Digital Commons Network^™

Genetics Of Lrg1 And Its Association With The Cardiometabolic Risk Traits In Mexican American Children And Adolescents, Aaron Rene Reyna

Theses and Dissertations

Leucine-rich alpha-2-glycoprotein 1 (LRG1) has become a major topic of research due to an increasing number of studies demonstrating its unique role in the pathogenesis of multiple human diseases including diabetes and cardiovascular disease. LRG1 has recently been identified as an adipokine, a signaling molecule secreted by adipose tissue. Furthermore, it has been correlated with intercellular signaling that promotes diet-induced hepatosteatosis and insulin resistance in mice. In this study, LRG1 serum concentrations were measured in a family-based cohort of 571 non-diabetic Mexican American children and adolescents aged 6-17 years old (mean age = 11.76 years and females = 48.2%) to …

Foxo4 Impacts Akt In Glioblastoma Multiforme, David Uribe

Theses and Dissertations

Glioblastoma Multiforme (GBM) is an aggressive cancer with patients surviving 13 months on average after diagnosis. The PI3K-PKB/AKT pathway is conserved from flies to mammals. The PI3K signaling pathway aids in the growth and survival of tumor cells. Forkhead box transcription factors subclass O (FOXO1, FOXO3, and FOXO4) act as tumor suppressors in some contexts. In GBM, our group and others showed that FOXO transcription factors drive stem gene expression to promote growth and survival. We disrupted the FOXO4 gene in U87MG cells using CRISPR Cas9 genome editing and performed RNA-seq to identify targets of this …

Development And Application Of Environmental Dna (Edna) Techniques To Detect Rough-Footed And Yellow Mud Turtles: A Seasonal Field Study To Detect Turtle Edna, Sakib Tahmid Rishan

Theses and Dissertations

The application of environmental DNA (eDNA) has improved the ability of humans to detect the existence and geographical distribution of aquatic organisms. The present study highlights the development and application of eDNA techniques to detect rough-footed mud turtles and yellow mud turtles in different areas in Texas. Both mud turtle species were successfully detected in lakes/resacas using direct eDNA sampling techniques. Moreover, passive eDNA sampling techniques were conducted using different membrane filters to detect mud turtle species. The findings indicated that only the mixed cellulose esters (MCE) filter membranes effectively identified eDNA of yellow mud turtles in the fall, but …

Utilizing Nanodiamond For Antiretroviral Drug Delivery To Hiv Infected Microglial Cells, Ebenezer Owusu

Theses and Dissertations

Combination antiretroviral therapy (cART) is widely used to treat HIV infection, but it fails to eradicate viral reservoirs, such as microglia in the brain, leading to HIV-associated neurological disorders (HAND). Advances in nanomedicine have enabled the development of targeted drug delivery systems, and nanodiamonds (NDs) and fluorescent nanodiamonds (FNDs) have emerged as a potential solution due to their biocompatibility, non-toxic nature, and efficiency as drug carriers. Our study builds on previous findings that NDs can cross the blood-brain barrier (BBB), aiming to utilize NDs and FNDs for their added traceability. We propose a multifunctional nanodrug platform that leverages NDs and …

Effects Of Nitrogen Or Phosphorus Depletion On Lipid Production In Bracteacoccus Sp. And Tetrastrum Sp., Cassandra J. Po

Theses and Dissertations

As global energy demands have risen in the past decades, various species of microalgae have been chosen and used as sources of lipids for third-generation biofuel. I selected two species of green microalgae, Bracteacoccus sp. and Tetrastrum sp., from isolates from South Texas to determine their potential as sources of biofuel. For comparison, Chlamydomonas reinhardtii was used as a model organism. To evaluate lipid productivity under different nutrient regimens, the microalgae were grown in nutrient-replete growth media until the population had reached the end of the logarithmic phase (roughly 14 days), and then transferred into growth media depleted of nitrogen …

Role Of Interferon-Induced Protein With Tetratricopeptide Repeats 3 (Ifit3) In Hiv-1 Associated Neurodegenerative Disorder And Alzheimer’S Disease, Ranjit Kumar Das

