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Articles 16501 - 16530 of 19640
Full-Text Articles in Entire DC Network
The Effects Of Parkinson's On Fixational Stability, Erin L. Mallahan
The Effects Of Parkinson's On Fixational Stability, Erin L. Mallahan
Theses and Dissertations
Parkinson's disease (PD) is a progressive, neurological movement disorder. The stability of eye movements in PD is not well understood but many patients report difficulty doing tasks that require stabilized fixation and gaze. The ability to stabilize an image on the retina is critical is acquiring visual information. The purpose of this study was to compare the stability of fixational eye movements of PD patients to those of age-matched controls. Eye movements during simple fixation tasks were recorded from 66 subjects (ages 52 to 84), and 36 age-matched controls (ages 58-85). The absolute velocity of the fixational eye movements were …
The Financial Feasibility Of Marriage For Women Receiving Tanf: An Analysis Of Six States, Sally Margaret Brocksen
The Financial Feasibility Of Marriage For Women Receiving Tanf: An Analysis Of Six States, Sally Margaret Brocksen
Theses and Dissertations
This project employed a descriptive case study methodology guided by rational choice theory to examine the financial feasibility of marriage for low income women. By modeling the income and expenses of eight different low income family types in six states (Arizona, California, New York, Oklahoma, Virginia, and Wisconsin) this study illustrates the financial situation of various low income families. The family types under investigation include: a single parent family, a family receiving TANF, cohabiting couple with two wage earners, cohabiting couple with one wage earner, a married family with two wage earners, a married couple with one wage earner, a …
Iterative Methods For The Reconstruction Of Tomographic Images With Unconventional Source-Detector Configurations, Abey Mukkananchery
Iterative Methods For The Reconstruction Of Tomographic Images With Unconventional Source-Detector Configurations, Abey Mukkananchery
Theses and Dissertations
X-ray computed tomography (CT) holds a critical role in current medical practice for the evaluation of patients, particularly in the emergency department and intensive care units. Expensive high resolution stationary scanners are available in radiology departments of most hospitals. In many situations however, a small, inexpensive, portable CT unit would be of significant value. Several mobile or miniature CT scanners are available, but none of these systems have the range, flexibility or overall physical characteristics of a truly portable device. The main challenge is the design of a geometry that optimally trades image quality for system size. The goal of …
Evaluation Of The Pharmacokinetic-Pharmacodynamic Relationship, Metabolism And Plasma Protein Binding Of The Novel Antitumor Agent, 2-Methoxyestradiol (2me2), Following Oral Administration In Patients With Solid Tumors., Nehal Jagdish Lakhani
Theses and Dissertations
The goal of this study was to determine safety, tolerability and pharmacokinetics of 2ME2 in patients with solid tumors and determine maximum tolerated dose (MTD). The following hypotheses were tested: 1) 2ME2 will be well tolerated in clinic when given orally and will have quantifiable effects on the ex vivo markers of angiogenesis and apoptosis; 2) 2ME2 will exhibit linear pharmacokinetics; 3) Plasma protein binding will be extensive and linear; 4) Sulfation will be the major metabolic pathway for 2ME2.This was a phase I dose escalation study. Twenty patients with refractory solid tumors were enrolled. 2ME2 was administered orally starting …
Co-Parenting In Intact And Divorced Families: Its Impact On Young Adult Adjustment, Jill A. Ferrante
Co-Parenting In Intact And Divorced Families: Its Impact On Young Adult Adjustment, Jill A. Ferrante
Theses and Dissertations
Co-parenting is the ideal parenting relationship after divorce, characterized by involvement of both parents in all decisions regarding their children. Children who report that their parents demonstrate healthy co-parenting are generally better adjusted than their peers who experience unhealthy co-parenting. The present study examined the potential mediating roles of co-parenting and parenting practices upon the relationship between marital status and young adult adjustment. Data were analyzed via structural equation modeling. Participants were 340 undergraduate students from intact and divorced/separated families. Data were obtained via questionnaires that tapped a range of adjustment factors (i.e., mental health, fear of intimacy, work ethic, …
Predictors Of Sun Protection Practices Among Adult Women In The United States, Anne Ridgely Minter
Predictors Of Sun Protection Practices Among Adult Women In The United States, Anne Ridgely Minter
Theses and Dissertations
Background. Skin cancer is the most common form of cancer in the United States. The main modifiable risk factor for skin cancer is exposure to excessive sun and UV radiation. More than 90% of all skin cancers are known to be caused by sun exposure. However, studies on excessive sun and UV exposure are limited. The purpose of this study was to examine risk and protective factors affecting sun protection behaviors of adult women in the United States. Methods. Data on U.S. adult women (n=17,425) from the 2003 National Health Information Survey (NHIS) was analyzed. Sun protection behaviors were assessed …
The Extraction Of Type Ii Collagen And The Electrospinning Of Nano-Fibrous Scaffolds, Danielle Careen Knapp
The Extraction Of Type Ii Collagen And The Electrospinning Of Nano-Fibrous Scaffolds, Danielle Careen Knapp
Theses and Dissertations
Articular cartilage lining joints, such as in the knee, functions to reduce friction and absorb shock. Collagen type II is the largest constituent in the extracellular matrix of articular cartilage and its restoration is of the highest interest to tissue engineers. Cartilage has little ability to naturally regenerate due to the absence of vascularity and the inability of the chondrocytes to proliferate at a high rate. It would be ideal to create a mimicking extracellular matrix/scaffold from type II collagen that could possibly be used to replace damaged articular cartilage that has the same function and morphology. Three different groups …
Flight Signs, Flight Symbols, Margaret Mary Urban
Flight Signs, Flight Symbols, Margaret Mary Urban
Theses and Dissertations
I am investigating the significance of historic events of flight through image making; particularly incidents that captured the collective imagination and became part of our cultural memory. These events have surpassed mere entries in historical texts and become mythic. In the terms of Jungian psychology, they have become symbolic. In terms of Semiotics, they have become signs. Through photographs and installation, I seek to understand their presence in my, and our, unconscious mind.
