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Full-Text Articles in Entire DC Network
The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher
The Dubr/Mir-210-5p/Retsat Axis In Cholesterol-Associated Steatohepatitis: Clinical Signatures And Molecular Mechanisms, Hana Mahmoud Abdelzaher
Theses and Dissertations
Metabolic-associated fatty liver disease (MAFLD) represents an increasing global health challenge, with cholesterol-associated steatohepatitis (CASH) emerging as a distinct pathological entity warranting investigation. While CASH demonstrates unique features compared to traditional triglyceride-driven steatohepatitis, its underlying molecular mechanisms remain poorly understood. This study investigates a novel regulatory axis involving DPPA2 Upstream Binding RNA (DUBR), miR-210-5p, and retinol saturase (RETSAT). 170 patient samples revealed progressive axis dysregulation in disease states, with RETSAT emerging as a highly accurate diagnostic marker (AUC=1.000). Using novel in vitro models of MASH and CASH, we demonstrated that miR-210-5p modulation significantly affects lipid accumulation and cellular phenotype, with …
Development Of Preventive Dental Guidelines In The Primary Healthcare Setting In Egypt: A Delphi Method, Basant Mehriz
Development Of Preventive Dental Guidelines In The Primary Healthcare Setting In Egypt: A Delphi Method, Basant Mehriz
Theses and Dissertations
This study addresses the critical need for standardized preventive dental care guidelines within Egypt's primary healthcare system amid the rising burden of oral diseases. Through a systematic two-phase methodology combining a comprehensive literature review and a Delphi consensus-building process engaging 35 dental professionals, the research established priorities for contextually appropriate preventive measures. The consensus framework revealed strong support for clinical interventions (mean of 83% agreement), particularly fluoride-based prevention; community initiatives (mean of 83%), especially school-based programs; policy measures (mean of 77%) such as workforce and educational development, though with variable support for taxation and social determinants approaches. Statistical analysis demonstrated …
Exploring The Relationship Between Country Socioeconomic Characteristics And Electronic Waste, Keliiakekaipuka Aria Mccomber
Exploring The Relationship Between Country Socioeconomic Characteristics And Electronic Waste, Keliiakekaipuka Aria Mccomber
Theses and Dissertations
Electrical and electronic waste (e-waste) is one of the fastest-growing and most hazardous waste streams globally. Despite efforts to improve global e-waste management, 77.7 percent of e-waste remains improperly disposed of, particularly in low- and middle-income countries where environmental and health risks are greatest (Baldé et al., 2024). This study evaluates whether national socioeconomic, cultural, and governmental characteristics can predict three key e-waste outcomes: generation per capita, formal collection rates, and resulting burden per capita. Using data from 2015-2022 for 127 countries, we applied mixed effects models incorporating variables such as GDP, Human Development Index, institutional integrity, financial openness, and …
Multi-Field Quantum Conference Key Agreement Using An Integrated Photonic Green Machine, Benjamin J. Fisher
Multi-Field Quantum Conference Key Agreement Using An Integrated Photonic Green Machine, Benjamin J. Fisher
Theses and Dissertations
Quantum Conference Key Agreement (QCKA) enables a group of users to generate a shared secret key, which reduces the latency and equipment overhead of establishing multiple Quantum Key Distribution (QKD) links. Conventional QCKA protocols send a multi-photon entangled state from one user to others and a key is generated only when all photons are detected, which is inefficient at high loss and opens side-channels at the receiver side. Here, we overcome this barrier through a multi-field QCKA protocol enabled by designing, fabricating, and testing an integrated photonic Green Machine that implements an eight-mode Hadamard unitary transformation through a beam-splitter network. …
Language Style Evaluation Validation For Implementation On Artificial Intelligence-Enhanced Augmentative And Alternative Communication Devices, Meghan A. Hunter
Language Style Evaluation Validation For Implementation On Artificial Intelligence-Enhanced Augmentative And Alternative Communication Devices, Meghan A. Hunter
Theses and Dissertations
This study explored various methods of evaluating language style for integration into prompts designed for a sophisticated augmentative and alternative communication (AAC) device. A total of 395 individuals without a language disorder were recruited via a crowdsourcing platform to complete five surveys. The initial four surveys were designed to assess individuals' language style using different approaches (questionnaire developed with ChatGPT, self-written, questionnaire developed by Hartman and McCambridge, and choosing tags). Following the completion of these four surveys, a fifth survey was dynamically created based on the responses in the previous four surveys. Each possible response in the fifth survey was …
