Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network

Open Access. Powered by Scholars. Published by Universities.®

Theses and Dissertations

Discipline
Institution
Keyword
Publication Year
File Type

Articles 31 - 60 of 19581

Full-Text Articles in Entire DC Network

Developing An Understanding Of Concavity Built On Covariation, Jade E. Gregg Jul 2026

Developing An Understanding Of Concavity Built On Covariation, Jade E. Gregg

Theses and Dissertations

This study investigated how six students developed a quantitative understanding of concavity founded in covariational reasoning through a series of task-based teaching interviews. A key finding was the importance of multivariational reasoning--the coordination of more than two variables--in helping students reason deeply about concavity in context. Common difficulties, including confusion about negative rates and overreliance on visual representations, served as productive opportunities for learning when addressed through carefully designed tasks and discussions. The findings extend existing frameworks of covariational reasoning and highlight instructional approaches that can support students in developing a robust, quantity-based understanding of concavity.


Repetition As Ritual Structure: Sound, Movement, And Electrodermal Activity In A Hmong Shaman Ceremony, Maile Williams Jul 2026

Repetition As Ritual Structure: Sound, Movement, And Electrodermal Activity In A Hmong Shaman Ceremony, Maile Williams

Theses and Dissertations

This thesis examines the relationship between repetitive sound, physiological arousal, and embodied participation in a Hmong shamanic ritual. Drawing on scholarship about music, trance, absorption, repetition, and Hmong ritual journeying and communication, I consider how sonic layers such as chant, rattle and gong help structure ritual time and sustain the shaman's altered state. The project uses electrodermal activity (EDA) data from wearable sensors, video and audio recordings, and my own event coding of sonic and physical activity during a selected 30-minute section of a recorded Hmong shaman ceremony. By aligning EDA data with a timeline of chanting, rattling, gong playing, …


How Young Mothers’ Interpersonal And Emotional Well-Being Impacts Parental Stress And Dating Violence, Jonathan Jin Jul 2026

How Young Mothers’ Interpersonal And Emotional Well-Being Impacts Parental Stress And Dating Violence, Jonathan Jin

Theses and Dissertations

This two-part dissertation investigated two distinct, yet interconnected aspects of young mothers’ wellbeing which span individual and interpersonal factors. Study 1 examined how adverse childhood experiences (ACEs) are related to parental stress, and how symptoms of anxiety and depression might mediate this association. Within a sample 255 young mothers with an average age of 22.2 (SD = 2.3), the pooled results of a parallel mediation model across 10 imputed datasets indicated a significant average direct effect of ACEs on parental stress (0.25, p < .01), suggesting that experiencing a history of ACEs was significantly associated with more parental stress. Study 2 examined the relationship between young mothers’ romantic attachment, emotion regulation, and dating violence (DV) victimization. In a different sample of 256 young mothers with an average age of 19.8 years (SD = 1.1), more avoidant (less secure) romantic attachment styles (β = 0.26, SE = 0.1, p < 0.01) and more anxious romantic attachment styles (linear component β = 3.81, SE = 0.9, p < 0.001 and quadratic component β = -2.86, SE = 0.9, p < 0.01) were significantly associated with greater DV victimization. Future research may extend this work by using longitudinal designs to test bidirectional links between interpersonal and emotional wellbeing factors among young mothers.


Do I Belong Here?: A Narrative Inquiry Into Ableism, Accommodation, And Professional Identity Among Medical Students With Mobiilty Disabilities, Nicole J. Albano Robinson Jul 2026

Do I Belong Here?: A Narrative Inquiry Into Ableism, Accommodation, And Professional Identity Among Medical Students With Mobiilty Disabilities, Nicole J. Albano Robinson

