Digital Commons Network^™

Occupational Exposure, Biomarker Profiles, And Safety Practices Among Egyptian Pesticide Factory Workers, Mireille M. Hanna

Theses and Dissertations

Background: Pesticide factory workers represent a critically understudied occupational population in Egypt, where existing literature has focused predominantly on agricultural field workers and spray teams, leaving the industrial manufacturing workforce virtually uncharacterized. Despite the potential for continuous, year-round, high-intensity mixed chemical exposure in factory settings, no contemporary comprehensive study has examined the multi-system health correlates of pesticide exposure among Egyptian factory workers.

Aim: This study aimed to assess the occupational health correlates of pesticide exposure among factory workers across neurological, hematological, hepatic, renal, endocrine, and reproductive outcomes, and to evaluate the role of exposure intensity, personal protective equipment use, safety …

Nanoscale Water Confinement And Coordination-Driven Ion Transport In Eutectogel Electrolytes For Electrochemical Energy Storage Applications, Abdallah Akar

Theses and Dissertations

The rapid expansion of renewable energy systems, portable electronics, electric vehicles, and smart grid technologies has intensified the demand for advanced electrochemical energy storage devices capable of delivering high power density, long cycling life, operational safety, and environmental sustainability. Among these technologies, supercapacitors have attracted considerable attention because of their rapid charge-discharge capability, excellent cycling stability, and high-power performance. However, their relatively low energy density remains a critical limitation that restricts their broader practical application. Since the energy density of supercapacitors scales with the square of the operating voltage, expanding the electrochemical stability window of the electrolyte represents one of …

Simulation-Based Assessment Of Operational And Retrofit Solutions For Effluent Compliance Of A Capacity-Limited Oxidation Ditch Wwtp, Ahmed Sameh Harash

Theses and Dissertations

Oxidation-ditch wastewater treatment plants (WWTPs) across Egypt's Nile Delta are increasingly carrying hydraulic and organic loads beyond what they were designed for. This work can be considered pioneering as this work compared operational and structural retrofit alternatives for such a plant within a single verified simulation framework. The present study fills that gap by building a digital twin of the Qaha WWTP, a dual-train Carrousel oxidation ditch in Qalyubia Governorate, calibrated to a baseline flow of 7,420 m³/day in the SUMO24 platform (a third-generation, open-source wastewater treatment process simulation software) using the SUMO2c biokinetic model (a simplified variant of Activated …

Sustainable – Low-Cost - Upgrade Of Activated Sludge Process For Nitrogen And Phosphorus (N&P) Removal From Wastewater, Abanoub N. Basta

Theses and Dissertations

Many municipal wastewater treatment plants (WWTPs) in developing countries were designed primarily for organic matter and suspended solids removal and therefore face increasing difficulty in meeting modern nitrogen (N) and phosphorus (P) discharge requirements. Conventional biological nutrient removal upgrades commonly require additional reactor volume, recirculation systems, aeration energy, and capital investment. Accordingly, sustainable retrofit strategies that improve nutrient removal within existing treatment footprints are increasingly needed, particularly in water-scarce and land-constrained regions.

This study investigated the integration of water hyacinth (Eichhornia crassipes) into the aeration stage of an activated sludge process as a hybrid nature-based enhancement for nitrogen and phosphorus …

Comparative Performance Of Physiological Vital-Sign Forecasting Under Random And Patient-Wise Splitting Using Deep Learning, Lavanya Vasavi Chittem Reddy

Theses and Dissertations

Physiological vital-sign forecasting estimates future measurements based on recent temporal patterns and can support analysis of continuously recorded monitoring data. This study comparatively evaluated deep feedforward, recurrent, bidirectional recurrent, long short-term memory, and bidirectional long short-term memory architectures for one-step-ahead forecasting of peripheral oxygen saturation, heart rate, and pulse rate. Each model received consecutive observations of peripheral oxygen saturation, heart rate, pulse rate, respiratory rate, and age, while separate single-output models predicted the next value of the selected target.

