Digital Commons Network^™

A Method For Single-Particle Magnetic Particle Spectroscopy With A Nanofabricated Coplanar Stripline, Jacob Martin

Theses and Dissertations

Drawing from magnetic particle imaging principles, magnetic particle spectroscopy (MPS) serves as a valuable tool employing superparamagnetic iron-oxide nanoparticles (SPIONs) in diverse applications ranging from medical imaging to biosensing and the comprehensive study of magnetic particles’ characteristics. MPS leverages the nonlinear response exhibited by SPIONs when a external magnetic field is applied, enabling a highly sensitive method for examining biological systems and more. However, conventional MPS setups demand a high particle concentration of approximately 10^15 particles per liter to generate a detectable response. The first objective of this work is to simulate the dynamics of a system with the ability …

The Role Of Insulin Signaling In Controlling Oogenesis In Drosophila Melanogaster, Tancia W. Bradshaw

Theses and Dissertations

Adult stem cell activity responds to organismal nutrient status to maintain and support tissue homeostasis. Despite the intricate relationship between dietary input, adipose tissue and peripheral organ function, we are at the tip of the iceberg regarding our understanding of the cellular and molecular mechanisms underlying adipose communication to other tissues. The Drosophila ovary receives nutritional signals from the fat body with multiple nutrient-sensing pathways functioning in adipocytes to control distinct stages of oogenesis. Insulin/insulin-like growth factor signaling (IIS) within adult adipocytes remotely controls oocyte production at distinct stages of oogenesis. The PI3K/Akt1 axis in adipocytes promotes germline stem cell …

My Journey Toward A Culturally Relevant Music Pedagogy, Adam Michael Steele

Theses and Dissertations

In this study I utilized critical autoethnography to examine my role as a White, male implementing Culturally Relevant Pedagogy (CRP) in an early childhood music classrooms. Five research questions were posed: (a) In what ways does White supremacy appear in an elementary music school curriculum? (b) What curricular transformations occur when I, as a White teacher, seek to make my curriculum more relevant to students of Color? (c) What dispositional transformations occur when I, as a White teacher, seek to make my music curriculum more relevant to students of Color? (d) What happens when students of Color engage in a …

Counter-Stories From Former Foster Youth: College Graduates Disrupting The Dominant Narrative, Amanda May Moon

Theses and Dissertations

In the past decade, research on children in foster care or adults with foster care backgrounds has begun to explore factors that contributed to successful trajectories. Little work has been done, however, on factors that can be controlled, such as resources and support offered by K-12 schools, or for K-12 schooling. In this qualitative study, I explored the beliefs and perceptions of former foster youth college graduates about the impact of K-12 experiences on their academic and life trajectories. After surveying and interviewing five former foster youth college graduates, I used narrative analysis to understand the impact of their K-12 …

Impact Of The Engineering Design Process On Rural Female Students’ Achievement And Self-Efficacy, Whitney Lowery Oberndorf

Theses and Dissertations

Nearly one-fifth of U.S. children attend rural schools; however, these students have fewer opportunities for high-quality STEM learning. Rural students are also less likely to attend college and less likely to enroll in STEM majors than their urban and suburban peers. In conjunction with these factors, female students are also less likely to pursue STEM degrees and work in STEM fields. Broadening access and exposure to these areas, as well as improving female perceptions about STEM fields, is critical to closing the gap. This mixed-methods action research study was an effort to increase female achievement and self-efficacy in science and …

Adapting Deep Learning Techniques For Geologic Investigations Of Hydrothermal Venting At Seafloor Spreading Ridges Using Auv Surveys, Isaac Keohane

Theses and Dissertations

Locating hydrothermal chimney sites unlocks research into their correlations with geology, lithospheric cooling, and deep-sea biogeography at seafloor spreading ridges. High-resolution bathymetry and sidescan sonar collected by Automated Underwater Vehicles allows for chimneys, only a few meters wide and tall, and fissures, only a few meters wide, to be resolved across large areas (>100 km2). We developed a Chimney Identification Tool (CIT) that utilizes a Convolutional Neural Network (CNN), a Machine-Learning model able to classify based on shapes and textures, to identify chimneys in 1m-gridded bathymetry. We then utilized the CIT to identify many potential off-axis chimney structures at …

The Association Between Symptoms Of Adhd And Alcohol Use And Related Consequences In College Students: Social And Environmental Protective And Risk Factors As Moderators Of This Relation, Cameron Shepard Massey