Theses and Dissertations

Abstract Nicole J. Robinson DO I BELONG HERE?: A NARRATIVE INQUIRY INTO ABLEISM, ACCOMMODATION, AND PROFESSIONAL IDENTITY AMONG MEDICAL STUDENTS WITH MOBILITY DISABILITIES 2025-2026 Ane Turner Johnson, Ph.D. Doctor of Education in Educational Leadership Despite federal and institutional disability policy designed to protect equitable access to education, medical students with mobility disabilities encounter systemic barriers shaped by ableism, inconsistent accommodation practices, cultural bias, and exclusionary learning environments. This qualitative study sought to describe the lived experiences of undergraduate medical students with mobility disabilities within U.S. MD and DO programs. A qualitative narrative inquiry using Kim’s (2016) two-phase life story interview …


Hybrid Lipid-Gold Nanoparticles Designed For Simultaneous Gene Therapy And Photothermal Therapy Against Cancer, Navya Sree Devaguptapu Jul 2026

Hybrid Lipid-Gold Nanoparticles Designed For Simultaneous Gene Therapy And Photothermal Therapy Against Cancer, Navya Sree Devaguptapu

Theses and Dissertations

Traditional cancer treatments such as chemotherapy and surgery include adverse side effects and acquire resistance. Here, I developed a novel hybrid lipid-gold nanoparticle technology (LGNP) to achieve simultaneous gene regulation and photothermal therapy, specifically targeting pediatric acute myeloid leukemia (AML) and ovarian cancer. This core material consists of slice core/gold nanoshells, which are efficient heat transducers where NIR light activates nanoshells embedded in tumors, generating localized heat for tumor ablation. The ionizable lipid coating facilitates intracellular delivery of nucleic acids, such as mRNA or siRNA, to modulate gene expression effectively. Lipid-gold hybrid nanoparticles (LGNPs) are synthesized via a controlled self-assembly …


Leveraging Oxaziridines In Transition Metal Catalysis And As Reactive Intermediates, Jenna Marie Doran Jul 2026

Leveraging Oxaziridines In Transition Metal Catalysis And As Reactive Intermediates, Jenna Marie Doran

Theses and Dissertations

Oxaziridines are versatile three-membered nitrogen–oxygen heterocycles that can function both as reactive intermediates and as components of transition-metal catalysts, enabling selective and diverse organic transformations. This work explores the dual role of oxaziridines in facilitating alkene functionalization and amide synthesis. We discovered that vanadooxaziridines catalyze intermolecular allylic amination with high regio- and chemoselectivity, providing a mild route to allylic amines, whereas molybdooxaziridine complexes display an unexpected preference for vinyl sulfonation, revealing a divergent pathway from the typical nitrogen-transfer reactions and offering access to synthetically valuable sulfur-containing motifs. In parallel, oxaziridine intermediates derived from imines mediate efficient formation of amides from …


Fraud And Focus: Examining Self-Control Strategies In Students Experiencing Impostor Phenomenon, Francesca Angela Catalano Jul 2026

Fraud And Focus: Examining Self-Control Strategies In Students Experiencing Impostor Phenomenon, Francesca Angela Catalano

Theses and Dissertations

Impostor phenomenon (IP) is a common experience among individuals in achievement contexts characterized largely by feelings of self-doubt, attributions of success that focus on external factors, and beliefs that one is “fooling” others about their competence. Current research suggests the effects of IP are complex (e.g., IP is associated with higher grade point average and productivity but also self-handicapping, psychological distress, and difficulties adjusting to college). To better understand these complex effects, this study proposes a self-control perspective for IP, where this phenomenon is seen as involving additional self-control burdens. Specifically, the study examines whether IP is associated with grade …


Friction Stir Processing Of Cobalt-Chromium-Molybdenum For Improvements In Biomedical Applications, Kaleb Kiyoshi Bates Jun 2026

Friction Stir Processing Of Cobalt-Chromium-Molybdenum For Improvements In Biomedical Applications, Kaleb Kiyoshi Bates

