Digital Commons Network^™

Development And Characterization Of Β-Cyclodextrin Inclusion Complexes With Enzalutamide For Easing Administration And Efficacy Of The Drug In Crpc, Meghana Kolli

Theses and Dissertations

Prostate cancer (PC) is prevalent among men in the US, often leading to castration-resistant prostate cancer (CRPC) with therapy. This is marked by androgen receptor (AR) overexpression, resistance, mutations, and splice variants. Enzalutamide (ENZ), a nonsteroidal antiandrogen, surpasses first-gen AR inhibitors like Bicalutamide. It's the go-to drug for CRPC. We explore ENZ for self-assembly complex formation, crucial for CRPC treatment. Using the solvent evaporation method, we developed β-cyclodextrin and ENZ self-assembly complexes (β-CD-ENZ). β-CD acts as both agent and solubilizer, FDA-approved and safe. Efficacy was tested on PC cell lines (C4-2B) and (22Rv1), including 3D cultures for cytotoxicity and a …

Modulating Covalency In A Ni-H-Al Subunit: Synthesis And Characterization Of A Series Of Electronically Differentiating Ni-Al Heterometallics, Aleida Guadalupe Gonzalez

Theses and Dissertations

Metal hydrides are moieties that are present in a variety of applications as intermediates in catalysis. Despite the vast utilization of metal hydrides, monometallic metal hydride complexes bear limitations in inert-bond activation and functionalization. A strategy to overcome these limitations and access more challenging reactivity is utilizing metal-metal cooperativity on a single platform to further activate hydride moieties. Although incorporating multiple metal centers on a single ligand scaffold has been realized, access to heterometallic hydride-bearing complexes is a greater synthetic challenge. Given the limitations in accessing such systems, the reactivity and electronic structure of heterometallic hydrides are seldom studied. Recently, …

A Deep Dive Into The Conformations Of Fluorine-Substituted Benzoic Acids And Ethanesulfonic Acid And Spectroscopic Characterizations Of Their Hydrogen-Bonded Complexes, Alitza Gianina Gracia

Theses and Dissertations

Microwave spectroscopy is a technique used to study the molecular structures of a wide range of systems. The first part of the thesis focuses on fluorinated benzoic acids and complexes they form through hydrogen bonding to explore the fluorination effect, while the last part shifts to ethanesulfonic acid and its interaction with water. The study of 3,4,5-triflurorbenzoic acid with formic acid offers insight on the proton tunneling process, which is a process that occurs in many chemical and biological processes. Microwave spectroscopy can help provide dynamic information for the better understanding of this fundamental process. Solvation is another topic that …

They See Themselves In The Lesson: Leveraging Students’ Scientific And Cultural Insights Through The Cultural Biohealth Synergy Science Curriculum [Se Ven A Sí Mismos En La Lección: Aprovechando Los Conocimientos Científicos Y Culturales De Los Estudiantes A Través Del Currículo De Ciencias De Sinergia De Bio Salud Cultural], Miriam M. Ortiz

Theses and Dissertations

In response to the global crisis of type 2 diabetes prevalence, this dissertation investigated the impact of a culturally sustaining, health-centric science curriculum contextualized in type 2 diabetes. Using a case study methodology, it explored how the curriculum shaped math and science preservice teachers’ (PSTs) perceptions of science and how it can be taught and how prepared they felt to design and implement culturally sustaining, health-centric lessons. Four themes that emerged across both cases included: 1) connecting health, nutrition, everyday science, and culturally sustaining pedagogy through the CBSS curriculum, 2) connecting science to health and wellness concepts through the CBSS …

The Effect Of Advertising On Consumer Self-Improvement Motivation: When And How Advertising Motivates Consumers, Suwakitti Amornpan

Theses and Dissertations

In today's modern world, advertising permeates nearly every facet of consumers’ daily lives, from billboards over city streets to posts seamlessly integrated into social media feeds. The current research identifies a positive unintended consequence of advertising on consumer behavior: increased consumer self-improvement motivation. Across four studies, I find that exposure to mass (vs. luxury) advertising increases consumer motivation to engage in self-improvement. Specifically, I argue that because advertisements for mass (vs. luxury) products prime attainable (vs. unattainable) consumption goals, they increase consumer confidence in their ability to achieve their consumption goals (i.e., they enhance self-efficacy perceptions). This, in turn, puts …

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC …

Lexical Access In Women With The Fmr1 Premutation, Nadia Sabeh Ayon

Theses and Dissertations

Background: Emergent research indicates that women carrying the FMR1 premutation (FXpm) may encounter difficulties in language skills, including increased dysfluencies, a reduction in the quantity and diversity of words produced, and increased word retrieval errors with age (Sterling et al., 2013; Bredin-Oja et al., 2021). Objectives: The present study aims to assess semantic and phonological lexical access skills in FXpm women as well as to examine the impact of cognitive load (time pressure) on lexical access.