Theses and Dissertations

Alcohol use, while common in college student populations, can bring about significant mental health and educational problems that have negative consequences (Harris et al., 2017; White & Hingson, 2013). Attention-deficit/hyperactivity disorder (ADHD) can also result in significant impairment in academic settings (Kuriyan et al., 2012; Blase et al., 2009, Barbaresi et al., 2007), and those with ADHD often show increased rates of alcohol consumption and related problems, which can greatly increase the risk for students to struggle in college (Barbaresi et al., 2013; Baker et al., 2012). Examining the impact that specific risk and protective factors play in this relation …

Examination And Application Of Body Condition Methods In Cetaceans, Kira Anne Telford

Theses and Dissertations

Body condition assessments are a valuable tool for evaluating the relative health of a population through various metrics, indexes, or proxies. Long-term data collection can be used to examine the relationship between fluctuations in body condition and natural or anthropogenic drivers. Application of this information is vital for monitoring the success of the conservation management decisions for a species or population. Cetaceans have a variety of methods available to assess body condition, including invasive methods like biopsies and necropsies or observational methods such as photogrammetry. Exploration of the application of these methods in the literature revealed an emphasis on necropsies …

Sustained Attention And Object Manipulation In Autism Spectrum Disorder, Alexis Federico

Theses and Dissertations

Infants interact with their environment from the moment they are born. These interactions can assist in shaping a child’s development, including the skills they gain. Object manipulation has been specifically associated with numerous important outcomes in childhood, such as cognitive skills, motor skills, and language skills. This study aims to characterize object manipulation behaviors at 9 months of age between infants who are at an elevated genetic likelihood for ASD and infants who have no family history of ASD. This study also investigates associations between object manipulation behaviors and a biological measure of attention in both participant groups. While differences …

Bohuslav Martinů’S Eight Preludes For Piano H. 181: Style Analysis And Pedagogical Approaches In Piano Performance, Jinkyung Kim

Theses and Dissertations

This treatise delves into Bohuslav Martinů’s Eight Preludes for Piano H. 181, offering a comprehensive exploration of the twentieth-century Czech composer’s life; discussing his compositional significance; analyzing the style of his Eight Preludes using the framework of Sound, Harmony, Melody, Rhythm, and Growth (SHMRG); and suggesting pedagogical approaches for advanced piano learners. The study examines Martinů’s life and the socio-cultural influences that shaped his artistic language. His compositional journey, combining elements of Czech folk music with Parisian influences of impressionism, neoclassicism, and jazz, illustrates his versatility and ingenuity. Through the SHMRG framework by Jan LaRue, the style analysis of Eight …

Deep Learning For Studying Materials Stability And Solving Thermodynamically Consistent Pdes With Dynamic Boundary Conditions In Arbitrary Domains, Chunyan Li

Theses and Dissertations

Deep learning has achieved remarkable success in various fields, including image processing, natural language processing, and signal processing, ushering in a transformative era in research and real-life applications. This rise underscores the transformative capabilities of deep learning, with its innovative approach to function approximation. Traditionally, approximation theory relied on additive constructions, but deep neural networks have introduced a compositional approach, reshaping the landscape of function approximation. This thesis explores the efficacy of this compositional construction within the realm of material science and the solution of thermodynamically consistent partial differential equations with thermodynamically consistent dynamic boundary conditions in arbitrary domains. As …

Antimicrobial Polymers And Small Molecules From Multicyclic Compounds And Engineering Of Sustainable Polymers, Leman Buzoglu Kurnaz

Theses and Dissertations

In this dissertation, the synthesis of polymers and small molecules from multicyclic compounds and the development of sustainable polymers from renewable feedstock were investigated. The antimicrobial biomaterials and sustainable polymers were characterized and their properties were discussed. In Chapter 1, the overall background and recent developments of antimicrobial biomaterials and their application were discussed. Later, sustainable polymers from renewable biomass and their synthesis methods were given. Afterward, the main research objectives of this doctoral research study were described. In Chapter 2, the synthesis of multiple charged small molecules from multicyclic compounds was discussed. These compounds were obtained by using various …

The Use Of Project-Based Learning To Scaffold Student Social And Emotional Learning Skill Development, Science Identity, And Science Self-Efficacy, Michelle Sutton Spigner