Exploring Consequences Of The Double Empathy Problem Across The Autistic Trait Spectrum: First Person Accounts, Cammy C. Peck
Exploring Consequences Of The Double Empathy Problem Across The Autistic Trait Spectrum: First Person Accounts, Cammy C. Peck
Theses and Dissertations
Historically, individuals on the autism spectrum were believed to have deficits in empathy. However, recent research suggests that empathy-related issues occur on both sides of the communication dynamic. This concept known as the Double Empathy Problem (DEP), posits that the perceived lack of empathy is not exclusive to autistic individuals; rather, neurotypical (NT) individuals also experience difficulty empathizing with autistic individuals (Milton, 2012). Milton et al. (2022) describes this as a "breakdown in mutual understanding". Such mutual misunderstanding can have adverse consequences for both autistic and neurotypical individuals. To our knowledge, no studies have directly examined these consequences in relation …
The Effect Of Personalized Profiles On Generating Customized Content In Artificial Intelligence Augmentative And Alternative Communication Devices, Rachel Johnson
Theses and Dissertations
With advancements in artificial intelligence (AI), several augmentative and alternative communication (AAC) devices have begun incorporating AI with the purpose of accelerating and improving message transmission for users. The results have shown that AI can significantly reduce a user's keystrokes, but the generated responses may lack personalization. The objective of this study was to investigate whether integrating a personalized profile containing user information enhances the perceived accuracy and personalization of AI generated messages. Various methods of collecting profile information and differing levels of information within the profile were evaluated. One hundred eighty-one neurotypical English-speakers with no history of language disorder …
Comparison Of Elementary Dual Language Immersion Programs And Non-Dual Language Immersion Classes Before And After Attrition, Nathaniel Blain Mitchell
Comparison Of Elementary Dual Language Immersion Programs And Non-Dual Language Immersion Classes Before And After Attrition, Nathaniel Blain Mitchell
Theses and Dissertations
Using a longitudinal, multi-cohort design, this study examines the academic and linguistic effects of student attrition from Spanish-English dual language immersion (DLI) programs, particularly among multilingual learners (MLs). Drawing on 10 years of assessment data from two schools, the study addresses four research questions through multinomial logistic regression and hierarchical linear modeling to evaluate predictors of attrition, reading growth trajectories, and English language proficiency across student subgroups. Results indicated that attrition was most common in the early grades and was modestly associated with disability rates. At the same time, assessment scores were not predictive of program exit. Growth modeling revealed …
Enhance K-12 Student Online Learning Engagement Through Parental Support And Parent-School Collaboration, Qi Guo
Theses and Dissertations
This dissertation investigates the role of parental support in K-12 online learning through a three-part research agenda grounded in the Academic Communities of Engagement (ACE) framework. The first article presents a systematic review of 31 empirical articles, identifying five key themes for effective parent-school collaboration, including improved communication, shared expertise, increased involvement, role clarification, and researcher-practitioner partnerships. The second study used a survey collecting data from 567 parents across eight online programs to explore challenges parents face in supporting their students' affective, behavioral, and cognitive (ABC) engagement. Eight primary challenges are identified, ranging from student struggles with focusing and motivation …
The Efficacy Of Open Educational Resources On Achievement Outcomes In Different Higher Education Institutions, Angela Grace Findlay
The Efficacy Of Open Educational Resources On Achievement Outcomes In Different Higher Education Institutions, Angela Grace Findlay
Theses and Dissertations