Methods: Forty-two FXpm women and 25 control women, aged 26-65 years (M=46.22, age-matched: p=.115), participated. The Network Production Task (Oomen & Postma, 2001), featuring …

Innovative 4d Printing Of Biomimetic Collagen-Tcp Scaffolds For Bone Regeneration, Karly Morgan Liebendorfer

Theses and Dissertations

Bone tissue engineering (BTE) is a promising alternative approach to autografts and allografts when treating various bone diseases and disorders. BTE enables the fabrication of biocompatible, biomimetic, and osteo-stimulating constructs for the repair and regeneration of damaged bone tissue. The native bone environment primarily consists of anisotropic type 1 collagen (organic) and hydroxyapatite nanocrystals (inorganic). Composite biomimetic scaffolds fabricated by combining collagen with bioceramics have shown immense promise for BTE applications. Prior work has reported on different biofabrication methods to synthesize collagen-based composite scaffolds for use in BTE applications. However, to date, a customizable 3D composite scaffold that resembles the …

Using Unmanned Aircraft Systems (Uas) To Assess Body Condition Of Common Bottlenose Dolphins (Tursiops Truncatus Truncatus) In The Indian River Lagoon, Florida, Jessica Jane Provenzano

Theses and Dissertations

Common bottlenose dolphins (Tursiops truncatus truncatus) in the Indian River Lagoon (IRL) have experienced four Unusual Mortality Events (UMEs). This stock is considered immunocompromised and is routinely subjected to persistent anthropogenic stressors such as fishing gear entanglement, vessel strikes, contaminants, and harmful algal blooms. Previous body condition assessments of this stock have involved invasive capture-release examinations or subjective methods using lateral body images. To improve precision, we investigated the use of photogrammetry data collected from noninvasive unmanned aircraft systems (UAS) combined with models developed from capture-release data to estimate morphometric parameters and subsequently determine the body condition of …

Investigating Microbe-Plant Symbioses In Space, David Handy

Theses and Dissertations

As life has evolved on Earth, gravity has been a constant around which biological processes have developed, rather than a pressure that has been adapted to. As humanity ventures into space, we remove this constant and can observe a variety of changes in biological systems, such as bone loss in humans, stunted plant growth, or increased virulence in pathogens. The growing body of data shows that life adapts to spaceflight and microgravity in unique ways that, due to our limited understanding, can be difficult to predict. A particularly under-studied area is that of host-microbe interactions. Despite efforts to limit their …

Characterizing The Quorum Sensing (Qs) System In The Model Eukaryote Chlamydomonas Reinhardtii, Kirstin Donnette Cutshaw

Theses and Dissertations

Group behaviors in microorganisms are often regulated by low-molecular weight molecules that enable them to sense population density, a signaling system known as quorum sensing (QS). QS in prokaryotes has provided insight into the role ‘social’ behaviors play in the bacterial world and refined our models of virulence, bacterial motility, and more. While less common, similar behaviors are observed in certain fungi, primarily yeasts, in which QS controls cell morphology, biofilm production, and other phenotypes. We have recently pursued the potential for QS to be more broadly distributed among unicellular eukaryotes, which could significantly alter our understanding of social behaviors …

Enhancement Of Polytetrafluoroethylene-Polyvinyl Alcohol Nanofibers Triboelectric Effect With Carboxylic Functionalized Multiwalled Carbon Nanotubes Coating, Fernando Viesca

