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Uncertainty Analysis For Runoff, Crop Yield, Sediment, And Nutrient Loads In The Mississippi Delta Region Using Apex, Javier Fernando Méndez Monroy May 2024

Uncertainty Analysis For Runoff, Crop Yield, Sediment, And Nutrient Loads In The Mississippi Delta Region Using Apex, Javier Fernando Méndez Monroy

Theses and Dissertations

Understanding the dynamics of agricultural basins has been difficult for decision-makers when developing cost-effective plans. An uncertainty analysis evaluates the impact of information gaps on hydrologic model’s output and performance. The Agricultural Policy/Environmental Extender (APEX v1501) was used to predict runoff, crop yield, sediment load, total phosphorus, and total nitrogen from agricultural fields in the Mississippi Delta to investigate the impact of using different input variables (climate, soils, and management practices) on mechanistic models. Results indicated that the use of surrogate information such as weather data from close weather stations, a predominant soil series, and simulated irrigation schedules, could be …


Deep Learning Based Soil Moisture Retrieval Using Gnss-R Observations From Cygnss, M M Nabi May 2024

Deep Learning Based Soil Moisture Retrieval Using Gnss-R Observations From Cygnss, M M Nabi

Theses and Dissertations

The National Aeronautics and Space Administration’s (NASA) Cyclone Global Navigation Satellite System (CYGNSS) mission has grown substantial attention within the land remote sensing community for estimating soil moisture (SM), wind speed, flood extent, and precipitation by using the Global Navigation Satellite System-Reflectometry (GNSS-R) technique. CYGNSS constellation generates important earth surface information called Delay-Doppler Maps (DDMs) from GNSS reflection measurements. Many previous findings considered only designed features from CYGNSS DDMs, such as the peak value of DDMs, whereas the whole DDMs are affected by SM, topography, inundation, and overlying vegetation. This dissertation explores a deep learning approach for estimating SM by …


Tummysafe: The Influence Of Student Engagement And Demographic Variables On Certification Exam Performance In An Online Food Safety Course, Lauren Colby Nickels May 2024

Tummysafe: The Influence Of Student Engagement And Demographic Variables On Certification Exam Performance In An Online Food Safety Course, Lauren Colby Nickels

Theses and Dissertations

This study was conducted to see if the engagement variables from the TummySafe 2022 online course as well as the participants’ demographic variables were positively correlated with the TummySafe certification exam score. The study examined factors that explained participants’ exam performance. The results indicated that there was little to no correlation between demographics or engagement variables and the certification exam score. Findings indicated that 22.8% of the overall variance in certification exam performance was explained by number of prior certifications (10%), race (6.5%), gender (3.5%), ethnicity (.2%), days between last course activity and exam (1.7%), in-course assessment (1%), total activity …


Where’S The Food? Food Insecurity And Black Food Geographies In The Mississippi Delta, Taylor Patterson May 2024

Where’S The Food? Food Insecurity And Black Food Geographies In The Mississippi Delta, Taylor Patterson

Theses and Dissertations

This thesis examines the historical and contemporary roots of food apartheid in the Yazoo-Mississippi Delta, while employing a Black Food Geographies approach to highlight and interpret the lived experiences of people in the Delta. This work draws on interviews and participant observation in Clarksdale, Mississippi, to decenter popular narratives around food insecurity and region and instead center the ideas and opinions of people directly impacted. The thesis highlights Black Deltans’ experiences and understandings of food and foodways to provide a nuanced picture of how residents interpret, negotiate, and challenge the region’s unequal food geographies in light of a longer history …


Evaluating Simulated Tarnished Plant Bug Damage During Late Bloom On Cotton Yield, Seth Thomas Permenter May 2024

Evaluating Simulated Tarnished Plant Bug Damage During Late Bloom On Cotton Yield, Seth Thomas Permenter

Theses and Dissertations

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is an important economic pest of cotton, Gossypium hirsutum (L.), in the Midsouth region of the United States. Continuous season long infestations may result in four or more insecticide applications per growing season. However, late season applications may only be preventing minor losses when compared to overall yield. Results from this study suggest an opportunity to increase thresholds and potentially eliminate one to two insecticide applications in late bloom. Results from this experiment show no significant differences in yield when all square removal levels were simulated in the fourth and fifth …


Exploring The Relationship Between Network Topology And Braess Paradox, Samuel Giftson Prabhakar May 2024