Students suffer from achievement gaps in higher education. Achievement gaps refer to differences in graduation rates, retention rates, persistence rates, and student's grades. Achievement gaps may negatively affect students who are culturally or ethnically diverse and/or have a lower socioeconomic status. The use of open educational resources (OER) may mitigate achievement gaps as OER assists student success through higher academic performance and cost savings for students. Average quiz scores were obtained at different higher education institutions using an Introduction to Psychology OER. The scores from each course were analyzed using hierarchical linear modeling. Colleges were nested by demographics to evaluate …
Compliant Mechanisms For Scalable Systems And Precision Deployment, Jared Rodney Hunter
Compliant Mechanisms For Scalable Systems And Precision Deployment, Jared Rodney Hunter
Theses and Dissertations
Compliant mechanisms offer advantages in precision applications where size, scaling, and environmental effects render traditional mechanisms inadequate or likely to fail. However, designing compliant mechanisms and integrating them into larger, more complex systems remains a challenging problem. This thesis presents work that addresses this issue with analytical models and experiments on flat springs, scalable compliant mechanisms, and origami arrays. Storing and releasing energy in tiny, flat compliant mechanisms opens the door for the design of innovative actuators and products in space-constrained situations. Scaling compliant mechanisms allows novel systems to be made that can operate across scales. By designing for scalability …
Preserving The Past: Creating And Keeping An Archive Of The History Of Park Hill Baptist Church In North Little Rock, Arkansas, Jessica Ann Gates
Preserving The Past: Creating And Keeping An Archive Of The History Of Park Hill Baptist Church In North Little Rock, Arkansas, Jessica Ann Gates
Theses and Dissertations
An archive serves as a custodian of history, preserving materials such as records, documents, and objects that offer insight into people, organizations, and places. Park Hill Baptist Church, located in North Little Rock, Arkansas, was founded in 1947 and celebrated its 75th anniversary in 2022. This paper explores the process of creating a well-organized archive to transform the church's cluttered History Room into a valuable resource. Starting with minimal knowledge of archival practices, I conducted research on how to organize, preserve, and make accessible historical materials, including decisions on what to keep, why it matters, and how to ensure its …
How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred
How Transitioning Autistic Adults Consciously Perform Neurotypical Communication, Makenna J. Allred
Theses and Dissertations
Using semi-structured interviews this research explored the experiences of transitioning autistic adults with online communication. Participants shared information about navigating online communication, highlighting specific challenges such as interpreting tone and sarcasm, managing unspoken social norms, like emoji use, and responding to ambiguous or unexpected interactions. Participants shared that misunderstandings do occur in their online communication and how they recognize those miscommunications and strategize around preventing and mitigating them. These findings reveal that while computer-mediated communication offers opportunities for connection, it also presents unique obstacles that can exacerbate feelings of frustration due to miscommunications or misunderstandings. To prevent these social frictions …
Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton
Exploring The Feasibility Of Using Virtual Reality With Children With Autism, Gemma Leighton
Theses and Dissertations
This study explored the feasibility and social validity of teenagers with autism spectrum disorder (ASD) using a virtual reality (VR) head-mounted display (HMD). VR is emerging as a promising tool for teaching and therapeutic intervention among ASD. Therefore, this study serves to contribute to the field's development by comprehensively evaluating the accessibility for young people with ASD to independently using a VR HMD in a meaningful way. Five teenagers participated (four female, aged 13-15, with mild and mild to moderate support needs) and independently completed tutorials in a virtual environment when learning to operate the VR HMD controllers and hand-tracking …
Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch
Semitic Root Encoding: Tokenization Based On The Templatic Morphology Of Semitic Languages In Nmt, Brendan T. Hatch
Theses and Dissertations
The morphological structure of Semitic languages like Arabic and Hebrew is based on non-concatenative roots and templates. This complex word structure used by humans is obscured to neural models that use traditional tokenization algorithms. In this work, I present and evaluate Semitic Root Encoding (SRE), a tokenization method that represents Semitic words with distinct root and template stem tokens, and apply it to neural machine translation (NMT). I evaluate whether tokenization with the SRE method leads to increases in translation quality, whether it allows NMT models to hypothesize unseen word forms needed at inference, and how impervious resulting NMT models …
