Educating Outdoors: A Qualitative Case Study On School Readiness Development In A Nature-Based Preschool, Lauren Lefevre

Theses and Dissertations

Play is widely considered one of the most crucial activities for healthy early childhood development, yet many current early childhood education (ECE) programs prioritize academics at the expense of this critical activity. Despite this focus on math and literacy skills, a significant number of children arrive at kindergarten unable to demonstrate proper school readiness. Nature-based early childhood education (NbECE) is a growing alternative education option that prioritizes risky play, loose parts play, and nature play, potentially providing children with countless opportunities for school-readiness development through play. Guided by the biophilia hypothesis (Wilson, 1984), which suggests that humans are innately drawn …

Ai: A Path Forward In Education - Teachers’ Insights On Implementation, Challenges, And Future Innovations, Mercedes Cordoba Meeks

Theses and Dissertations

Artificial intelligence (AI) is a global phenomenon permeating the fabric of society and transforming the course of culture and commerce (Kishor et al., 2023; Moore, 2024). A review of the extant literature indicates that while many industries have seen significant innovations due to the infusion of AI, the field of education has witnessed a technological evolution inspired by AI-based tools and strategies (Bessen, 2018; W. M. Lim et al., 2023). Artificial Intelligence in Education (AIED) has a history that parallels the development of AI. AIED has shown steady growth and influence in educational programs around the world, with the growth …

From Ink To Code, From Binary To Boundless Reality—Until All Returns To Emptiness, Weitong Sun

Theses and Dissertations

This thesis explores the entangled relationship between language, memory, and technology through the lens of immigrant experience. Moving from programming to visual storytelling, I investigate how dyslexia, bilingualism, and cultural displacement have shaped my ways of reading, writing, and coding.

Beginning with personal reflections on switching from computer science to art, I trace how code offered a form of clarity and expression where written language had once failed me. Yet as I ventured into real-time simulation and XR storytelling, I encountered new forms of mistranslation—where narratives dissolved, mutated, or resisted coherence altogether.

Through a series of experiments in code-driven art, …

Comparative Evaluation Of Three Endodontic Rotary File Systems In S-Shaped Root Canals: An In-Depth Analysis, Mudher Bahar

Theses and Dissertations

Objective: This study compares three endodontic file systems—XP‐3D Shaper⁺, EdgeFile X7 and WaveOne Gold in S‐shaped simulated canals in resin blocks. It aimed to quantify canals volumetric changes post‐instrumentation to guide clinical selection of a system that preserves tooth structure while efficiently shaping root canals.

Methods: Thirty S‐shaped canals in resin blocks were divided into three groups (n=10) for instrumentation with XP‐3D Shaper⁺, EdgeFile X7 or WaveOne Gold using the crown‐down technique and manufacturers recommended settings. A no‐treatment control provided a baseline for volumetric changes measured via CBCT scans analyzed with ITK‐SNAP. Data were analyzed using ANOVA and Tukey’s test …

Between "Hippies In Suits" And "Money Is The Name Of The Game": Farm Animal Advocates' Analyses Of Political Power In The Farm Bill, Jeff Thomas

Theses and Dissertations

The animal agriculture industry annually slaughters roughly ten billion land animals in the United States. What can be done to improve their welfare and lessen their suffering?

Over the past decade, the problem of farm animal welfare and suffering has drawn increasing interest from the effective altruism community, a loose movement of utilitarian advocates seeking technocratic solutions to social problems (Singer, 2015). As effective altruism has become a more potent driver of the animal welfare movement, an increasing number of nonprofits have begun engaging in political advocacy for farm animal welfare. Facebook co-founder Dustin Moskovitz’ Open Philanthropy is the largest …

Dosimetric Validation Of An Electron Monte Carlo (Emc) Algorithm For Small Cutouts And Extended Ssd’S: Assessing Emc In Small Field Dosimetry, Anil Basavaaraju

Theses and Dissertations

This thesis validates the accuracy and limitations of Electron Monte Carlo (eMC) simulations in Eclipse treatment planning systems for small-field electron dosimetry and extended source-to-surface distances (SSDs). Systematic measurements were performed using a microDiamond detector across various electron energies and field sizes. The study examines the discrepancies between measured and calculated (eMC) dose distributions, validating challenges due to lateral scatter disequilibrium and extended air gaps. Our findings provide systematic data for eMC dose calculations and demonstrate that eMC performs within clinical tolerances, with the ultimate goal of enhancing the precision and safety of radiation treatments.