Method Of Infant Feeding As A Predictor Of Maternal Responsiveness, Emily Eiwen Drake
Method Of Infant Feeding As A Predictor Of Maternal Responsiveness, Emily Eiwen Drake
Theses and Dissertations
Infants need to develop effective, secure attachment to their primary caregivers in the first year of life. Researchers have not been able to identify all the factors that may influence the development of infant attachment. Most of the studies in this area have been done without regard to infant feeding as a potential factor. Maternal responsiveness appears to be key in the child's development of secure attachment behaviors, yet even after decades of research on infant attachment and maternal responsiveness, there is little evidence available to assist with early identification of families at risk and few interventions known to be …
Identification And Characterization Of The Expression Profile Of Oligodendrocyte-Derived And Associated Proteins Via Unilateral X-Irradation Of The Rat Optic Nerve, Nicholas Greco
Theses and Dissertations
Recent studies examining cell-cell interactions during CNS development and following disease or trauma have highlighted our limited understanding of the in vivo functions of the myelinating cell of the CNS, the oligodendrocyte. With this in mind, our laboratory has developed techniques by which a profile of proteins derived from or regulated by oligodendrocytes can be elucidated. Specifically, we have demonstrated that oligodendrocytes can be selectively eliminated from one optic nerve of a rat by treating the animal with a unilateral exposure of X-irradiation at the time of birth. Consequently, this approach allowed us to experimentally create, within the same animal, …
Type-5 Phosphodiesterase Inhibition In The Prevention Of Doxorubicin Cardiomyopathy, Patrick William Fisher
Type-5 Phosphodiesterase Inhibition In The Prevention Of Doxorubicin Cardiomyopathy, Patrick William Fisher
Theses and Dissertations
Prior studies have demonstrated the effect of diazoxide in protecting against apoptosis via mitochondrial KATP channel opening in vitro. The current investigations are designed to determine if sildenafil, a phosphodiesterase-5 inhibitor and known mitochondrial KATP channel opener, would protect against chronic doxorubicin cardiomyopathy both in vivo and in vitro.Male ICR mice were randomized to 1 of 4 treatments: saline, sildenafil (0.7 mg/kg IP), doxorubicin (5 mg/kg IP), and sildenafil (0.7 mg/kg IP)+doxorubicin. Apoptosis was determined using the terminal deoxynucleotidyl transferase mediated dUTP nick-end labeling and in situ oligo ligation methods. Desmin distribution was determined via immunofluorescence. Bcl-2 was analyzed by …
Discovering Work Relationships And Their Effect On Job Satisfaction : An Exploratory Study Of A Small Organization In The Upper Midwest, Heather Brooke Berglove
Discovering Work Relationships And Their Effect On Job Satisfaction : An Exploratory Study Of A Small Organization In The Upper Midwest, Heather Brooke Berglove
Theses and Dissertations
No abstract provided.
Finite Element Analysis Of Bjork-Shiley Convexo-Concave Heart Valve, Sumit Agrawal
Finite Element Analysis Of Bjork-Shiley Convexo-Concave Heart Valve, Sumit Agrawal
Theses and Dissertations
No abstract provided.
Brownian Dynamics Simulation Of The Interaction Between Lactate Dehydrogenase (Ldh) And G- Or F-Actin, Njankwa N. Njabon
Brownian Dynamics Simulation Of The Interaction Between Lactate Dehydrogenase (Ldh) And G- Or F-Actin, Njankwa N. Njabon
Theses and Dissertations
No abstract provided.