Random and patient-wise data splitting were compared using identical input definitions, preprocessing procedures, model architectures, and training hyperparameters. The strongest architecture …

A Fundamental Study Of Fatty Acid Ionic Liquids And Their Effects On Biomolecules, Achismita Dutta

Theses and Dissertations

Fatty acid ionic liquids (FAILs) are a class of ionic liquids (ILs) with relatively low toxicity and potential applications in biological systems. This study examined the interactions of tetramethylguanidinium decanoate, tetramethylguanidinium octanoate, choline decanoate, and choline octanoate with lipid membranes, proteins, and nucleic acids. Membrane leakage experiments using model lipid vesicles showed that decanoate-based FAILs produced greater membrane permeabilization than octanoate-based analogues, consistent with their higher membrane permeability. These effects were stronger for the ILs than for decanoate alone and occurred below the critical micelle concentration (CMC), suggesting that micelle formation may not be essential for membrane disruption. The ability …

A Hybrid Rule-Based And Large Language Model Framework For Extracting Acronym–Definition Pairs From Scientific Literature, Petro Skrypnyk

Theses and Dissertations

Authors of scientific papers rely heavily on acronyms and often use them without defining them, making the literature harder to read and index. This thesis develops and evaluates a hybrid rule-based and large language model (LLM) framework that extracts acronym–definition pairs from scientific PDF documents. It extends an earlier Rowan University system that combined a regular-expression parser with a single LLM on 200 papers. That system showed that neither the parser nor the LLM alone is sufficient for accurate extraction of the pairs. The framework is a fully automated pipeline from PDF input to scored results. It compares four LLM …

Dual-Polymer Concrete With Recycled Pet And Hdpe Aggregates: Mechanical And Durability Performance Assessment, Omar Abd El Mageed Hammouda

Theses and Dissertations

This study investigates the fresh, mechanical, durability, thermal, performance as well as preliminary financial aspects of dual-polymer concrete incorporating recycled polyethylene terephthalate (PET) as a partial replacement for fine aggregate and recycled high-density polyethylene (HDPE) as a partial replacement for coarse aggregate, with silica fume as a supplementary cementitious material held constant at 10% by weight of cement. The study responds to the convergence of two pressing challenges in the Egyptian context: the scale of plastic waste mismanagement, which results in widespread informal open burning and environmental contamination, and the high operational energy demand of residential buildings in Egypt's hot …

Developing An Object Level Understanding Of Sine And Cosine As Ratios And A Coherent Trigonometry, Jeffrey Peter Nair

Theses and Dissertations

Solving right-triangle problems as well as integrating right-triangle and circular trigonometry into a coherent understanding are documented challenges for students. Prior research has deeply investigated students constructing ratio meanings for sine and cosine using a circle-first approach, which then can be extended to right triangles. Also, past work has separately documented distinct meanings that are useful for sine and cosine, in addition to the ratio meaning, including as lengths in a unit circle and coordinate points. This study took these existing ideas and put them together into one possible developmental progression, based on APOS theory, where students can learn length, …

Synthetic Strategies For Bioactive Peptides: From Aggregation Inhibitors To The Total Synthesis Of Tunicyclin C, Stephanie Graciela Garcia Morin

Theses and Dissertations

In Alzheimer's disease (AD), a brain protein called "tau" abnormally clumps and forms neurofibrillary tangles (NFTs), causing damage to brain cells. Ac-PHF6-NH2 is a hexapeptide segment of tau protein that plays a dominant role in tau aggregation and is used as a model to design tau protein aggregation inhibitors. In this research we synthesized four dehydroamino acid (□AA) containing PHF6 analogues with △Abu (derived from L-threonine) and △Val (derived from □-OH-Valine) at position 2 or 3 via dehydrations or azlactone ring-openings as key reactions. We evaluated their proteolytic resistance, ability to inhibit aggregation of PHF6, and impact on the morphology …

Measuring Proteostasis Changes In Apolipoprotein E Mouse Models Using Quantitative And Kinetic Proteomic Methods, Ariel E.A. Denos

Theses and Dissertations

Alzheimer's Disease (AD) is a neurological disorder associated with brain mass loss and cognitive decline. It affects millions of elderly people and is currently uncurable. Since 1906, when the disease was first described, researchers have uncovered many components of AD pathology. However, it is now evident that curing Alzheimer's Disease will require intervention before the pathological onset of amyloid beta plaque deposition, tau neurofibrillary tangles, and associated neuronal loss. Studying AD from the perspective of early intervention requires special attention to small changes that may disrupt the normal processing of cells. Cells undergo a natural cycle of creation and destruction …

Family Religious Socialization Index: Development And Preliminary Validation, Kaelie Rene Crockett

Theses and Dissertations

A key area of interest for religious scholars is how religious beliefs are passed across generations, or religious socialization. To expand this field of study, a theoretically grounded, validated measure of this construct is needed. This article describes the development and validation of the Family Religious Socialization Index (FRSI), a multi-informant, multidimensional assessment of the processes through which parents socialize religion and faith in their children. Based on Social Cognitive Theory and through a rigorous development and validation process, three subscales were developed to represent the primary processes of religious socialization. The FRSI consists of two parallel scales, a parent …

