Digital Commons Network^™

Development Of Bifunctional Peptides As Scaffolds For Bifunctional Catalysis And A Novel Method Of Peptide Stapling Using Squaric Esters, Adam X. Wayment

Theses and Dissertations

Enzymes are some of nature's most powerful tools in chemical processes. However, their molecular complexity makes them difficult to synthesize and complicates their application in traditional organic synthesis. Peptides, a building block of enzymes, can be rapidly synthesized and have been used as a possible alternative in achieving enzyme-like catalysis. However, most peptide-based catalysts are limited in reaction-scope and are unable to incorporate traditional organic catalysts. We have designed a helical peptide scaffold capable of being functionalized with a wide variety of organocatalysts as well as transition-metal based catalysts. In order to understand how the peptide structure effects reactivity and …

Ecological Drivers Of Plasticity And Parental Care In Poison Frogs, Olivia Brooks

Theses and Dissertations

Parents increase their offspring fitness prospects by providing care, but at the cost of lost current or future reproductive opportunities. Parents often rear multiple offspring simultaneously, and because parents cannot supply unlimited care to their offspring, parents benefit from distributing resources non-randomly within a brood. Having access to information that helps inform allocation decisions can be valuable to parents, and parents may use a variety of information types that are either intrinsic or extrinsic to the offspring to help inform these decisions. Here, I explore the types of information that parents use when allocating resources within broods, and I explore …

Ecosystem Services Provided By The Novel Winter Cash Cover Crop, Pennycress, Ryan Thomas Meyer

Theses and Dissertations

Nutrient loss from agricultural practices in the Midwest contributes to degradation in ecosystem structure and function. Subsurface drainage systems in tilled corn-soybean rotations that rely on fertilization results in up to 50% of fall fertilizer being lost to the environment. Solutions are needed to reduce nutrient pollution from Midwestern agriculture. Cover crops are a best management practice that shows potential to reduce nutrient loss from Illinois farms. However, due to economic concerns, cover crop usage in Illinois is low (6%). A novel winter oilseed, pennycress, has the potential to act both as a cover crop and a cash crop, benefitting …

Deciphering How Uropathogenic Escherichia Coli Defends Itself Against The Neutrophilic Oxidant Hypochlorous Acid, Sadia Sultana

Theses and Dissertations

The objective of this dissertation was to investigate how uropathogenic Escherichia coli (UPEC) responds to and defends one of the most potent oxidants produced in neutrophils, hypochlorous acid (HOCl).While most bacteria have no negative effect on human health or are even beneficial, some pathogenic species can cause serious infections, resulting in increased morbidity and mortality. However, the immune system allows the host to efficiently fight back and eradicate pathogens. Innate immune cells (i.e., neutrophils) generate reactive oxygen and chlorine species (RO/CS) to kill invading pathogens, among which HOCl is considered the most potent and abundant one. HOCl exerts its bactericidal …

Personal Dosimeter Testing For High Altitude Air Crew, Seth D. Bacon

Theses and Dissertations

In 2014 the Thermo Scientific N2 electronic personal dosimeter became the aircrews’ sole means to record ionizing radiation dose. The production of this dosimeter was discontinued in July of 2021, motivating the Air Force to seek a flight-certifiable replacement. The Thermo Scientific Trudose NG, Mirion DMC 3000, and Fuji NRF-51 electronic personal dosimeters, as well as the Landauer InLight optically stimulated luminescent dosimeter, were subjected to mixed gamma and fast neutron fields simulating a high-altitude flight environment. Dosimeters are evaluated on their consistency and accuracy in reporting dose and compared to the current N2 dosimeter’s reported dose.

