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Factors Influencing White-Tailed Deer Mortality Risk Within A Multi-Predator System In Michigan, Usa, Todd M. Kautz Dec 2018

Factors Influencing White-Tailed Deer Mortality Risk Within A Multi-Predator System In Michigan, Usa, Todd M. Kautz

Theses and Dissertations

I monitored cause-specific mortality and factors influencing mortality risk for white-tailed deer in the Upper Peninsula of Michigan, USA, during two high mortality risk periods: adult female deer during Feb–May, and fawns from birth to 6 months. I observed high rates of predation and starvation for adult female deer during Apr–May, suggesting that late winter represents a survival bottleneck due to nutritional declines. A strong negative relationship existed between snow free days during late winter and mortality risk. Predation was the dominant mortality source for fawns but predation risk decreased with larger birth mass. Black bears and coyotes accounted for …


Assessment Of On-Arrival Vaccination And Deworming On Health And Growth Performance In High Risk Stocker Cattle, Richard Tucker Wagner Dec 2018

Assessment Of On-Arrival Vaccination And Deworming On Health And Growth Performance In High Risk Stocker Cattle, Richard Tucker Wagner

Theses and Dissertations

The study objective was to evaluate the effects of vaccination (respiratory and clostridial vaccination or no vaccination) and deworming (fenbendazole and levamisole or no deworming) of high risk stocker calves on-arrival on health and growth performance. Eighty sale barn origin calves were purchased three separate years (n=240) from local order buyer. Steers (n=61) and bulls (n=179) were received over three days (d -3 to -1). On d 0 calves were stratified by arrival BW and FEC into 20 pens of 4 calves each, and treatment was applied to pens in 2 x 2 factorial. Vaccination increased the likelihood of BRD …


Assessment Of Live Attenuated Vaccines Against Enteric Septicemia Of Channel Catfish, Iman Abdelwahab Ahmed Ibrahim Dec 2018

Assessment Of Live Attenuated Vaccines Against Enteric Septicemia Of Channel Catfish, Iman Abdelwahab Ahmed Ibrahim

Theses and Dissertations

Edwardsiella ictaluri causes enteric septicemia of catfish (ESC), one of the most important bacterial diseases of farmed channel catfish in the USA. Use of live attenuated vaccines (LAVs) is an effective strategy for combating mortalities in catfish farms. Our research group has developed three live attenuated E. ictaluri strains [EiΔevpB, EiΔgcvPΔsdhCΔfrdA (ESC-NDKL1), and EiΔhemRΔfrdAΔsdhC (triple-hemR)] that provide various levels of protection against ESC. However, the protective mechanisms of these vaccine candidates are mostly unknown. The overall objective of my study was to investigate protective mechanisms of these LAVs. To accomplish this, catfish fry were immersion challenged with EiΔevpB, ESC-NDKL1, and …


Breeding Of Cool-Season Forage Grasses For Abiotic And Biotic Stress Tolerance In The Southern United States, Eric Douglas Billman Dec 2018

Breeding Of Cool-Season Forage Grasses For Abiotic And Biotic Stress Tolerance In The Southern United States, Eric Douglas Billman

Theses and Dissertations

Abiotic stress tolerance and biotic stress resistance have long been targets for trait improvement in the field of plant breeding. To date, much of the target crop focus has been centered on commodity crops such as corn, soybean, wheat, and rice. However, little work has been conducted on improvement of these traits in forage grasses. This is due to a number of issues, particularly that most species are obligately outcrossing, the traits are governed by many genes at unknown loci, and are greatly affected by environmental variation. This creates major complications in successfully selecting and breeding populations of forage grasses …


Villë Luksoze, Eglantina Buja Dec 2018

Villë Luksoze, Eglantina Buja

Theses and Dissertations

“Objekti përceptohet me sytë që shohin, me kokën që lëvizë, dhe me këmbët që ecin...” Ludwing Mies Van Der Rohe

Ndryshimet e vazhdueshme dhe konceptet e ripërtëritura të stilit të jetesës së njerëzve sjellin dhe krijojnë gjithnjë e më tepër nevoja për kualitetet e përgjithshme të banimit. Për më tepër kërkesat për vila dhe rezidenca kanë marshuar drejtë sferës së dimensionit psikologjik dhe kulturor. Si rrjedhojë edhe ka lindur një trend i ri dizajni dhe kërkesa të reja për qasjen ambientale, organizimin e kthinave, përzgjedhjen e materialeve dhe konceptin e dizajnit. Kjo qasje rezulton në krijimin e hapësirave më natyrale …