Theses and Dissertations

In this study, we fabricated a TENG using Forcespinning® (FS) Polytetrafluoroethylene microfibers (FS-PTFE-MFs) and Electrospun (ES) Polyvinyl alcohol nanofibers (ES-PVA-NFs). The FS-PTFE-MFs were physically linked with functionalized carboxylic multiwall carbon nanotubes (MWCNTs-COOH) employing water dispersions. MWCNTs-COOH were dispersed using three different surfactants: Sodium Dodecyl Sulfate (SDS), Sodium dodecylbenzenesulfonate (SDBS), and Triton X-100 (TX-100). Coated FS-PTFE-MFs were then characterized using a field emission scanning electron microscope (FESEM) with an energy dispersive X-ray spectroscopy (EDS) attachment and Fourier-transform infrared spectroscopy (FTIR). While no significant difference in performance was observed with different surfactants, electrical results of the TENG recorded a notable enhancement of …

Greenhouse Gas Emissions From Urban Lawn Soil Amended With Biochar And Compost Under Contrasting Redox Conditions, Angel Salinas

Theses and Dissertations

Green fields around the world are being converted to urban land uses to cope with population growth and urbanization. The objective of this study was to investigate how urban lawn soils can contribute to greenhouse gas (GHG) emissions in relation to soil saturation-drainage cycles. We measured carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) emissions as well as redox potential (Eh) from garden soils amended with biochar, compost, or biochar + compost under a mesocosm scale. Bermuda turfgrass seed was seeded in each column (5-gallon bucket) and three water saturation conditions (half-saturated, full-saturated, and unsaturated soils) were maintained for …

Decisions, Decisions: Dna Damage Induced Modification Of P53 And The Effect Of Modifications On P53 Differential Binding To The Dna, Savannah Gabrielle Keating

Theses and Dissertations

p53 is the most frequently mutated tumor suppressor protein in cancer. It is highly regulated, most often via post-translational modifications (PTMs). Different pathways and target genes are differentially activated by p53 and there is much left to understand how this occurs. The regulation of p53 at the post-translational level is incredibly important to its DNA damage response, and, therefore, it is understood that PTMs are often involved in the differential activation of pathways by p53. This project aimed to identify some of the types and locations of post-translational modifications on p53 in response to different modes of DNA damage with …

Investigating The Mediating Effect Of Social Support In Team Sport Participation On Adolescent Mental Health Outcomes, Olivia Schmitke

Theses and Dissertations

Peer and non-familial adult supportive relationships are a critical part of healthy adolescent development, positively influencing psychological, behavioral, and social domains (e.g., Panza et. al., 2020). Extracurricular sports activities are a source of peer (e.g., teammates) and adult (e.g., coaches) relationships and are associated with favorable impacts on mental health which may be an impactful protective factor given the rise of mental health crisis in youth today. The present study aimed to clarify the relationship mechanisms underlying the benefits of sports participation by examining and effecting social support has on mental health outcomes in adolescents engaged in sports. In doing …

Accessory Eyes And Dynamic Color Change In Palaemon Vulgaris, Nicholas Raymond Steichmann

Theses and Dissertations

Eyes are physiologically costly organs to produce and maintain, making the development of secondary eyes intriguing. Caridean shrimp possess reflecting superposition primary eyes, but some species across fourteen families possess an additional pair of eyes called accessory eyes along the dorso-posterior margin of the primary eyes. Secondary eyes are found in lizards, lampreys, and insects, where they often function as illumination detectors. Some shrimps may use accessory eyes to signal endocrine organs in their eyestalks to alter the pigmentation of their carapace providing better camouflage through disruptive coloration. To investigate the role of accessory eyes in dynamic color change we …

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC compared …

Sexual Quality Of Life In Sexual And Gender Minority Women After Cancer, Heather Schneider Miles

Theses and Dissertations

Sexual quality of life (SQoL) is a critical aspect of well-being, encompassing physical, emotional, and social dimensions. For sexual and gender minority women (SGMW)—lesbian, bisexual, transgender, or queer—cancer presents unique challenges. This dissertation examined the relationships between cancer treatment symptoms, social support, and communication with the cancer care team (CCT) on SQoL among SGMW survivors of breast, gynecological, and colorectal cancers. Quantitative data from 37 participants were collected using PROMIS® measures, assessing demographics, treatment history, post-treatment symptoms, perceived social support, and communication with the CCT. Additionally, in-depth interviews with five participants provided qualitative insights into their experiences and the meaning …

