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Metal Free Multicomponent C-C And C-N Bond Formation Via Cross – Coupling And Cross – Dehydrogenative Coupling Methodologies For The Synthesis Of Diversely Functionalized N – And O – Heterocyclic Compounds, Reicha Pandey Ms

Theses and Dissertations

Heterocyclic compound is a significant domain of organic chemistry that focuses with synthetic, design and characteristics. This molecule is characterized by ring structure including one or more atom of an elements other than carbon (C), typically nitrogen (N), Oxygen (O) or Sulphur (S). The synthesis of heterocyclic compound via sustainable strategy encompasses various approaches such as design and implementation of real time analysis aimed at pollution prevention. It demonstrates wide range of medicinal application by showing various activities such as anticancer, anti-inflammatory, anti-microbial and many more. Additionally, many functional materials including dye, polymers etc. are the other application of heterocyclic …

Development Of Salinomycin Analogs As Potential Anti-Cancer Agents, Pavan Goud Juluri

Theses and Dissertations

Salinomycin, a poly-ionophore antibiotic originally isolated from Streptomyces albus, exhibits antimicrobial activity against Gram-positive bacteria. Over the years Salinomycin has been studied in the effects it has on cancer, specifically cancer stem cells. Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. Inhibiting PARP has been explored as a strategy in cancer treatment, particularly in cancers with defective DNA repair mechanisms, such as those with BRCA mutations. The benzo-thiazoles, and -imidazoles are identified as inhibitor scaffolds, which compete with nicotinamide in the binding pocket of human poly- and mono-ADP-ribosylating enzymes. Benzothiazole, and benzimidazole based compounds particularly with modification at …

Topological Data Analysis Of New York City Taxi Trip Data Using Advanced Dimensionality Reduction And Clustering Techniques – Uncovering Structure And Timeliness, Mahalakshmi Sakthivel

Theses and Dissertations

In this project, we used Topological Data Analysis (TDA) to explore the shape and structure of high-dimensional data and the timeliness dimension of information quality through topological data analysis, with the long-term goal of automatically computing timeliness values that reflect how useful data items are for decision making. The project followed a two-phase approach: in the first half, we employed the Kepler Mapper library along with techniques like Principal Component Analysis (PCA), Uniform Manifold Approximation and Projection (UMAP), T-SNE (t-Distributed Stochastic Neighbor Embedding) and Customized Embedding to analyze and visualize complex datasets. In the second phase, we specifically applied our …

Comparative Evolution Of Caenorhabditis Hermaphrodites, James Francis Kennedy

Theses and Dissertations

The Caenorhabditis genus produced three independently-evolved hermaphroditic species, C. elegans, C. briggsae, and C. tropicalis. This convergence happened by the independent co-option of male programs for use in a female body. This required two distinct steps: (1) mutations in the sex-determination pathway that activated spermatogenesis in XX animals, and (2) mutations that expressed one of the redundant sperm activation signals in XX animals. My project focused on characterizing how sex-determination genes work in C. briggsae and C. tropicalis. Loss-of-function alleles were used to compare the core sex-determination pathway to that of C. elegans. I found that the somatic sex-determination pathway …

Densest Subgraph Discovery On The Cpu, Hunter Gerard Gareau

Theses and Dissertations

The Densest Subgraph Discovery (DSD) problem is a prevalent problem in the field of graph mining, aiming to find the cohesive subgraph. Given a graph �� = (��,��) and an integer �� ≥ 2, the goal is to find a vertex sub- set �� ⊆ �� whose induced subgraph �� (��) maximizes the ��-clique density, defined as the number of ��-cliques per vertex. Larger val- ues of �� capture higher-order connectivity patterns beyond edges, enabling the discovery of more cohesive structures. There have been many solutions to this problem. However, one avenue that other graph mining problems have gone down …

Acoustic Analysis Of Prosodic Speech Pause In Autistic And Neurotypical Adults, Rachel Johnson

Theses and Dissertations

The purpose of this study is to examine prosodic speech pause across two groups: neurotypical and autistic young adults. Conversational speech samples were collected from 11 neurotypical and 11 autistic young adults between the ages of 18 and 26. Speech samples were subsequently transcribed and analyzed using Praat Software. The boundaries of between- and within-utterance pauses were identified, as well as acoustically determining if the pause was filled, silent, or a combination of both. Results found a significant difference in the frequency of pauses as a function of location, pause type, and neurological status. As expected, combination pauses were the …

