Digital Commons Network^™

Topological Variability In Water Distribution Networks, James M. Anderson

Theses and Dissertations

Water distribution networks are critical infrastructure characterized by difficulties in their assessment and deteriorating performance due to aging components. Resilience analysis of networked infrastructure has replaced traditional risk analysis to focus on performance. Global Resilience Analysis can provide useful information to decision makers and system managers regarding repair and expansion of networks. Network performance has been found to be directly informed by network structure. This work leverages graph theory to assess network qualities that correlate with resiliency characteristics across 69 real world water networks. These networks are then grouped by their structural properties through k-means clustering and compared using parametric …

The Kinetics Of Biocontaminant Inactivation: A Comparative Study With Bacillus Globigii And Bacillus Anthracis, Leigh M. Durden

Theses and Dissertations

Bacillus anthracis has been a biological threat for decades and after the 2001 terrorist attack via the U.S. Postal Service where five people died, there was heightened awareness and inquiry on the subject (Goel, 2015; Greenberg et al., 2010; Nicholson & Galeano, 2003; Spotts Whitney et al., 2003). The health risk to humans makes this biological agent, a Tier 1 agent and one of the most likely to be used in an attack (Anthrax as a Bioterrorism Weapon | CDC, n.d.; Driks, 2009; Rose & Rice, 2014). B. anthracis is one of most resistant and potent biological warfare agents as …

Civilian And Military Civil Engineer Mission In The Space Domain, Linda E. Kuster

Theses and Dissertations

Military and civil interest in space-based operations has increased dramatically in recent years due to the discovery of life sustaining properties such as water on Mars and advancements in cyber technology. Civilian sector discussions and research have centered on the establishment of permanent extraterrestrial infrastructure, while discussions from the military perspective have focused on providing reliable, resilient infrastructure, capable of withstanding cyber-based and kinetic attacks. Both perspectives account for known threats and sustainment methods required to ensure success in the space domain. With the existence of threats for the military and civilian missions, civil engineers will undoubtedly be critical to …

The Effects Of Introversion And Treatment Delivery Modality On Therapeutic Outcomes In A Community Mental Health Clinic, Maria Olga Consbruck

Theses and Dissertations

Objective: The present study examines the effectiveness of teletherapy services for individuals with varying levels of introversion. This study also investigates the comparability of teletherapy to in-person services provided by clinicians in training. Introduction: Virtual platforms, such as teletherapy, have exponentially increased in use by clinicians and community members due to the Covid 19 pandemic. The pandemic has illuminated surprising secondary benefits of teletherapy. Research has shown that teletherapy results in greater accessibility, feasibility, and acceptability of treatment. Teletherapy platforms can reach remote and rural communities, and better address financial and time barriers. Current research indicates that teletherapy services are …

Back Country: Queer Rural Temporalities, Pansies In The Bluegrass, Cooper Lane Gibson

Theses and Dissertations

My practice utilizes an intermedia and anti-disciplinary approach to conjure a reflexive vision of my experience as a gay and gender non-conforming person in rural Kentucky. Concepts that are important to my practice are storytelling, embodiment, and assemblage. Coming up gay in rural Kentucky I often felt like an assemblage. Not quite one thing entirely, but many parts swirling together in a fluidity that isn’t easily categorizable. Part farm boy, part faggot, part miss piggy. I am also interested in assemblage as a way of making. Found objects and images are tools I employ as a way of inviting the …

Investigating The Molecular Mechanisms Of Spore Killing By Neurospora’S Meiotic Drive Elements, Nicholas Rhoades

Theses and Dissertations

Meiosis is a fundamental and highly conserved biological program that is required for sexual reproduction in eukaryotes. During meiosis, duplicated chromosomes synapse with their homologous partner and undergo a physical exchange of genetic material through recombination. The meiotic products resulting from this program contain novel combinations of alleles that are inherited by individuals in the succeeding generation. The random assortment of alleles during meiotic recombination allows for the chance that any such allelic combination may provide an increase (or decrease) in fitness for an individual. Alleles, or combinations of alleles, that are beneficial to the organism may be retained within …