Building Brains And Relationships Beginning From Birth: Exploring Multilingual Parents' Experiences With A Babies Initiative Family-School Partnership, Diane D. Joyce
Theses and Dissertations
This study examined multilingual families’ experiences in a family-school early literacy program during the critical period of brain development, the Phlournoy Babies Initiative (PBI). Participants included five multilingual (ML) and immigrant families who have participated in this program for multiple years. In addition, this study probed how families were applying the strategies shared during PBI sessions within the context of their culture and home environment. Sociocultural, ecological systems, and culturally responsive teaching theories formed the framework of this study. A narrative inquiry approach was applied, which provided the researcher the opportunity to share the stories and experiences of the participants. …
First Generation Graduate Student Experiences, Andrew Torres
First Generation Graduate Student Experiences, Andrew Torres
Theses and Dissertations
The purpose of this qualitative research study was to gain a better understanding of the experiences, inspiration, motivations, and varying aspects of what it is to be a first- generation master’s level student. Throughout the 2024-2025 academic year, I conducted interviews with three first-generation undergraduate students, three first-generation graduate students, and two first-generation postgraduate professionals at a single university to understand how their higher education experiences were similar and different. I pursued this research topic to understand further what resources graduate students used and which were lacking for their needs. The pursuit motivated me to discover why there was such …
Developing Indicators For Comprehensive Evaluation Of Equity In Transportation Systems, Ruqaya Emad Alfaris
Developing Indicators For Comprehensive Evaluation Of Equity In Transportation Systems, Ruqaya Emad Alfaris
Theses and Dissertations
Achieving transportation equity is essential for social inclusion, access to opportunities, and reducing disparities. However, traditional evaluation methods are often fragmented and fail to capture equity’s multidimensional nature. This dissertation develops a comprehensive framework for creating indicators to evaluate transportation equity effectively. It begins with a literature review to comprehend the theoretical background, followed by expert interviews highlight gaps in current evaluation practices. Statistical modeling and machine learning analysis was conducted to first explore indicators’ impact on transportation equity, and then investigate transportation safety disparities in underserved communities. Findings from literature review, interview with professionals, and analysis results are used …
Creativity And Crisis. Case Studies Of Bureaucracy Under Pressure – Determining Factors Affecting Creativity, Andrew Lee Carlson
Creativity And Crisis. Case Studies Of Bureaucracy Under Pressure – Determining Factors Affecting Creativity, Andrew Lee Carlson
Theses and Dissertations
I studied creativity and how it interacts with the crisis environment to devise a way of determining if future situations are amenable to creativity. Through studying creativity theories and crisis responses, I developed a framework and instrument that answers the following questions, semi-quantitatively and qualitatively: 1) Is the future situation or problem amenable to creativity? 2) How much “energy” needs to be expended in solving the problem or situation? 3) Where best can I use creative energy as it relates to the subject matter or process of the situation? I studied situations ranging from personal (pursuit of this PhD), critical …
Building And Demonstrating A Framework And Guide For Human-Centered Threat Modeling, Warda Usman
Building And Demonstrating A Framework And Guide For Human-Centered Threat Modeling, Warda Usman
Theses and Dissertations
As researchers increasingly seek to understand threats faced by people rather than systems, there remains little consensus on how to study these threats in ways that are grounded in human experience. Traditional approaches to threat modeling are often designed for system vulnerabilities and offer limited guidance for eliciting or analyzing threats as understood by individuals in their social and cultural contexts. This dissertation addresses this gap by advancing human-centered threat modeling (HCTM) in security and privacy research as both a conceptual framework and through a set of empirical studies. The dissertation employs a mixed set of qualitative methods across four …
Navigating The Transition: Experiences Of Former Collegiate Softball Athletes, Breanna Alleen Bryant
