depression, and emotional fatigue. Understanding the impact of COVID-19 on employee turnover and the influence of the employee-manager relationship …

Non-Binary Experiences In The Context Of Gender Dichotomization: A Qualitative Systematic Review, Chyna (C.J.) Parker

Theses and Dissertations

Gender diverse persons have historically and presently faced unique challenges, marginalization, and discrimination. The lived experiences of the transgender nonconforming population are still widely unresearched, and most research treats transgender and transgender nonconforming (TGNC) people as a homogeneous group. This neglects the nuanced and diverse experience of the TGNC population. This integrative systematic review of the literature was conducted in order to identify and highlight the experiences of transgender nonconforming persons in the context of a binarily set world. The following questions guided this study: (a) What are the identity-related experiences of non-binary individuals in the context of gender dichotomization?, …

Effectiveness Of Cognitive Behavioral Therapy Versus Therapeutic Play For Hospitalized Children Diagnosed With Cancer: An Integrative Systematic Review, Dianne Kong

Theses and Dissertations

Psychotherapy provides essential coping mechanisms and strategies for children who are diagnosed with cancer, as they experience the extraordinary burden of physical, emotional, and mental strains. While many medical advancements have been made within the past few decades, progress related to psychotherapy for pediatric cancer patients has not been commensurate, evidenced by the limited current literature. Given the sparsity of relevant research, it is presently difficult to compare and evaluate the various psychotherapeutic interventions available for pediatric oncology patients. Additionally, there are significant challenges in providing psychotherapeutic care for patients and their families, including lack of consistency, disruption of care, …

The Use Of Dance And Movement For The Embodied Healing Of Interpersonal Trauma In Women And Girls: A Systematic Review, Catherine Xinyu Liang

Theses and Dissertations

Interpersonal trauma is a serious and devastating problem for women and girls from all walks of life. Research has shown that there are physiological consequences for experiencing trauma, and as such, treatment for trauma may need to target the body. Dance/Movement Therapy (DMT) has been emerging in the current literature as one body-oriented treatment approach that is effective in helping women and girls heal from interpersonal trauma. This review examines how practitioners are currently using DMT for this population, what treatment outcomes have been observed, and what the racial/ethnic identities and international contexts are for survivors who have benefited from …

The Impact Of Non-Affirming Christian Secondary Schools On Students Who Identify As Lgbtqia+: A Phenomenological Inquiry, Alexis C. Schneider

Theses and Dissertations

In the United States, nearly 100,000 LGBTQIA+ (Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual) students attend non-affirming religious secondary schools yearly (Green et al., 2019; Institute of Education Sciences [IES] & National Center for Education Statistics [NCES], 2019a, 2019b). Because organized religion can have both beneficial and harmful outcomes on LGBTQIA+ youth (Wolff, 2016) and a secondary school environment has a significant impact on a student’s sense of academic success and well-being (Forber-Pratt et al., 2021), it is essential to understand and implement best practices that support LGBTQIA+ students in non-affirming religious secondary schools. Using phenomenological methods within a qualitative …

Exploring Prosocial Theories For Teaching Civility In Baccalaureate Level Business Communication, Mikelle Barberi-Weil

Theses and Dissertations

The paralysis of civility and the heightened acrimony in both public and private fora is considered a detriment to the health of a high-functioning and prosperous society. In the context of contemporary culture, the potential conflict between people with antithetical values and antithetical ideologies in a nonconsensual and neutral-ground locale is at a heightened level. When two people are obligated to each other in professional environments, they need to get along. Yet, as organizations have flattened and gone casual over recent decades, the boundaries of traditional politeness and respect have diminished (Andersson & Pearson, 1999). Leadership and organizational environments are …

The State Of Psychological Services For People With Physical And Cognitive Disabilities: An Integrative Systematic Review, Megan K. Benton

Theses and Dissertations

The present study investigated the state of psychotherapy for people with physical and cognitive disabilities in a systematic review. Specifically, this study analyzed qualitative and quantitative studies which examined therapists’ abilities to conceptualize disability as a dimension of cultural competence, the models and conceptualizations of disability and psychotherapy being used with people with disabilities (PWD) in psychotherapy, and the experiences of PWD in psychotherapy. This study analyzed 18 empirical studies and integrated both qualitative and quantitative methods. Source eligibility criteria for this systematic review was the same for both qualitative and quantitative studies. Eligibility criteria included being: peer-reviewed journal articles, …