"Ain’T No Slump...I Just Ain’T Hittin’": Investigating Psychological Momentum And Loss Aversion In Major League Baseball, Josephine Matalone

Theses and Dissertations

Throughout the history of America’s pastime, it has long been concluded among fans, athletes, and coaches alike that momentum is a key element necessary should one want to win when it counts. However, this issue of “hot hand” existence in the context of baseball has been largely glazed over since the canon of literature on the topic was initiated, and even more so has the concept of a “cold hand.” This study seeks to make a novel contribution by exploring streaks in professional baseball. Using 10-years’ worth of regular season MLB data between 2012 and 2021, a comparative analysis of …

Understanding Cancer Grade And Survival Disparities Among Young Adults Diagnosed With Non-Hodgkin’S Lymphoma (Nhl) Residing In South Carolina, Prema S. Bhattacharjee

Theses and Dissertations

Introduction. Previous research has shown that age and cancer grade differences must be carefully considered when developing initiatives to improve outcomes for NHL among the young adult population. The aims of this study are 1) to examine differences between low vs. high grade in NHL by race/ethnicity, healthcare insurance, and geographic factors among YAs aged 18-39 years of age in South Carolina, 2) to examine delays in the first course of cancer treatment for NHL by race/ethnicity, healthcare insurance, and county of residence (urban vs. rural) among YAs aged 18-39 years of age in South Carolina, and 3) examine differences …

Antioxidant And Anti-Inflammatory Potential Of Engineered Ceria Nanoparticles In The Management Of Alzheimer's Disease, Shanshan Shi

Theses and Dissertations

Alzheimer's disease (AD) is a devastating neurodegenerative disorder that affects millions worldwide. Unfortunately, there are currently no effective therapies available to prevent or cure the disease. While current therapies aim to change AD progression, there is a growing need for novel therapeutic strategies that can effectively penetrate the blood-brain barrier (BBB) to target the underlying pathology of the disease. The BBB is a highly selective semipermeable barrier that separates circulating blood from the brain. It plays a crucial role in amyloid-β (Aβ) homeostasis and clearance dynamics, as Aβ accumulation is a key factor in the pathogenesis of AD. Aβ aggregation …

Optimization Of A Nanotechnology-Based System For The Treatment Of Electroplating Wastewater, Madeleine Mary Meyer

Theses and Dissertations

To protect humans and the environment, human actions that may expose living organisms to toxic metals are heavily regulated in developed countries. The use and production of toxicants in commercial applications is tightly controlled in the United States of America by federal and state laws. Due to this fact, United States manufacturing companies are required to control the amount of regulated toxicants that leave their facilities. Toxic metals in wastewater are heavily regulated by federal and state law, with manufacturing facilities permitted individually for the concentrations of metals they are allowed to discharge via their wastewater. From previous research conducted …

Altered Sensory Processing And Pain In Youth With Sickle Cell Disease: Risk Factors And Moderators, Julia Johnston

Theses and Dissertations

Introduction: Youth with sickle cell disease (SCD) experience recurrent pain and increased risk for chronic pain. Neuropathic pain, characterized by alterations to the central and/or peripheral nervous systems, is not well understood among youth with SCD. Based on our current understanding of pain systems and existing literature on pain in SCD, this study aimed to elucidate psychosocial correlates of altered sensory processing (ASP) and neuropathic pain, determine biomedical risk factors contributing to the development of ASP among youth with SCD, and identify how sensory processing and biopsychosocial factors collectively influence pain experiences by assessing two plausible models. Methods: Thirty-five youth …

Enabling Novel Nanopore Sensing Approaches For Personalized Medicine Through Chemical Modifications To Analytes, Zehui Zhang

Theses and Dissertations

Nanopore sensors have garnered significant attention recently, not only for their groundbreaking advancements in single-molecule DNA sequencing but also for their diverse applications in stochastic sensing, single-molecule chemistry, and protein unfolding. The interaction of single molecules with the nanopore sensing interface leads to characteristic ionic current modulations, reflecting the composition, charge, distribution, structure, and sequence of the translocating molecule. With the electrical resistive pulse nanopore sensing, its single-molecule sensitivity and specificity have opened doors to numerous potential applications in personalized medicine. I will discuss recent advancements in the sensitivity and specificity of personalized medicine using nanopore sensors, focusing on proteomic …