Navigating The Transition: Experiences Of Former Collegiate Softball Athletes, Breanna Alleen Bryant
Theses and Dissertations
The purpose of this research study was to explore the different ways former female collegiate athletes transitioned out of playing their sport. Through qualitative interviews, the research aimed to understand the challenges these athletes faced, such as loss of identity, emotional distress, the absence of structure and support after leaving their teams. It also examined how unprepared these athletes were while going through the transition. The participants in this research study are all former division three college softball players who have just graduated college or have been out for a maximum of ten years. The most significant findings were these …
Engineered Peptide Biomaterials And Synthetic Transmembrane Receptors For Native And Programmable Cell Interactions, Matthias Recktenwald
Engineered Peptide Biomaterials And Synthetic Transmembrane Receptors For Native And Programmable Cell Interactions, Matthias Recktenwald
Theses and Dissertations
Peptide-functionalized biomaterials enable cell-material interactions through peptide-induced activation of native and synthetic receptors. This dissertation expands the clinical potential of biomaterials by harnessing native and synthetic receptor-peptide interactions. Key advancements include: (1) developing a novel method to functionalize rigid biomaterials with peptides, (2) designing antimicrobial peptide-modified hydrogels and plastics, (3) functionalizing hydrogels with N-cadherin peptides to improve stem cell manufacturing, and (4) engineering synthetic mammalian transmembrane receptors that initiate non-native intracellular responses to peptide-ligands. Using thiol-norbornene click chemistry, we functionalized rigid plastics and soft hydrogels using therapeutic peptides with spatial and temporal control. While advances in synthetic biology have enabled …
New Student Orientation Programs: Understanding The Perceptions And Experiences Of First-Generation Community College Students, April J. Catching
New Student Orientation Programs: Understanding The Perceptions And Experiences Of First-Generation Community College Students, April J. Catching
Theses and Dissertations
This study examines first-generation community college students' perceptions of New Student Orientation programs. The research questions focus on specific aspects of students' experiences and transitions to gain an understanding of their perspectives. The objective is to see if there is a connection between what researchers ascertain are the most valuable experiences for new students and what students feel and perceive while enrolled in their first semester of college. Qualitative data was collected to provide targeted insights for improving orientation programs and practices. The research questions focused on understanding specific aspects of students’ orientation experiences and their impact on their college …
Can Social And Emotional Lessons Improve Student Behavior In A First Grade Classroom? A Program Evaluation, Tara Freeman Mozee
Can Social And Emotional Lessons Improve Student Behavior In A First Grade Classroom? A Program Evaluation, Tara Freeman Mozee
Theses and Dissertations
This program evaluation discusses how using a social and emotional (SEL) curriculum taught first-grade students how to manage and regulate their behavior in a first-grade classroom. The purpose of this program evaluation was to evaluate if the SEL curriculum helped first-grade students manage and regulate their behavior in the classroom so the teacher would create fewer behavior management plans and spend more time on classroom instruction. The methodology used in this program evaluation was a logic model. This model presented the inputs, activities, outputs, and outcomes of the program evaluation. The implications of this program evaluation are based on the …
Heat Pumps And Sustainable Building Operations: An Analysis Of Energy Efficiency, Emissions, And Life Cycle Costs, Mahdiyeh Zafaranchi
Heat Pumps And Sustainable Building Operations: An Analysis Of Energy Efficiency, Emissions, And Life Cycle Costs, Mahdiyeh Zafaranchi
Theses and Dissertations
Heating, ventilation, and air conditioning (HVAC) systems are a major contributor to energy demand. Heat pump technologies, particularly Ground Source Heat Pumps (GSHPs) and Air Source Heat Pumps (ASHPs), have emerged as key solutions to reduce energy use worldwide. However, their adoption is challenged by economic, operational, and environmental trade-offs. This dissertation develops a comprehensive framework for evaluating the energy efficiency, lifecycle emissions, and cost-effectiveness of GSHP and ASHP systems in sustainable building operations. Through advanced energy modeling, lifecycle assessments (LCA), and lifecycle cost (LCC) analyses, this research provides data-driven insights to optimize heat pump system selection. This study is …
