Digital Commons Network^™

Utilizing Case Studies To Increase Critical Thinking In An Undergraduate Anatomy & Physiology Classroom, Sarah E. Lehman

Theses and Dissertations

The purpose of this study was to determine the effectiveness of the implementation of case-based learning compared to traditional lecture in increasing critical thinking skills in an undergraduate Anatomy & Physiology I classroom. Throughout the course of one semester, five units were taught with the addition of a case study as an instructional tool while the other four units were taught utilizing only didactic (lecture) methods and did not teach content utilizing case study methodology. Two types of content-specific critical thinking data were analyzed: selected multiple-choice exam questions and End of Chapter (EOC) assignments. The Cornell Critical Thinking Test (CCTT) …

Injury Prevention Exercise Guidelines For Flutists, Ziqing Guan

Theses and Dissertations

Playing-related musculoskeletal disorders (PRMDs) have long been a common topic among performing musicians. There are studies of PRMDs specific to flutists, but not much detailed guidance of playing-related injury prevention has been provided. As increasing numbers of students have taken up the flute in recent years, PRMDs in flutists have become more of a concern. However, large numbers of flutists are still lacking education on prevention of PRMDs. The purpose of this document is to help flutists better understand the major muscle groups that we use in playing the flute, how these muscles are affected by flute-playing, and to introduce …

Statistical Methods For Single Cell Sequencing Data Analysis, Fei Qin

Theses and Dissertations

The recent emergence of single cell sequencing (SCS) technology has provided us with single-cell DNA or RNA sequencing (scDNA/RNA-seq) information to investigate cellular evolutionary relationships. Despite many analysis methods have been developed to infer intra-tumor genetic heterogeneity, cluster cellular subclones, detect genetic mutations, and investigate spatially variable (SV) genes, exploring SCS data remains statistically challenging due to its noisy nature.

To identify subclones with scDNA-seq data, many existing studies use an independent statistical model to detect copy number profile in the first step, followed by classical clustering methods for subclone identification in downstream analyses. However, spurious results might be generated …

Archetypes Revisited: Investigating The Power Of Universals In Soviet And Hollywood Cinema, Iana Guselnikova

Theses and Dissertations

This paper examines the concept of archetypes in Soviet and Hollywood films, drawing perspectives from ancient philosophy and the thought of Carl Jung and post-Jungians. While psychoanalysis provides a valuable framework for understanding the human psyche and the idea of archetypes, it has its limitations and gaps that require further exploration. To address these issues, this paper proposes the adoption of a structuralist approach, with reference to the work of Vladimir Propp on the morphology of the fairy tale. Incorporating Propp's ideas can complement psychoanalytic theory and provide a more comprehensive understanding of the underlying patterns and structures that shape …

Deep Learning Methods For Some Problems In Scientific Computing, Yuankai Teng

Theses and Dissertations

Deep learning has emerged as a powerful approach for solving complex problems in scientific computing due to the increasing availability of large-scale data and computational resources. This thesis explores the potential of deep learning methods for three specific problems in scientific computing: (i) reducing the dimensions of variables in function approximation, (ii) solving linear reaction-diffusion equations, and (iii) finding the parametric representations of parameters in the numerical schemes for solving time-dependent partial differential equations.

For the first problem, a novel deep learning architecture is developed for reducing the dimensions of variables in function approximation. The proposed method achieves state-of-the-art performance …

Modulation Of Eif2Α Signaling And The Integrated Stress Response By Targeted Therapeutic Attenuation Of Pkr Activity Contributes To Protection Of Dyt-Prkra Cells From Apoptosis, Kenneth L. Frederick

Theses and Dissertations

Luteolin is a natural flavonoid present in vegetables, fruits, and medicinal herbs that possesses anti-oxidative, anti-cancer, and anti-inflammatory properties. In this study, we investigated the effect of luteolin on the integrated stress response (ISR), which is an evolutionarily conserved intracellular signaling network essential for adapting to environmental stresses to maintain healthy cells. Dysregulated ISR is involved in the etiology of many human diseases including the movement disorder DYT-PRKRA which is caused by mutations in the PRKRA gene. PRKRA encodes for PACT, the protein activator of interferon-induced, double-stranded RNA (dsRNA)-activated protein kinase PKR.PACT-mediated PKR activation regulates the …