Single Particle Analysis Of Operation Roller Coaster Environmental Samples, Caleb J. Sapp

Theses and Dissertations

The release of plutonium and other actinides into the environment following a nuclear detonation or accident, poses a health risk to biological systems. The spread, or transportation of that plutonium and its daughter products through environmental and meteorological means increases the potential affect and inherent danger within the surrounding area. In the 1960’s, a study was conducted in a joint effort by the US and Great Britain to collect information regarding the spread of plutonium released into the environment through a sub-critical detonation. Soil samples from these tests were collected by the USAF in 2015, approximately 50 years after these …

On Intrinsic Dimensionality Of Data Sets And Neural Networks, Ori Chachmo

Theses and Dissertations

The concept of Intrinsic Dimensionality (ID) is of special interest in the field of Neural Networks (NNs) since it promotes both (a) a deeper understanding of the underlying mechanisms, and (b) embraces parsimonious modeling (that is, building the right-sized model for the task) with associated benefits to processing speed and storage requirements. This thesis explores the concept of ID via two separate, but related, questions. First, we study the potential of NN ID prediction by exploiting easily obtained quantities measured on the data. We then explore NN ID as an independent concept by comparing the results of different methods for …

Retrospective Cohort Study Of Pure Tone Audiometry Hearing Changes From Ototoxic Metalsand Solvents, Continuous Noise, And Impulse Noise Exposures At Hill Air Force Base From 2005 To 2019, Zachary I. Johnson

Theses and Dissertations

This retrospective cohort epidemiological study investigated the relative risks of hearing loss associated with ototoxicants in combination with noise exposure. Utilizing Department of Defense (DoD) industrial hygiene and hearing conservation data, this research expanded on a 2020 thesis conducted on Tinker Air Force Base (AFB), applying a similar methodology to Hill AFB, adding 893 evaluated individuals. Grouped into twelve exposure combinations with a minimum of three years of exposure duration, the study assessed various hearing loss indicators, including DoD Standard Threshold Shift (STS) and NIOSH STS. Ototoxic substances consistently elevated relative risk (RR) compared to noise-only exposure groups, but none …

Integrating Eod And Readiness Competencies Into The Ce Cgo Competency Framework, Kristina L. Johnson

Theses and Dissertations

In the last few years, the strategic focus of the United States defense posturing has shifted from legacy conflict in the Middle East to focusing on the Pacific with increased emphasis that Airmen must be educated and trained to deter or prevail in any conflict. To achieve this goal, the Department of Air Force (DAF) has evolved to utilizing a competency-based education framework with the Civil Engineer career field adopting this strategy and releasing the first version of their occupational competencies in 2020. However, DAF force posturing has evolved since 2020. With the new deployment system, Agile Combat Employment scheme …

Artificial Intelligence And Perception: An Empirical Study, Anthony J. Neil

Theses and Dissertations

This thesis investigates the impact of adjusting artificial intelligence explainability levels’ outputs on user perception. The overarching study extends within the Explainable Artificial Intelligence (XAI) domain. It examines a spectrum of variables, including performance, cognizance, familiarity, transparency, system bias, and the overall impact of AI, to understand their collective and individual effects that enable effective professional use in an organization. The study aims to illuminate the relationship between the degree of explainability provided by large language models such as ChatGPT, Bard, and Bing AI and the performance of these models when tasked with XAI adjustments.

An Analysis Of China’S Perceived Geographic Locations Of Interest By Use Of Value Informed Facility Location Models, Layton C. Hedge

Theses and Dissertations

This research examines China and derives insights specific to it and the First Island Chain and the Second Island Chain. In doing so, this research demonstrates a methodology to examine other competitors and their geostrategic interests. In the first phase of analysis, it develops a value hierarchy to depict objectives within subregions of the area of interest and considers four alternative weightings of the value hierarchy. In the second phase of analysis, it applies four location-covering models to assess how the competitor would emplace a range of limited resources to deter and/or control points of interest. Results indicate that land-based …

Bayesian Augmentation Of Object Detection Algorithms To Enhance Object Classification Stability, Taylor D. Markham

Theses and Dissertations

Neural networks, despite their prowess in computer vision, often exhibit "flickering". Flickering occurs when networks fail to maintain consistent object representation across frames, leading to inaccurate and inconsistent output. This problem is particularly critical in mission-surety applications where reliable object recognition is crucial. This research presents a novel approach that combines existing object detection and tracking algorithms like YOLO and SORT with a Bayesian backend model. This Bayesian backend incorporates probabilistic reasoning to analyze the network's confidence in its predictions and infer the most likely object identity across multiple frames, effectively reducing flickering and enhancing robustness.