Exploring The Relationship Between Network Topology And Braess Paradox, Samuel Giftson Prabhakar

Theses and Dissertations

The Braess Paradox is a rare phenomenon that only occurs under specific scenarios. This project aims to study the probability of the Braess Paradox occurring in a Directed Weighted Graph while the number of edges increases. The graphs in the experiment are focused on studying the occurrence of the Braess Paradox in a directed weighted scale-free network while transforming it into a directed weighted complete graph. A simulation model is used to simulate the bots traveling through a network to detect the occurrence of the Braess Paradox, considering the increase of directed weighted edges. A Graph Neural Network (GNN) is …


Investigating The Pretesting Effect Under Cognitive Load Through Increased Playback Speed, Oscar Ramirez Perez May 2024

Investigating The Pretesting Effect Under Cognitive Load Through Increased Playback Speed, Oscar Ramirez Perez

Theses and Dissertations

Pretesting prior to a study session has been shown to benefit memory for pretested information compared to traditional study. While previous research has not found a detriment to non-pretested but related material, it is possible that taxing attention by increasing the playback speed of presented material could reveal such impairments. The current study (N = 239) compared multiple-choice learning from educational videos at 1x, 1.5x, and 2x speeds. Three videos (one at each speed) were presented after a pretest, for which half of the tested material was pretested, and half was not (non-pretested related). Another three videos were presented without …


The Effects Of Cover Crops And Reduced Tillage Practices On Soil Moisture, Cotton Yield, Irrigation Water Use, And Profitability, Carson David Roberts May 2024

The Effects Of Cover Crops And Reduced Tillage Practices On Soil Moisture, Cotton Yield, Irrigation Water Use, And Profitability, Carson David Roberts

Theses and Dissertations

Aquifer resources in the mid-southern USA are declining because of irrigation water use in row crops. This study assesses the effectiveness of conservation tillage and cover cropping systems in reducing irrigation water use while improving or maintaining cotton yield and profitability. The effects of different tillage and cover crop cropping systems on soil moisture, irrigation water use, cotton yield, and profitability were investigated near Stoneville, MS on a Dubbs silt loam (fine-silty, mixed, active, thermic Typic Hapludalfs) and a Bosket very fine sandy loam (fine-loamy, mixed, active, thermic Mollic Hapludalfs). Reducing tillage reduced irrigation water use by 3.3 cm ha-1, …


Role Of A Precision Biotic And A Protease Fed Alone And In Combination To Dekalb White Laying Hens At Peak Production Phase, Elsianna Rodewald May 2024

Role Of A Precision Biotic And A Protease Fed Alone And In Combination To Dekalb White Laying Hens At Peak Production Phase, Elsianna Rodewald

Theses and Dissertations

A precision biotic (PB) in standard and reduced CP diets, and a protease (PRO) used alone and in combination with PB in the reduced CP diet were evaluated. Effects on performance, digestibility, and blood biomarkers were determined in Dekalb White hens from 24 to 42 weeks of age. Nine diets were fed: 1) a standard diet with a 17.5% formulated CP level (T1); 2) T1 with 500ppm PB (T2); 3) T1 with 700ppm PB (T3); 4) a reduced CP diet with a 15.5% formulated CP level (T4); 5) T4 with 500ppm PB (T5); 6) T4 with 700ppm PB (T6); 7) …


A Tripartite Study On Climate Change, Nitrogen-Sulfur Interactions, And Sulfur’S Role In Mississippi Corn Production, Ramandeep Kumar Sharma May 2024

A Tripartite Study On Climate Change, Nitrogen-Sulfur Interactions, And Sulfur’S Role In Mississippi Corn Production, Ramandeep Kumar Sharma

Theses and Dissertations

Three studies were conducted with the objectives as i) to assess the impact of climate change on Mississippi (MS) corn production using 1970 to 2020 datasets, employing autoregressive distributed lag model (ARDL), ii) A narrative review on the role of sulfur (S) in crop production, and iii) to investigate the corn response to multiple rates of nitrogen (N) and S. The first study findings revealed that the maximum temperature and precipitation had a negative effect on MS corn yield while minimum temperature and CO2 emissions posed a positive effect on corn yield. The second review study discussed the need for …


Preparing To Come Home, Not Recidivate: Juvenile Offenders' Perceptions Of The Juvenile Justice System, Robbie Kaitlyn Salters May 2024

