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Vocabulary Assessment And Washback: English Teachers' Practices In Preparing Students For The Wassce In Ghana, Ishmael Nii Amon Neequaye Jan 2026

Vocabulary Assessment And Washback: English Teachers' Practices In Preparing Students For The Wassce In Ghana, Ishmael Nii Amon Neequaye

Theses and Dissertations

Persistent concerns in WAEC Chief Examiners’ Reports consistently attribute declining student performance on the WASSCE English Language examination to limited vocabulary knowledge. Despite these recurring observations, little research has explored how teachers respond to the vocabulary demands embedded within this high-stakes examination. This qualitative study investigates (1) how Senior High School English teachers prepare students for the vocabulary demands of the WASSCE English paper and (2) how the assessment pressures influence instructional practices and classroom decision-making.  Drawing on communicative competence, multiliteracies, and washback, the study employed a descriptive case study design and thematic analysis of semi-structured interviews and focus group …


An Evolution Of Drag In Theatre: A Historical Reflection, Krista Peters Jan 2026

An Evolution Of Drag In Theatre: A Historical Reflection, Krista Peters

Theses and Dissertations

This thesis will serve as an overarching analysis and historical discussion on the art of drag within the traditional theatrical space. By employing queer theory, I will analyze how the use of drag has evolved throughout the history of Broadway and the United States and how it is responding to the contemporary social attitude. Drawing from the arguments of Butler, Lorde, Rich, Foucault, and others, this thesis uses historical survey to examine the direct representation of drag in theatrical spaces in conjunction with each representation’s sociopolitical and cultural environments. Sociopolitical contemporary contexts of each representation influence not only the form …


Transforming Instructional Spaces: Professional Development And The Design Of Culturally Responsive Classroom Displays, Tisha M. Ortega Jan 2026

Transforming Instructional Spaces: Professional Development And The Design Of Culturally Responsive Classroom Displays, Tisha M. Ortega

Theses and Dissertations

This qualitative action research study examined how secondary teachers at a Midwest high school engaged in the process of designing classroom displays for culturally responsive teaching. The semester-long study explored how teachers’ understandings of culturally responsive teaching informed their design decisions, how they engaged students with display content, and how ongoing reflection and participation in a professional development study group shaped their practices over time. Data were collected through interviews, surveys, study group transcripts, and photographs of classroom displays.

Findings indicated that participation in the study group served as both validation and inspiration, supporting teachers in refining their approaches to …


Transgender Representation In Japanese Video Games And Their Corresponding American Fandoms, Aj Abad Jan 2026

Transgender Representation In Japanese Video Games And Their Corresponding American Fandoms, Aj Abad

Theses and Dissertations

This thesis explores transgender and gender non-conforming characters within Japanese media and their corresponding American fandoms. In this thesis, I use a methodology named trans negotiated readings, stemming from Stuart Hall’s theory of dominant codes and negotiated readings. Through focusing on two characters from two different Japanese media—Arashi Narukami from Ensemble Stars!! and Mizuki Akiyama from Project Sekai: Colorful Stage Feat. Hatsune Miku, I uncover some of the dominant codes encoded the original source material. After, I also examine their corresponding American fandoms, uncovering the negotiated readings from the fanbase. This thesis attempts to show different cultures’ interpretation of transgender …


Interactive Effects Of Bti Larviciding And Predation On Culex Pipiens And Its Ephemeral Pond Communities, Jaclyn S. Everly Jan 2026

Interactive Effects Of Bti Larviciding And Predation On Culex Pipiens And Its Ephemeral Pond Communities, Jaclyn S. Everly

Theses and Dissertations

Populations of adult vector mosquitoes can be controlled by reducing larval mosquito abundances in aquatic habitats. This can be achieved via predation by introduced or naturally-occurring enemies (i.e., biocontrol or conservation control) or by applying pesticides to larval mosquito habitats (i.e., larviciding). The larvicide Bacillus thuringiensis israelensis (Bti) is commonly applied to ephemeral ponds to control populations of Culex pipiens mosquitoes that vector West Nile virus. However, there is concern that Bti may directly or indirectly harm non-target organisms such as dragonfly and damselfly naiads, which provide a natural source of mosquito biocontrol. Bti or predators may also induce positive …


From Stage To Screen: Hamilton: An American Musical, Emotional Communication, And Digital Audience Discourse, Christopher J. O'Quinn Jr Jan 2026