The Factors Contributing To The Perceived Strength Of Female Truck Drivers, Carlinda Tabor

Theses and Dissertations

The perceptions of women in the workforce take different forms. Customarily, the perception of women in the workforce leans toward women being somewhat docile and powerless and needing external empowerment, especially women in male-dominated/oriented fields. The literature conveys this mindset and philosophy that permeates our culture, perpetuates this perception, and influences many women. Nonetheless, women with a different reality or experience need corroboration that supports them and dispels the described cultural influences and the ensuing impact on the next generation. This study investigated women in the trucking industry to unveil the factors contributing to women's innate strength. This qualitative study …

Molecular Target And Circuitry Underlying The Preclinical Effects Of Psychedelics In Models Of Opioid Use Disorder, Alaina M. Jaster

Theses and Dissertations

Opioid use disorder (OUD), like other substance use disorders (SUD), is characterized by maladaptive behavioral allocation away from other rewarding aspects of life following prolonged use, as well as large rates of relapse. While pharmacotherapies exist for OUD, they tend to only target the opioid receptors rather than the underlying mechanisms behind the maladaptive behaviors. Serotonin (5-hydroxytryptamine; 5-HT) is involved in modulation of cravings and regulation of motivational reward-related behaviors, thought to be due to a top-down processing method of external and internal stimuli. Serotonin 2A receptors (5-HT_2AR) are widespread throughout the brain and most densely populate layer …

The Age And Primary Reason For The First Dental Visit In Children With Special Health Care Needs, Amanda Dickerson

Theses and Dissertations

Purpose: The aim of this project is to evaluate the average age and primary reason for the first dental visit among patients with special health care needs as well as to examine socioeconomic factors and other barriers related to children with special health care needs accessing care.

Methods: This is a cross-sectional survey that was distributed to caregivers of children with special health care needs. Study data was collected through REDCap, a secure web-based survey application. The inclusion criteria for participating in the survey included having a child with a special health care need that presented for a recall or …

Dental Treatment Planning: Decisions With Interdisciplinary Cases, William W. Porzio

Theses and Dissertations

Purpose: To explore the variance in treatment planning options with interdisciplinary cases that involve a combination of endodontic, periodontic, and prosthodontic factors.

Methods: A REDCap survey was emailed to Virginia based American Academy of Periodontology (AAP) members, American College of Prosthodontists (ACP) members, and periodontal residents to assessing various treatment planning options for six interdisciplinary cases.

Results: A total of 56 individuals responded to the survey; 10 periodontal residents, 35 practicing periodontists, 11 practicing prosthodontists. Response rate was not able to be evaluated based on the fact that third-party organizations were used to disseminate the survey in …

Histone Acetylation In Periodontal Diseases, Sarang Saadat

Theses and Dissertations

Background: Emerging data has indicated the significant role of epigenetic control in inflammation. Acetylation of lysine residues on histones is a major epigenetic modification of chromatin, which is required for cytokine gene expression and regulated in inflammatory diseases. It has been shown that periodontal bacteria induce histone acetylation in oral epithelial cells and experimental periodontitis in rodents. In this study, we investigated the acetylation level of histone 3 (H3) in gingival tissue from healthy and periodontitis patients. We hypothesize that cytokine over-production in periodontitis is associated with the hyper acetylation of histones. Methods: Periodontitis and healthy subjects who need periodontal …

The Wound Healing And Antibacterial Properties Of Mesenchymal Stromal Cell Extracellular Matrix Nanoparticles, Emily N. Wandling

Theses and Dissertations

Treatments for acute respiratory distress syndrome (ARDS) are still unavailable and the prevalence of the disease has only increased due to the Covid-19 pandemic. Mechanical ventilation regiments are still utilized to support declining lung function, but they also contribute to lung damage and increase the risk of bacterial infection. The anti-inflammatory and pro-regenerative abilities of mesenchymal stromal cells (MSCs) have shown to be a promising therapy for ARDS. We propose to utilize the regenerative effects of MSC secretome and the extracellular matrix (ECM) into a nanoparticle. Our mouse MSC (MMSC) ECM nanoparticles were characterized using size, zeta-potential, and mass spectrometry …

Combining Novel Direction Modulated Brachytherapy Tandem-And-Ovoids Applicators For Treatment Planning Of Multi-Institutional Cervical Cancer Cases: Removing Needles In Intracavitary-Interstitial Techniques, Sharmin Alam

Theses and Dissertations

Lack of standard guidelines for optimal needle insertion during high-dose-rate (HDR) intracavitary-interstitial (IC-IS) brachytherapy of the cervix means a sophisticated and technical skillset of inserting needles next to IC applicators must be developed to enhance plan quality. This study sought to evaluate the performance of two separate direction modulated brachytherapy (DMBT) tandem applicators used in conjunction with one set of novel DMBT ovoids, to effectively obviate the need for IS needles.