An Examination Of Physical Exercise And Its Impact On Augmenting Self-Determination Levels Of College-Aged Students, Kenneth William Kirsch Jr Dec 2018

An Examination Of Physical Exercise And Its Impact On Augmenting Self-Determination Levels Of College-Aged Students, Kenneth William Kirsch Jr

Theses and Dissertations

Research has demonstrated a positive link with motivation, physical exercise, and academic success. A current trend within higher education has been to increase student retention as well as deemphasize physical education. Students, who possess a higher degree of self-determined behavior, sustain greater overall success. Administrators have intensified efforts focusing on student retention; however, little research exists connecting physical exercise with self-determination and how these elements could provide solutions to address this problem. Motivation is an element, which drives people to accomplish a task and has the propensity to change when engaged in physical exercise. The motivational reasons why people participate …


An Examination Of The Relationship Between High School Seniors And High School Seniors Participating In A Multi-Year, Looping, School-Based Mentoring Program, Devon Alaine Lassetter Dec 2018

An Examination Of The Relationship Between High School Seniors And High School Seniors Participating In A Multi-Year, Looping, School-Based Mentoring Program, Devon Alaine Lassetter

Theses and Dissertations

Researchers have indicated that secondary school students were more likely to be truant than primary school students which lead to students dropping out of school and becoming less productive citizens as adults. Researchers have also shown that participation in a school-based mentoring program can positively influence the students and help them make better life decisions. The purpose of this study was to determine to what extent a multi-year, looping, school-based mentoring program has on the attendance data, behavioral data, achievement data, and graduation rate of high school seniors at a rural high school in west Georgia. The researcher conducted a …


Higher Education Social Responsibility: An Empirical Analysis And Assessment Of A Hispanic-Serving Institution's Commitment To Community-Engaged Scholarship, Student Integration And Sense Of Belonging, Juan Salinas Jr. Dec 2018

Higher Education Social Responsibility: An Empirical Analysis And Assessment Of A Hispanic-Serving Institution's Commitment To Community-Engaged Scholarship, Student Integration And Sense Of Belonging, Juan Salinas Jr.

Theses and Dissertations

Current efforts in higher education institutions to increase persistence and success among Hispanic students continue to be ineffective and thus new conceptual frameworks need to be explored. Data from the Hispanic Association of Colleges and Universities asserts that increasing the number of Hispanics that graduate is vital for our country’s future. In turn, Hispanic-Serving Institutions need to nourish and nurture their students to ensure that they graduate and institutional frameworks would benefit from cultural and epistemological congruence with Hispanic students, their families, and their communities.

Educational leaders have urged educators to take on the responsibility and commitment to students’ success …


A Systematic Approach To High Blood Pressure Risk Analysis And Healthcare Cost Reduction In Young Adults [Metodología Sistemática Para El Análisis De Riesgo Y Reducción De Costos De Servicios Médicos De Hipertensión En Adultos Jóvenes], Francisco Rafael Torres Diaz Dec 2018

A Systematic Approach To High Blood Pressure Risk Analysis And Healthcare Cost Reduction In Young Adults [Metodología Sistemática Para El Análisis De Riesgo Y Reducción De Costos De Servicios Médicos De Hipertensión En Adultos Jóvenes], Francisco Rafael Torres Diaz

Theses and Dissertations

The purpose of this research is to utilize publicly available data to estimate the current rate of occurrence of undiagnosed High Blood Pressure (HBP) in young adults (18 to 24 years old) and the out-of-pocket healthcare expenses associated with complications of HBP, to provide feasible alternatives to mitigate the effects on a region's economy. This has been done by building a Risk Factor Simulation Model that utilizes known HBP risk factors’ correlation to HBP, insurance coverage data, and rate of diagnosis to formulate the average Risk Factor Value for a region, which through an Annual Expected Cost Function estimates the …


Effects Of And Influences On Microbial Populations Of Missouri Maize Fields, Madsen Paul Sullivan Dec 2018

Effects Of And Influences On Microbial Populations Of Missouri Maize Fields, Madsen Paul Sullivan

Theses and Dissertations

The role of individual soil microorganisms changes over the course of a plant's life - microorganisms that have no discernable role at one developmental stage may affect the plant later in its growth. Traditional analysis of the soil microbiome, which has focused principally on the relative abundances (RA) of individual organisms, may be incomplete, as underlying differences in population size cannot be addressed. We conducted a metagenomic analysis of soil microorganisms from various maize (Zea mays L.) fields at two depths, accompanied by crop yield components, to provide insight into influences of edaphic microbes on maize productivity under commercial maize …