Marginalized Populations And Trauma-Informed Practices At The Secondary Level: Understanding The Connections Between Trauma Exposure And Academic Outcomes Through An Intersectional Framework, Kirsten Hany

Theses and Dissertations

This research seeks to understand the relationship between marginalized identities and trauma in adolescents in relation to classroom outcomes, both behavioral and academic, through an intersectional framework. A synthesized review of literature as well as a quantitative study using the HSLS:09 data was conducted to discern how marginalized populations experience trauma in the school environment, and how that trauma impacts academic outcomes. The conclusions drawn through the review of literature and research suggest that marginalized students experience trauma at higher rates as well as disruption of academic outcomes. These conclusions are disseminated in chapter III which is a practitioner piece …

Developing Methods For Measuring In Vivo Lipid Metabolism, Russell L. Denton

Theses and Dissertations

Lipid metabolism is critically important to the normal function of individual cells and for signaling between tissues of the human body. There is a great need to quantify changes in lipid metabolism because of its implications in both normal healthy conditions and during disease development. In our first study, we developed a liquid chromatography mass spectrometry based workflow to assess in vivo metabolism of murine brain lipids. This involved sample preparation, data acquisition, and analysis software development and improvements. Regarding sample preparation, we maintained the mice at 5% body water for the duration of the experiment. As mouse metabolism proceeds, …

Effective Organizational Change Management In The Public Sector: The Case Of The Egyptian Drug Authority, Amany Shehata Mahran

Theses and Dissertations

The thesis investigates the change management process in the public sector, with specific focus on a recent change process that took place in an Egyptian public organization as a case study, the Egyptian Drug Authority (EDA). The research aims to explore the change management process that took place after the issuance of the founding law of case under study, the EDA, to achieve the organizational goals and objectives, and provide recommendations for improvement. The study used a mixed methods approach to answer the overarching research question as well as the sub questions. The qualitative part of the research used interviews …

Neuroprotective Effects Of Green Tea (Camellia Sinensis) And Broccoli (Brassica Oleracea) Extracts In An In Vitro Model Of Multiple Sclerosis, Sara Taha Fathallah

Theses and Dissertations

Multiple Sclerosis (MS) is a neurodegenerative autoimmune disease in which the immune system attacks the central nervous system (CNS) resulting in demyelination. Currently, there is no specific treatment for MS. Here, we propose testing the neuroprotective potential of Green tea (Camellia sinensis), and Broccoli (Brassica oleracea) extracts in an in vitro model of multiple sclerosis.

Methods and Results: Green tea and Broccoli plant extracts were analyzed with GC-MS and tested for their neuroprotective effects in an in vitro MS model using Cuprizone (CPZ) on the Human neuroblastoma SH-SY5Y cell line. Cell viability assays proved the safety of the extracts …

Perceptions Of The Culinary Art Community On Their Higher Education Programs In Egypt: The Way Forward, Kadria Ali Abdel Motaal

Theses and Dissertations

Culinary art education used to have a narrow focus that forgoes its richness and ignores its infiltration into economic, political, and cultural aspects within society. Recently the world witnessed an evolution in this field of study as it reached tertiary education institutions. However, in Egypt, culinary art studies are integrated into hospitality education and are still confined to a shallow concept. This study aimed to explore the perception of the culinary art community in Egypt on their higher education programs from a sociocultural perspective. It also explored the possible new frameworks, and core competencies to improve culinary arts higher education …

Preparation And Characterization Of Salvia Triloba Extract And Evaluation Of Its Cytotoxic Effect On Bone Cancer Cell Line, Basma Hossam Abdelmonem

Theses and Dissertations

Background: Osteosarcoma is a tumor of mesenchymal origin characterized by uncontrolled production of immature osteoid tissue. It is more common in children and adults over the age of 65. Many studies reported the cytotoxic effect of many plant extracts, including Salvia triloba, on different cancer cell lines when used alone or in combination with other chemotherapeutic agents.