Predictors Of Driving Performance Post-Stroke, Halle Elise Prine

Theses and Dissertations

Driving is a complex skill involving the interaction of various brain functions, making it challenging to determine the independent contributions of each process to driving proficiency. While past studies have identified assessments such as the Useful Field of View Test (UFOV) and the Trial Making Test (TMT) as strong predictors for driving skills, little research has explored the impact of visual search and movement inhibition on driving after stroke. This cross-sectional study includes participants between the ages of 21 to 80 years with residual disability caused by a unilateral middle cerebral artery stroke at least six months prior. The participants …

Predicting Material Structures And Properties Using Deep Learning And Machine Learning Algorithms, Yuqi Song

Theses and Dissertations

Discovering new materials and understanding their crystal structures and chemical properties are critical tasks in the material sciences. Although computational methodologies such as Density Functional Theory (DFT), provide a convenient means for calculating certain properties of materials or predicting crystal structures when combined with search algorithms, DFT is computationally too demanding for structure prediction and property calculation for most material families, especially for those materials with a large number of atoms. This dissertation aims to address this limitation by developing novel deep learning and machine learning algorithms for effective prediction of material crystal structures and properties. Our data-driven machine learning …

Diversity, Function, And Phenotypic Plasticity Of Cryptophyte Phycobiliproteins, Kristiaän Merritt

Theses and Dissertations

Cryptophytes are a group of unicellular eukaryotic algae that can be found in a wide range of underwater habitats. Part of their ecological success can be attributed to their diverse array of cryptophyte phycobiliproteins (Cr-PBPs), a pigment class that captures wavelengths of light that are poorly absorbed by chlorophylls. Cryptophytes gained photosynthesis via secondary endosymbiosis in which their ancestor engulfed a red algal endosymbiont. Following endosymbiosis, they deconstructed the red algal photosynthetic machinery to form the Cr-PBP. Since then, the Cr-PBPs have diversified into at least 9 spectrally distinct forms. I investigated the diversity of Cr-PBP light absorption across 76 …

Mechanisms Of Social Stress Susceptibility And Resilience In Female Rats, Brittany Sara Pate

Theses and Dissertations

Social stress is the most common form of stress humans experience and often precipitates the onset of several comorbidities, including anxiety, depression, post-traumatic stress disorder, and cardiovascular diseases. While many individuals experience social stress and can respond, cope, and recover, some individuals are more likely to develop subsequent health conditions. Importantly, women are particularly susceptible to stress-related disorders, and the prevalence rates for these comorbid conditions are 2-3-fold higher among females compared to males. Epidemiological data suggest that cycling ovarian hormones may play a role in promoting stress susceptibility in females. Therefore, the current studies aimed to examine the effects …

Dissolved Oxygen Dynamics And Nutrient Cycling In Marine And Lacustrine Benthic Communities, Corrianna R. Boucher

Theses and Dissertations

The delivery of biodetritus to the sediment water interface supports a complex series of biogeochemical reactions collectively referred to as early diagenesis. From the abyssal ocean to littoral freshwater ecosystems, this work explores the dynamics of these reactions in deep ocean detrital aggregates and lacustrine benthic algal mats. In the ocean, periods of increased export flux to abyssal depths increase the organic carbon export as aggregates to the seafloor while in littoral freshwater, proliferations of benthic algae such as Microseira wollei have grown to fill much of the shallow water column they inhabit.