Theses and Dissertations

Project-based learning (PBL) offers an ideal approach for cultivating a robust STEM workforce, empowering students to actively construct their knowledge. This process has the potential to enhance science identity and self-efficacy. Furthermore, because PBL is inherently collaborative, it fosters the development of 21st-century skills, many of which align with social and emotional learning (SEL). While past studies have explored the relationship between PBL, SEL, science identity, and self-efficacy, there is a research gap in examining all three variables collectively within a high school context. Thus, this mixed-methods action research study aimed to determine if the implementation of a PBL unit, …

From Oceans To Public Health: Impact Of Climate Change And Socioecological Factors On Non-Cholera Vibrio Spp., Karlen Enid Correa Vélez

Theses and Dissertations

Climate change-induced stressors, such as temperature, salinity, pH, and wildfire, are contributing factors to the increase in frequency of Vibrio infections, altering Vibrio geographical constraints. At the same time, the expansion of the coastal population is resulting in increased input of treated municipal wastewater into areas that are also experiencing Vibrio proliferation. Given that increases in ocean temperature and sea level coupled with increases in human activity in coastal waters support greater Vibrio-human interactions, it is important to examine factors and mechanisms within this socio-ecological coupled system that may further strengthen this interaction. This study aimed to better understand the …

Structural, Functional And Biochemical Studies To Elucidate The Molecular Basis Of Xenobiotic Metabolism Of Tetranychus Uritcae, A Major Agricultural Pest, Ricardo Hernandez Arriaza

Theses and Dissertations

The two-spotted spider mite, Tetranychus urticae, is a major cosmopolitan pest that feeds on more than 1,100 plant species, including 150 crops. Such a wide host range indicates this mite’s unparalleled xenobiotic responsiveness that is also coincident with their ability to rapidly develop resistance to pesticides. An unprecedently large detoxifying machinery is one of the main biological traits responsible for their extraordinary adaptation potential and devastating effect on crops. Availability of the whole genome sequence revealed expansions in all major detoxifying families and demonstrated that this genome has been enriched by horizontally transferred genes from bacteria and fungi. Motivated by …

A User Needs Assessment For Snowvision/World Engraved, Sam Toren Mcdorman

Theses and Dissertations

Paddle stamped pottery has a long history in what we now call the southeastern United States. From 100-800 CE, intricate curvilinear designs were carved into paddles and impressed in ceramic vessels in Georgia, Florida, Alabama, Tennessee, and South Carolina. Called Swift Creek Complicated Stamped, this type has been long recognized by archaeologists for its uniqueness. Artists Bettye J. Broyles and Frankie Snow reconstructed hundreds of paddle designs from sherds and modern archaeologists use these designs to study the movements and connections of the people who made the pottery. The Snowvision team has developed a machine learning computer vision algorithm to …

Broken Bottles: Understanding The Relationship Between Alcohol Outlet Availability And The Proximity To Alcohol Outlets With Binge Drinking Behaviors In College Fraternity Men At Southeastern Public Universities, Jarod Alan Holt

Theses and Dissertations

Alcohol use among fraternity affiliated men presents a concerning trend with harmful consequences (DeSimone, 2009; Hingson et al., 2017; McCreary et al., 2021; Nuwer, 2001; Patrick et al., 2022; Ranker & Lipson, 2022). The availability theory of alcohol-related problems suggests alcohol use could be influenced based on the availability and proximity of alcohol outlets in the environment (Dimova, 2023; Kypri et al., 2008; Scribner et al., 2008; Single, 1984; Weitzmann et al., 2003). However, no existing studies of fraternity-affiliated students have examined the relationship of binge drinking and access to alcohol through alcohol outlet availability or proximity. This study examined …

The Effect Of Instructionally Embedded Cognitive Reframing On Students’ Self-Beliefs Of Their Mathematical Competence, Kelly Eyre Frazee

Theses and Dissertations

Many students lack the ability to maintain positive perceptions of their mathematical self-belief, resulting in undesirable social, emotional, and academic outcomes. The purpose of this study was to investigate the impact of a cognitive reframing strategy on third and fourth grade math intervention students’ perceptions of their mathematical competence. This study sought to understand the impact of this emotional regulation strategy on students’ ability to autonomously regulate their negative or irrational thoughts related to their mathematics abilities, as well as the impact on their self-beliefs. Data for this study were collected through semi-structured interviews with students, student reflections, and researcher …

Pursuing Culturally Responsive Math Teaching By Secondary Math Educators: A Professional Development Action Research Study, Emily Bell Redding