Theses and Dissertations

Friction Stir Processing (FSP) has been investigated as a means of microstructural modification aimed at improving mechanical properties such as corrosion resistance and wear resistance of biomedical-grade cobalt-chromium-molybdenum (CoCrMo) alloy. FSP was successfully completed on high-carbon ASTM F1537 CoCrMo plates with operating temperatures ranging from 630°C to 850°C by adjusting spindle speed, traverse speed, and forge force. Hardness, wear resistance, and corrosion resistance testing were performed, along with Electron Backscatter Diffraction (EBSD) to analyze grain refinement and phase structure. FSP produced grain refinement up to 97% relative to the untreated baseline across the investigated temperature range, with lower processing temperatures …


Receiving Isaac Again: Joy And Return To The Finite In Fear And Trembling, Jeffrey M. Matheson Jun 2026

Receiving Isaac Again: Joy And Return To The Finite In Fear And Trembling, Jeffrey M. Matheson

Theses and Dissertations

This thesis argues that joy is a constitutive but underexamined feature of faith in Søren Kierkegaard’s Fear and Trembling. While the text is often interpreted through sacrifice, silence, dread, paradox, and the teleological suspension of the ethical, these categories do not exhaust Johannes de Silentio’s account of Abraham. By foregrounding Abraham’s joy, this thesis shows that faith is not merely the willingness to surrender the finite, but the capacity to receive the finite again after it has been given up. Isaac is not only Abraham’s beloved son, but the child of promise, the visible form of God’s covenant, and the …


A Mathematical Model Of The Interactions Between A Collagen Lattice, Fibroblasts, And Fixed Surfaces With Varying Topographies, Mary Jenkins Jun 2026

A Mathematical Model Of The Interactions Between A Collagen Lattice, Fibroblasts, And Fixed Surfaces With Varying Topographies, Mary Jenkins

Theses and Dissertations

Collagen is an important structural protein in the body, which plays a role in wound healing, particularly the contraction process. Collagen lattices have been studied for nearly 50 years to provide insight into wound contraction. In some cases, collagen interacts with surfaces that have fixed shapes, such as medical implants. Our model focuses on the interactions of a collagen lattice with such a fixed surface. We mathematically model a collagen lattice as a network of nodes connected by springs. We also model fixed surfaces that have various topographies. Our model includes fibroblast cells that connect to both surfaces and remodel …


Advancing Data Usability, Activity Modeling, And Stability Optimization In Computational Enzyme Design, Spencer Gardiner Jun 2026

Advancing Data Usability, Activity Modeling, And Stability Optimization In Computational Enzyme Design, Spencer Gardiner

Theses and Dissertations

A grand challenge of computational biology is to computationally design, in a single pass, a protein sequence that catalyzes an arbitrary chemical reaction at a high rate under specified conditions [1]. This work details advances in three essential areas on the path to that goal: data quality, activity prediction and modeling, and stability optimization. The structure and implementation of the Allotrope Simple Model (a FAIR data format for many scientific instruments) was examined in [2], setting the stage for training deep learning models on high-quality experimental datasets from diverse sources. In [3], the limits of physics-based and deep learning tools …


Maternal Perspectives On Support Needs: Insights From The Fonofale Model, Sara Lani Ditto Jun 2026

Maternal Perspectives On Support Needs: Insights From The Fonofale Model, Sara Lani Ditto

Theses and Dissertations

This interpretative phenomenological analysis (IPA) explored the lived experiences of parents raising children with disabilities in American Samoa. Five participants across two focus groups shared their perspectives on navigating educational, healthcare, and community systems while supporting their children with disabilities. Using the fonofale model as a cultural framework, the study incorporated culturally responsive methodology including card sort activities to facilitate dialogue on potentially sensitive topics. Analysis followed the Nizza et al. (2021) IPA approach, progressing from exploratory notes to experiential statements, clustered themes, and finally overarching themes. Findings revealed four major themes: systemic burden on parents, structural and service gaps, …


Hierarchical Parcel Swapping: A Novel Model In Turbulence, Masoomeh Behrang Jun 2026