Theses and Dissertations

The advent of cART has revolutionized the management of HIV-1 infection and saved the lives of millions of people worldwide. Yet, HAND continues to be clinically relevant with aging people with HIV-1 (PWH). The underlying mechanism of HAND remains poorly understood. In this regard. Signal transducer and activator of transcription 1(STAT1) and IFIT3 genes have been shown to induce neuroinflammation and neuronal cell death. However, the role of IFIT3 in HAND pathology has not been well established. Therefore, the present work investigated the significant role of IFIT3 gene in development of HAND. In the current study, …

Cultural Norms And The Expression Of Affection In Nigerian Yoruba Families, Tolulope G. Banjo

Theses and Dissertations

Affectionate behaviors have biological and physiological implications for humans. Affectionate communication encompasses behaviors that convey affection to the senders and receivers. The purpose of this qualitative study was to investigate the role of culture and cultural traditions in the expression of affectionate behaviors among members of the Nigerian Yoruba family. Two focus groups were conducted in which participants (18-39 years of age) identified the affectionate behaviors they use in their families. Participants also shared how they perceived their culture playing a role in their affectionate communication. The findings revealed 18 categories of affectionate behaviors used by Nigerian Yoruba …

Particle Swarm Optimization For Training Quadrotor Pid Controller, Eric Xavier Rodriguez

Theses and Dissertations

The objective of this research is to establish a fundamental approach to tuning PID (Proportional-Integral-Derivative) parameters for a simulated quadrotor drone. Implementing a PID controller for autonomous flight provides a straightforward and efficient method for monitoring and correcting robotic movement based on the robot's current state. However, applying a PID approach to a quadrotor's flight controller poses challenges, such as assigning multiple parameters to control an inherently under-actuated system. This includes the need to find optimal parameter values that reduce the likelihood of large overshoots and lengthy adjustment times. Ineffectively tuning PID parameters can have detrimental effects on autonomously …

Developing Resilient Defense Strategies Against Pheromone-Based Attacks In Foraging Robot Swarms, Ryan A. Luna

Theses and Dissertations

This thesis delves into the security of stochastic pheromone-based foraging algorithms within swarm robotic systems, a subset of foraging algorithms distinguished by their reliance on probabilistic decision-making mechanisms inspired by the natural world. Such algorithms face vulnerabilities in stigmergic communication that threaten to disrupt swarm operations. This research investigates these vulnerabilities, presenting two distinct contributions.

The first contribution examines the implementation of quarantine strategies as a defensive measure to isolate and mitigate the impact of fake resource attacks. By simulating these attacks, this study quantitatively assesses their detrimental effects on swarm efficiency and explores the efficacy …

A Phenomenological Study Of Latina Poets As Leaders At Higher Education Institutions, Rodney Gomez

Theses and Dissertations

This interpretive phenomenological study addresses the underrepresentation of Latinas in higher education leadership roles by focusing on the lived experiences of Latina poets who have served as higher education leaders. Data, collected through semi-structured participant interviews and participant writing samples, was analyzed through a standard method of thematic analysis. Latin American and U.S. theories of decoloniality and Yosso’s community cultural capital guided interpretation of participant experiences. Five themes emerged from the analysis: border negation, foundational values, othered leadership, importance of community, and writing as necessity. Discussion of participation experiences suggests that ways that poetry and creative writing can be used …

Bayesian Estimation Of Reproduction Numbers From Distributions Of Outbreaks Sizes: Branching Process Approach, Alberta Araba Johnson

Theses and Dissertations

The Generalized Poisson distribution is useful in modeling epidemiological processes as a branching stochastic processes problem. Our goal is to construct accurate and reliable estimators for the reproduction number (R0) (i.e., the number of secondary infections), particularly in the context of disease outbreaks modeled by a Galton-Watson process. Towards this goal, we construct the classical Bayes estimator, the Maximum Likelihood estimator, and the Empirical Bayes (EB) estimator under the Square Error Loss function in Chapter II. We prove that the Empirical Bayes estimator is asymptotically optimal and estimate the rate of convergence. We then proceed to monotonize the Empirical Bayes …

Soil Carbon Sequestration Efforts In Arid And Semi-Arid Climates Under Conservation Agriculture And Reforestation, Samantha Lynn Colunga