Assessment Of Drivers Of Light Attenuation In Virginia Reservoirs, Jackson Barnett

Theses and Dissertations

Water clarity in aquatic ecosystems is crucial for submerged vegetation and algal dynamics. We investigated the factors influencing light attenuation (kd) by measuring total suspended solids (TSS), chlorophyll-a (CHLa), and chromophoric dissolved organic matter (CDOM) across thirteen stations located in seven reservoirs. Average kd was 1.69 m^-1 (range: 0.37-3.99 m^-1), with photic depths averaging 3.27 m (range: 1.15-12.43 m). TSS was the primary predictor of light attenuation (R² = 0.57, P = 0.003, SE = 0.053). Average TSS values for each site were multiplied by the slope of the kd-TSS relationship to find the proportion of kd …

Infinite Finite: A View On Human Progression Through Emergent Generative Systems, Fatima Abbas

Theses and Dissertations

Contemporary crises reveal an imbalance in human progression, prioritizing material advancement while neglecting ethical, compassionate, and spiritual dimensions. This thesis examines natural progression through the lens of emergence, where simple interactions produce complex outcomes. Analyzing natural patterns across different scales, from cosmic formations to neural interactions, underscores emergence's universal nature.

Within this context, Infinite Finite introduces a generative digital tool simulating emergence through iterative cycles of construction and deconstruction. Depicting a century of human progression informed by historical behaviors via simulated cellular interactions, the tool visually differentiates ethical from unethical progression. This is represented through ten data visualization tiles composed …

Subgingival Microbiomes Of Healthy And Periodontitis Subjects, Tareq Abdulrasoul

Theses and Dissertations

Background: Periodontitis is a common chronic inflammatory disease triggered by the dysbiosis of the subgingival microbiome. 16s rRNA sequencing has been used to profile the subgingival plaque samples in healthy and periodontitis subjects. Here, we have collected subgingival plaque samples from subjects and analyzed the microbiome profile from 16s rRNA sequencing. We hypothesized that periodontitis patients will have a different subgingival microbiome profile than that of healthy subjects.

Methods: Subgingival plaque samples were collected from periodontitis and healthy subjects who were indicated for periodontal surgeries (osseous resective and regenerative surgery for periodontitis patients or crown lengthening for healthy …

Development Of A Mediation Model Of Pain Cognition In Adult Patients With Sickle Cell Disease, Daniel M. Sop

Theses and Dissertations

Pain is a hallmark of Sickle Cell Disease (SCD), a genetic hemoglobinopathy characterized by chronic hemolytic anemia, vaso-occlusion, and organ damage. While acute vaso-occlusive crises (VOC) have been extensively studied, the mechanisms underlying chronic pain and its interplay with brain function remain unclear. This dissertation investigates the relationships between cerebral blood flow (CBF), fluid cognition, and pain sensitivity in adults with SCD, utilizing advanced imaging techniques and validated assessment tools.

Arterial spin labeling (ASL) and functional magnetic resonance imaging (fMRI) were employed to measure CBF and brain activity, respectively. Pain sensitivity was assessed using the Pain Sensitivity Questionnaire (PSQ), and …

The Trauma-To-Prison Pipeline: A Multi-Level Theoretical Framework Exploring The Intersection Of Inequality, Trauma, And Exclusionary Discipline, Dana Ainsworth

Theses and Dissertations

The school-to-prison pipeline (STPP) is a widely recognized and extensively studied metaphor used to describe the process by which school discipline policies increase the risk of juvenile justice system involvement, particularly among historically marginalized populations. While it has been instrumental in shaping educational policy, the STPP framework has not evolved to account for the critical impact of trauma on learning and behavioral outcomes. Furthermore, it overlooks the role of systemic inequality that increases trauma exposure and produces concentric patterns of marginalization.

Drawing on research across the fields of education, public health, sociology, and criminal justice, this study proposes a theoretical …

Investigating The Temperature Effects On Aedes Aegypti And Dengue Virus In Central Argentina: Perspectives From Mathematical Modeling, Morgan H. Jackson

Theses and Dissertations

Dengue virus (DENV) causes over 390 million infections and around 40,000 deaths worldwide each year. DENV is primarily transmitted by the mosquito Aedes aegypti, and both the life cycle of these mosquitoes and DENV transmission are significantly impacted by temperature. In the temperate region of Central Argentina, where dengue outbreaks first began in 2009, outbreaks only occur following new introductions of DENV from other regions. Due to the relationships between temperature and DENV and temperature and Ae. aegypti, the risk of an outbreak changes throughout the year. Here, we develop and analyze mathematical models for both mosquito population dynamics and …