Data collected at Station M (Sta. M) …

Teaching About Transfer: Making The Invisible Visible Through Explicit Instruction, Brittany Morgan Capps

Theses and Dissertations

Transfer of learning—or the act of adapting previously learned knowledge to new contexts—is an inherently complex process made even more mystifying by its often unconscious and therefore “invisible” occurrence. Writing, too, is a complicated activity that depends on and responds to a number of internal and external factors. Transferring writing knowledge, then, is a challenging task for writers of all experience levels. Researchers in writing studies have designed curricula intended to help college students transfer writing skills, knowledge, and practices from the writing classroom to other disciplinary and workplace contexts. Those teaching for transfer (TFT) and writing about writing (WAW) …

Breaking Down The Human: Disintegration In Nineteenth-Century Fiction, Benjamin Mark Driscol

Theses and Dissertations

This dissertation brings together nineteenth-century texts written by Mary Shelley, Edgar Allan Poe, Gustave Flaubert, Benito Pérez Galdós, Rachilde, and Oscar Wilde in order to trace a common thread weaving in and out of literature produced during this period: the theme of corporeal disintegration and its psychic and social ramifications. Each of the analyzed works considers the human condition from diverse perspectives and portrays the breakdown in interpersonal relationships as characters become estranged from society and each other. Of course, the examples considered here are canonical ones widely discussed in criticism—some of them as forebears of literary Modernism, for which …

The Impact Of Progerin On Genome Maintenance In Mammalian Cells, Liza Alexandra Joudeh

Theses and Dissertations

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by accelerated aging. The cause of HGPS is a point mutation in the LMNA gene, which encodes lamins A and the splice variant lamin C. Lamins are components of the nuclear lamina, a complex that plays structural and catalytic roles in the nucleus that are essential to chromatin organization, DNA replication, and DNA repair. The mutation associated with HGPS activates a cryptic splice donor site which alters the lamin A protein in a way that does not allow prelamin A to be fully processed, and ultimately results in the accumulation …

Sleep, Physical Activity, And Sedentary Time In The First Year Postpartum, Erin Elizabeth Kishman

Theses and Dissertations

The postpartum period is a unique time for women, where many women experience changes in sleep and activity patterns. Sleep, physical activity, and sedentary time have all been associated with health outcomes, but there is limited research on how these behaviors change throughout the postpartum period. The purpose of the first aim (Study 1) of this dissertation was to examine trajectories of sleep characteristics in Black and White women during the first year postpartum and to examine if there were any racial differences. The purpose of the second aim (Study 2) was to examine trajectories of the percentage of time …

Biobehavioral Synchrony In Autism Spectrum Disorder, Carly Glenn Moser

Theses and Dissertations

Social communication difficulties are a core feature of autism and are associated with a range of long-term consequences, including persistent deficits in pragmatic language and fewer and poorer quality friendships. High-quality synchronous interactions between parents and their children play a crucial role in children’s social functioning. The theory of biobehavioral synchrony suggests that the dyadic coordination of behavioral and physiological processes is essential to maximally benefit from a communicative exchange. Respiratory sinus arrhythmia (RSA) serves as an indicator of physiological regulation and is reduced in those with autism; thus, dyadic coordination of RSA may also be impacted and could play …

Prenatal Depression And Breastfeeding Practices Healthy Start Participants, 2019-2022, Peyton Ashleigh Mosher

Theses and Dissertations

Background: Breastfeeding has health benefits for both mother and child, but breastfeeding practices among Black and lower-income women are the poorest in the United States. Few studies have examined the associations between maternal prenatal depression and breastfeeding duration, even fewer among a predominantly low-income Black population. Objective: To explore the association between prenatal depression and breastfeeding practices among low-income Black women during the COVID-19 pandemic.

Methods: Prospective cohort data from Midlands Healthy Start (MHS) was analyzed to examine women’s depression symptoms during pregnancy and their breastfeeding initiation and duration through two and six months. Perinatal depressive symptoms were identified using …

Comorbid Adhd And Pediatric Sickle Cell Disease: Prevalence And Risk Factors, Sarah Bills

Theses and Dissertations

Objective: Sickle cell disease (SCD) is a genetic blood condition that places youth at increased risk for deficits in attention and executive functioning suggestive of increased rates of Attention Deficit/Hyperactivity Disorder (ADHD). There is pronounced inconsistency in reported prevalence rates for attention deficits and ADHD diagnoses among youth with SCD, which is due in part to variability in methodology of previous studies. The primary aim of the present study is to use systematic screening to identify the prevalence of inattentive ADHD symptoms and ADHD diagnoses in a pediatric SCD population seen at a large hematology clinic. A secondary aim is …