From Stage To Screen: Hamilton: An American Musical, Emotional Communication, And Digital Audience Discourse, Christopher J. O'Quinn Jr

Theses and Dissertations

This study examines how musical theatre functions as a communicative and affective medium that extends beyond live performance into digital spaces where audiences actively construct and share meaning. Focusing on the Broadway musical Hamilton: An American Musical (throughout the thesis, I will refer to it as Hamilton), this research explores how audiences interpret, express, and create emotional responses through social media platforms. Using a modified digital ethnographic approach, data were collected from Instagram comments on posts from 2024 to 2026. Subsequently, a discourse analysis was employed to identify patterns in emotional expression, lived experience, meaning-making, performer appreciation, and shared …


Does The Powder River Pass Shear Zone Exist? Geologic Map And Geochronology Of The Bighorn Mountains Caribou Creek 7.5-Minute Quadrangle, Lula G. Staley Jan 2026

Does The Powder River Pass Shear Zone Exist? Geologic Map And Geochronology Of The Bighorn Mountains Caribou Creek 7.5-Minute Quadrangle, Lula G. Staley

Theses and Dissertations

This study produced a 1:24000-scale geologic map of the Caribou Creek 7.5-minute quadrangle in the Bighorn Mountains, Wyoming, by integrating field observation and U-Pb zircon age data. The results of this study will contribute to the USGS EDMAP program by subdividing the southern gneiss terrain. The quadrangle occurs almost entirely in the Bighorn National Forest and is in the drainage of Clear and Crazy Woman creeks. Elevations range from 6,800-9,400 ft. The quadrangle is dominated by Archean crystalline rocks of the Wyoming Province Beartooth-Bighorn Magmatic terrane, mainly granodiorite and tonalite gneiss with lesser migmatite. Several orientations and ages of mafic …


The Synergy Between A Silver-Ruthenium Antimicrobial And Aminoglycosides Is Based On Severe Macromolecular Damage, Emmanuel Parkay Oladokun Jan 2026

The Synergy Between A Silver-Ruthenium Antimicrobial And Aminoglycosides Is Based On Severe Macromolecular Damage, Emmanuel Parkay Oladokun

Theses and Dissertations

The rise of multidrug-resistant (MDR) bacterial pathogens, including uropathogenic Escherichia coli (UPEC), highlights the urgent need for alternative treatment strategies to restore antibiotic efficacy. The silver-ruthenium antimicrobial AGXX exerts potent bactericidal effects through the production of reactive oxygen species (ROS); however, its potential synergy with antibiotics has not been thoroughly investigated. Here, we show that sublethal concentrations of AGXX strongly enhance aminoglycoside-mediated killing across a diverse panel of Gram-negative and Gram-positive MDR clinical isolates, including highly aminoglycoside-resistant strains. Combinational treatments significantly reduced the effective concentrations of gentamicin, tobramycin, kanamycin, and amikacin required to kill bacteria. Mechanistic analyses revealed that AGXX/aminoglycoside …


From Rocks To Rockets: How Mineral Wealth Fuels The Arms Trade, Samuel G. Majka Jan 2026

From Rocks To Rockets: How Mineral Wealth Fuels The Arms Trade, Samuel G. Majka

Theses and Dissertations

This study addresses a critical gap in the resource curse literature by examining how strategic mineral wealth, central to the global clean energy transition, influences international arms transfers. While the relationship between oil rents, militarization, and conflict is well-established, the role of non-hydrocarbon resources and conflict-related variables remains underexplored. This paper posits that mineral rents provide governments with unearned, discretionary income, relaxing fiscal constraints and creating powerful incentives for both resource-rich states and major power suppliers to increase arms flows to secure political control, suppress internal dissent, and maintain access to valuable deposits. Using a country-year panel dataset spanning 1990-2023 …


Comparison Of Basil (Ocimum Basilicum L.) Cultigens In A Controlled Environment Vertical Farm, Sarah R. Stevens Jan 2026

Comparison Of Basil (Ocimum Basilicum L.) Cultigens In A Controlled Environment Vertical Farm, Sarah R. Stevens

Theses and Dissertations

Vertical farming is the production of plants in a completely controlled, enclosed environment and represents an advanced, sustainable method to grow basil and other leafy crops. Vertical farming offers 365 days of continual production, using minimal input and efficient, low water usage. For this study we compared five different basil cultivars side-by-side under the same growing conditions in a controlled environment. The basil cultivars compared were, Sweet Thai, Genovese, Holy, Cinnamon, and Greek basils. During growth, data was collected three times for each cultivar including plant length, internode length, number of nodes, number of leaves per stem, SPAD (Soil Plant …