Theses and Dissertations

This action research study examines the use of professional development to build the self-efficacy of secondary math teachers in culturally responsive mathematics teaching (CRMT), with the hope to address achievement gaps of Black and Hispanic students. Seven math teachers from a school division in Southwest Virginia participated in a 9-week professional development that included virtual meetings to learn about CRMT, collaboration with colleagues, classroom applications, and self-reflection. Quantitative and qualitative data were collected throughout the 9 weeks in the forms of questionnaires, meeting transcripts, and reflection journals. The research study results found the professional development to build teacher self-efficacy, especially …

Infection Intensity And Prevalence From Perkinsus Marinus In The Eastern Oyster, Crassostrea Virginica (Gmelin 1791) And Their Association With Salinity, Temperature, And Sex In South Carolina Estuaries, Deja E. Best

Theses and Dissertations

This project aimed to identify the associations between the infection intensity and prevalence of Perkinsus marinus infection (i.e., Dermo ) in the Eastern oyster, Crassostrea virginica (Gmelin), with extrinsic environmental factors such as changes in salinity and temperature along with oyster host factors such as sex ratio. The objectives of the study were to: (1) identify significant associations between the dependent variables, P. marinus prevalence and infection intensity, in relation to salinity and water temperature which may be affected by climate change; and (2) identify any intrinsic factors related to sex (i.e., male, female, intersex, and indeterminant) that may affect …

Replenishment Of Essential Natural Resources: An Assessment Of The Ability Of Freshwater Algae To Enhance Crop Quality And Soil Health, Lala Christina Ek

Theses and Dissertations

Disregard for soil, an essential natural resource, hinders global food production. Food insecurity is a major concern for both public health officials and environmental scientists due to soil quality decline, pollution, and climate change. Alternatives or targeted additions to chemical fertilizers can bolster soil quality, improve crop yields, lengthen crop shelf life, and mitigate environmental pollution. One potential alternative to chemical fertilizers is replacement of them with biological soil amendments, including algae, to enhance crop growth and improve soil health. Research was conducted at the University of South Carolina-Columbia campus garden to determine impacts of non-toxic freshwater algae on crop …

Structure V-1: A Mississippian Mica Workshop In Kershaw County, South Carolina, John Mclellan Dodge

Theses and Dissertations

This thesis reanalyzes the pottery assemblage of Structure V-1 at the Mulberry site (38KE12). Because Structure V-1 was originally hypothesized to be evidence of a late seventeenth century occupation at the Mulberry site, the framework I use for this research focuses on identifying evidence of community coalescence after Mulberry’s initial occupation ended. However, new evidence from both the pottery and radiocarbon analysis conclusively dates the structure to around the sixteenth century Mulberry I phase. With that new date in mind, I explore the role mica craft production within Structure V-1 might have had in linking the community at Mulberry to …

Dietary Inflammatory Index During Pregnancy And Changes Over Time: Associations With Post-Partum Sleep Duration And Quality And Depressive Symptoms., Nowrin Tamanna

Theses and Dissertations

STUDY OBJECTIVES: Sleep and mental health are two important factors for a new mother, as adequate sleep and a healthy mind help her prioritize self-care, seek support when needed, and create a nurturing environment for both her and her baby. Among various plausible theories exploring the etiology of sleep disturbances and depression, the concept of inflammation is gaining attention. This study examined the hypothesis that more pro-inflammatory diets during pregnancy are associated with a decrease in sleep quality and duration, abnormal sleep timing and higher Edinburg Postnatal depression score (EPDS) scores 6 months and 12 months post-partum.

METHODS: A secondary …

Correlates Of Immunization Timeliness In Three South Asian Countries: Secondary Analysis Of Demographic And Health Surveys, Tanzir Ahmed Shuvo

Theses and Dissertations

Despite the availability of effective vaccines, 1.5 million children under the age of 5 years die every year because of vaccine preventable diseases. Improvements in vaccine delivery infrastructure have resulted in relatively high coverage of vaccines, but many children are not receiving their vaccines on a timely basis. Timely administration of routine vaccines recommended by the Expanded Programme on Immunization (EPI) ensures maximum efficacy. It is vital to explore rates of vaccination timeliness and the correlates of timely vaccination among children to design targeted interventions for improving both coverage and timeliness. We conducted a secondary data analysis of the Demographic …