Hierarchical Parcel Swapping: A Novel Model In Turbulence, Masoomeh Behrang

Theses and Dissertations

Turbulent mixing plays a central role in a wide range of engineering and natural systems, particularly in reactive flows where turbulence--chemistry interactions strongly influence reaction rates, flame structure, and emissions. Accurately modeling these interactions remains a major challenge due to the multiscale and stochastic nature of turbulence, as well as the nonlinear coupling between transport and chemical kinetics. This dissertation develops and evaluates the Hierarchical Parcel Swapping (HiPS) model, a fully stochastic framework designed to represent turbulence-driven transport and scalar mixing without relying on traditional gradient-based closures. HiPS is investigated both as a standalone turbulence model and as a subgrid …


I Will Defend My Self, Emily Ward Hawkins Jun 2026

I Will Defend My Self, Emily Ward Hawkins

Theses and Dissertations

This thesis examines caregiving and motherhood as forms of load-bearing infrastructure. Cultural narratives often portray motherhood through sentimental images of joy, tenderness, and devotion, obscuring the structural labor that sustains family life. This project examines maternal labor as a largely unseen system of support that organizes family life while often remaining backgrounded. Caregiving reorganizes time, space, ambition, embodiment, and future orientation within maternal life. Through sculptural works using architectural materials and construction systems, such as oriented strand board, blueprint racks, metal armatures, and graph paper, the project visualizes caregiving as a structural condition. These materials reference the language of architecture …


Practical Implementation Of Ethnomathematics To Increase The Engagement, Math Self-Efficacy, And Hawaiian Cultural Identity Of HawaiʻI Algebra 2 Students, Kamalani George Mamatuki Kaluhiokalani Jun 2026

Practical Implementation Of Ethnomathematics To Increase The Engagement, Math Self-Efficacy, And Hawaiian Cultural Identity Of HawaiʻI Algebra 2 Students, Kamalani George Mamatuki Kaluhiokalani

Theses and Dissertations

The underrepresentation of Hawaiian cultural practices in mathematics education has contributed to a disconnect between students' cultural identities and their academic experiences, resulting in diminished engagement among Native Hawaiian learners. This design-based research examines the integration of ethnomathematics into high school mathematics curricula, with a focus on Hawaiian cultural practices as frameworks for teaching mathematical concepts. Participants include approximately 100 students in Hawaiʻi from a public school and a private school, as well as two mathematics teachers with varying degrees of experience in culturally responsive pedagogy and ethnomathematics. Employing a mixed-methods approach, the study collects data through classroom observations, teacher …


Calibration And Validation Of An Ogden Material Model For Thermoplastic Polyurethane In 3d-Printed Tensegrity Structures, Caleb C. Swain Jun 2026

Calibration And Validation Of An Ogden Material Model For Thermoplastic Polyurethane In 3d-Printed Tensegrity Structures, Caleb C. Swain

Theses and Dissertations

This work is motivated by ongoing efforts within the Smart Materials, Adaptronics, and Shock Laboratory (SMASH Lab) at Brigham Young University (BYU) to develop variable-stiffness, external fixators using 3D-printed tensegrity structures. In the process of designing and evaluating these systems, the need arose to accurately model the nonlinear mechanical behavior of thermoplastic polyurethane (TPU), the primary material used in prototype fabrication. This thesis investigates how accurately a calibrated Ogden material model can predict the nonlinear mechanical response of TPU in 3D-printed tensegrity structures. Experimental data were used to calibrate the parameters of the hyperelastic constitutive model through nonlinear optimization. An …


Effects Of A Peer Mentoring Program For Adolescent Newcomers On Feelings Of Peer Connectedness And School Belonging, Eden Elizabeth Moon Barnhill Jun 2026

Effects Of A Peer Mentoring Program For Adolescent Newcomers On Feelings Of Peer Connectedness And School Belonging, Eden Elizabeth Moon Barnhill

Theses and Dissertations

There is a significant lack of empirical evidence regarding the effectiveness of peer mentoring to support newcomer students, particularly for refugee populations. This study evaluated the effects of a peer mentor program for newcomer students on their feelings of peer connectedness and school belonging in a high school setting. Participants were made up of 15 newcomer student mentees across three high schools. Measures were administered pre- and post-intervention, and participants were also interviewed about their experience. Results indicated no quantitative findings of significance but did yield a small positive effect size for peer connectedness. According to qualitative data, many participants …