Cannabis Use Among Cancer Survivors And The Impact On Cancer-Related Pain, Tiffanie A. Vargas

Theses and Dissertations

With a growing population of older adult cancer survivors—many of whom experience cancer-related pain—interest in medical cannabis as a pain management strategy has increased. This secondary analysis used data from the 2022 U.S. Behavioral Risk Factor Surveillance System (BRFSS) to examine cannabis use behaviors among cancer survivors and assess associations with cancer-related pain. The study had three aims: (1) to describe 30-day cannabis use (prevalence, intensity, and administration routes) by chronic health condition and cancer diagnosis, focusing on non-melanoma skin cancer, melanoma, and other cancers; (2) to compare demographics, health characteristics, and tobacco use by cannabis use status among cancer …

Modeling Synergistic Effects Of Integrin And Tgf-Β Signaling In Epithelial Mesenchymal Transition, Prerak Thakkar

Theses and Dissertations

The induction of Epithelial Mesenchymal Transition (EMT) is initiated by a

number of protiens and growth factors, one of which is the profibrotic cytokine Trans-

forming Growth Factor β (TGF-β). Within the extracellular matrix (ECM), TGF-β

is found in a latent, inactive form bound to proteins such as fibronectin (FN). For

TGF-β to contribute to EMT induction, it has to be extracted from the latent com-

plexes into a soluble form. This soluble, activated TGF-β can then bind to receptors

on the cell membrane, which causes the transduction of signals that begin EMT. Re-

search has shown that the release …

Existing In The Context: A Conjunctural Analysis Of Kamala Harris Memes, Amaya Mcneal

Theses and Dissertations

Political memes have become a common way for people to express their political views online, helping politics reach young adults who weren’t previously interested. Consequently, politicians have begun sharing and creating memes themselves. The memeification of American politics has diminished debate about ideas, ideals, issues, and people’s vital interests, debasing voters by treating them not as citizens but as passive “consumers” and “spectators” of mediated politics. This paper helps make sense of this crisis, focusing on the example of former Vice President Kamala Harris. Vice President Kamala Harris' memeified presidential campaign during the 2024 U.S. election targeted voters through a …

Investigating Mitochondrial Stress Response Mechanisms In Aging, Aileigh E. Daniel

Theses and Dissertations

Mitochondrial dysfunction is widely recognized as a key contributor to aging and age-related diseases. The concept of mitohormesis suggests that low levels of ROS can activate stress-responsive transcription factors, promoting adaptive mechanisms that enhance longevity. We hypothesized that changes in protein abundance under conditions of mild mitochondrial stress reflect an adaptive response, and that commonly altered proteins across diverse genetic backgrounds of mitochondrial stress can help identify key regulators of stress resilience and aging. Our study identified conserved mitochondrial stress response pathways and highlighted candidate regulators for further investigation. These regulators appear to impair mitochondrial energy production by downregulating ATP …

Substrate Preference And Foraging Behavior Of Two Declining Warblers In Appalachian Shrublands, Samantha Fishman

Theses and Dissertations

Abstract Shrubland and early successional habitats (ESH) support a diversity of wildlife, including many declining songbirds. However, nonnative shrubs increasingly dominate these habitats, potentially altering habitat quality by influencing prey availability. Habitat quality can be assessed by observing foraging behaviors of songbirds and identifying preferred and avoided substrates as well as testing the predictions of optimal foraging theory; specifically that birds will maximize their energy gain relative to the costs. We examined foraging behaviors of Golden-winged Warblers (Vermivora chrysoptera; GWWA) and Chestnut-sided Warblers (Setophaga pensylvanica; CSWA) in ESH on private lands in Virginia with varying amounts …

Unleashing Serine Palmitoyltransferase In Test Tubes And Mice, Matthew W. Peart

Theses and Dissertations

Canonically known both for structural contributions to lipid bilayers and roles in cell signaling, the sphingolipids comprise a dynamic, multifaceted class of molecules which are studied to understand homeostatic cell biology as well as pathophysiology. Sphingolipids contribute to tissue-specific structures such as myelin, a multilayer membrane that allows for rapid conduction of action potentials along neuronal axons. All sphingolipids are downstream products of the rate-limiting and initiating enzyme in the de novo sphingolipid synthesis pathway, Serine palmitoyltransferase (SPT). Demonstrative of its status as the enzyme that catalyzes a crucial step in a biochemical pathway, SPT activity is strictly regulated. This …

Hafnium Oxide-Based Nanoheterostructures For Catalytic Radiosensitization And Enhanced X-Ray Radiotherapy, Marlen Dariela Calix Quezada

Theses and Dissertations

Orthovoltage X-ray beams are attractive for surface and intra-operative radiotherapy. Yet, their clinical utility is constrained by rapid attenuation and the limited dose that can be delivered without harming healthy tissue. High-Z hafnium oxide (HfO₂) nanoparticles can boost local energy deposition through the photoelectric effect, while catalytic surface defects accelerate water radiolysis. Harnessing both mechanisms in a single nano-heterostructure could enable potent radiosensitization at diagnostic-range energies.