Incorporating Propensity Score Weighting And Nonresposne Adjustments Into Complex Survey Data With Survival Outcomes, Xinrui Shi
Theses and Dissertations
Propensity score weighting (PSW) plays a key role in minimizing confounding in observational research, especially when estimating treatment effects for time-to-event outcomes. However, its integration into survey data with complex design – particularly data with multiple stage sampling and censoring – remains underexplored. One significant challenge in such settings is the presence of nonresponse, which can introduce additional bias and complicate the use of standard weight adjustments. Moreover, there has been limited study on how PS weights can be effectively combined with nonresponse weighting adjustments in complex survey data that include survival outcomes. This dissertation aims to extend current methodologies …
The Development Of The Disclosed Reasons Of Partners' Premature Discontinuation In Couple Therapy Questionnaire (Dropped-Ct), Luca Codeca'
The Development Of The Disclosed Reasons Of Partners' Premature Discontinuation In Couple Therapy Questionnaire (Dropped-Ct), Luca Codeca'
Theses and Dissertations
Premature discontinuation from couple therapy presents a substantial challenge for clients, therapists, and society. Inconsistent data on the frequency and reasons for premature discontinuation may be attributed to a lack of methodological rigor in assessing the phenomenon. This study addresses this gap by developing the Disclosed Reasons Of PrEmature Discontinuation in Couple Therapy Questionnaire (DROPPED-CT), a comprehensive instrument designed to assess the reasons why couples prematurely discontinue therapy. Utilizing a mixed-method approach, the DROPPED-CT was developed through the integration of qualitative and quantitative data. The questionnaire demonstrates strong potential for enhancing the consistency of construct operationalization and improving the comparability …
University Counseling Center Therapists' Perspectives Of Counseling About Nutrition, Ana Lucia Pacheco
University Counseling Center Therapists' Perspectives Of Counseling About Nutrition, Ana Lucia Pacheco
Theses and Dissertations
This study examined university counseling center therapists' perspectives on discussing nutrition in therapy. Despite the established link between nutrition and mental health, minimal research has explored how therapists approach these discussions. This study used interpretative phenomenological analysis (IPA) to analyze semi-structured interviews with 10 university counseling center therapists from the Mountain West region. Four overarching themes emerged: a deficit view of nutrition, perceived utility, ethical practice, and holistic care. Therapists unanimously recognized the connection between nutrition and mental health and primarily discussed nutrition with clients presenting with eating disorders or disordered eating, those who express interest, or as part of …
Behavioral Skills Training: Comparing Parent Implementation To Registered Behavior Technician Implementation, Jessica Anderson
Behavioral Skills Training: Comparing Parent Implementation To Registered Behavior Technician Implementation, Jessica Anderson
Theses and Dissertations
Behavioral Skills Training (BST) is an evidence-based practice appropriate for practitioners, parents, clients, and other populations. It is frequently used in Applied Behavior Analysis (ABA) therapy to support and augment skill development. Parent training in ABA has been found to be beneficial, and often critical, in the progress of children with autism spectrum disorder (ASD). While BST is a popular method of parent training, it is unclear how effective this type of training is in comparison to the training given to a Registered Behavior Technician (RBT). This study took place in conjunction with an ABA clinic providing in home therapy. …
The Influence Of Father Involvement On Early Childhood Outcome In China, Shuiyan Guo
The Influence Of Father Involvement On Early Childhood Outcome In China, Shuiyan Guo
Theses and Dissertations
Using a sample from China, this study examined the influence of father involvement on child outcome in early childhood in areas of internalizing problems, externalizing problems and prosocial behaviors. The participants were drawn from the larger PACIFIC project, a cross-cultural study of family processes in Asia. 479 families with a preschool or kindergarten child living in Beijing and Dalian, China were included in this study. Using multiple regression analysis, result indicated that father involvement was not significantly associated with child’s internalizing problems, externalizing problems, and prosocial behaviors. Moderation analysis was also conducted and found that the effect of father involvement …