A Rho5-Cnc1-Dnm1 Signalling Module Coordinates Multi-Organelle Execution Of Regulated Cell Death In Yeast, Justin Bauer Jun 2026

A Rho5-Cnc1-Dnm1 Signalling Module Coordinates Multi-Organelle Execution Of Regulated Cell Death In Yeast, Justin Bauer

Theses and Dissertations

Regulated cell death is a conserved process with major implications for health and disease, yet how yeast cells integrate stress signals to determine survival versus death remains unclear. This thesis investigates Cyclin C (Cnc1), a conserved Mediator kinase module component with both transcriptional and mitochondrial roles. Together with Cdk8 Cnc1 primarily represses stress response genes, while upon stress it translocates to the mitochondria to induce mitochondrial fragmentation with the dynamin-related GTPase Dnm1. Using structure-guided separation-of-function mutants, I demonstrate that Cnc1-dependent death requires its mitochondrial function rather than its transcriptional role, and that its effector Dnm1 acts as a signaling node …


Anatomy And Function Of Vasopressin Receptor 1a-Expressing Neurons In The Limbic Thalamus, David Joseph Kahn Jun 2026

Anatomy And Function Of Vasopressin Receptor 1a-Expressing Neurons In The Limbic Thalamus, David Joseph Kahn

Theses and Dissertations

The vasopressin (Avp) system modulates social behavior through region-specific and sex-dependent mechanisms, yet the role of Avp receptor 1a (Avpr1a) signaling in the thalamus has remained largely unexplored. This dissertation examined the distribution and functional contributions of Avpr1a-expressing neurons across the mouse thalamus using a combination of genetic labeling, anatomical quantification, and chemogenetic manipulation. Mapping of Avpr1a-expressing neurons revealed a presence in most thalamic nuclei, with highest densities in the anterior thalamic nuclei and midline nuclei. Notably, Avpr1a-expressing neuron densities did not mirror previously described patterns of Avp innervation, and no sex differences in Avpr1a-expressing neuron density were observed. Chemogenetic …


Engagement With Tailored Physical Activity Interventions Among Women In Midlife With Elevated Risk For Cardiovascular Disease, Kiri Baga Jun 2026

Engagement With Tailored Physical Activity Interventions Among Women In Midlife With Elevated Risk For Cardiovascular Disease, Kiri Baga

Theses and Dissertations

Women in midlife (ages 40-65) with risk factors for cardiovascular disease (CVD) need physical activity (PA) interventions that are informed by and address their daily challenges and life circumstances, to reduce their chances of premature mortality from CVD. Sustaining engagement with PA interventions remains a substantial challenge for women in midlife. The aims of the proposed study were to describe participants’ PA-relevant characteristics and intervention preferences and to identify their patterns of engagement with different PA support tools (tailored PA website, intervention involving pairing women as PA partners). With respect to engagement, there was limited between-person stability in engagement outcomes …


Development And Standardization Of Teds Actuator Templates Under Ieee 1451 Framework, Jim Kang Jun 2026

Development And Standardization Of Teds Actuator Templates Under Ieee 1451 Framework, Jim Kang

Theses and Dissertations

The IEEE 1451 standard is a family of standards that defines a framework for smart transducers, including both sensors and actuators, to support consistent, interoperable, and cost-effective integration across diverse applications. However, the current IEEE 1451.4 standard templates only define the method for encoding Transducer Electronic Data Sheet (TEDS) information for a broad range of sensor types and applications; they do not address actuator TEDS. Specific types of sensors and actuators are being developed to assess underground environmental conditions in cold regions with widespread permafrost. Evaluating subsurface conditions before construction can help prevent high construction expenses for structures built on …


Engineering Nanoelectrocatalytic Systems For Co2 And Nitrate Conversion Into Value-Added Chemicals, Abdelrahman Mohamed Abdelmohsen Jun 2026