Preparing To Come Home, Not Recidivate: Juvenile Offenders' Perceptions Of The Juvenile Justice System, Robbie Kaitlyn Salters

Theses and Dissertations

Crimes committed by juvenile offenders are a significant concern of society. In response to this concern, the juvenile justice system addresses juvenile crimes in a developmentally appropriate manner. The goal of the juvenile justice system is to rehabilitate juvenile offenders and steer them from a life of crime and toward becoming productive members of society. Yet, some juvenile offenders continue to offend. While research has explored juvenile offenders’ perceptions of juvenile delinquency, re-entry, and recidivism, less is known about how the detention center prepares juvenile offenders for re-entry. The following study explores the perceptions of detained juvenile offenders in a …


Evaluating Efficacy Of Modified Barrier Operations To Limit Silver Carp Movements In The Mississippi Alluvial Valley, Joshua Stafford May 2024

Evaluating Efficacy Of Modified Barrier Operations To Limit Silver Carp Movements In The Mississippi Alluvial Valley, Joshua Stafford

Theses and Dissertations

Invasive Silver Carp (Hypophthalmichthys molitrix) have spread throughout the Mississippi River basin and threaten native species. The Lower Mississippi Alluvial Valley has numerous water-control structures. These structures could potentially be operated to limit expansions of invasive fishes. My goal was to examine the effects of two water-control structures on movements of Silver Carp within a floodplain network of waterbodies, including an oxbow lake (Eagle Lake; LA, MS). I monitored Silver Carp movements with an acoustic array and bi-monthly active tracking. No movements occurred through the structure managed to deter carp while nine carp passed through the structure that is not …


Maternal And Paternal Appearance-Related Pressure And Body Esteem In Emerging Adults: Moderation By Self Compassion And Gender, Alligrace Story May 2024

Maternal And Paternal Appearance-Related Pressure And Body Esteem In Emerging Adults: Moderation By Self Compassion And Gender, Alligrace Story

Theses and Dissertations

Previous research has shown that appearance-related pressures from multiple sources can influence body esteem in emerging adults. Furthermore, research has shown that self-compassion and gender play a role in body image and the relation between sociocultural pressures and body esteem. Less research has examined how these variables interact in their association with body esteem in emerging adults. Thus, the current study sought to assess these interactions. Participants (N = 877; 492 women) were primarily White (78.9% for women and 76.4% for men) and ranged in age from 18 to 28 (M = 18.70 for women and 19.10 for men). Participants …


Characterization Of The Behavioral Patterns In Salmonella Biofilms Across Different Serovars And Environmental Conditions, Hudson Thames May 2024

Characterization Of The Behavioral Patterns In Salmonella Biofilms Across Different Serovars And Environmental Conditions, Hudson Thames

Theses and Dissertations

Biofilms have the potential to form on various abiotic surfaces and have been found to be more resistant to environmental stressors. Therefore, there is a need to investigate the biofilm forming ability and characteristics of Salmonella strains isolated from poultry meat. These studies characterized the biofilm forming capabilities of 5 Salmonella strains on abiotic surfaces, and investigated changes in gene expression that are associated with Salmonella biofilm formation in 3 Salmonella strains. Salmonella biofilms were cultivated on stainless steel, concrete, rubber, and polyethylene under static and shear stress conditions. Biofilm matrix density was determined using a modified crystal violet assay, …


Southern Pine Beetle Colonization: Dispersal Phenology And Host Selection, John William Thomason May 2024

Southern Pine Beetle Colonization: Dispersal Phenology And Host Selection, John William Thomason

Theses and Dissertations

The southern pine beetle, Dendroctonus frontalis Zimmermann (Coleoptera: Curculionidae), is a prime example of a bark beetle of high ecological and economical importance. As these bark beetles adapt to a changing environment, forest managers must continue to evolve management strategies to improve forest resilience to these pests. Herein, we examined the validity of phenological trap timing cues for the annual spring D. frontalis risk assessment survey and found the traditional use of flowering dogwood (Cornus florida) (Cornaceae) bloom occurred an average of 3 weeks after peak D. frontalis spring flight activity. We also examined the natal host influence on adult …


A Determination Of Host Receptors To Choline-Binding Proteins Of Streptococcus Pneumoniae, Milisen Tvarkunas May 2024

A Determination Of Host Receptors To Choline-Binding Proteins Of Streptococcus Pneumoniae, Milisen Tvarkunas