Design Considerations For The Use Of The Julia Programming Language In Future Quantum Networking Simulation Software, Takashi Joubert

Theses and Dissertations

Given the prevalence of Python-based packages in the existing quantum network simulation ecosystem, we attempt to assess what might be realistically gained by switching to Julia. We focus our experimental activities on three areas: 1) surveying the characteristics of Julia as they tie into robust framework development, 2) presenting benchmarks that compare Julia and Python with respect to elements of possible simulation workloads, and 3) producing a tangible lightweight Julia architecture for modeling components in a manner similar to SeQUeNCe. Our analysis suggests that while Julia does o.er performance advantages over Python over certain workloads, knowing the reasons for why …

Improving Rogue Radio Emitter Detection Using Siamese Networks, Mason Wright

Theses and Dissertations

Radio Frequency Fingerprinting (RFF) is the process of creating discerning signatures of emitted radio signals, most often with the goal of identifying specific devices again in the future. The security benefits of this task are intended to build upon current software-based authentication by making use of multi-factor authentication (MFA), but the related task of being able to reject unwanted emitters is limited. This paper presents a Siamese network trained on two different extracted fingerprints of raw Wi-Fi signals, along with a verifier to perform classification and rogue device detection. It was found that fingerprints using the Distortion Reconstruction (DR) technique …

Gamma Protection Factor For A Surrogate Armored Vehicle Exposed To The Us Army Fast Burst Reactor, Ian J. Poropat

Theses and Dissertations

This work measures the Gamma Protection Factor (GPF) of a steel cube, which is meant to serve as a surrogate for armored vehicles. The GPF is measured at the White Sands Missile Range Fast Burst Reactor (FBR) and is modeled using MCNP® v6.2 transport simulation software. When exposed to the FBR, the GPF is found to depend roughly linearly on the distance between the reactor core and steel cube. The GPF is determined to be 1.176 ± 0.00067 at 9.21 m, 1.098 ± 0.0011 at 26.16 m, and 1.033 ± 0.00082 at 42.92 m. MCNP® estimates the GPF for the …

A Framework For Dynamic Combat Support Exercises, Sean R. Mccarty

Theses and Dissertations

Future armed conflict will be characterized by the unknown as adversaries innovate and evolve—surprise is inevitable. Current exercises provide inadequate opportunities for combat support forces to develop improvisational skills. This research proposes an extensible framework for human-in-the-loop control of exercises using a graph network for modeling combined with topological analysis and the resource-constrained project scheduling problem. This framework is assessed using the United States Air Force Silver Flag exercise as a case study with promising results.

Deploying Field-Capable Genome Sequencing: Human Performance Considerations Under Various Personal Protective Equipment Ensembles, Steven A. Torres

Theses and Dissertations

Field-portable genome sequencing enhances the Department of Defense's strategy for detecting biological threats, particularly in resource-limited environments. While current field-capable detection methods are effective, challenges in identifying emerging threats pose risks to personnel safety. As biotechnological advancements like portable nanopore genome sequencing can advance biological detection capabilities, the viability of conducting laboratory tasks under Mission-Oriented Protective Posture (MOPP) ensembles lacks sufficient data. This research assesses the effectiveness of tools like pipettes, centrifuges, vortexes, and nanopore sequencing within a MOPP ensemble. Novice participants were utilized to explore the extension of this capability, and they completed tasks in three conditions: Fatigues, Laboratory …

Radiological Decontamination Methodologies On Litter-Bound Patients In Arctic Environments, And The Associated Airborne Risks Posed To First Responders, Juan S. Alb

Theses and Dissertations

This study was conducted to determine if air-based decontamination (decon) methods would be effective at both treating patients exposed to dry, radiological contamination as well as reducing its re-aerosolization during the disrobing process, such that these methods could be applied on litter-bound patients in extreme cold environments. A litter-bound, full-size mannequin dressed in a set of standard military issue extreme cold weather jacket and pants coated in 27 g (1 Tbs) of Copper Oxide (density 6.315 g/cm³ ) was given one of three treatments for dry aerosol decon. The three cleaning treatments included high-efficiency particulate air (HEPA) vacuum, a …