The West And The Rest: Misplaced Blame Of Underdevelopment, Rana R. Abadeer

Theses and Dissertations

This paper will discuss the link between the history of colonialism and the genesis and evolution of International Law and in turn the role played by this relationship to maintain it, directly or indirectly, to our current day. The blame of underdevelopment is often misplaced, and its responsibility falls on the Global South for their inability to follow the same momentum of development as the Global North. Nevertheless, the aim of this paper is to prove that this blame of underdevelopment given its original reasons should be placed elsewhere. With that, the discussion of where the blame should be is …

The Role Of Exotic Plants In The Diet Of Black-And-White Colobus Monkeys (Colobus Guereza) In Kibale National Park, Uganda, Michelle Gaykov

Theses and Dissertations

Exotic plants have both positive and negative impacts on their environment. They may act as additional food sources for the local fauna or as competition for local flora or leading to changes within a landscape or ecosystem. To considere the role of exotics in primate diet, this study focused on the dietary role of exotic plant species in the diet of a leaf-eating foregut fermenting monkey, the black-and-white colobus monkeys (Colobus guereza) in Kibale National Park, Uganda. Int this study, I followed individuals in two groups of black-and-white colobus monkeys for 21 days recording their food intake (0700-1900). I also …

O Esqueleto De Um Romance, Lanna Leite

Theses and Dissertations

In O Esqueleto de um Romance: The Film (2025), a Berlin legal dispute between a mayor and evangelicals sparks filmmaker Lanna Leite’s reflection on faith, memory, and belief. Using archival, 16mm, and 8mm footage, the experimental film frames filmmaking as an ephemeral, performative practice resisting closure and conventional narrative finality.

Qualitative Exploration Of Hallucinations Among Adolescents With Suicide Ideation And/Or Attempts, Rebecca E. Lewis

Theses and Dissertations

A qualitative study exploring and characterizing how psychotic experiences (PEs), specifically hallucinations, may affect suicidal behaviors in adolescents. Thematic analysis revealed eight key themes within the connection, capturing unique perspectives and nuanced meanings. Exploring this intersection may increase the understanding of adolescent PEs and help inform more targeted interventions.

Structural Characterization Of Peptide Nanoaggregates At Varying Concentrations And Their Impact On Cellular Responses, Malika Rozmetova

Theses and Dissertations

Peptide nano-assemblies can regulate cellular pathways in a structure-dependent manner. Here, we show that the enzyme-responsive peptide NapFFK(NBD)Yp forms distinct nanoscale assemblies at different concentrations, triggering differential ER stress and extracellular vesicle release in MDA-MB231 cells. These results highlight the importance of supramolecular organization in peptide–cell interactions.

"The Very Milk And Sperm Of Kindness": Democratic Pleasures And Echoes Of Intimacy In Moby-Dick And Absalom, Absalom!, Nicholas Profeta

Theses and Dissertations

This paper examines homosocial relationships in Moby-Dick and Absalom, Absalom! to evaluate the ways male bonds have transformed between the nineteenth and twentieth centuries, and how these relationships comment on the strength and possibilities of American democracy. I argue that Melville’s novel presents a utopian vision of America defined by democratic bonds developed through labor and homoerotic intimacy that cut across racial lines and melt individual identities, while Faulkner’s novel reflects many of those imagined possibilities, only to see them wither away under the weight of racial divisions. Ishmael and the crew of the Pequod embrace this erasing of self, …

Capturing The Spirit Of Childhood: An Analysis Of Robert Henri’S Portraits Of Children, Alex C. Maccaro

Theses and Dissertations

Robert Henri (1865-1929) is perhaps best known as the prominent leader of the turn-of-the century American movement The Eight, commonly known as “the Ashcan School,” and as a leading teacher in the United States during the early twentieth century. However, his artistic output as a portrait painter, particularly of children, is also significant. Beginning in 1904 and throughout his career as an artist, Henri painted hundreds of images of children in the various foreign or remote locales to which he traveled, often depicting the same subject in multiple instances. These portraits range from the roughly painted, rosy-cheeked Dutch youth of …