Methods: In our study, the methanolic extract obtained from the air-dried leaves of Salvia triloba leaves from Palestine was screened for its total phenolic and flavonoid contents. The major components of phenolics and flavonoids were detected using LC-QToF-MS technique. The two phenolics …

Molecular Diagnosis Of Non X-Linked Ectodermal Dysplasias Using Next Generation Sequencing, Eman Abdelalim Rabie

Theses and Dissertations

Ectodermal Dysplasias (EDs) are rare heterogenous monogenic developmental disorders sharing the impairment of at least two surface ectoderm-derived organs. Symptoms characteristically manifest developmental abnormalities of the teeth, and three skin derivatives: hair follicles, nails, and sweat glands. The disease-causing gene was identified for only fewer than half of 160 characterized ED phenotypes. Expectedly, ED-causing genes regulate or function in ectodermal-developmental processes. The most common phenotype is hypohidrotic ED featuring teeth agenesis, and diminished or complete absence of hair and sweat production. Disease-causing variants of EDA, EDAR, EDARADD and WNT10A genes were identified in 60-90% of ED patients in …

Effects Of Date Seed (Phoenix Dactylifera) Extract In An Animal Model Of Diabetes Mellitus, Sara Refaat

Theses and Dissertations

Diabetes mellitus is a chronic illness and a global epidemic. The commercial diabetic medicines available are expensive and have several adverse effects. Alternative natural products are still being sought for. Date seeds ( Phoenix dactylifera) are either thrown away as garbage or utilized as animal feed. The use of seed extract as an alternative therapy for diabetes offers a cost-effective and all-natural method for managing the disease. Methods Sprague dawley rats were randomly distributed into groups with a sample size of 4 rats per group. Date seed powder was boiled producing a 10% date seed extract which was administered in …

Factors Affecting Consumers’ Purchase Intentions Towards Recycled Products, Sherine Esmat

Theses and Dissertations

The work executed addresses the status of recycling industry in Egypt and its relation to the current sustainability trends as well as climate change issues. It also identifies the main concerns of consumers when purchasing recycled products. Consequently, identifies the key pillars that need to be applied or communicated with the target consumers to enhance the concept of selling recycled products and increase its market share. Since this industry is significantly broad, the focus of the study was only on recycled PET plastic bottles (rPET), this is to ensure attaining accurate and reliable results.

An interview and a site visit …

Sperm Dna Integrity In Absolute Teratozoospermia Patients And Its Impact On Assisted Reproductive Technology Outcome, Dina Faris

Theses and Dissertations

Sperm DNA Fragmentation (SDF) is a common cause of male infertility, although it is underdiagnosed due to lack of routine testing. High levels of SDF are reported in men with abnormal sperm morphology. However, the implications of such findings on live birth following Intracytoplasmic Sperm Injection (ICSI) have not been studied in absolute teratozoospermia men (100% abnormal sperm morphology). In this prospective study, the severity of DNA damage was evaluated in absolute teratozoospermia patients and its impact on ICSI outcomes, particularly live birth rate. My study included 36 men with absolute teratozoospermia and 30 men with normal sperm. Real-time assessment …

Named Entity Recognition From Biomedical Text, Maged Guirguis

Theses and Dissertations

As vast amounts of unstructured data are becoming available digitally, computer-based methods to extract relevant and meaningful information are needed. Named entity recognition (NER) is the task of identifying text spans that mention named entities, and to classify them into predefined categories. Despite the existence of numerous and well-versed NER methods, the bio-medical domain remains under-studied. The objective of this research is to identify an efficient technique for NER tasks from biomedical data. This is achieved by investigating using deep learning technologies namely pre-trained BERT [1] model and its variances SciBERT [2] and BioBERT [3]. Preprocessing the data before passing …

Human Gut Microbiota And Parkinson's Disease In An Egyptian Population, Sara Hashish

Theses and Dissertations

Multiple lines of evidence suggest the role of the gut microbiome in the predisposition and progression of Parkinson’s disease. This present cross-sectional study was performed to compare the composition of the gastrointestinal microbiota in patients with Parkinson's disease to their counterparts. Stringent inclusion criteria were followed to reliably identify our target population. Parkinson’s patients (n = 40) along with reference subjects (n = 39) were recruited from November 2021 to August 2022. Detailed demographic and clinical data were obtained at baseline using a set of questionnaires and clinical assessment tools. Fecal specimens were collected from all participants, and gut commensals …

Enhancing Performance Of Gravity Driven Membranes For Water Purification In Small Rural Communities, Amr Ezzat Melligy Mr.