Theses and Dissertations

Streptococcus pneumoniae (pneumococcus), a gram-positive bacterium, is commensal to the human nasopharynx. It is also a common cause of respiratory tract infections and multiple invasive diseases worldwide. Pneumococci attach to the nasopharynx, lung, and vascular endothelial cells, which contributes to colonization as well as to the development of pneumonia, bacteremia, and meningitis. Choline binding proteins (CBPs) are a unique set of cell wall proteins conserved within pneumococci. CBPs bind noncovalently to the phosphocholine of the cell wall through choline binding domains. The choline binding domains of the CBPs are highly conserved; however, they are diverse in their affinities and functions …


Identity Status And Identity Style In The Emo Subculture: Exploring Identity Between Emo Vs. Non-Emo Emerging Adults, Melanie Rebekah Uggen May 2024

Identity Status And Identity Style In The Emo Subculture: Exploring Identity Between Emo Vs. Non-Emo Emerging Adults, Melanie Rebekah Uggen

Theses and Dissertations

Emerging adulthood can be viewed as a time of exploration and experimentation for college-aged adults (Arnett, 2000). As individuals begin trying on their possible selves as they explore personal identity, they can gravitate to peer groups that fit their interests. For some, that can mean being drawn to the emo subculture. This subculture focuses on its fashion, often based on dyed black hair, dark clothing, studded accessories, and black eyeliner (Chernoff & Widdicombe, 2015), centered around music with lyrics often interpreted as depressive or angst?ridden. Emo subculture has been subject to criticism and stereotypes, especially those with mental health themes …


Application And Feasibility Of Visible-Nir-Mir Spectroscopy And Classification Techniques For Wetland Soil Identification, Caleb Whatley May 2024

Application And Feasibility Of Visible-Nir-Mir Spectroscopy And Classification Techniques For Wetland Soil Identification, Caleb Whatley

Theses and Dissertations

Wetland determinations require the visual identification of anaerobic soil indicators by an expert, which is a complex and subjective task. To eliminate bias, an objective method is needed to identify wetland soil. Currently, no such method exists that is rapid and easily interpretable. This study proposes a method for wetland soil identification using visible through mid-infrared (MIR) spectroscopy and classification algorithms. Wetland and non-wetland soils (n = 440) were collected across Mississippi. Spectra were measured from fresh and dried soil. Support Vector Classification and Random Forest modeling techniques were used to classify spectra with 75%/25% calibration and validation split. POWERSHAP …


Effects Of Moderate Exercise Regimen On Reproductive Development Of Replacement Beef Heifers Reared In Drylots At A High Stocking Density, Logan M. Whipple May 2024

Effects Of Moderate Exercise Regimen On Reproductive Development Of Replacement Beef Heifers Reared In Drylots At A High Stocking Density, Logan M. Whipple

Theses and Dissertations

Raising beef females in drylots is gaining popularity because a more intensive management style facilitates adequate feeding for growth. However, drylots increase stocking density which has previously been shown to be stressful and impair reproductive development, whereas exercise has been shown to alleviate stress. Therefore, the objective was to determine if providing access to an exercise area would improve reproductive development of replacement beef heifers reared in drylots. Body weight, pedometer readings, and blood samples for plasma cortisol were collected weekly. Additional blood samples for genes associated with welfare, hair cortisol samples, and heifer temperament was assessed periodically throughout the …


Choosing A Foundational Mathematics Course In Higher Education: How Is The Decision Made?, Heather Marie Wood May 2024

Choosing A Foundational Mathematics Course In Higher Education: How Is The Decision Made?, Heather Marie Wood

Theses and Dissertations

This qualitative research used the tenants of phenomenological research to structure a study that begins to identify faculty coordinator’s decision processes in selecting a general education mathematics course. In this study, I examined the question if a faculty member's experiences or beliefs had any influence on the decision process. The interviews occurred with faculty in degree programs grouped by the following a) no specific mathematics requirements (e.g., Humanities) degree programs, b) mathematics-light degree programs (e.g., Social Sciences) and c) mathematics-intensive degrees (e.g., Computer Science). The results of this study are varied but suggest that faculty tasked making decisions on mathematics …


Performance Evaluation Of Low-Cost Gps Machine Guidance Systems For Livestock Production Forage And Pasture Management Applications, Conner Childress Wright May 2024