Theses and Dissertations

Soil organic carbon (SOC) plays a vital role in the global carbon cycle and aids in climate change mitigation. However, deforestation and intensive agricultural practices threaten topsoil and carbon (C) pools through soil disturbances releasing vast amounts of carbon dioxide (CO2) by enhancing the decomposition of organic materials. Degraded soils typically lack stable aggregates, nutrient and water retention, and overall low fertility. In arid and semi-arid regions, soils are in an even more dire situation, as low precipitation and high temperatures slow down the accumulation of SOC. This thesis has two objectives: 1) to evaluate whether conservation tillage practices increase …

How Mathematics Instructors Foster The Development Of Black Students' Mathematics Identity In Undergraduate Active Learning Mathematics Courses, Ashly J. Olusanya

Theses and Dissertations

Black students must overcome unique challenges to succeed in mathematics. Educators are tasked with identifying equitable teaching practices to support these students. Active learning (AL) is a teaching pedagogy that engages students in rigorous mathematical activities and encourages student participation. This research study will explore the professors’ beliefs about how students learn mathematics and why they use active learning in their collegiate mathematics courses. The study explores the connections between these beliefs and their reported use of instructional practices. The study also identifies the instructors’ beliefs about developing students’ mathematics identities, particularly their Black …

Escúchame, Mi Ciencia Cuenta: Leveraging Cultural Ways Of Knowing To Increase Chicana Stem Engagement, Patricia Ramirez-Biondolillo

Theses and Dissertations

This paper is about leveraging cultural ways of knowing such as ethnobotany in order to increase STEM engagement in Chicanx populations. The conceptual framework utilized in this study combines social justice, Chicana feminist epistemology, land-based pedagogy, critical place-based pedagogy, pedagogical praxis, pluralism and ecological sustainability to achieve this end. Four pre-service Chicana science teachers provided testimonio from their elder assignment and engaged in two focus groups in order to identify relevant themes that impact Chicana engagement in STEM. Major themes identified were challenges in bilingual education, elder knowledge as a form of pedagogy, stagnation in common science teaching practices, tensions …

Studies Of Novel And Well-Defined Dinickel Architectures Utilizing An N-Atom Bridge, David Anthony De Los Santos

Theses and Dissertations

There has been a growing interest in organometallic chemistry to utilize late Earth-abundant metals towards challenging molecular functionalization of abundant feedstocks to value-added products. There is precedent of utilizing cooperativity to try and address some of the shortcomings of traditional mononuclear complexes by integrating metal-metal and or metal-ligand cooperativity to facilitate multi-electron transformations. The utility of a redox-noninnocent scaffold allows for the metal centers to be stable over a range of oxidation states, using the ligand to store electrons. Despite recent progress, complexes harnessing cooperative states towards challenging transformations is still an emerging field. Our group has synthesized a multinucleating …

Synthesis Of Nano-Microstructured Barium Titanate (Batio3) Incorporated In Pvdf-Hfp/Peo For Sustainable And Green Energy Generation, Rigobert Ybarra Jr.

Theses and Dissertations

The global reliance on fossil fuels and natural gas, has largely dominated the energy production field, but due to finite resource depletion and escalating greenhouse gas emissions, the immediate exploration of sustainable energy alternatives to mitigate climate change and ensure resource security has been a major concern. There has been extensive research into other more renewable methods of energy production such as wind and hydropower. Of these current energy generation types there are many areas of untapped potential from the mechanical movements generated ambiently not only in the large scale of power generation but also on a smaller scale. The …

Improving Static Cold Storage Life Of The Human Heart Before Transplant, Juan Sebastian Rodriguez Paez

Theses and Dissertations

Organ storage and transportation are critical steps for the success of organ transplantation. Static cold storage (SCS) of hearts for heart transplantation (HTx) remains the standard approach. However, SCS may involve damage to the tissue resulting from extended hypothermic preservation, potentially affecting organ viability. More over, the temperature distribution on and within the heart is unknown during heart transplantation. Therefore, there is an interest to study different stages of the heart transplantation process towards determining the 3D temperature distribution on and within the heart. There could be a possibility of having a hypothermic injury in different parts of the heart …

Microwave Imaging Technique For Breast Cancer Detection, Nure Alam Chowdhury

Theses and Dissertations

Breast cancer is a global problem, and it is inevitable to detect cancerous cells at early stages. In recent years, microwave imaging technology has been widely applied in biomedical applications for its non-ionizing radiation. In this study, we design a micro-strip patch antenna with an inverted T-type notch in the partial ground to detect tumor cells inside the human breast. The size of the current antenna is small enough (18 mm × 21 mm × 1.6 mm) to distribute around the breast phantom. The operating frequency has been observed from 6–14 GHz with a minimum return loss of −61.18 dB …