Children’S And Adult Perspectives On Mental Health In Children’S Youth Literature And Media, Edcel J. Cintron-Gonzalez Jan 2026

Children’S And Adult Perspectives On Mental Health In Children’S Youth Literature And Media, Edcel J. Cintron-Gonzalez

Theses and Dissertations

My dissertation extends existing work on mental health in children’s literature to examine the different narratives strategies that text, film, and media for young audiences use to connect childhood, caregiving, and emotional wellbeing. Three areas of scholarship—children’s literature scholarship, health humanities work, and feminist care ethics—inform my project. Overall, I am interested in how a variety of genres for young readers represent mental health not only as an individual experience, but also as something shaped by family, culture, community, and adult-child relationships. It is therefore important to delineate the different concepts and frameworks that help make sense of how mental …


Why Make Books In Art Class Or Art In Reading Class? How Storytelling Impacts Youth Literacy And Cultural Dialogue, Holly Lewis Jan 2026

Why Make Books In Art Class Or Art In Reading Class? How Storytelling Impacts Youth Literacy And Cultural Dialogue, Holly Lewis

Theses and Dissertations

Given complex factors affecting reading literacy and students’ need for empowerment through creativity, this thesis project will investigate possibilities for combining artmaking with written narrative. Creative solutions, such as integrated and project-based learning activities, are documented as having some of the best positive impacts on overall learning growth (Laur, 2021; Aydin & Mutlu, 2023). Therefore, my thesis includes a discussion on Arts Integration initiatives and an illustrated book for students ages 10-15, which can be used as an example for their own studies into personal narrative. While the research presented here touches on multiple factors affecting students’ self-esteem and willingness …


Reconceptualizing Instructional Supervision For Stem Education In The Digital Age, Armen Alvarez Jan 2026

Reconceptualizing Instructional Supervision For Stem Education In The Digital Age, Armen Alvarez

Theses and Dissertations

This conceptual thesis reconceptualizes instructional supervision for AI-enabled STEM teaching in the Digital Age. Traditional supervision models, including clinical, developmental, and cognitive coaching, emphasize human-centered observation and feedback but lack guidance for supervising AI-mediated instruction, interpreting algorithmic outputs, and addressing neurodiverse learner variability. Using integrative literature review methodology, this thesis synthesizes scholarship across five theoretical foundations: epistemic perspectives, the neurodiversity paradigm, Universal Design for Learning, human-centered AI and educational leadership, and supervision literature.

The resulting conceptual framework organizes supervisory attention into four interconnected domains:

  • human-centered AI use in teaching and assessment,
  • neurodiversity- and UDL-informed pedagogy,
  • relational and compassionate classroom climate, …


Prevalence Of Grip And Leg Strength Asymmetries In U.S. Youth, Elyse M. Deschryver Jan 2026

Prevalence Of Grip And Leg Strength Asymmetries In U.S. Youth, Elyse M. Deschryver

Theses and Dissertations

Early-life physical activity is important for building muscular strength, supporting healthy growth and disease prevention, and for establishing physical activity and strength habits that often track into adulthood. Although grip strength asymmetry is a well-documented risk factor in older adults, evidence in children and adolescents is limited and largely based on small, sport-specific samples. PURPOSE: To describe grip and leg extension strength asymmetries in a nationally representative sample of U.S. youth aged 6–15 years using the National Youth Fitness Survey (NNYFS). METHODS: The analysis included 1,214 participants (606 boys, 608 girls) with valid grip or leg extension data. Age, sex, …


Turning 30 In 600 Feet, Tate Lewis-Carroll Jan 2026

Turning 30 In 600 Feet, Tate Lewis-Carroll

Theses and Dissertations

This thesis is a poem; it records fourteen consecutive months of the poet’s life through rigorous, daily typing habits with nonoptimal tools and material: a typewriter and 600 feet of receipt paper. Through the adoption of these conditions, and through the dailiness of the habit, this thesis crips and deploys a poetics of chronic impediment for accessing constraint and its role in making. This thesis includes a critical preface which explores some of the poet’s specific relationships to chronic pain, both physical and emotional; forgetfulness and dissociation; and disruption by remembering a decade-long flare of chronic illness and abuse. With …


The Right To Read: Opposing The Censorship Of Young Adult Literature On Grounds Of Sexually Explicit Content, Kate Fortner Jan 2026