A cohort of 32 retrospective clinical HDR brachytherapy plans was re-planned with Varian’s BrachyVision^® treatment planning system, using VEGO^® inverse optimization algorithm, with dose heterogeneity accounted for …

Dune Building Dynamics Impact Cross-Island Connectivity And Barrier Island Characteristics, Alexander Sabo

Theses and Dissertations

Located at the land-sea interface, barrier islands are important protective features that reduce wave energy and erosion from mainland areas. Further, barrier islands provide habitat for many different organisms and serve as popular areas for recreation and tourism. As sandy landforms, barrier islands are easily disturbed, but often recover after disturbance as a result of island plant communities, specifically dune building grasses. Disturbance on barrier islands is driven by storms, tides, and overwash events. After disturbance has occurred, dune grasses colonize the dunes allowing for dune building and habitat restoration. On the Virginia barrier islands, there are three dominant dune …

Pre-Clinical Trials With Precision-Medicine Based Therapeutics In Basal-Like Patient-Derived Xenografts, David C. Boyd

Theses and Dissertations

Breast cancer treatments have improved over time, but the diseases seeing the most benefit from these improvements have the estrogen receptor, progesterone receptor, or are positive for HER2. Basal-like breast cancer tends to not have these biomarkers, which necessitates their treatment to be traditional, untargeted therapeutics which are less effective and tend to have harsh adverse effect profiles – this is an important unmet need. These studies utilize a variety of techniques, including tissue culture, viability assays, high-throughput screening, in vivo drug treatments and imaging, pathway analyses, molecular techniques such as Western blot, antibody arrays, RNA sequencing, sc RNA sequencing, …

The Type Iv Pilus Secretin Bfpb: Structural Analysis And Binding Interactions, Janay I. Little

Theses and Dissertations

Enteropathogenic Escherichia coli (EPEC) causes severe diarrhea in young children. The type IV pilus (T4P) of EPEC, known as the bundle-forming pilus (BFP), plays an important role in EPEC pathogenesis. T4Ps are a family of surface appendages that are important for adhesion, colonization, biofilm formation, virulence, twitching motility and many other functions. One essential component of the BFP system is the secretin, BfpB. Secretins are a large family of integral outer membrane proteins found in T4Ps as well as type II and type III secretion systems, and filamentous phages. Details of the secretin structure have been limited to the overall …

Pms And Gas Pollutants Removal By Electret Filter Media And Metal-Organic Frameworks (Mofs), Yu Zhang

Theses and Dissertations

Indoor air quality (IAQ) has been becoming a major concern worldwide because statistical data showed that the indoor concentrations of gas pollutants, e.g., volatile organic compounds (VOCs) and particulate matters (PMs) are often 2–5 times higher than that of outdoors. Especially, people spend 87% of their time indoors and increasing to more than 90% during COVID-19 pandemic. The high concentration of these indoor air pollutants is mainly due to the reduced air exchange rate for the design of energy-efficient building construction and the increased usage of furnishings, glues, paints, furnaces, etc., leading to VOC outgassing and particle emission. Evidence has …

Patterns, Mechanisms, And Characterization Of Carbon Cycling Stability Following Partial Forest Disturbance, Kayla C. Mathes

Theses and Dissertations

Among the most essential questions in the era of climate change is how the forest carbon (C) cycle will respond to an increase in the extent of biotic disturbances from insects and pathogens. While research has focused on stand-replacing disturbance regimes, less is known about C cycling stability following partial disturbances that produce gradients of disturbance severity. Belowground C cycling responses to disturbance are especially poorly understood, even though temperate forest soils contain up to 50% of total ecosystem C and soil respiration (R_s) accounts for more than half of temperate forest C loss. Interpreting trends and mechanisms …

Intrinsic Efficacy As A Determinant Of Opioid Effectiveness In Treatment Of Pain-Depressed Behavior, Edna Santos