Theses and Dissertations

Due to the rapid population growth in Egypt, providing safe drinking water is becoming an ongoing challenge especially in rural scattered communities. It became more crucial than ever to find innovative and affordable solutions to purify water and reduce water-borne diseases. Ultrafiltration and micro-filtration membranes has been successful in large, centralized plants and is currently one of the popular solutions to provide high quality product water. However, using those membrane systems in rural areas is challenged by several parameters; among which are; the absence of skilled workers, stable energy sources and availability of chemicals. The goal of this thesis is …

Vr-Based Safety Training Program For High-Rise Building Construction, Sahar Badr

Theses and Dissertations

The rates of fatal and non-fatal accidents within the construction industry across the globe are surging despite the massive efforts that are being exerted toward maintaining a safe working environment. Past research has proved that the provision of effective safety training programs is a primary course of action that should be taken to minimize construction accidents, fatalities, and both fatal and nonfatal injuries.

However, in acknowledging the limitations of traditional safety training programs within the construction industry, several researchers have addressed the urge to incorporate novel training practices that are based on the modern virtual reality (VR) technology to promote …

Invisibility And Dis-Identification Of Algerian Women: Feminist Jurisprudence Eyes On The Legal Provisions Related To Personal Status And Criminal, Sophia Lina Meziane

Theses and Dissertations

Much of the debate around women’s rights in legal systems focuses on the increase of protection as a legal mechanism for approaching and guaranteeing gender equality. Yet, what extensive or comprehensive analysis has been done on how effective such laws are when applied? This thesis discusses the extent to which a feminist legal theory, separate and distinct from the patriarchal legal system, can demonstrate how an Islamic or Napoleonic order is conceptually another male rationality. While one could possibly identify inefficiencies of laws proclaiming equality and protection for women, the context of the question is inevitably entrenched in the very …

Formulation Of Encapsulated Nanoparticles Of Leek Extract As Antimicrobial And Anticancer Agent, Rawan Hassan Mohamed Elghanam

Theses and Dissertations

Leek extract (LEK) has broad therapeutic activity. However, plant extract use has many drawbacks, which could be resolved using nanocarriers. The purpose of this research work was to prepare chitosan nanoparticles (CS NPs) encapsulating LEK and investigate their antioxidant, antimicrobial, and anticancer activity. Gas chromatography-mass spectroscopy was used to determine the LEK components. The CS-LEK NPs were produced by tripolyphosphate (TPP) crosslinking with chitosan (CS) the ionic gelation methodology. The particle size was 331 nm, zeta potential (ZP) was 28.9 mv, polydispersity index (PDI) was 0.4, encapsulation efficiency (EE) was 65.6%, and loading capacity (LC) was 28.8 % of the …

An Enhanced Cloud-Native Deep Learning Pipeline For The Classification Of Network Traffic, Ahmed Sobhy Elkenawy

Theses and Dissertations

In a rapidly changing world, the way of solving real-world problems has changed to leverage the power of the advancements in multiple fields. Cloud-native computing approaches can be utilized with deep learning techniques to provide solutions in several important areas. For instance, with the emergence of the pandemic, much dependence on modern technologies came out as a replacement for face-to-face interaction. Deep learning can reach a high level of accuracy, which makes it very effective in the support of modern services and technologies. However, there are some challenging issues because deep learning requires many large-scale experiments, which demand a lot …

A Review Of Covid-19 Lockdown Across Different Countries During 2020: Characterization Of Risk Factors And Severity Of Covid-19 In Egyptian Patients, Hanya Mohamed