The Effect Of Antibiotics On Immune Cell Infiltration Of Colon In A Mouse Model Of Early Onset Colorectal Cancer, Valerie Hinsch

Theses and Dissertations

Early onset colorectal cancer (EOCRC) is an aggressive form of colorectal cancer diagnosed before the age of 50. While colorectal cancer cases in patients 50 years and older have been declining, EOCRC cases have been steadily increasing globally in the last few decades, and the cause is unknown. Many agents, called exposomes, have been associated with EOCRC based on their emergence and prevalence prior to and in parallel with the rise in EOCRC cases. Among these are antibiotics (Abx). Abx are indispensable in our fight against infectious diseases, however their overuse is becoming a global epidemic. They are prescribed globally, …

Dephosphorylation Of Mpk6 And Mpk3 By Phosphatases Modulates Responses To Herbivory In Arabidopsis, Claire Teresa Hann

Theses and Dissertations

As sessile organisms, plants rely on extracellular signals and chemical responses to defend against stressors. Extracellular stress signals inducing defense responses originate both from biotic or abiotic threats, and from products of tissue damage or hormones. In defense against herbivores, essential responses include rapid generation of jasmonic acid (JA) at the wound site, followed by the global expression of genes that impede digestion and growth. Early defense gene expression amplifies JA production, while later JA-responsive gene expression causes the accumulation of defense products. MAP kinase (MAPK) pathways play a central role in mediating the perception of self, non-self, and hormonal …

Floodplain And In-Channel Sedimentation In The Bedrock Congaree River, Sc, Mahsa Ahmadpoor

Theses and Dissertations

The Congaree River planform is characterized by an abrupt increase in channel sinuosity in the downstream direction. Such a change is not typical of alluvial meandering rivers but has been observed in mixed bedrock-alluvial rivers. This motivated the first study of this dissertation, specifically designed to determine if the Congaree River is indeed a mixed bedrock-alluvial river in its low sinuosity (upstream) reach. To test this hypothesis, sonar-based measurements of channel bed and sublayer elevation were performed from Columbia to the Congaree River-Wateree River confluence. The sublayer is here defined as the first surface visible in the sonar measurements underneath …

Particle-Free High Spatial Resolution Velocimetry For Slip Flow Detection, Malhar Prasad Joshi

Theses and Dissertations

Microfluidic systems have a wide range of applications, including biomedical devices, lab-on-a-chip technologies, and aerospace propulsion. Understanding and quantifying the slip flow phenomenon in these microscale and nanoscale channels is of paramount importance for precise control and optimization of fluidic processes. Our study presents a novel approach to directly measure the velocities in a microchannel using Laser Induced Fluorescence Photobleaching Anemometer (LIFPA) and Travel Time After Photobleaching Velocimetry (TTAPV). In this experimental study, microchannels with micrometer dimensions were used, and slip flow conditions controlled. The LIFPA-TTAPV approach was applied to measure slip velocities in the near wall regime, providing accurate …

Exploring The Assembly Of Soluble Triphenylamine Bis-Urea Macrocycles; Synthesis Of Nsc243928 Derivatives For Triple-Negative Breast Cancer Treatment, Rahul Prakash

Theses and Dissertations

This dissertation is divided into two topics: I. Supramolecular polymerization of triphenylamine (TPA) bis-urea macrocycle behavior in solution, and II. Synthesis of fluorophore appended and biotinylated derivatives of NSC243928 for the treatment of triple-negative breast cancer. Supramolecular polymers are of interest due to their self-healing and stimuli responsiveness. Chapter 1 gives a brief overview of the importance of self-assembly to construct ordered structures from smaller building blocks, highlighting the mechanisms of self-assembly to form supramolecular polymers. The bis-urea macrocycle assembly unit is introduced and its assembly into tubular structures and crystals is highlighted, which are used as a control for …

Weathering The Covid-19 Pandemic: A Study Examining How The Lived Experience Affected English Learners, Mary Kathryn Maxwell

Theses and Dissertations

The COVID-19 pandemic profoundly impacted many students, especially the English learners who require specialized instruction and additional support to develop English language proficiency. This study examines how the pandemic created barriers that caused a decline in the academic achievement and engagement in the learning process of sixth-eighth grade English learners in an urban district in Ohio. In this mixed-methods study, using an explanatory sequential research design, quantitative data were collected through an online Likert survey while qualitative data were gathered from semi-structured interviews, artifacts, and researcher field notes. A total of 21 participants completed the survey and interviews. The merged …