Anticancer Efficacy Of Methyl-Cantharidimide (Mca) In Liver Cancer, Yidong Li

Theses and Dissertations

Cancer is still one of the major public health challenges worldwide to the present day. Multi-drug resistance (MDR) that occurs in cancer chemotherapies is a non-negligible cause of cancer treatment failure and tumor recurrence. Overexpression of ATP-binding cassette (ABC) transporters is one of the most frequent mechanisms of MDR occurrence. Therefore, the establishment of a chemotherapy agent whose anticancer efficacy would not be affected by the overexpression of ABC transporters is in demand. Methyl-cantharidimide (MCA), a cantharidin (CTD) analog, has been approved in China for clinical liver cancer treatment. This study revealed that MCA was efficacious in the ABCB1-, ABCG2-mediated …

Evaluation Of The Mechanism Of Cell Death After Exposure To Amorphous Silicon Dioxide Nanoparticles In Rat Pleural Mesothelial Cells And Golden Syrian Hamsters, Rachel P. Renda

Theses and Dissertations

Amorphous Silicon Dioxide Nanoparticles (SiO2 NPs) are widely used in the industrial processes, chemical, and cosmetics industries. Amorphous SiO2 NPs are abundant in the earth’s crust and can be released into the air through industrial and manufacturing activities. Such particles are overlooked and not as commonly studied when compared to their crystalline counterpart. Amorphous SiO2 NPs are pulmonary toxicants; however, the mechanism of toxicity is uncertain. In the current study, toxicity was assessed using both in vitro and in vivo systems to understand a possible mechanism of cell death. Rat Pleural Mesothelial Cells (RPMCs) were exposed to 50-800 μg/ml SiO2 …

Utilizing A Genetically Diverse Species To Investigate Gene-Drug Interactions And Drug Efficacy, Jerry Nawongbay Gbarlea

Theses and Dissertations

Gene-drug interactions are fundamental to understanding variability in drug response and therapeutic efficacy. In this project, we leverage the natural genetic divergence between ecotype morphs of the blind Mexican cavefish (Astyanax mexicanus) to investigate differential responses to neuroactive compounds—specifically, the convulsant pentylenetetrazol (PTZ) and the anxiolytic Buspirone Hydrochloride. Astyanax Mexicanus is a tetra species consisting of both surface-dwelling (ancestral) and cave-dwelling (mutant) populations that have highly variable genetic backgrounds. Independently evolved populations of cavefish exhibit a suite of convergent traits that can be functionally interrogated to discover new genetic functions and interactions. These attributes make A. mexicanus an ideal model …

Deconstructing Shifting Narratives: Critical Discourse Analysis Of Terminology Trends In Unfpa’S State Of World Population Reports (1978-2024), Naqib A. Noory

Theses and Dissertations

Rooted in both scholarly inquiry and lived experience in global development, this study explored how language shapes power, inclusion, and representation. It analyzed the evolution of population and development discourse in UNFPA’s State of World Population reports (1978–2024) using Fairclough’s Level 1 Critical Discourse Analysis framework. Giddens’ Structuration Theory provided a broader lens linking linguistic change to the interaction between institutional structures and human agency. A theory-based coding framework, drawing on Malthusian, Senian, Spivakian, and MDG/SDG paradigms, guided the analysis of evolving discourse. Findings revealed a layered narrative: earlier scarcity framings persisted beneath newer development language; rights and empowerment rhetoric …

Exploring The Leadership Qualities Of Lgbtq+ School Administrators Through The Prism Of The Developmental Model Of The Closet, Andrew Mcintosh

Theses and Dissertations

This qualitative study explored how LGBTQ+ school administrators perceive the influence of their lived experiences on their leadership qualities. Additionally, this study examined post-closet growth, closet adaptations, and how legal protections influence LGBTQ+ school administrators. A narrative methodology was employed to shed light on the lived experiences of participants. A mix of purposive, convenience, and snowball sampling was used for this study. The researcher recruited school administrators from public school districts and private schools located in the Northeastern United States. School administrators include positions such as assistant principal, principal, assistant superintendent, director, superintendent, and head of school. Eight participants took …

An Exploration Of The Perceptions Of Black Women Leading Interscholastic Sports Programs, Leslie Zeelika Pieters-Klatsky