Identifying The Brain Circuits Involved In Religious Obsessive-Compulsive Disorder, Kiana Bunnell

Theses and Dissertations

Obsessive-compulsive disorder (OCD) is an often-debilitating psychiatric disorder involving a pattern of obsessive thoughts and compensatory compulsions. Symptoms tend to be chronic, leading to substantial emotional burden and significant impairment across multiple domains of daily functioning. Previous research has identified some consistency in the brain regions implicated in OCD. In particular, cortico-striato-thalamo-cortical (CSTC) circuitry has been linked to behavioral features commonly observed in OCD. Moreover, some studies suggest that distinct patterns of brain activation and functional connectivity may be associated with different OCD symptom dimensions, though findings have not been consistent. One symptom dimension of OCD (scrupulosity) is characterized by …

Modifying Lta Zeolites For Reversible Hydrogen Sulfide Capture And Elucidating The Structure Of The Incorporated Metal And Sulfur Ions, Adeyemi D. Ojaide

Theses and Dissertations

Hydrogen sulfide (H2S) is a highly toxic and corrosive gas that poses significant environmental and industrial challenges, particularly within the wastewater treatment and oil and gas sectors. H2S leakage is among the deadliest industrial hazards, highlighting the urgent need for the development of highly efficient, non-corrosive adsorbents. This dissertation provides an in-depth examination of the use of metal-zeolites for H2S capture. We carefully investigate the impact of multiple divalent and one monovalent transition metals on LTA zeolites to optimize H2S removal. While Linde Type A (LTA) zeolites offer a robust structural framework for gas separation, a comprehensive understanding of how …

Behavioral Effects Of Novel Treatments For Pain Management Using Combinatorial Methods, Rohit Rajeev Nambiar

Theses and Dissertations

Pain, despite being an uncomfortable feeling to experience, is a necessary protective mechanism for the body1. Understanding that pain results from several different mechanisms within the body is important to discovering the optimal way to treat and manage a person’s pain. Modern medicine has seen numerous advancements in treating or managing acute and chronic pain, particularly with opioid drugs. However, these treatments come with potential side effects, including opioid use disorder (OUD) and fatal overdose. Finding new treatment methods, or improving existing methods, is crucial for patients with pain. This thesis explores two projects looking to develop safer analgesia using …

A Coupled Reaction-Diffusion Model Of Promoting And Suppressing Interactions Among Cancer Hallmarks In Endometrial Cancer, Jeddy Bennett

Theses and Dissertations

Spatial transcriptomics enables the scoring of Cancer Hallmarks at a high resolution across a tissue biopsy, yet current analyses of these data remain largely descriptive, treating each spot as a static, independent observation. This thesis develops a coupled system of advection-diffusion-reaction partial differential equations to model the hallmark landscape as the steady-state solution of an underlying spatial process, and casts the recovery of its physical parameters as a PDE-constrained inverse problem. The framework is implemented in FEniCSx on tissue-specific finite element meshes derived from two endometrial cancer biopsies provided by the Huntsman Cancer Institute, with subdomains, boundary interfaces, and an …

Media Emotion Regulation And Executive Function In Childhood: Associations With Respiratory Sinus Arrhythmia, Lara M. Almeida

Theses and Dissertations

Media emotion regulation (MER), or the use of media to help children manage emotions, may influence children's development by shaping opportunities for practicing self-regulatory skills. Guided by the Dynamic, Relational, Ecological Approach to Media Effects Research (DREAMER) model, this study examined longitudinal associations between MER and executive functioning (EF) in early childhood and explored whether respiratory sinus arrhythmia (RSA), a physiological index of regulation, predicted developmental changes. Participants included 175 parent-child dyads assessed across two annual waves when children were approximately 4 and 5 years old. Structural equation modeling was used to test bidirectional associations between MER and EF while …

Physical Activity, Trauma, And Posttraumatic Stress: The Indirect Role Of Exercise Addiction, Anastasiia Rozumna

Theses and Dissertations

Exercise is often conceptualized as a protective factor for mental health, including for individuals exposed to trauma. However, less is known about whether exercise may relate to posttraumatic stress symptoms differently when it is accompanied by compulsive or addictive features. The present study examined whether volume and intensity of physical activity were associated with posttraumatic stress symptom severity indirectly through exercise addiction symptoms. This secondary cross-sectional analysis included 557 adults living in the United States who reported regular participation in sport or physical activity. Participants completed self-report measures of physical activity behavior, exercise addiction symptoms, trauma exposure, and posttraumatic stress …