Gut Microbiota Regulates The Interplay Between Diet And Genetics To Influence Insulin Resistance, Jeralyn Jones Franson Dec 2018

Gut Microbiota Regulates The Interplay Between Diet And Genetics To Influence Insulin Resistance, Jeralyn Jones Franson

Theses and Dissertations

Insulin resistance and obesity are major public health concerns. The impact of diet and genetics on insulin resistance and obesity is well accepted. Additionally, the gut microbiota has been shown to influence obesity and metabolic disorders. However, much remains to be understood about the role of gut microbiota in the development of insulin resistance and obesity. We utilized a mouse model lacking PAS kinase, a protein involved in cellular metabolism, in order to better understand the relationship between diet, genetics and the gut microbiota. Previous research has shown that mice lacking PAS kinase were protected from the effects of a …


Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher Dec 2018

Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher

Theses and Dissertations

The Intermountain West is comprised of impressive land formations, numerous ecoregions, and a unique biota. The area has many flora and fauna that have been investigated, but the region is generally considered undersampled when it comes to insects. However, I propose the matter to be a lack of shared experience in identifying key insect species and the underutilization of professional and personal collections. These impediments are highlighted by two insect groups in the Intermountain West: spongillaflies and tiger moths.Spongillaflies can be difficult to recognize for the general entomologist and have rarely been recorded in the Intermountain West. My colleagues and …


The Antimicrobial Properties Of Honey And Their Effect On Pathogenic Bacteria, Shreena Himanshu Mody Dec 2018

The Antimicrobial Properties Of Honey And Their Effect On Pathogenic Bacteria, Shreena Himanshu Mody

Theses and Dissertations

Honey has been used to heal wounds since ancient times. There are many references in ancient literature that cite honey for its medicinal uses. It is used as an alternative agent to cure infections of wounds, burns, ulcers etc. Researchers have shown some of the antimicrobial properties of honey when used as an ointment. When applied to an affected area, it helps to promote the growth of healthy tissue. One of the factors on which the quality of the honey depends, is its geographical origin. Based on the location, honey types can vary as much as 100-fold from each other …


Impacts Of Habitat Attributes And Community Gardens On Urban Bird Communities, Samuel Glenn Ortiz Dec 2018

Impacts Of Habitat Attributes And Community Gardens On Urban Bird Communities, Samuel Glenn Ortiz

Theses and Dissertations

The Rio Grande Valley of Southern Texas is a major agricultural region yet has some of the highest hunger rates in the USA. Urbanization and agriculture affect biodiversity, which is well studied, but little is known about how agriculture affects biodiversity in urban areas. We investigated how different urban attributes, including those related to urban farming, impact bird communities in Brownsville and Harlingen, TX, and compared sites that have community gardens to those that do not. To study three key urban habitat characteristics, we identified sites that exhibited all possible combinations of these factors, quantified land cover classes related to …


Effects Of Invasive Nilgai Antelope (Boselaphus Tragocamelus ) Browsing On Black Mangrove (Avicennia Germinans) In South Texas: A Study On Microenvironmental, Physiological, Structural, And Reproductive Parameters, Tianna Picquet Dec 2018

Effects Of Invasive Nilgai Antelope (Boselaphus Tragocamelus ) Browsing On Black Mangrove (Avicennia Germinans) In South Texas: A Study On Microenvironmental, Physiological, Structural, And Reproductive Parameters, Tianna Picquet

Theses and Dissertations

Mangroves are important for coastal systems because they provide habitat for fish and bird species, mitigate erosion, and create an area for carbon sequestration. Along the Gulf of Mexico, at the southern tip of Texas, recent observations have shown that A. germinans stands (the dominant species in Texas) are being browsed on by invasive nilgai antelope (Boselaphus tragocamelus). The antelope were introduce to the south Texas region via King Ranch in the 1930’s and have since significantly increased in population and distribution. Previously thought to be grazers, B. tragocamelus were captured on camera utilizing A. germinans as a …


About Men: A Retrospective Into The Evolution Of The Male Form Through The Female Gaze, Laura Briseño Dec 2018

About Men: A Retrospective Into The Evolution Of The Male Form Through The Female Gaze, Laura Briseño

Theses and Dissertations

It is philosophized that subjectivity is founded on subjection, a subjection based on the view point of the viewer. Through the centuries the idea of the male form has been transformed through various representations from the context of art, architecture, and culture from Ancient Greece (Classical period of 5th and 4th centuries BC) to Contemporary art (1946–present).