Utilization Of The System Engineering Design Process To Design And Test A Low-Cost Infectious Aerosol Control Mechanism For Patient Aeromedical Evacuation, Sara Shaghaghi

Theses and Dissertations

The aeromedical evacuation of military patients is a critical component of care for Armed Forces members. The Air Force’s ability to transport patients relies on the technology and systems available. A vital transport responsibility is keeping the patient and medical personnel safe during transport. The historical and legacy systems provide reliable transport mechanisms for the Armed Forces’ patients infected with high-level biological agents, but drawbacks must be considered. This dissertation will discuss the development, conceptual design, and initial evaluation of a new low-cost, litter-mounted patient transport system, Biological-Mitigation in Patient Transport (B-MIPT), using the “V” model of the system engineering …

Development Of Salinomycin Derivatives As Potential Anticancer Agents, Viren Soni

Theses and Dissertations

Salinomycin is a poly-ionophore antibiotic that was originally isolated from Streptomyces albus by Miyazaki and colleagues from Kaken Chemicals Co., Ltd., Tokyo, Japan. Salinomycin exhibits antimicrobial activity against Gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus, Micrococcus flavus, Sarcina lutea, Mycobacterium spp. Some filamentous fungi, Plasmodium falciparum, and Eimeria spp. as well as protozoan parasites responsible for the poultry disease coccidiosis. Hence, it is used in veterinary medicine. In 2009 Gupta et al demonstrated that salinomycin selectively killed human breast cancer stem cells (CSCs) with great efficacy, and the mechanism of action of this novel CSCs molecule was explored. To name …

The Clash Of Sustainable Development Goals With The Reality In Egypt: The Role Of The Media On The Perception Of Clean Energy Implementation., Nourhan Salah Hamed Ebrahim

Theses and Dissertations

Media has promoted sustainable development goals as essential for a country's social, economic, environmental, and political development. However, the SDGs may collide with the reality and impede development due to certain circumstances and challenges that might hinder the country’s ability to achieve these goals the same way they planned for. Besides, such challenges are not being covered in the media agenda, addressed by the government, or even been tackled in previous research. Thus, this study aims to examine whether there is a conflict between the SDGs and the reality in Egypt, focusing on SDG 7 (Clean Energy) by analyzing the …

The Romani People In The European Cultural Imagination: Alexander Pushkin, Prosper Mérimée And Virginia Woolf, Nadya Siyam

Theses and Dissertations

Scholarly literature on Roma is scarce compared to other racial groups as a lack of academic interest, financial limitations, and other social and political factors has constrained it. This resulted in a cross-cultural circulation of misinformation about Romani people and the reproduction of Romani myths and stereotypes in fiction. This project aims to analyze selected literary works on Gypsies from three Eastern and Western European countries and two periods to unpack the cultural and political roots of Romani literary misrepresentation. This research employs a range of theoretical frameworks chosen to put the Gypsy protagonists under maximum spotlight without unnecessary repetition, …

Applicability Of Using Bio-Receptive Concrete For Building Facades In Egypt, Gina Roupheil

Theses and Dissertations

The significant increase in carbon dioxide emissions caused by the construction industry is detrimental to our planet. This is rapidly increasing with the urbanization of cities that is gradually taking its toll on the available green spaces, which help in balancing such emissions. Recently, researchers have been trying to make use of bio-receptivity to create biomaterial systems that could be spread on building envelopes and support the growth of small plant species and microorganisms to establish on. Out of those materials, comes the concrete as a promising material for bio-colonization.

Within this context, this study aims at investigating the applicability …

Reforming Egypt’S Alternative Child Care System Through Deinstitutionalization: An Assessment Of The Current Status And Readiness To Change In The Residential Care Sector, Dina Elbawab

Theses and Dissertations

The main objective of this study was to assess the current status and readiness of the sector of residential care institutions for children to take part in the deinstitutionalization of children in alternative care in Egypt. The assessment was carried out using an adapted version of the Community Readiness Model (CRM), a tool developed by the Tri-Ethnic Center at Colorado State University. Accordingly, the assessment comprised semi-structured interviews with fourteen key informants to assess the following six readiness dimensions: efforts, knowledge of the efforts, leadership, community climate, knowledge of the issue, and resources related to the issue. The study briefly …