Using Youth Participatory Action Research To Scale Up Pre-Exposure Prophylaxis (Prep) In The Southern United States, Mariajose Jhamira Paton

Theses and Dissertations

The recently launched initiative, Ending the HIV Epidemic (EHE), provides a targeted plan to end HIV in the United States (US) by 2030, and prioritizes key demographic groups and geographic areas that are disproportionately burdened by HIV. Sexual and gender minority (SGM) youth, especially Black and Latiné youth (SGMBLY), are a key population for EHE as they have experienced the largest increase in new HIV rates in recent decades. States identified by EHE are disproportionately located in the Southern US, where increasing the uptake of pre-exposure prophylaxis (PrEP) for HIV has been a challenge. Though proven effective, youth participatory action …

Surface Acoustic Waves-Based Point-Of-Care Biosensor, Debdyuti Mandal

Theses and Dissertations

A biosensor is an analytical tool consisting of biologically active material used in close conjunction with a device that converts a biochemical signal into a quantifiable electrical signal. The early detection of the disease biomarkers can enhance the increased curability of the disease, reduce healthcare costs, and finally, improve the quality of life for patients. Thus, for the following purpose, there is always a need for an effective biosensor as a diagnostic device. The biosensor typically consists of an actuator, a bio-recognition component, and a transducer that converts captured signals into a meaningful display. The bio-recognition component uses biomolecules to …

“Finally Somebody Wants To Hear Us”: Soviet Women And Political Violence In Svetlana Alexievich’S Narratives, Liubov Kartashova

Theses and Dissertations

This dissertation explores the emotional and social impact of significant Soviet historical events, including World War II, the Soviet-Afghan War, and the Chornobyl disaster, on collective memory. Svetlana Alexievich, a Belarusian Nobel Prize laureate, employs a polyphonic narrative technique to challenge official histories of these events and foreground the voices of ordinary people, particularly women. Focusing on her works – The Unwomanly Face of War, Zinky Boys, and Chernobyl Prayer – the study delves into the gendered experiences and narratives of women involved in these events. Integrating feminist scholarship on international relations and security, this research analyzes women’s roles in …

Improving Drug Repurposing Success: Integrating Large Database Claims Analysis In Drug Discovery, Joseph Magagnoli

Theses and Dissertations

Drug repurposing has emerged as an innovative strategy to identify new therapeutic uses for existing medications. However, with few notable exceptions, repurposing existing drugs has limited overall success, often failing in randomized controlled trials (RCTs) due to inadequate treatment efficacy in new clinical settings. To improve success rates, I propose a framework titled REMIDY: Retrospective and Experimental Methods Integration for Drug DiscoverY. The REMIDY framework incorporates retrospective claims analysis into the drug discovery process. I demonstrate that retrospective analysis can leverage extensive administrative and clinical data to address translational gaps between pre-clinical experimental models and RCTs. For example, pre-clinical experimental …

Understanding Stressors, Coping Strategies, And Physical Activity Among African American Women Using Ecological Momentary Assessment, Asia Brown

Theses and Dissertations

Psychological stress is a normal part of the human experience and can be adaptive in certain contexts. However, chronic, cumulative, or uncontrollable stressors, such as those associated with living in poverty or being a member of a marginalized group, contribute to pervasive inequities among African American women including lower rates of physical activity. Given the social and political forces that continue to shape inequities, and which have exacerbated Covid-19’s impact on African Americans, it is important to gain a better understanding of how this population is experiencing and coping with current stressors, many of which are embedded within the social …

Humanizing Healthcare: Supporting Lgbtq+ Healthcare Professionals And Trainees, Atticus Wolfe

Theses and Dissertations

The public perception of the healthcare profession has been shifting in recent years largely attributed to the rise of scientific and medical skepticism impacting perceptions of the value of healthcare professionals and care itself (Goddard & Patel 2021). While healthcare professions remain associated with higher public value, healthcare professionals and trainees are expected to adhere to rigid expectations of medical professionalism that may contradict other aspects of their identities. LGBTQ+ identity in particular may pose conflicts to the expectations of healthcare professionalism, contributing to lower self-perceived value for LGBTQ+ healthcare professionals and trainees compared to non-LGBTQ+ healthcare professionals and trainees …