The Right To Read: Opposing The Censorship Of Young Adult Literature On Grounds Of Sexually Explicit Content, Kate Fortner

Theses and Dissertations

In this thesis, I use intersections between sexuality studies, feminism, queer theory, and theories of children’s and young adult literature to examine and historicize the prevalence of book bans and challenges between 2020 and 2025 that target young adult literature on the basis of sexually explicit content. To understand the opposition to portrayals of underage heterosexuality, I analyze John Green’s Looking for Alaska, considering its history of censorship as well as the author’s response to those bans. To understand the challenges to depictions of LGBTQ+ identities aimed at young people, I look at Maia Kobabe’s Gender Queer and Juno …


Promoting Emotion Regulation: A Group Based Program For Children With Autism Spectrum Disorder And Their Caregivers, Emily Jasinski Jan 2026

Promoting Emotion Regulation: A Group Based Program For Children With Autism Spectrum Disorder And Their Caregivers, Emily Jasinski

Theses and Dissertations

Emotion regulation skills lay the foundation for effective social interactions and future success. Children on the autism spectrum experience greater difficulties regulating their emotions than their neurotypical peers, leading to difficulties in social and academic settings. Therefore, it is essential to directly teach these children emotion regulation strategies. Additionally, autistic children often have difficulties generalizing what they have learned from one setting to another, and as such it has been helpful to involve caregivers in their treatment. Currently, the scant research that exists primarily describes emotion regulation interventions implemented in individual settings, which are both time intensive and expensive. One …


Exploring The Role Of Racial Microaggressions And Campus Climate In Fostering Sense Of Belonging For Black Latiné College Students, Lourdes D. Concepción Cabán Jan 2026

Exploring The Role Of Racial Microaggressions And Campus Climate In Fostering Sense Of Belonging For Black Latiné College Students, Lourdes D. Concepción Cabán

Theses and Dissertations

Racial microaggressions are subtle verbal or nonverbal behaviors that convey hostility and exclusion toward People of Color (Sue et al., 2007). These acts negatively impact the well-being, perceptions of inclusivity, and sense of belonging of marginalized groups in higher education (Solórzano & Pérez Huber, 2020). Black Latiné college students face unique challenges at the intersection of anti-Blackness and racialized Latinidad, compounding the effects of racial microaggressions in historically white institutions (Torres et al., 2012). I conducted a study with 77 Black Latiné undergraduate students from Midwestern universities to examine the relation between racial microaggressions, perceptions of campus climate, and sense …


Tensions And Possibilities: A Study Of International Graduate Students' Encounters With Critical Pedagogy In The United States, Munchuree Kaosayapandhu Jan 2026

Tensions And Possibilities: A Study Of International Graduate Students' Encounters With Critical Pedagogy In The United States, Munchuree Kaosayapandhu

Theses and Dissertations

This study investigates the question, “How do international graduate students experience and negotiate their encounters with critical pedagogy across time and educational contexts?” The research was motivated by the researcher’s own experience in encountering critical pedagogy and prior studies focusing on critical pedagogy from the teacher perspective. This left a gap in understanding the student experience. The research used the phenomenology paradigm. The participants included six international graduate students in education studies programs. Using the phenomenological interview approach, each participant was asked over a series of three interviews about past experiences of education, their initial encounters with critical pedagogy and …


Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat Jan 2026

Digital Truth Making, Creative Resistance, And Power Negotiation Through Social Media: A Digital Ethnography Of The 2024 Gen Z Uprising In Bangladesh, Mustafizurrrahman Rahat

Theses and Dissertations

This research investigates how social media shaped political participation during the 2024 July Uprising in Bangladesh, focusing on the production and negotiation of political truth, legitimacy, and resistance through everyday digital practices. Rather than conceptualizing social media solely as a communication tool, the study analyzes digital platforms as contested spaces where activists, state-aligned actors, and other participants constructed, circulated, and challenged competing political narratives throughout the uprising.