Consumers' Acceptance To Buy And Dispose Of Recycling Textile Products, Roa Alsayed

Theses and Dissertations

The textile industry is the second most polluting worldwide, following food manufacturing. It is one of the industries that is rarely scrutinized in the Middle East and North Africa (MENA) region. This work analyzes the fashion industry from the perspective of consumer attitudes towards the purchase and disposal of clothing, and their behavior with regards to old garments. The study was conducted in Saudi Arabia and Egypt, two countries that achieved similar results in the fashion industry. The methodology is divided into three phases. First, the manuscript begins with a review of topics such as sustainability, consumer behavior in the …

Properties Of Portland Cement Concrete Incorporating Basalt-Based Pozzolanic Cement, Rana Khalil

Theses and Dissertations

Over the last decade, the world's population has increased dramatically. Due to this growth, the demand for concrete and Portland cement, in return, have increased. Manufacturing of Portland cement is an energy-intensive process that, alone, contributes to about 8% of global CO2. For decades, efforts have been exerted to reduce the harmful environmental impacts of Portland cement by reducing its use in concrete as well as considering alternate binders that may fully or partially replace it. This study aims to assess the properties of concrete incorporating a novel basalt-based pozzolanic cement. To meet this objective, four sets of concrete mixtures …

Integrative Genomic Insights Into Coral Resilience: Adaptive And Acclimatory Responses To Seasonal Environmental Shifts, Tasnim Ghanim

Theses and Dissertations

Coral reefs, critical to marine biodiversity and coastal protection, face escalating threats from climate change-related phenomena such as ocean warming. This warming is leading to widespread thermal stress that contributes to coral bleaching and infectious disease in corals, leading to the disruption of marine ecosystems and the economies that depend on them. Focusing on the brain coral Platygyra daedalea, known for its thermal resilience in the Persian Arabian Gulf—a region that exemplifies the extreme stressors of climate change—our study aims to dissect the genetic, transcriptomic, and microbiological underpinnings of coral survival in high-temperature environments predicted for the end of …

Green Fame On Tiktok Analyzing Digital Persuasion Appeals On Climate Change Discourse Among The Public And Youth., Sherry Ayad

Theses and Dissertations

In a constantly changing media ecosystem, TikTok is gaining prominence and attention, particularly among youth and Gen Z. The platform’s unique affordances are recently being utilized by young voices to promote self-expression and social activism. Consequently, TikTok’s changing nature is giving space for serious social and political issues impacting the future of young generations on topics such as climate change. By analyzing the top N=400 TikTok videos from the 27th Conference of the Parties (COP27) to the 28th Conference of the Parties (COP28), this study contributes to rare knowledge of utilizing TikTok’s affordances in scientific and political topics such as …

Vulnerability Assessment Of Mangroves In Western Shore Of Red Sea, Nada Negm

Theses and Dissertations

Mangroves are vital to environmental sustainability and acts as a global warming control, although they endure severe vulnerability due to some human activities. Climate change and other extrinsic stresses are factors that play a vital role when assessing the vulnerability of mangroves in the Red Sea. The aim of this study is to assess the vulnerability of mangroves using field and RS data to apply a vulnerability index of mangroves at Hamatta and Safaga in Egypt. Mangrove Vulnerability Index covers includes hazard mangrove index, biological mangrove index and physical mangrove index.

Mangrove height has been measured using meter tape and …

Assessing Adoption Barriers Of Sustainable Packaging In Egypt, Carol Ramses Morgan

Theses and Dissertations

Sustainable packaging has become an essential part of business decisions and corporate directions. With the rise of environmental damages due to improper waste management and unsustainable practices, businesses have a major responsibility to analyze their products’ life cycles and redesign them with sustainability in mind. Applying sustainable packaging could save companies large amounts of resources, therefore cutting costs, while also achieving the legal and social duty as a corporation towards society and the environment. Many developing countries, with specific focus on Egypt, have recently focused on legislative and corporate decisions in order to encourage more sustainable practices. Egypt’s new Waste …