Isoperimetric Soft Robots, Mihai Stanciu

Theses and Dissertations

This thesis presents two advances in isoperimetric soft robotic trusses that improve their performance, modularity, and configurability. The first contribution introduces a large-scale modular robotic truss designed as a lightweight, reconfigurable structure for lunar applications. The system consists of inflatable fabric tubes routed through motorized roller units and interconnected by a newly developed spherical joint that enables multiple robotic triangles to connect at a common vertex. The resulting truss can be assembled into structures beyond a single octahedron while retaining compact stowage when deflated and untethered operation after initial inflation. Experimental validation demonstrates modular assembly, long-term pressure retention, load-bearing capabilities …

Thermophysical Property Studies: 1. Thermodynamic Consistency For Associating Compounds 2. Autoignition Temperature, Cassandra Jane Guffey

Theses and Dissertations

Accurate thermophysical property data are essential for the design, optimization, and safe operation of chemical processes. Properties such as vapor pressure, enthalpy of vaporization, heat capacity, density, and autoignition temperature--which are among the properties studied in this work--are required for equipment sizing, process simulation, hazard assessment, and economic evaluation. A major focus of this dissertation is the application of multi-property thermodynamic consistency techniques to compounds that exhibit strong vapor-phase association. These methods improve confidence in recommended property values by enforcing rigorous thermodynamic relationships among ideal-gas heat capacity, liquid heat capacity, vapor and liquid densities, vapor pressure, and enthalpy of vaporization. …

Helicopter Pilots’ Safety Behaviors: Identifying Factors That Affect Risk Perception Among Helicopter Pilots, Khaled J. Alzaabi

Theses and Dissertations

Helicopter operations frequently take place in complex, high-risk environments, where pilots continuously assess hazards and make critical decisions under pressure. Despite standardized procedures, regulations, and training designed to enhance safe operations, helicopter pilots may perceive risk differently when encountering similar flight situations. Understanding the factors that influence helicopter pilots’ perception of risk is essential for improving helicopter operation safety.

The purpose of this study was to investigate the effect of various factors on risk perception among helicopter pilots. Using an explanatory correlational design, the study assessed whether helicopter pilots’ demographics, flight experience, and affective domain factors explain differences in their …

The Rpm-1/Phr Signaling Hub Modulates Tau-Induced Neurodegeneration Through Regulation Of Microtubule Stability And Mapk Pathways In C. Elegans, Xinxing Ding

Theses and Dissertations

Neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia, are characterized by the accumulation of pathological tau proteins and progressive neuronal loss. Although research regarding tau-mediated toxicity is extensive, the specific pathology that determine whether neurons maintain homeostasis or succumb to collapse under tau-induced stress remain incompletely elucidated. A central, yet still insufficiently understood, feature of these diseases is the disruption of the microtubule (MT) cytoskeleton . The PHR protein family is evolutionarily highly conserved; within this family, RPM-1 in C. elegans functions as an intracellular signaling hub that regulates axon development, synapse formation, axon termination, and various microtubule-associated processes. This …

From Anaerobic Digesters To The Human Gut: Ecological Responses Of Microbiomes To Environmental And Biological Perturbations, Maliea Annholden Nipko

Theses and Dissertations

Microbial communities regulate essential ecological and metabolic processes across both engineered and host-associated ecosystems. Although these systems differ substantially in composition and function, they are governed by common ecological principles including community succession, resilience, species interactions, and responses to environmental and biological perturbations. This dissertation investigates how perturbations influence microbiome structure, function, and stability through three complementary studies spanning anaerobic digestion and the human gut microbiome. First, the effects of an extremophilic biological pretreatment using Caldicellulosiruptor bescii were evaluated in industrial-scale anaerobic digesters treating dairy manure. High- temperature pretreatment substantially altered microbial community composition, with bacterial populations remaining metabolically active …

Biomechanical And Talar Cartilage Responses To Running In Individuals With Chronic Ankle Instability, Minsub Oh

Theses and Dissertations

Context: Chronic ankle instability (CAI) has shown altered movement patterns and joint loading, which increase the risk of posttraumatic ankle osteoarthritis. Abnormal vertical ground reaction force (vGRF) during running may contribute to talar cartilage degeneration; however, the acute biomechanical and cartilage responses to running in individuals with CAI remain unclear. Purpose: The purpose of this study was to compare running biomechanics and changes in talar cartilage thickness and T2 relaxation times before and after running between individuals with CAI and healthy controls. Methods: Twenty individuals with CAI and 20 healthy controls completed running biomechanics and magnetic resonance imaging (MRI) sessions. …