Motives Behind The Use Of Visual Artifacts In Catholicism And Sunni Islam : Contribution To Discussion Of Representation, Alevtina Naumova
Motives Behind The Use Of Visual Artifacts In Catholicism And Sunni Islam : Contribution To Discussion Of Representation, Alevtina Naumova
Theses and Dissertations
No abstract provided.
An Exploratory Study Of The Members At A Latino Organiation [Sic], Michael P. Stevens
An Exploratory Study Of The Members At A Latino Organiation [Sic], Michael P. Stevens
Theses and Dissertations
No abstract provided.
Diffusion And Remediation Of Organic Chemicals In Softwood, Nidhi Jalan
Diffusion And Remediation Of Organic Chemicals In Softwood, Nidhi Jalan
Theses and Dissertations
No abstract provided.
Calcium Kinetic Studies In Animal Models For Osteoporosis Using ⁴⁷Ca/⁴¹Ca Radiotracers, Jennifer Ann Sattler
Calcium Kinetic Studies In Animal Models For Osteoporosis Using ⁴⁷Ca/⁴¹Ca Radiotracers, Jennifer Ann Sattler
Theses and Dissertations
No abstract provided.
Web-Based Learning : Investigating The Role Of Visual Communication Strategies Between Students And Technology, Brandon J. Semler
Web-Based Learning : Investigating The Role Of Visual Communication Strategies Between Students And Technology, Brandon J. Semler
Theses and Dissertations
No abstract provided.
Community Dynamics Of Terrestrial Vertebrates In Aspen Parkland-Mixed Grass Prairies Habitats At J. Clark Salyer National Wildlife Refuge In North Dakota, Neil J. Kadrmas
Community Dynamics Of Terrestrial Vertebrates In Aspen Parkland-Mixed Grass Prairies Habitats At J. Clark Salyer National Wildlife Refuge In North Dakota, Neil J. Kadrmas
Theses and Dissertations
No abstract provided.
Planning Ability Components Of Executive Functioning In Women With A History Of Self-Harm Behavior And Suicidality, Patrick L. Kerr
Planning Ability Components Of Executive Functioning In Women With A History Of Self-Harm Behavior And Suicidality, Patrick L. Kerr
Theses and Dissertations
No abstract provided.
The United Nations Security Council : Impact Of Its Characteristics As A Public Organization On The Conflict Resolution Process, Pavel Tchikov
The United Nations Security Council : Impact Of Its Characteristics As A Public Organization On The Conflict Resolution Process, Pavel Tchikov
Theses and Dissertations
No abstract provided.
Development Of An Automatic Instrument For Rapid Analysis Of Selenium In Food Grains, Sathyendra K. Ghantasala
Development Of An Automatic Instrument For Rapid Analysis Of Selenium In Food Grains, Sathyendra K. Ghantasala
Theses and Dissertations
No abstract provided.
Reevaluation Of Species Concepts Of Uppermost Cretaceous Unionidae (Mollusca: Bivalvia) : Hell Creek Formation, Montana, U.S.A., Marron J. Bingle
Reevaluation Of Species Concepts Of Uppermost Cretaceous Unionidae (Mollusca: Bivalvia) : Hell Creek Formation, Montana, U.S.A., Marron J. Bingle
Theses and Dissertations
Species are the basic units of life relative to taxonomy, and a practical definition of species is imperative to paleontology in order to promote reproducible, unambiguous criteria for accurately interpreting past species relationships. The need for a well-defined rubric for identifying species is evident in the freshwater mussel assemblage (Family Unionidae) in the Hell Creek Formation. The Hell Creek Formation unionid species were first described by Whitfield in 1903 and 1907. His descriptions were often based on differences of a single trait. In 1976, Russell reevaluated the original species descriptions, I but still based the classification of species on only …
Biochemical And Molecular Nutrition Blocks As Dietary Supplements In Llamas (Lama Glama) In The Last Third Of The Gestation Period Of The Ceac, Janette Illanes Callejas
Biochemical And Molecular Nutrition Blocks As Dietary Supplements In Llamas (Lama Glama) In The Last Third Of The Gestation Period Of The Ceac, Janette Illanes Callejas
Theses and Dissertations
The present work consisted in the use of biochemical and molecular nutrition blocks (BMN) in llamas during the last third of the gestation period, at the Agricultural Experiment Center of Condori (CEAC), located 49 km north of the city of Oruro, and 12 km north of the Caracollo population, in the province of Cercado. For this research work, we used 20 pregnant llamas in the last third of their gestation period, between the ages of 2 and 3 years old, 10 of which belonged to the Khara breed, and 10 to the Thampulli breed. Two corrals of 7 x 7 …
Vimentin Overexpression Contributes To The Biological Properties Of Metastatic Head And Neck Cancer Cells, Rachel J. Paccione
Vimentin Overexpression Contributes To The Biological Properties Of Metastatic Head And Neck Cancer Cells, Rachel J. Paccione