This thesis develops and evaluates HfO₂-based nanoheterostructures, both bare and Au-decorated, as catalytic radiosensitizers.

Two types of HfO₂ were evaluated, one was synthesized following a specific route and the …

Targeting The Achilles’ Heel Of Lung Cancer Induced By Oncogenic P53, Brandon G. Velasco

Theses and Dissertations

Mutations of the tumor suppressor gene, TP53, are the most prevalent oncogenic mutations in lung cancer, occurring in up to 70% of human non-small cell lung cancer (NSCLC). The majority of mutations in p53 are missense mutations that cause not only a loss of tumor suppressor function, but also gain of oncogenic functions, like tumorigenicity, immune suppression, and chemoresistance. Previous studies have shown that the depletion of gain-of-function (GOF) p53 or disruption of its ability to transactivate the expression of genes related to oncogenesis eliminates its tumorigenic properties indicating a dependency of human lung cancer cells expressing GOF p53 …

Enhancing Clinical Trial Matching In Molecular Diagnostics: Using Natural Language Processing And Clustering Approaches In Hematological Malignancies, Gillian Fanning

Theses and Dissertations

Clinical trial matching is a critical component of personalized medicine, particularly in the management of hematologic malignancies. At Virginia Commonwealth University (VCU) Health, the Molecular Diagnostics (MDX) Lab produces somatic variant reports and recommends clinical trials based on the presence of clinically significant mutations. However, the current manual trial recommendation process is time-intensive and lacks scalability.

This study introduces a computational framework to streamline and standardize clinical trial matching using natural language processing (NLP) and unsupervised clustering. Trial brief descriptions were analyzed to extract frequent terms, and trials were grouped based on term similarity using joint dimensionality reduction and clustering. …

Developing Bioinformatics Expertise Through The Annotation Of The Gut Microbiome Of Odontotaenius Disjunctus, Keidra E. Carter

Theses and Dissertations

Next-generation sequencing (NGS) technologies have revolutionized biological research by generating unprecedented volumes of genomic data, necessitating advanced bioinformatics tools and specialized expertise to fully interpret complex microbial communities. This study outlines an integrated workflow to characterize the gut microbiome of the wood-feeding beetle Odontotaenius disjunctus. Prokka is employed for functional annotation to identify protein-coding genes and other genomic features, while Kaiju is used for taxonomic classification. DIAMOND is then applied to locate and validate the taxonomic assignments generated by Kaiju by aligning sequences within the contigs to a comprehensive protein database, proGenomes. Functional analysis revealed that the contigs encode proteins …

Health Equity In Times Of Crisis: The Impact Of Economic And Public Health Shocks On Access To Care Among Women In Zimbabwe And The United States, Vimbainashe Dihwa

Theses and Dissertations

Abstract

This dissertation examines health equity during times of national public health and economic crises by examining access to care among women of reproductive age. Papers 1 and 2 estimate the effects of the 2020 Covid-19 pandemic in the United States (US). Paper 3 examines the potential effects of the 2008 hyperinflation and subsequent economic crisis in Zimbabwe.

Paper 1 assessed the role of health professional shortage areas (HPSAs) in the Covid-19 pandemic-related temporal trends in mental health access among women in the 18 to 44 years age group with self-reported anxiety and/or depression. The findings suggest decreased unmet prescription …

Climate Change-Induced Shifts In Mediterranean Fungal Fruiting Phenology And Productivity, Rachel Demay

Theses and Dissertations

We used a 29-year dataset of mushroom fruiting from the Pinar Grande forest in northern Spain to investigate the effects of climate change on the phenology, productivity, and diversity of mycorrhizal and saprotrophic mushrooms. We investigated the long-term trends in fruiting season length, yield (by count, total weight, and average weight), and genus richness. Additionally, we identified associations between monthly temperature and monthly precipitation with these fungal responses across functional groups: mycorrhizal, saprotrophic, litter-decaying saprotrophic, and wood-decaying saprotrophic mushrooms, and the economically-important edible genera Boletus and Lactarius. We found that autumnal season length in the Pinar Grande has shortened over …