Examining The Relationship Between Past Involvement In Sexual Violence, Gender, And Rape Myth Acceptance In College Student-Athletes, Sarah Baker

Theses and Dissertations

Sexual violence (SV) is a persistent concern on U.S. college campuses, with student-athletes at higher risk for both perpetration and victimization. Rape myth acceptance (RMA) reflects beliefs that excuse or downplay SV, but it is unclear how these beliefs relate to student-athletes’ personal experiences with SV. This study examined RMA based on past SV involvement and gender, with attention to individuals reporting both perpetration and victimization. Participants were 350 NCAA Division III student-athletes who completed measures of SV perpetration and victimization, RMA, and sexism. Analyses evaluated differences in RMA by past involvement in sexual violence and gender while controlling for …

Investigations Into Biophysical Mechanisms Of Amphiphilic Molecules At Protein And Membrane Interfaces, Samuel Richard Pennock

Theses and Dissertations

Amphiphilic compounds play a key role in chemical biology due to their ability to associate with biochemical complexes through a diverse set of noncovalent interactions. Interactions between amphiphiles and biological targets elicit a wide array of modulatory effects, structural stability, and activity. However, due to the inherent complexity of these interactions, there has yet to be a broadly predictive framework for determining whether a given amphiphile-target interaction will be beneficial or deleterious. This thesis seeks to advance the mechanistic understanding of amphiphile-target interactions by investigating two distinct but unified systems. In the first study, the effects of fatty acid ionic …

Using C/Μ Test To Investigate The Coding And Noncoding Regions To Identify Selective Pressures In Hiv-1 Virus., Annie Tran

Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) is a single-stranded RNA retrovirus whose error-prone reverse transcriptase drives a high mutation rate, enabling adaptive mutations on drug target proteins that confer antiviral resistance and complicate long-term treatment. This study therefore aims to detect such adaptive mutations on HIV-1 drug target proteins using our novel analysis framework (c/µ) on 5,711 genomic sequences, with findings expected to inform timely therapeutic adjustments and guide the development of more robust antiretroviral strategies. In Chapter 1, our novel mathematical framework (c/µ) and the Near Neutral Unbalanced Selection Theory (NNUST), which posits that most mutations experience weak but …

Identifying Failure Behaviors In Stereolithography From Varied Print Orientations, Kevin Veltre

Theses and Dissertations

Stereolithography (SLA) is an additive manufacturing (AM) technique that utilizes photopolymerization to create three-dimensional shapes by strategically printing layers of material. Printing parameters such as layer orientation, print resolution and post cure can affect a specimen’s homogeneity, longevity and mechanical characteristics. Because of this variability, print parameters must be carefully considered when designing products and print processes for desired components, as manufacturers often fail to include all relevant print settings when advertising mechanical properties. For this study, 130 SLA-printed specimens were created with 100-micron print layer thickness and print orientations varying between 0 and 90, including intermediate orientations, to observe …

Blended Learning Development In Mongolian K-12 Education: A Systematic Review And Psychometric Study Of Teacher Readiness, Batbold Bukhchuluun

Theses and Dissertations

This dissertation examines blended learning (BL) in Asian K-12 education through a systematic review and an empirical validation study in Mongolia. The first study reviews peer-reviewed K-12 BL research published between 2000 and 2024 using PRISMA procedures. We analyzed 42 studies to identify publication trends, geographic representation, BL model adoption, articulation of physical and pedagogical design layers, implementation challenges, and reported outcomes. Findings indicate that BL research is concentrated in a limited number of countries, frequently employs flipped learning models, and often lacks detailed pedagogical specification. Common challenges include infrastructure limitations, teacher preparedness, and institutional support. The second study adapts …

Transcriptomic And Genomic Insights Into Nutrient Stress Responses And Subgenome Evolution In Chenopodium, Ashley Kathleen Marcheschi

Theses and Dissertations

Chenopodium is a diverse genus of nutritionally and ecologically important species in the Amaranthaceae family. This thesis investigates two outstanding questions in the genus: how Chenopodium quinoa responds transcriptionally to nutrient deficiency and how Australian Chenopodium species are related through their subgenomic ancestry and evolutionary history. First, we characterized transcriptomic responses of C. quinoa to deficiencies of twelve essential macro- and micronutrients across leaf and root tissues using RNA sequencing. Leaves showed the strongest responses under nitrogen, potassium, magnesium, and zinc deficiency, while roots responded more evenly across conditions. Recurring responses included suppression of photosynthesis, remodeling of translational machinery, reactive …