The purpose is to create an exhibition that provides a female gaze on the representations of the male form through or in art. Examining how and why male forms are represented in the content we know them as of current curation. Which brings …


Green Synthesis/Biosynthesis Of Silver Nanoparticles By Using Orange Peel Extract, Leela Joshi Dec 2018

Green Synthesis/Biosynthesis Of Silver Nanoparticles By Using Orange Peel Extract, Leela Joshi

Theses and Dissertations

Joshi, Leela, Green Synthesis/Biosynthesis of Silver Nanoparticles by Using Orange Peel Extract. Master of Science (MS), December, 2018, 40 pages, 23 figures, references, 36 titles. In this work, we report synthesis of silver nanoparticles (AgNPs) with an average size of ~6 nm. The aqueous solution of Ag+ ions is reduced using an aqueous extract from orange peel (Citrus Sinensis) at varying pHs. Reduction of Ag+ ions in solution was monitored using UV-visible absorption spectroscopy, and the corresponding surface plasmon resonance of AgNPs at 435 nm. The solution changed color from yellow to reddish-brown upon bioreduction of silver nitrate in orange …


Propensity To Trust And The Impact On The Academic Success Of Student-Athletes: Implications For Athletic Officials In Higher Education, Trevor Thomas Wilson Dec 2018

Propensity To Trust And The Impact On The Academic Success Of Student-Athletes: Implications For Athletic Officials In Higher Education, Trevor Thomas Wilson

Theses and Dissertations

Student-athletes enter higher education in the United States with diverse backgrounds and academic preparation. In some cases, student-athletes are underprepared for the academic rigor, social structure, and ethical expectations of these institutions. Athletic coaches are charged with the recruitment of highly skilled, competitive, and prepared student-athletes, while other athletic officials are responsible to provide the proper academic support, care, and overall well-being of student-athletes. If coaches, athletic administrators, advisors, and learning specialists could identify educational and demographic patterns related to student-athletes' propensity to trust, they would be better equipped to gain these students' trust and help them navigate the stress …


Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher Dec 2018

Biogeography And Natural History Of Tiger Moths And Spongillaflies Of Intermountain North America With Experimental Studies Of Host Preference In The Lichen-Feeder Cisthene Angelus (Insecta: Lepdioptera: Erebidae: Arctiinae And Neuroptera: Sisyridae), Makani Layne Fisher

Theses and Dissertations

The Intermountain West is comprised of impressive land formations, numerous ecoregions, and a unique biota. The area has many flora and fauna that have been investigated, but the region is generally considered undersampled when it comes to insects. However, I propose the matter to be a lack of shared experience in identifying key insect species and the underutilization of professional and personal collections. These impediments are highlighted by two insect groups in the Intermountain West: spongillaflies and tiger moths. Spongillaflies can be difficult to recognize for the general entomologist and have rarely been recorded in the Intermountain West. My colleagues …


Effects Of Exercise On Clinical Couple Interactions, Samantha Karma-Jean Simpson Dec 2018

Effects Of Exercise On Clinical Couple Interactions, Samantha Karma-Jean Simpson

Theses and Dissertations

Research has shown that exercise has the potential to improve couple relationships. This study contributes to current literature by examining the associations between exercise, its duration, and its intensity and daily clinical couple interactions. Participants were 22 married couples in a treatment-as-usual setting who completed daily diaries about daily behaviors and marital interactions. Multilevel models were run, and results showed that wives who exercised were more likely to report a negative interaction with their husband that day. When wives exercised longer, both they and their husbands were more likely to report positive interactions that day. Interestingly, if husbands exercised longer …


Carbon Dioxide Treatment On Strawberry Fruit Prep And Its Effect On Shelf Life, Bryan Sterling Dawson Dec 2018

Carbon Dioxide Treatment On Strawberry Fruit Prep And Its Effect On Shelf Life, Bryan Sterling Dawson

Theses and Dissertations

This research evaluates the effectiveness of using carbon dioxide (CO2) pressurization to extend strawberry fruit prep shelf life for the eventual use in yogurt applications. In this experiment, CO2 treatments of 5, 15, and 25 pounds per square inch were used as a processing step to inactivate microorganisms, which in turn could aid in the preservation and maintenance of product quality during storage thus improving consumer acceptance of the yogurt. Microbial levels of the fruit prep treatments were monitored over a six-week period by enumerating aerobic plate counts and yeast and mold levels. The color, pH, and texture of the …