Investigating Endothelial Damage During Ischemic Stroke Treatment Using In Vitro And Computational Models, Zackary Lorton

Theses and Dissertations

Large vessel occlusion during acute ischemic strokes requires mechanical thrombectomy (MT) procedures using stent retrievers (SR). However, complete clot removal typically takes several attempts, which can amplify endothelial cell injury (EI). This project aims to characterize the extent of EI during MT using an in vitro vascular platform and a finite-element model (FEM). Impact of SR diameter and characterization of SR mechanical forces are assessed and correlated with human umbilical vein endothelial cell (HUVEC) response. HUVECs were seeded on fibronectin (4 µg/cm²) coated true-scale PDMS arterial phantoms with 2.5 mm luminal diameter. Test groups (n=6) either …

Optimization Of Coral Restoration Along The Florida Reef Tract, Raymond Barry Banister

Theses and Dissertations

Historically, the reefs of Florida were dominated by two framework-building corals, Acropora cervicornis and A. palmata. However, these two populations have declined by 95% since the 1970s. The predominant contributors to the coral decline have been ocean warming and disease. In response to the decline, restoration organizations were established to improve survival, growth, and reproduction. Yet, there are gaps in current restoration practices and our knowledge of effective restoration techniques. This study uses large datasets to develop models that predict the most optimal locations for coral restoration in Florida and examines the relationships between the occurrence of wild acroporids …

High Intraspecific Diversity Of Pocillopora Damicornis In Southeast Asia Reflects Adaptive Potential To Climate Change, Maria Lucille Carr

Theses and Dissertations

Marine heatwaves are increasing in intensity and frequency because of increased emissions of greenhouse gases. On coral reefs, warmer temperatures cause coral bleaching, mortality, and shifts in benthic composition. However, coral bleaching responses and survival vary geographically. Several hypotheses may explain such geographical differences in thermal tolerance, including the possibility that some localities may support higher intraspecific diversity than other localities, increasing the likelihood of survival of some individuals through heatwaves. Here we assessed geographic patterns of intraspecific genetic diversity in the ubiquitous coral Pocillopora damicornis. Intraspecific genetic diversity was assessed for 428 sequences across 44 sites in the Pacific …

Synthesis Of Highly Selective Fluoroionophores For Metal Cations And Their Biological Applications, Md Abdur Rahim Badsha

Theses and Dissertations

Fluoroionophore for ionic and neutral analytes are extensively used in a number of fields for example: pharmacology, physiology, biology, and environmental sciences. The concept of this fluoroionophore in other word fluorescent chemo sensor has been used in the past 150 years. In recent years, a wide range of fluoroionophores have been developed for the detection of chemical species which are important for environment and biology. Instead of the progress, still there are challenges and problems in this area of research. This thesis addresses novel sensors for the measurement of biologically important cations. The sensors are based on fluoroionophores which shows …

Usda Wildlife Services Management Efforts At The Grand Forks Wastewater Treatment Plant, Dorothy Celeste Daulton

Theses and Dissertations

Wildlife collisions with aircraft (wildlife strikes) are a costly and dangerous issue. In recent decades, wildlife strikes within airport boundaries have decreased partly due to on-airfield wildlife strike mitigation efforts. Landscape attractants surrounding airfields within an 8 km radius have been found to influence the occurrence of wildlife strikes by increasing wildlife presence and abundance on or near airfields. The effectiveness of mitigation efforts can be increased by extending operations to include landscape features in an 8 km radius from airports. However, not much is known about the long-term effects of wildlife strike mitigation operations when conducted on neighboring properties, …

Analyzing The Effects Of Land Use, Land Cover, And Infrastructure On Water Quality Standards Within The Itasca And St. Louis Moraine Region Of Minnesota., Jamesguy Gierisch

Theses and Dissertations

The river and lake systems in the United States are essential to commerce and human existence. A study of the water quality of the upper Mississippi River watershed was conducted within Itasca State Park, Minnesota. This research focused on ten lakes within the perimeter and backcountry parts of the State Park. The focus of this research was the water quality between lakes, the water quality compared to anthropogenic features, and water quality compared with the land cover of its watershed. Water samples were collected from July 2022 through May 2023 and analyzed for selected ions, field parameters of temperature, pH, …