Drawing on digital ethnography, this study integrates netnographic observation of Facebook groups, pages, hashtags, memes, and protest-related visual content with content analysis, reflexive participant observation, and semi-structured interviews with Generation Z participants. The …


Cultivating Culturally Responsive Special Educators: A Qualitative Study Of Self-Efficacy Journeys Across Preservice Preparation And Inservice Professional Development, Ashley R. Norton Jan 2026

Cultivating Culturally Responsive Special Educators: A Qualitative Study Of Self-Efficacy Journeys Across Preservice Preparation And Inservice Professional Development, Ashley R. Norton

Theses and Dissertations

In an increasingly diverse society, educators must be prepared to effectively instruct students from a wide range of cultural, linguistic, and ability backgrounds. Teacher self-efficacy in culturally responsive practices (CRP) is critical to achieving equitable educational outcomes, particularly in special education, where students often experience multiple forms of marginalization. Despite the importance of culturally responsive teaching, limited research has examined how special educators develop culturally responsive teaching self-efficacy (CRTSE) over the course of their professional careers, particularly in urban school districts serving culturally and linguistically diverse (CLD) populations.

This qualitative study explored the self-efficacy journeys of special educators and their …


Structural Framework And Tectonic Implications From Field Investigations In The Ramelau Mountains, Timor-Leste, Tanner A. Nielsen Dec 2025

Structural Framework And Tectonic Implications From Field Investigations In The Ramelau Mountains, Timor-Leste, Tanner A. Nielsen

Theses and Dissertations

Recent advances in petroleum exploration off the southern coast of Timor-Leste and emerging mineral discoveries onshore have underscored the need for a more comprehensive structural understanding of the nation's geology. Although new structural models have been proposed for other parts of Timor, limited progress has been made toward developing detailed models for the Ramelau Mountains, which presents the highest structural relief of the Timor Ranges. Previous mapping in this area has been largely reconnaissance in nature and focused primarily on surface bedrock geology. This study presents a new 1:62,500-scale geologic map and a geometric structural analysis of the Ramelau region …


Language Attitudes And Maintenance Within Latino Families In Utah County, Megan Elise Magleby Townsend Dec 2025

Language Attitudes And Maintenance Within Latino Families In Utah County, Megan Elise Magleby Townsend

Theses and Dissertations

While there has been research done on Latino individuals' and parents' language attitudes and maintenance practices, there is little known about children's language attitudes and their perceptions of their parents' views towards both Spanish and English. This thesis looks at what the current picture is in terms of Spanish maintenance in Utah County's immigrant families as well as those factors that affect the parents' language attitudes and maintenance efforts. This study also seeks to fill the gap in the literature concerning what children (ages 8-13) think of English, Spanish, their respective cultures, as well as their possible plans to pass …


A Systematic Study Of Passkey User Experience Consistency, Bernhardt Ramat Dec 2025

A Systematic Study Of Passkey User Experience Consistency, Bernhardt Ramat

Theses and Dissertations

Passkeys have emerged as a more secure authentication method than passwords, providing a passwordless alternative resistant to phishing and credential theft attacks. Despite their growing adoption, a systematic study into the user experience of passkeys across various websites has yet to be conducted. Usability heuristics suggest that users transfer their expectations from one product to another, and therefore, inconsistencies in passkey deployments can increase cognitive load, resulting in frustration and possible rejection. To address this knowledge gap, this paper presents a comparative analysis of the external functional consistency of the passkey user experience across 111 websites. Our research reveals that …


Cybernest: A Step Forward For Training Cybersecurity Professionals, Justin Mott Dec 2025

Cybernest: A Step Forward For Training Cybersecurity Professionals, Justin Mott

Theses and Dissertations

The growing complexity of cyber threats has exposed a critical gap between academic cybersecurity education and the operational demands of the workforce. This thesis presents a pilot study for a use-case of CyberNEST, a simulation-based training platform that integrates adversary emulation and threat-informed learning to create realistic, hands-on experiences for cybersecurity students.(17) The system was designed to replicate Security Operations Center (SOC) environments and incident response workflows, allowing participants to investigate, analyze, and respond to simulated attacks under authentic conditions. This pilot-study performed training simulations using the CyberNEST platform, developed by Brigham Young University, with students, collecting data from pre- …


Kuleana Mākua: Native Hawaiian Parents' Exercise Of Agency In K-12 School Selection, Joseph Piikeha Kahaka`Ulamaikalaniki`Eki`E Hao Dec 2025

Kuleana Mākua: Native Hawaiian Parents' Exercise Of Agency In K-12 School Selection, Joseph Piikeha Kahaka`Ulamaikalaniki`Eki`E Hao