An Exploration Of The Relationship Between School Counselor Access And Latine Students’ College-Going Behaviors, Kristen Tuxbury

Theses and Dissertations

This study examined the relationships between school counselor access and Latine students’ college-going behaviors using data from the High School Longitudinal Study of 2009 (HSLS:09). The study was guided by critical race theory and Yosso’s community cultural wealth model (2005). Binary logistic regression models, Chi-square tests of independence, and descriptive statistics were used to explore the associations between school counselor access, Latine student college-going behaviors, and caregiver expectations. The findings show stronger associations between caregiver expectations and Latine student college-going behaviors than school counselor access. Additionally, findings provide evidence that experiences of oppression are likely barriers to Bachelor’s degree programs …

Integration Of Phenotyping Into A Preliminary Investigation Of Stand-Alone Web-Based Cognitive Behavioral Therapy Among A Non-Treatment Seeking Sample, Anna B. Parlier-Ahmad

Theses and Dissertations

Alcohol use disorder (AUD) is the most common substance use disorder. However, most people with AUD do not receive treatment. Among those who do, it is only moderately effective largely due to the heterogeneity of people with AUD. Many of these individuals, particularly those with mild AUD, can reduce or cease alcohol use without specialized treatment. However, efforts to refer those with more severe AUD to community residential or outpatient programs have been largely unsuccessful, especially among women who often face practical barriers like lack of transportation and childcare. Technology offers innovative opportunities to make treatment more readily accessible to …

Rehabilitation In Stroke-Related Flexor Synergy, Shawn J. Dirocco

Theses and Dissertations

Upper extremity abnormal flexor synergy caused by stroke can impair individuals by coupling upper extremity muscles with deltoid activation. Previous studies have shown that reduction in deltoid loading can decrease flexor synergy. Robotic rehabilitation has the ability to allow for reduced deltoid loading while assisting or constraining joints along the arm to increase rehabilitation outcomes. The effects of higher degree of freedom low impedance robotics needs to be tested to learn how various parameters affect flexor synergy in comparison to end point robotics. During the first experiment, we tested 16 chronic stroke patients with flexor synergy problems in 3 tasks. …

Trauma-Informed Beliefs And Our Child Welfare System, Gabriela Ana Aisenberg

Theses and Dissertations

The integration of trauma-informed care (TIC) into behavioral health and child welfare systems has garnered increasing attention, reflecting a growing acknowledgment of the pervasive and multifaceted impacts of trauma on individuals, families, and service delivery structures (Barnett et al., 2019; Bartlett et al., 2018; Bassuk et al., 2017; Substance Abuse and Mental Health Services Administration [SAMHSA], 2014). Legislation such as the Family First Prevention Services Act (FFPSA) has led to increased adoption of trauma-informed practices through increased funding for training and services (Bowen & Murshid, 2016; Brown et al., 2023). Research shows that providers’ understanding and implementation of TIC is …

Machine Learning Models Leveraging Patient-Similarity And Clinical Temporality For Disease Prognoses, Ahmad F. Al Musawi

Theses and Dissertations

Electronic Health Records (EHRs) constitute a comprehensive and high-dimensional repository of clinical data, encompassing a wide array of patient-level information such as diagnoses, procedures, medications, laboratory results, and unstructured clinical narratives. These data hold immense potential for advancing predictive modeling in healthcare, including tasks such as disease progression modeling, hospital readmission prediction, and length of stay (LoS) estimation. However, the intrinsic complexity of EHR data—manifested in its heterogeneity, sparsity, and temporal dynamics—poses significant analytical challenges that limit the generalizability and interpretability of conventional machine learning models. Recent methodological advancements in deep learning and graph-based learning, particularly Graph Neural Networks (GNNs), …

Treatment Resistant Obesity Among Midlife Women Receiving Care From A Specialized Weight Management Clinic, Emily C. Stevens

Theses and Dissertations

Background: Obesity is a complex chronic disease that conveys significant health risk. Women with obesity are at greater risk for associated conditions including heart disease, hypertension, ischemic stroke, and sex-specific cancers compared to their male counterparts. Midlife may present unique challenges for women as it is during this life phase that they experience an increase in their overall obesity prevalence and severity. Some midlife women experience treatment resistant obesity (TRO), a phenomenon not previously explored in the research literature, conceptualized as failure to achieve clinically meaningful weight loss of ≥ 5% after having received medically specialized obesity care for one …