Performance Evaluation Of Low-Cost Gps Machine Guidance Systems For Livestock Production Forage And Pasture Management Applications, Conner Childress Wright

Theses and Dissertations

Global Positioning System (GPS) machine guidance aids in the precise navigation and piloting of farm machinery and serves to boost productivity and optimize farm operations. Characterization of low-cost GPS guidance systems for livestock production operations is necessary for return on investment (ROI) decision making. The objective of this research is to characterize the accuracy of four commercially available low-cost ($985 - $4,200) wide area augmentation system (WAAS) corrected GPS guidance systems. Testing procedures were designed in accordance with the ASABE/ISO standard 12188-2 for testing of satellite-based guidance systems during straight line travel. The vehicles lateral deviation of a planned path, …


Selective Noise Cancelling Application For Misophonia Treatment, Timothy Wunrow May 2024

Selective Noise Cancelling Application For Misophonia Treatment, Timothy Wunrow

Theses and Dissertations

Misophonia is a sensory disorder where specific stimuli, usually auditory, trigger the fight-flight-freeze response, causing extreme reactions, typically anger, panic, or anxiety. Research into treatment for misophonia is limited, primarily consisting of case studies applying common methods of therapy. However, research into similar disorders like tinnitus shows that there are many avenues of treatment that should be investigated, including audiological treatment. To apply audiological treatment to misophonia, selective noise cancelling must be used to control specific trigger sounds. In this research, a basic selective noise cancelling algorithm was developed using a convolutional neural network and was evaluated using a survey. …


Growing Salvia Miltiorrhiza In Mississippi, Zhiheng Xing May 2024

Growing Salvia Miltiorrhiza In Mississippi, Zhiheng Xing

Theses and Dissertations

Salvia miltiorrhiza is a traditional Chinese herbal medicine widely used to prevent and treat cardiovascular and other diseases. With the increasing awareness and use of herbal medicines worldwide, there has been a rapid increase in the use of medicinal plants in the United States. Currently, the majority of medicinal plants used in the US are imported from foreign countries. However, increasing concerns over safety such as heavy metal and chemical contaminations pose significant challenges to US pharmaceutical and related industries in sourcing quality plant materials. It is critical for US industries to have access to high-quality medicinal plants, which provides …


Sleep, Eat, Repeat: An Examination Of The Influence Of Sleep And Biological Sex On Eating-Related Inhibitory Control In Overweight Emerging Adults, Shelby Mika Seipert-Raine May 2024

Sleep, Eat, Repeat: An Examination Of The Influence Of Sleep And Biological Sex On Eating-Related Inhibitory Control In Overweight Emerging Adults, Shelby Mika Seipert-Raine

Theses and Dissertations

Background: Lower inhibitory control has been shown to associate with greater risk for obesity in adolescence. On average, females have moderately higher rates of behavioral inhibitory control than males. These difference in inhibitory control across sex may influence overeating and development of obesity. This study examined whether sleep duration and sleep quality are associated with food-related inhibitory control and whether this association is moderated by biological sex. Methods: A total of 59 emerging adults ages 18 to 25 (37 males, 22 females) who had a BMI within the overweight or obese categories (BMI ≥25) completed self-report measures of eating and …


Synthesis Of High-Quality Cost Effective Zno Nanorods For Photovoltaic Applications, Ghusoon Jalil Ibrahim Al Bazzar May 2024

Synthesis Of High-Quality Cost Effective Zno Nanorods For Photovoltaic Applications, Ghusoon Jalil Ibrahim Al Bazzar

Theses and Dissertations

Due to its outstanding structural, optical, and electrical properties, zinc oxide (ZnO) has received considerable attention from researchers. Even though there is a high demand for functional devices involving ZnO films and nanostructures, synthesizing devices comprising ZnO nanostructures requires expensive and time-consuming techniques that have limited their viability for comprehensive applications. Thus, there is a high demand for high-quality, cost-effective ZnO nanostructures. We have optimized the simple, low-cost, and time-efficient electrochemical deposition (ECD) technique to successfully synthesize high-quality vertically aligned ZnO nanorods to bridge this gap between fundamental and applied research. Characterization of their structural properties through x-ray diffraction and …


Neurobiological Underpinnings Of Autistic Traits, Sensory Processing, And Mental Health In Young Adult Males And Females, Miranda Jane Mcquarrie May 2024

Neurobiological Underpinnings Of Autistic Traits, Sensory Processing, And Mental Health In Young Adult Males And Females, Miranda Jane Mcquarrie