Engineering Nanoelectrocatalytic Systems For Co2 And Nitrate Conversion Into Value-Added Chemicals, Abdelrahman Mohamed Abdelmohsen

Theses and Dissertations

The thesis addresses two major related environmental crises: nitrate pollution of water systems and the ever-increasing levels of atmospheric carbon dioxide. Both challenges are closely linked to anthropogenic disturbance of nitrogen and carbon cycles and require sustainable, energy efficient mitigation techniques. In this study, we investigate electrochemical conversion routes as a unified approach to convert these pollutants into value-added compounds: ammonia (NH3) via nitrate reduction (NO3-RR) and ethylene (C2H4) via carbon dioxide reduction (CO2RR). The first half of this work deals with the design and engineering of Cu-Zn alloy electrocatalysts for efficient NO3-RR. Tuning the alloy composition and surface nanostructure …


Sense Of Belonging Among Undergraduate Students At The American University In Cairo: Demographic Trends, Barriers And Facilitators, Lamiaa M. Mohamed Jun 2026

Sense Of Belonging Among Undergraduate Students At The American University In Cairo: Demographic Trends, Barriers And Facilitators, Lamiaa M. Mohamed

Theses and Dissertations

A sense of belonging is widely recognized as a key determinant of undergraduate students’ academic success, well-being, and persistence in higher education. However, existing research is largely grounded in Western contexts and often emphasizes institution-level measures, with limited attention to how belonging is experienced and constructed by students in non-Western settings. This study examines undergraduate students’ sense of belonging at the American University in Cairo, focusing on factors that shape belonging and institutional practices that may strengthen it. Using a sequential mixed-methods design, the study examined 87 responses from a quantitative survey adapted from the University Belonging Questionnaire, followed by …


The Experience Of Newly Formed Syrian Female-Headed Households Refugees In Egypt: Challenges And Opportunities, Wasim Dia Jun 2026

The Experience Of Newly Formed Syrian Female-Headed Households Refugees In Egypt: Challenges And Opportunities, Wasim Dia

Theses and Dissertations

This thesis examines the lived experience of Newly Formed Syrian Female-Headed Households in Egypt. It focuses on how the extended displacement reshapes gender roles, decision-making, and survival strategies. Since the beginning of the Syrian conflict in 2011, extensive family separation, death, disappearance, and male migration have occurred, leading to a significant rise in female-headed Syrian refugee households. As a result, displacement has intensified women’s vulnerability, generating new responsibilities and limited spaces for agency, especially within restrictive legal and socio-economic environments.

Based on in-depth qualitative interviews conducted in 2023, this research explores how Syrian refugee women navigate everyday life in Egypt …


Integrative Assessment Of Body Composition And Micronutrient Status In An Adult Egyptian Population, Roua Aref Nouh Jun 2026

Integrative Assessment Of Body Composition And Micronutrient Status In An Adult Egyptian Population, Roua Aref Nouh

Theses and Dissertations

Integrative Assessment of Body Composition and Micronutrient Status in an Adult Egyptian Population: A Functional and Biochemical Approach

Obesity and metabolic dysfunction are increasingly recognized as heterogeneous conditions that cannot be sufficiently characterized by body mass index (BMI) alone. Alterations in body composition, particularly central adiposity and skeletal muscle mass, may coexist with micronutrient imbalances even among individuals who fall outside conventional BMI-based obesity classifications. In clinical settings, such metabolic vulnerability is frequently accompanied by non-specific functional symptoms, highlighting the need for integrative assessment approaches that extend beyond weight-centered metrics. This cross-sectional study aimed to investigate the associations between micronutrient …


“Between Cultural Norms And Economic Survival: Navigating Egyptian Lower And Middle Income Women’S Challenges In The Informal Versus The Formal Work: “A Case Study From Cairo”, Rowan Mahmoud Abdelnazer Jun 2026

“Between Cultural Norms And Economic Survival: Navigating Egyptian Lower And Middle Income Women’S Challenges In The Informal Versus The Formal Work: “A Case Study From Cairo”, Rowan Mahmoud Abdelnazer