A Qualitative Case Study Of Students' Of Color Perceptions And Experiences Of Academic Success In College Algebra At Snow College, Melanie Larsen Jenkins

Theses and Dissertations

This qualitative case study explored perceptions of learning support and student success, particularly for students of color who had enrolled in a college algebra course. The purpose of this study was primarily to include student voices in the conversations about student success. The study uses a qualitative case study approach in two ways: 1) to interview nine students who found success and students who did not find success in College Algebra to glean information about their personal experiences and perceptions of learning and 2) to interview three professors of College Algebra to understand their pedagogical strategies that are designed to …

Stem Teacher Shortage In American Schools: A Case Study Exploring The Recruitment Of Stem Majors Into Teacher Education Programs, Adekunle Lawal

Theses and Dissertations

There has been a STEM (science, technology, engineering, and mathematics) teacher shortage in K-12 schools across the United States (Klassen et al., 2021; Luft et al., 2005). To help provide a possible solution to the nationwide STEM teacher shortage, this study investigated the factors that influence STEM majors to change careers from STEM disciplines to teaching. In the current study, six American STEM teachers who have switched careers from the STEM profession to the teaching field were interviewed to find out the factors that led them to change careers; and how schools of education could use these factors in creating …

Performance Assessment Of Wastewater Treatment Processes: Evaporation, Microplastic Settling, Biosolid Air Drying And Gasification, Fangtian Li

Theses and Dissertations

The main contaminants in wastewater can be classified as suspended solid, dissolved inorganic and organic molecules. The dissolved inorganics in wastewater are salinity such as sodium chloride and sodium sulfate. Evaporation is one possible method to separate dissolved salt from high salinity wastewater, but the proper application of energy-saving evaporation depends on many conditions. Microplastic is a part of total suspended solids and can be effectively removed through settling process, and the removal efficiency can be predicted by settling model. Biological treatment eliminates organic matters and biosolids are the inevitable by-products. Air drying is a sustainable approach for reducing water …

Law Enforcement And Traumatic Experiences: A Qualitative Study With Administrators, Tami Jo N. Lieberg

Theses and Dissertations

The culture and work experiences of law enforcement lead to unique workplace trauma. The cumulative and complex trauma commonly faced by law enforcement officers can activate multiple stress-related illnesses, including Post-Traumatic Stress Disorder (PTSD). These illnesses can have high personal costs to the individuals, lead to loss of departmental productivity and effectiveness, and incur higher expenses for taxpayers due to overtime and high turnover rates and potential lawsuits. Research over several decades has identified risk and resiliency factors for officers. One identified risk and resiliency factor is relationship with management. This research study explores how department leaders can assist officers …

Additives Impact On Wet Strength And Size Development In Papermaking- Polyamide Epichlorohydrin (Pae), Alkenyl Succinic Anhydride (Asa) And Alkyl Ketene Dimer (Akd) Cases, Yao Parnell Ntifafa

Theses and Dissertations

Additives are ingredients used in papermaking to enhance fiber properties, introduce special properties to the paper and improve the efficiency of the paper making process. Wet strength agents, sizing agents, dry strength agents, fillers, retention aids, defoamers, dyes and pigments are common additives used in paper mills. Poor retention of wet strength additive such as PAAE (polyamide epichlorohydrin) and hydrophobicity loss due to ASA (alkenyl succinic anhydride) and AKD (alkyl ketene dimer) size reversion not only increase cost and reduce product quality in the mill but also increase customer complaints and rejections.In this study, a method was developed to quantify …

Detecting Flowering Coverage In North Dakota Right-Of-Ways For Supporting Pollinators: A Road Survey Approach, Yeqian Xu

Theses and Dissertations

Establishing and maintaining high-quality grasslands and conservation lands for pollinators can be difficult and costly. As an alternative, roadsides can provide additional forage resources. This study aims to examine the potential of roadside, road ditch, and right-of-way (ROW) land in North Dakota (ND) as alternative habitats for pollinators by quantifying the yellow flowering observed in these sites. The project encompasses a multifaceted approach to assess the viability of roadside ditches in supporting pollinator ecosystems. The research incorporates two essential components: 1) an extensive road survey through the Prairie Pothole Region (PPR) of ND in two consecutive summer seasons and 2) …