Theses and Dissertations
Epithelial to mesenchymal transition occurs in the later stages of epithelial tumor progression, with cells expressing mesenchymal markers. Of these, the intermediate filament protein vimentin is frequently upregulated in metastatic carcinomas. Previously, microarray studies showed that the gene encoding vimentin is highly upregulated in metastatic HN12 cells compared to a related primary tumor cell line. In this study, we confirmed this difference using real-time quantitative PCR, western blot analysis, and immunostaining. Furthermore, EGF and TGF-β, growth factors that induce migration and invasion of HN12 cells, produced synergistic increases in vimentin expression. To assess the contribution of vimentin to the biological …
Addiction And Recovery Experiences Of African American Women: A Phenomenological Study, Patricia Diana Hill
Addiction And Recovery Experiences Of African American Women: A Phenomenological Study, Patricia Diana Hill
Theses and Dissertations
Historically, substance abuse research has for the most part excluded African American women. The small body of existing substance abuse research regarding African American women does not examine gender and socio-cultural issues from African American women's perspectives. The purpose of this phenomenological study is to develop a deeper, contextual understanding of the experiences and perspectives of this marginalized population of women. The major goal of the study is to examine the perspectives of African American women about their substance abuse, treatment and recovery. The knowledge gained from this research with African American women regarding their experiences and specific needs in …
Electromechanical Characterization Of Poly(Dimethyl Siloxane) Based Electroactive Polymers, Wrutu Deepak Parulkar
Electromechanical Characterization Of Poly(Dimethyl Siloxane) Based Electroactive Polymers, Wrutu Deepak Parulkar
Theses and Dissertations
The main objectives of this thesis are 1) to evaluate the effect of cross-linking polar cyano phenyl (CN) groups on poly (dimethyl siloxane) (PDMS) and 2) to characterize the electromechanical properties of the resulting CN-PDMS blend as an electroactive actuator. Materials responding to an external stimulus are referred to as electroactive materials. There are several phenomena, which govern the mechanism in these materials, such as piezoelectricity, Maxwell's effect, ferroelectricity, electrostriction to name a few. These electroactive materials can be employed in several applications such as biomedical devices, robots, MEMs, aerospace vehicles, where the application is governed by the specific mechanism. …
Modulation Of Gene Expression By Tumor-Derived Mutant P53. Role Of Transactivation In Gain-Of-Function., Mariano J. Scian
Modulation Of Gene Expression By Tumor-Derived Mutant P53. Role Of Transactivation In Gain-Of-Function., Mariano J. Scian
Theses and Dissertations
It was hypothesized that the C-terminal sequences for mutant p53 would be required for oligomerization. and oligomerization may be critical for gain-of-function. An N-terminal deletion mutant of p53 that deletes amino acids 1-293 was used as a tool to perform hetero-oligomerization studies. This mutant retains the entire oligomerization domain but dispenses off the transactivation domain and a large portion of the sequence- specific DNA-binding domain. Co-transfection experiments show that p53 del. 1-293 forms hetero-oligomeric complexes with p53-D281G. Also. co-expression of p53 del. 1- 293 with p53-D281G inhibited p53-D28lG-mediated transactivation of the EGFR and MDRl promoters suggesting that hetero-oligomerization inactivates transcriptional …
Long-Term Cardioprotection With Phosphodiesterase-5 Inhibition Against Ischemia-Reperfusion Injury: Role Of Nitric Oxide., Vladimir Paul Daoud
Long-Term Cardioprotection With Phosphodiesterase-5 Inhibition Against Ischemia-Reperfusion Injury: Role Of Nitric Oxide., Vladimir Paul Daoud
Theses and Dissertations
Recent studies have shown that the potent phosphodiesterase-5 (PDE-5) inhibitor, sildenafil citrate, induces a powerful cardioprotective effect against ischemia-reperfusion (I/R) injury in rabbit and mouse hearts. However, the effect of this drug in inducing long-term protection against I/R injury remains unknown. The goal of this study was to identify the duration of the protective window of sildenafil citrate as well as vardenafil, a more potent PDE-5 inhibitor. Rabbits were treated with sildenafil (0.7 mg/kg, iv), vardenafil (0.143 mg/kg), or an equivalent volume of saline. After 24 hrs, 48 hrs, 96 hrs, or 7 days of sildenafil treatment, the hearts were …