Theses and Dissertations

The purpose of the study was to examine the perceptions of Black women leading interscholastic sports programs. Prior research examined the underrepresentation of women in sports leadership, but no study has examined prejudice toward the Black woman in an interscholastic sports leadership role. Data were collected through in-depth semi-structured interviews with Black women leading interscholastic athletics, using Kimberlé Crenshaw's intersectionality as a theoretical framework. This study sought to give voice to a select group of women who perceived being barred entry into the white-male-dominated field of interscholastic sports leadership by the Good Old Boys’ Network and the Good Old Girls’ …

Reading Between The Lines: Exploring How Technical High School Teachers Navigate Race And Neurodiversity Through Literacy Practices, Genesis A. Ryant

Theses and Dissertations

This qualitative study employed a hybrid hermeneutic phenomenological design to explore how technical high school teachers experienced and interpreted literacy instruction for Black and Brown neurodivergent students. Grounded in Critical Race Theory (CRT) and Disability Critical Race Theory (DisCrit), the research examined how educators’ perceptions, instructional practices, and collaborative relationships shaped access, equity, and empowerment in career and technical education contexts. Data was collected from seven academic and trade teachers through semi-structured interviews, focus groups, lesson artifacts, and reflective journals. Analysis followed Peoples’ (2020) hermeneutic explication process and Saldaña’s (2021) multi-cycle coding methods, integrating in vivo, process, and axial coding …

In The Wake Of The Anthropocene: The Ecopoetics Of Shakespearean Film Adaptations, Ioannis Garganourakis

Theses and Dissertations

This dissertation explores how Shakespeare’s plays and their film adaptations reflect and respond to the conditions of the Anthropocene, arguing that both forms of art can foster an environmental ethic attuned to the interconnectedness of human and nonhuman worlds. It proposes that the Anthropocene did not begin with industrialization but rather intensified a much older pattern of human ecological intervention, a process that becomes increasingly visible from the early modern period to the twentieth century. By situating Shakespeare within this expanded temporal framework, this dissertation reveals how his works anticipate and interrogate the very assumptions about anthropocentrism that underpin modern …

The Effects Of Youth Extracurricular Involvement On The Home Environment Of Millennial African American Families, Joyce Merius Speed

Theses and Dissertations

This phenomenological qualitative study explored how youth extracurricular involvement shapes the home environments of Millennial African American families. Guided primarily by Ecological Systems Theory, with Critical Race Theory as a complementary lens, the study examined how parents navigated interconnected systems of home, school, peers, and community while responding to racialized barriers embedded in youth programs. Data were collected through semi-structured interviews, observations, and document analysis with six African American mothers. Seven themes emerged: extracurricular activities, family dynamics, parental involvement, academic achievement, social development, cultural identity, and time management. Findings showed that extracurricular participation strengthened family communication, routines, and cohesion; supported …

The Influence Of Social Media On Elementary School Students: The Perceptions Of Administrators And Elementary Educators, Caitlin Krauszer

Theses and Dissertations

Each day, social media applications are downloaded, uploaded, and changed to meet the users' needs utilizing these apps (Tang & Patrick, 2020). With the constant change in social media platforms, utilization of such platforms is increasing daily and students navigating these platforms is occurring at younger ages (Fredrick at el., 2024; Perez-Chada et al., 2023). This study focused on the social, emotional, and academic impacts students are experiencing due to social media use from the perspectives of building administrators and faculty members. This study also investigated the policies in place within a specific school district that address student social media …

The Yeast Checkpoint Kinase Mec1p Functions In Transcription Termination By Facilitating Recruitment Of Pcf11p And Regulating The Torpedo Exonuclease Rat1p, Riddhi Patel

Theses and Dissertations

My dissertation includes two projects, centered on transcription regulation by checkpoint kinases of the DNA damage response (DDR). The first project focused on the role of checkpoint kinase Mec1p in transcription termination and regulation of the torpedo exonuclease Rat1p. Termination, closely linked with pre-mRNA 3’ processing, dissociates RNA polymerase II (RNAPII) from DNA and releases the nascent RNA transcript. Efficient termination is required for maintaining a pool of RNAPII that is available for re-entry into new transcription cycle. Previous results showed that inactivation of Mec1p in the absence of exogenous genotoxic stress downregulates the efficiency of transcription termination. This study …

Biogothic: New Directions In The Haunted Spaces Of Nineteenth Century Gothic Fiction, Jessica Mintzes