The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black

Theses and Dissertations

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder characterized by elevated rates of intellectual disability, autism, and anxiety. Social anxiety affects approximately 60 percent of individuals with FXS and is cited as one of the most impairing comorbid disorders in FXS; however, little is understood about the developmental patterns of social anxiety markers in young children with FXS. The current study investigates cardiac and behavioral markers of social anxiety across the first five years of life and tests the predictive utility of these variables on social anxiety symptomatology. Participants included 80 children with FXS and 50 neurotypical controls. Participants …

Mitigating Student Anxiety In The Secondary Classroom: A Culturally Sustaining Approach, Erin Hawley Cronin

Theses and Dissertations

This study emerged in response to broader trends of increasing anxiety among schoolchildren and my own observations as a teacher. Suicide is now the second-leading cause of death for youth (Curtin et al., 2022), and anxiety is a known factor in most deaths by suicide (Nepon et al., 2010). Teachers are often the first point of contact for anxious students, but a shortage of counselors in U.S. schools and other systemic barriers prevent widespread access to counseling services (Cratty, 2019). Moreover, identity-based anxieties are often misattributed to aggression or attention-seeking, and punished in school settings, instead of recognized and supported …

The Effects Of Variations In Light And Nutrient Availability On Phytoplankton And Zooplankton, Jake Anthony Swanson

Theses and Dissertations

Aquatic ecosystems experience a wide range of variation in resource availability; two of the resources that are most essential to phytoplankton and zooplankton are light and nutrients. Light can vary in both its color and intensity; these variations can directly impact phytoplankton by altering the amount and color of light available for photosynthesis. Nutrient variability, particularly increases in nutrient levels, also alter phytoplankton communities by favoring the growth of certain taxa such as cyanobacteria.

To understand whether phytoplankton respond differently to changes in light availability I investigated whether the diversification of cryptophytes, phytoplankton with diverse light-capturing pigments, showed evidence of …

Where Race Has No Place: English Teachers’ Efforts To Maintain Space For Diversity In The Ela Classroom, Muzical D. Waite

Theses and Dissertations

The anti-critical race theory movement began in 2020, propelled by the fear of topics on race and racism overtaking lesson objectives, course content, and class discussion, and, in turn, making some students feel uncomfortable (Duhaney, 2022). Opposition to critical race theory (CRT) and any initiative considered adjacent to the concept, such as the promotion of diversity, equity, and inclusion, set in motion legislative proposals in nearly every state and enactment in many (Greene, 2022). Anti- CRT regulation of the content and activities teachers can use comes at a time when American student enrollment has never been more diverse (Carrillo, 2022). …

The Hero Within: Developing The Psychological Capital Of First-Generation Students, Mary Elizabeth Sewell

Theses and Dissertations

Psychological capital (PsyCap) is a higher-order construct comprised of four psychological resources: hope, efficacy, resilience, and optimism (HERO), and has been linked to academic achievement and engagement (Hazan Liran & Miller, 2019; Luthans, et al., 2012). Interventions designed to build PsyCap may be particularly helpful for firstgeneration (FG) students who face additional challenges in higher education. This study aimed to: (1) explore differences in PsyCap among FG and continuing generation (CG) students; (2) investigate relationships between PsyCap, GPA, and persistence; and (3) examine the impact of a 2-hour PsyCap micro-intervention (PCI) on FG students’ academic PsyCap, academic achievement (GPA), and …

Extending The Convolution In Graph Neural Networks To Solve Materials Science And Node Classification Problems, Steph-Yves Mike Louis

Theses and Dissertations

The usage of graph to represent one's data in machine learning has grown in popularity in both academia and the industry due to its inherent benefits. With its flexible nature and immediate translation to real life observed objects, graph representation had a considerable contribution in advancing the state-of-the-art performance of machine learning in materials.