Theses and Dissertations

In this qualitative study the author investigates how Native Hawaiian parents on Hawai`i Island navigate educational choices for their children amidst a history of centralized, Western-dominated schooling and systemic cultural suppression. Grounded in Bandura’s Social Cognitive Theory (SCT), the research explores parent perceptions of different K–12 school types and the complex factors that drive their selection. Through semi-structured interviews and a card sort activity with sixteen Native Hawaiian parents (n = 16), the study confirms that parental choice is fundamentally an act of indigenous self-determination defined by Kuleana Mākua (parental responsibility, authority, and privilege). The findings reveal that parents’ choices …


An Analysis Of Ukrainians' Language Attitudes And Ideology: A Conflict-Catalyzed Language And Identity Shift, Kateryna Kravchenko Dec 2025

An Analysis Of Ukrainians' Language Attitudes And Ideology: A Conflict-Catalyzed Language And Identity Shift, Kateryna Kravchenko

Theses and Dissertations

On February 24, 2022, the Russian Federation invaded Ukraine. According to Vladimir Putin's speech, the main goal of the war was to protect the Russian-speaking population of the Donbas region in eastern Ukraine. Many Ukrainians indeed speak Russian on a daily basis, largely due to the long and complicated history between the two countries. Recently, there has been an increase in pro-Ukrainian ideologies (Kulyk 2016); however, as the full-scale invasion began, people started advocating for Ukrainian usage in all public domains, and many even vowed to never speak Russian again. Since then, there has been a profound change in language …


Enhancing Silicon Sampling In Large Language Models: Fine-Tuning Techniques Using Survey Data, Davis P. Forster Dec 2025

Enhancing Silicon Sampling In Large Language Models: Fine-Tuning Techniques Using Survey Data, Davis P. Forster

Theses and Dissertations

Large language models (LLMs) are increasingly used to simulate responses of human demographic groups, a task known as silicon sampling. This paper investigates whether supervised fine-tuning can improve algorithmic fidelity in such settings. We construct a dataset from the General Social Survey (GSS), converting demographic attributes into natural-language backstories and randomly selecting one attribute as a held-out target. Fine-tuning a LLaMA-3.1-70B model on this dataset yields significant improvements on two tasks: (1) imputing missing attributes at the individual level, and (2) reproducing response distributions for demographic slices, such as racial and age groups. Notably, these improvements are achieved with minimal …


Using Rhizobia Seed Coatings And Soil Amendments To Combat Herbicide Toxicity For Native Legume Establishment, Ryan Matthew Glover Dec 2025

Using Rhizobia Seed Coatings And Soil Amendments To Combat Herbicide Toxicity For Native Legume Establishment, Ryan Matthew Glover

Theses and Dissertations

Dryland ecosystems face widespread degradation from historical mismanagement, climate change, and invasive species proliferation. Although herbicides effectively control invasive annual weeds, they often suppress the establishment of desirable perennial species, limiting restoration success. Legumes enhanced with rhizobia inoculants offer a promising approach to overcome these challenges by facilitating nitrogen fixation, improving soil microbial communities, and potentially mitigating herbicide stress. We conducted paired greenhouse and field experiments to evaluate whether rhizobia seed coatings improve the establishment of three legume species Astragalus cicer (Cicer Milkvetch), Onobrychis viciifolia (Sainfoin), and Medicago sativa (Alfalfa), in soils treated with imazapic and glyphosate. In the greenhouse, …


Targeting Pancreatic Cancer With Rapamycin-Loaded Gold Nanoparticles Conjugated To Egf Peptide: Studies On Cytotoxicity And Uptake Mechanisms Aided By Proteomic Analysis, Adeolu Oluremi Dec 2025

Targeting Pancreatic Cancer With Rapamycin-Loaded Gold Nanoparticles Conjugated To Egf Peptide: Studies On Cytotoxicity And Uptake Mechanisms Aided By Proteomic Analysis, Adeolu Oluremi

Theses and Dissertations

Pancreatic cancer remains one of the most lethal malignancies, with a five-year survival rate below 5%. While rapamycin (Rap) has demonstrated therapeutic potential, its clinical utility is hampered by systemic toxicity. To address this limitation, this study developed a targeted nanocarrier system using gold nanospheres (AuNPs) functionalized with the Epidermal Growth Factor Receptor (EGFR) peptide GE11 for the specific delivery of Rap to pancreatic cancer cells. It is to note that pancreatic cancer overexpresses EGFR. The AuNP–GE11–Rap conjugates were successfully synthesized and characterized using physico-chemical techniques, which confirmed peptide conjugation and drug loading. In vitro studies using PANC-1 cells demonstrated …