Theses and Dissertations

The BioGothic is a set of biological metaphors in nineteenth century Gothic fiction that anticipates our contemporary understanding of what we now think of as biological processes. The BioGothic system in the novel captures the site of connection and interaction between the body and the interior spaces it inhabits. The Gothic genre, from its inception, shifts the focus onto interior spaces and the ways in which architectural spaces and the Gothic body interact with one another. This demonstrates, in part, how physical space and biological matter are not only capable of becoming integrated with each other, but also maintain the …

Metabolic Syndrome Beyond Diagnostic Criteria: Population-Scale Integrative Metabolomics Characterization, Marwa Talal

Theses and Dissertations

Background: Metabolic syndrome (MetS) is a complex cluster of interrelated metabolic abnormalities associated with elevated cardiometabolic risk. While diagnosis is based on well-established five clinical criteria, these may overlook early or atypical metabolic alterations. Large-scale metabolomic profiling offers an opportunity to identify biochemical signatures of MetS beyond diagnostic bias and to evaluate their relative importance across different presentations of the syndrome.

Methods: Data from 117,147 UK Biobank participants were analyzed in a cross-sectional design. High-throughput NMR quantified 75 circulating metabolites, for. Univariate analyses, MetS subtype stratification, and elastic net models with SHAP interpretation were applied to assess feature …

Evaluating Rate Of Perceived Exertion And Heart Rate In High School Weight Training Students For Assessing, Enhancing, And Maintaining Health-Related Fitness, Nicholas Searcy

Theses and Dissertations

This mixed-methods study evaluated the relationship between rating of perceived exertion (RPE) and heart rate (HR) among high school weight-training students during circuit training sessions. The purpose of this study was to determine whether RPE could serve as a practical method for gauging moderate to vigorous physical activity (MVPA) among high school weight-training students while allowing students to assess and enhance their health-related components of fitness. Participants were high school students enrolled in weight-training classes who completed upper- and lower-body circuit training sessions over a 4-week period, or a total of 16 school days. RPE was self-reported using Borg’s CR10 …

Machine Learning For Predicting Prosthetic Limb Movements, Jessica Alexandra Cegarra Arraiz

Theses and Dissertations

This thesis develops and evaluates a deep learning-based prediction model capable of identifying intended limb movement from surfaced electromyography (sEMG) signals using sequence learning techniques. sEMG signals change over time due to multiple factors such as muscle fatigue or user variability. Traditional prosthetics control methods rely on static feature extraction, ignoring how signals change over time, thereby limiting their ability to capture the temporal changes of muscle activity. As a result, these approaches often lead to poor accuracy, robustness, and generalization. Limited experimental validation has been conducted on sequence-based machine learning approaches using temporal sEMG data from publicly available datasets …

Impact Of Single-Gender Education On Academic Performance, Stacey Wilcher

Theses and Dissertations

This dissertation examines the performance of middle school students Grades 6–8 in single-gender versus coeducational schools in a large urban district in the southeastern United States. It evaluates whether single-gender education leads to better academic outcomes and higher engagement, offering important insights for educational leaders and policymakers.

The study utilized Social Cognitive Theory and gender segregation theory through a mixed-methods approach, collecting quantitative data from standardized assessments (2021-2025) like the GMAS and MAP. Statistical analyses, including t-tests and ANOVA, were used to assess academic performance. Qualitative data from interviews and focus groups explored classroom engagement and teaching practices.

Participants included …

The Role Of Body Composition In Predicting Fitness Performance Of Law Enforcement Officers, Taylor J. Parmentier

Theses and Dissertations

Law enforcement officers (LEOs) perform physically demanding tasks such as foot pursuits, lifting, carrying, dragging, and physical restraint. Effectively performing these duties requires significant muscular strength, endurance, and cardiorespiratory fitness. Lower fitness levels pose risks for reduced health, performance, slower recovery, increased fatigue, and potentially affecting decision-making under strenuous conditions. The purpose of this study was to identify the strongest predictor of physical fitness performance among active-duty LEOs. Body composition analysis and a comprehensive fitness evaluation of twenty-nine male LEOs (age: 36.2 ± 9.3 years, body mass (BM): 95 ± 13.7 kg, height: 1.8 ± 0.1 m) was completed. The …