In this dissertation proposal, we discuss how machines can learn from graph encoded data and provide excellent results through graph neural networks (GNN). Notably, we focus our adaptation of graph neural networks on three tasks: predicting crystal materials properties, nullifying the negative impact of inferior graph …

Feasibility Of A Parent-Focused, Stress Management Intervention To Decrease Adolescent Bmi, Reduce Stress, And Increase Well-Being Among African American Families, Colby J. Kipp

Theses and Dissertations

African American adolescents in the United States experience a higher prevalence of obesity as compared to their White counterparts. This health inequity presents a public health concern as consequences of weight-related chronic diseases often persist into adulthood and are increasingly problematic. As chronic stress has been found to be higher among African American youth compared to White adolescents, it presents as a potential barrier to participation for African American families in health promotion interventions. Additionally, it may be beneficial to target stress in health promotion programs as a modifiable factor in conjunction with health behaviors that may improve outcomes related …

Streamwise And Vertical Dispersal Of Tracer Stones From A Continuously Supplied Source, Amanda Grace Balkus

Theses and Dissertations

Individual movement of sediment grains is oftentimes studied with the use of tracer stones. Studies performed both in the field, in the laboratory and with numerical models involve installing a patch of stones (tracers) on the bed surface and rarely deep in the deposit. Once installed, particle displacement is monitored over time scales varying from one flood to several years. These studies are useful, for example, to study bedload transport dynamics, understand contaminant fate and transport as well as to identify and define stream restoration practices (e.g. quality of fish habitat). Here we use a vertically continuous model to study …

Automated Fiber Placement Through Thickness Defect Stacking Optimization, Noah Christopher Swingle

Theses and Dissertations

In its 2022 commercial market outlook, Boeing forecasted an 80% increase in the global fleet through 2041 compared to 2019 pre-pandemic levels. This sharp rise in demand will drive pressure onto airframe manufacturers to ramp up production and find more efficient ways to design and manufacture airplanes. Complicating this challenge is the industry’s recent transformation from traditional metal-based airframes towards hybrid composite-metal aircraft. While composites have been used in aviation for decades, aircraft manufacturers are still struggling to design and manufacture quality parts at a high rate. Automated Fiber Placement (AFP) is one of the main manufacturing techniques used to …

Development Of Atomistic Machine Learning Approaches For Thermal Properties Of Multi-Component Solids And Liquids, Alejandro David Rodriguez

Theses and Dissertations

Currently, heat transfer in many industries is the limiting factor for innovation, especially in the energy sector. For example, maximizing thermal conductivity of ceramic coatings in power plant devices improves the overall electrical to thermal energy ratio, whereas minimizing thermal conductivity is required for desirable heat-to-electricity conversion in thermoelectric devices. As such, rapid discovery of new materials with extreme thermal conductivity values is quintessential for the near-future deployment of current and developing energy applications.

The vibrational properties of crystalline materials are essential for their ability to conduct heat. Fundamentally, the restorative atomic forces of displaced atoms are sufficient to represent …

Evaluating The Use And Performance Of Marine Protected Areas To Conserve Reef Fish Biodiversity In The Caribbean, Mathias Tjarko Cramer

Theses and Dissertations

Reef fishes are an integral part of life in the Caribbean, fulfilling essential roles in their native marine ecosystems and the many human communities that neighbor them. Perhaps most directly to humans, reef fishes and their fisheries are an essential source of dietary protein, and further support local human communities through employment opportunities. More indirectly, reef fishes fulfill numerous ecological roles that help maintain their native reef ecosystems, which, in turn, confer benefits to humans. For example, a recent analysis estimated that every square kilometer of coral reef generates an average annual income of $473,000 (USD), which would represent 23 …

An Exploratory Study Of The Impact Of Quality Management Practices On Data Integrity Fda-483 Observations Received By Pharmaceutical Manufacturers In Florida, Sarah Mary Christie

Theses and Dissertations

Quality management systems and regulatory compliance have been studied in academic and practitioner settings (Andersson et al., 2006; Beattie & Sohal, 1999; Berrouiguet, 2013; McDowall & Ratcliff, 2016; Unger, 2019; Wechsler, 2019). While research has been performed on both topics independently, there has not been a definitive analysis of the relationship between quality management practices and regulatory compliance, especially in an FDA-regulated manufacturing environment. This research study attempts to link quality management practices and regulatory compliance and provides valuable insights for working managers on the practitioner level.