Theses and Dissertations

Pain is a major public health concern that is commonly associated with behavioral depression, and a major goal in pain treatment is alleviation of pain-related behavioral depression. High-efficacy mu opioid receptor (MOR) agonists (e.g. fentanyl, morphine, oxycodone) are effective to treat pain, but their use is limited by side effects that not only endanger the patient but may also obscure analgesic rescue of pain-depressed behavior. The ongoing epidemic of opioid abuse and overdose deaths has stimulated research to discover non-opioid alternative analgesics; however, this search neglects the clinical potential of safer intermediate-efficacy MOR agonists (e.g. buprenorphine). The objective of the …

X-Ray Crystallography: A Tool For Understanding Protein Function And Drug Discovery, Akua K. Donkor

Theses and Dissertations

Structural biology has become an indispensable tool for determining the 3D structures of proteins for a comprehensive understanding of their functions on molecular level, and for elucidating binding cavities that can be targeted for structure-based drug discovery. X-ray crystallography, the most widely used structural biology technique was utilized in addition to other techniques to: (1) understand the role of pyridoxal reductase (PDXI) in pyridoxal 5’-phosphate (PLP) homeostasis; (2) Determine whether the putative PLP binding protein, YggS, is involved in PLP homeostasis; (3) Elucidate the molecular basis underlying Agrobacterium receptor VirA pathogenesis; and (4) Elucidate the structural basis of aromatic aldehydes …

Family-Based Support As Social Determinants Of Health Protective Factor On Depression Of Parents Of Children With Autism Spectrum Disorder, Bisola E. Duyile

Theses and Dissertations

All parents experience challenges in their caregiving roles (Barańczuk & Pisula, 2020). However, parents raising a child/children with disabilities experience different social barriers (Oliver, 1996) that may also contribute to additional stressors in their caregiving role (Tomeny, 2016). Although these parents, on average, have reported greater symptoms of depression than parents of typically developing children, research shows that parents who reported receiving social support had lower symptoms of depression and stress (Das et al., 2017; Singh et al., 2017). Through the social determinants of health (SDOH) framework (ODPHP, 2022), the present study investigated informal/family-based support and its protective impact on …

Investigating The Dynamics And Fragmentation Of Nitroaromatic Radical Cations Through Femtosecond Time-Resolved Mass Spectrometry And Computational Chemistry, Hugo Andres Lopez Pena

Theses and Dissertations

Chemists have sought to control molecular dissociation with lasers for decades. Effective control of unimolecular dissociation was only achieved with the development of high-intensity ultrashort pulsed lasers and coherent control techniques that operate on timescales faster than vibrational energy redistribution. In view of this, our lab has specialized in the study of polyatomic radical cations using femtosecond time-resolved mass spectrometry (FTRMS). The interest in radical cations stems from the fact that they are highly reactive species that contribute to many physical, chemical, and biological processes. For instance, radical cations participate in shock initiation of detonated energetic materials used as explosives …

Asymmetric Cuh-Catalyzed Reductive Coupling Of Allenamides With Carbonyl Electrophiles & Development Of Nanocatalysts For Heterogeneously Catalyzed Buchwald-Hartwig Amination, Raphael K. Klake

Theses and Dissertations

Many drugs and natural products contain multiple stereogenic carbons bearing heteroatoms throughout their carbon framework. Therefore, methods that can efficiently install multiple heteroatoms on a molecule are valuable. Reductive coupling reactions have been extensively studied, and the allylation of carbonyls via the reductive coupling approach has been a key method for generating chiral tertiary and secondary allylic alcohols. This work utilizes inexpensive Cu for the asymmetric reductive coupling of allenamides with carbonyls to simultaneously install two heteroatoms (oxygen and nitrogen) on the product. These molecules have a polarity profile that make them difficult to make using traditional methods. Herein, we …

Addressing Death Distress In Caregivers Of Patients With Malignant Glioma, Kelcie D. Willis

Theses and Dissertations

The field of psychosocial oncology seeks to improve the quality of life of patients and families affected by cancer. This task becomes increasingly important when there are limited, non-curative treatment options, a high probability of recurrence, and rapid functional decline, such as in the case of a malignant glioma (MG). Indeed, the diagnosis of a MG is associated with negative sequalae that often translates to higher caregiver burden. Caregivers—who must manage the functional decline of the patient, changes within the family, and a complicated medical system—often feel overwhelmed, isolated, and ill-equipped to handle these myriad responsibilities. While they also report …