Theses and Dissertations

This study investigates the ongoing gender inequities experienced by low and middle-income women in Egypt’s formal and informal labor economy, specifically it is based in Cairo. Although there are many advances made globally on women's rights, yet women still face great challenges such as discrepancies in salary, fewer leadership roles and cultural expectations which put child-bearing duties before professional growth. On the one hand, flexible work for women in developing countries is through informal sector, which makes them vulnerable and serves as a source of their exploitation and insecurity (e.g., lack of social security; workplace hazards), on the other hand, …


The Human Side Of Humanitarian Work: Well-Being And Performance Among Aid Workers In Egypt, Mai Osama Kenawy Jun 2026

The Human Side Of Humanitarian Work: Well-Being And Performance Among Aid Workers In Egypt, Mai Osama Kenawy

Theses and Dissertations

Well-being and productivity are widely recognized as central to the work performance of humanitarian aid workers. Despite increasing attention to staff well-being, performance within the humanitarian sector in Egypt remains stagnant or, in some cases, declining. This study examines why expanded well-being initiatives have not yielded sustained performance improvements by examining how actors' external roles, organizational factors, and individual factors affect humanitarian workers’ well-being and work performance. A mixed-methods approach was adopted, combining ten in-depth interviews with humanitarian workers from international organizations, INGOs, and local NGOs, as well as a survey of eighty workers operating in the same context. The …


Design Principle For Staple-Mediated Stabilization Of Peptides And Proteins, Samantha C. Hatfield Jun 2026

Design Principle For Staple-Mediated Stabilization Of Peptides And Proteins, Samantha C. Hatfield

Theses and Dissertations

Macrocyclization, or stapling, has emerged as a powerful strategy to enhance the stability and function of peptides and proteins by constraining their conformational ensembles. Stapling can improve thermodynamic stability, increase resistance to proteolytic degradation, and enhance biomolecular recognition, making it particularly valuable for the development of peptide-based therapeutics. Despite these advantages, staple design remains largely empirical, relying on iterative screening of linker chemistries, lengths, and attachment sites. This trial-and-error approach limits scalability and hinders the rational design of stabilized peptide systems. In this work, we address this challenge by integrating large-scale experimental datasets with molecular dynamic simulations to develop predictive …


Differentiation Of Self As A Therapist Effect In Couple Therapy, Nathan D. Knebel Jun 2026

Differentiation Of Self As A Therapist Effect In Couple Therapy, Nathan D. Knebel

Theses and Dissertations

Murray Bowen proposed that a therapist's level of differentiation of self influences therapeutic effectiveness, particularly in clinically distressed relational systems. Although existing literature has demonstrated that therapist effects account for a meaningful portion of variance in couple therapy outcomes, differentiation of self has received limited empirical attention as a therapist-level predictor. The present article proposes a framework for empirically examining Bowen's hypothesis by investigating whether therapist differentiation predicts trajectories of couple relationship quality across treatment. Additionally, the article explores theoretical pathways through which therapists may increase their level of differentiation, assuming Bowen's hypothesis is supported.


Instagram Influencers And Egyptian Women: Links To Self- Perception And Behavior, Fatma El Sayad Jun 2026

Instagram Influencers And Egyptian Women: Links To Self- Perception And Behavior, Fatma El Sayad

Theses and Dissertations

The rapid rise of Instagram influencers has transformed the ways young women engage with media, shaping perceptions of appearance, lifestyle, success, and everyday behavior. This study examines how frequent exposure to Instagram influencers affects self-esteem, internalization of beauty and lifestyle ideals, perceived realism of influencer content, and behavioral and consumption habits among young Egyptian females. The study explores participants’ lived experiences, interpretations, and coping strategies in relation to influencer culture. Perceived influencer credibility emerged as a key factor for females to follow them, influencers viewed as relatable, specialized, and transparent were more likely to inspire adaptive behaviors, whereas those promoting …