Theses and Dissertations

Females may present with autism more frequently than is diagnosed, due, in part, to autistic trait and sensory processing differences. Unfortunately, recruiting enough autistic female participants is difficult, because of such underdiagnoses. By approaching autism as a continuous variable, neurotypical (NT) individuals can be studied to better understand autistic individuals. Thus, to examine potential neurobiological underpinnings of sex-based behavioral profiles, we recruited 52 NT individuals (22 male; 30 female). Participants underwent resting-state functional magnetic resonance imaging (fMRI) to examine how functional network connectivity (via group independent components analysis) underpinned overall male/female differences in previously measured behavioral autistic trait and sensory …


Dissecting Trypanosome Metabolism By Discovering Glycolytic Inhibitors, Drug Targets, And Glycosomal Ph Regulation, Daniel Hale Call May 2024

Dissecting Trypanosome Metabolism By Discovering Glycolytic Inhibitors, Drug Targets, And Glycosomal Ph Regulation, Daniel Hale Call

Theses and Dissertations

Trypanosoma brucei, the causative agent of African trypanosomiasis, and its relatives Trypanosoma cruzi and several Leishmania species belong to a class of protozoa called kinetoplastids that cause a significant health burden in tropical and semitropical countries across the world. While an improved therapy was recently approved for African trypanosomiasis, the therapies available to treat infections caused by T. cruzi and Leishmania spp. remain relatively poor. Improving our understanding of T. brucei metabolism can inform on metabolism of its relatives. The purpose of the research presented in this dissertation was to develop novel tools and methods to study metabolism in T. …


Fecal Genomics Provides Insights On Connectivity Of Endangered Wildlife In A Human Dominated Landscape, Abhinav Tyagi May 2024

Fecal Genomics Provides Insights On Connectivity Of Endangered Wildlife In A Human Dominated Landscape, Abhinav Tyagi

Theses and Dissertations

Many mammalian species, facing severe historic range reductions, now inhabit fragmented habitats. Habitat fragmentation involves the reduction of habitat into smaller patches, increasing distances between them, and eventually leading to small isolated populations. Species' responses to habitat alteration may vary based on factors such as body size, dispersal ability, and abundance. Understanding these differences is crucial for effective multispecies conservation planning. Genomic data, within a landscape genetic framework, are increasingly applied to evaluate the effects of habitat fragmentation and understand influential landscape features for connectivity. The quantity of data enhances the power and precision of assessing landscape impacts on gene …


A Case Study Of The Design Of The Developmental Mathematics Corequisite Courses At Arkansas’ Public Two-Year Colleges, Jean Anne Swillum May 2024

A Case Study Of The Design Of The Developmental Mathematics Corequisite Courses At Arkansas’ Public Two-Year Colleges, Jean Anne Swillum

Theses and Dissertations

Students determined to be underprepared for college-level mathematics would be enrolled in a sequence of developmental mathematics courses before taking their college-level mathematics course. Students who started in the lowest level of developmental mathematics had a twenty percent chance of completing their college-level mathematics credits (Bailey et al., 2010). Two innovative approaches were implemented to assist students with completing their college-level mathematics course. First, creating mathematics pathways courses aligned with student’s degree plans. Second, implementing developmental mathematics corequisite courses supporting the mathematics pathways courses. Thus, reducing the time it took an underprepared mathematics student to complete their college-level mathematics requirement. …


Investigating The Antibacterial And Immunomodulatory Effects Of Resolvin D2 On Monocytes And Macrophages, Cristina Maria Padovani May 2024

Investigating The Antibacterial And Immunomodulatory Effects Of Resolvin D2 On Monocytes And Macrophages, Cristina Maria Padovani

Theses and Dissertations

In the late phase of sepsis, immunosuppression occurs, where the host is unable to clear the pre-existing infection and is susceptible to secondary infections. It is believed that the ideal treatments for sepsis should attenuate immunosuppression so that the host can get back to homeostasis. Specialized Pro-resolving Mediators (SPMs) are endogenously- produced fatty acids that resolve infectious inflammation without being immunosuppressive. We hypothesize that an SPM – Resolvin D2 (RvD2) – can augment exhausted macrophage function during the immunosuppressive phase of sepsis. We developed a two-hit model to establish macrophage exhaustion in vitro, and found that RvD2 increased NF-κB activity, …