Theses and Dissertations

On March 12, 2020, The World Health Organization (WHO) announced the new coronavirus 2019 as a global pandemic. In January 2022, the number of COVID-19 cases reached 300 million confirmed cases with a total death count of 5.5 million cases. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was identified in a seafood wholesale market in Wuhan, China. At the time of the outbreak, there was no effective treatment to protect from the novel coronavirus; the only way to control the pandemic was through reducing person-to-person contact and taking preventive measures based on the severity of the disease among the population. The …

Plastivore: Identification And Functional Characterization Of Plastic Degrading Lipase And Carboxylesterase Enzyme Families From Galleria Mellonella, Joseph Boctor

Theses and Dissertations

[provided as attachment while patent is pending]

Electrochemical Sensors And Biosensors Of Biomarkers And Therapeutic Agents Detection, Mahmoud Abdelhakem

Theses and Dissertations

Electrochemical sensing is a pioneering tool amongst all other sensing techniques even though it had been started in the early 20th century. Due to their cost efficacy, accuracy, and real-time measurement, electrochemical sensing has been utilized in a vast of biomedical applications in therapeutic drug monitoring and biomarker detection. This thesis work concerned the monitoring of three therapeutic agents in spiked plasma, urine, dosage form, and interstitial skin fluid with high specificity and accuracy. Two of our sensing platforms utilized nanomaterials for sensing (sensors) of Cilostazol and Velpatasvir utilizing α-MnO2-V2O5 (metal oxide nanorods) and NH2- MIL-53 (Aluminum-based metal organic frameworks), …

How Do The Environmental Aspects Affect The Oil Drilling And Extraction Sector? Evidence From Firm-Level Data, Nadine Amr Hosny

Theses and Dissertations

There will and always be a tradeoff between achieving profitability and maintaining sustainability. This complex problem is especially portrayed in the Oil sector. MENA region countries dominate more than half of the Oil reserves globally. Therefore and due to their dominance, such oil firms may suffer from several adverse consequences from their oil drilling and extraction activities. Accordingly, the main objective of the thesis is to examine the impact of the changes in environmental conditions on the financial performance of selected oil drilling and extraction firms. The selected countries that were chosen are: Egypt, Morocco, Tunisia & Gabon. The results …

How To Boost Egyptian Pharmaceutical Exports? Challenges And Opportunities, Shereen Mohamed Abdelgawad

Theses and Dissertations

One of the key pillars of the Egyptian economic reform adopted in 2016 was to raise the export rate. Since the pharmaceutical sector is one of Egypt's most established industries, the Egyptian government worked on a national plan to support the exports of medicines. Despite the impact of pharmaceutical exports on economic growth, there was limited research on this topic in Egypt. This study aims to provide a better knowledge of the problems of exporting medications in Egypt by investigating barriers and Covid-19 influence on pharmaceutical export. In-depth semi-structured interviews with representatives from pharmaceutical exporting companies have been conducted. The …

Legality Of Autonomous Weapons: Where To Draw The Line?, Nayra Abdeltawab Ibrahim Abdeltawab

Theses and Dissertations

Inspired by Koskenniemi’s work, From Apology to Utopia, this paper attempts to engage in the discussion on the legality of autonomous weapons by showing the conflicting arguments presented by advocates of each side of the debate. The paper does not aim at finding the answer to whether autonomous weapons can be lawfully deployed or not, but rather its main interest is to highlight the indeterminacy within international law that allows both advocates and opponents of banning autonomous weapons to hold to their arguments and legally defend them on basis of the same legal rules used by their adversaries to refute …

A Captive’S Subjectivity, Rebeca J. Blemur

Theses and Dissertations

The project discusses the effects of Haiti’s colonization as the space transitions from Hispaniola to Saint-Domingue and later to the free state of Haiti. This is done by studying the concept of the right to conquest and the absurdities that exist around the first appearances of international law. The project focuses on the pre-revolutionary period starting around the 1750s, the revolutionary period that began in the 1790s, the French oligarchical class’s attempt for social equality, and the war for ultimate colonial conquest between the French, Spanish, and British. The project will display how legally objectifying a human being manifests subjects …