How Teacher Questions Affect The Development Of A Potential Hybrid Space In A Classroom With Latina/O Students, Casandra Helen Job Dec 2018

How Teacher Questions Affect The Development Of A Potential Hybrid Space In A Classroom With Latina/O Students, Casandra Helen Job

Theses and Dissertations

Questions have been shown to aid in student understanding of mathematics, particularly "novel" questions (Mesa, Celis, & Lande, 2013) that do not have a predetermined answer. However, students do not always understand what is intended by questions posed by teachers, particularly those students who come from different cultural and lingual backgrounds than those dominant in the classroom discourse. This project investigated the relationship between how a mathematics teacher acknowledged students funds of knowledge in her questions and how Latina/o students responded. It shows some research based questioning techniques that allow Latina/o students greater opportunity to participate in the mathematical problem-solving …


The Effects Of Exercise Training Intensities On Changes In Body Composition, Visceral Adipose Tissue, Adiponectin And C-Reactive Protein, Leslie E. Solis Oct 2018

The Effects Of Exercise Training Intensities On Changes In Body Composition, Visceral Adipose Tissue, Adiponectin And C-Reactive Protein, Leslie E. Solis

Theses and Dissertations

Obesity is currently characterized as a worldwide health pandemic. Despite many efforts to provide the optimal exercise prescription to obese and overweight individuals for maximization of fat loss and decreasing metabolic risks, findings in the literature continue to remain ambiguous. This investigation aimed to examine the effects of low- vs. high-intensity short-term training on body composition and visceral adipose tissue (VAT) under equivalent caloric expenditure in overweight and obese Hispanic adults of Laredo, Texas. Additionally, it aimed to analyze how changes in body composition and VAT affect serum levels of adiponectin and C-reactive protein (CRP),bioactive chemicals utilized in the detection …


Resilience And Academic Achievement In Minority Students, James A. Britton Oct 2018

Resilience And Academic Achievement In Minority Students, James A. Britton

Theses and Dissertations

Students can thrive within school programs and sustain their capacity for success despite seemingly overwhelming obstacles. A model of school-based resilience can insulate students from risk and help students acknowledge challenges, embrace them, and learn as students encounter challenge and surmount it.

This study of a high school program analyzed the relationship between educational resilience and academic achievement through a direct measure of resilience. The research investigated whether a program increased resilience for minority and low-income high school students and whether stronger resilience was associated with improved academic outcomes. Students in the program produced significantly better academic outcomes, as measured …


A Hermeneutic Exploration Of The Therapeutic Process Of Clinicians At An Eating Disorder Treatment Center, Sabree Anne Crowton Oct 2018

A Hermeneutic Exploration Of The Therapeutic Process Of Clinicians At An Eating Disorder Treatment Center, Sabree Anne Crowton

Theses and Dissertations

Eating disorders remain extremely difficult to treat and investigation has revealed that manual-based eating disorder treatment outcomes have failed to improve over the second half of the last century. Various studies have observed that clinicians use evidence-based treatments for eating disorders inconsistently and often exclude fundamental theoretical techniques. Some argue that this departure from evidence-based practice may in some cases be the efforts of clinicians to develop methods more sensitive to real world situations. It stands to reason that some of the techniques currently being used by clinicians are promising treatment approaches. The purpose of this study was to explore …


Neighborhood Socioeconomic Environment And Its Influence On Cardiorespiratory Fitness And Physical Activity In Youth, Morgan N. Clennin Oct 2018

Neighborhood Socioeconomic Environment And Its Influence On Cardiorespiratory Fitness And Physical Activity In Youth, Morgan N. Clennin

Theses and Dissertations

Among youth, inadequate cardiorespiratory fitness and physical inactivity are powerful markers of health associated with numerous health outcomes across the lifespan. Unfortunately, a majority of U.S. youth have inadequate cardiorespiratory fitness levels and do not meet physical activity guidelines. While previous research has identified several individual-level factors associated with youth cardiorespiratory fitness and physical activity, environmental factors have been increasingly recognized. Of particular interest is the neighborhood socioeconomic environment, which has been consistently associated with several health outcomes among adults. However, little is known regarding the relationship between the neighborhood socioeconomic environment, cardiorespiratory fitness, and physical activity among younger populations. …


The Association Of Hospital Practices To Breastfeeding Behaviors In South Carolina: Analysis Of 2013-2015 Pregnancy Risk Assessment Monitoring System (Prams) Data, Larisa Donnette Bruner Oct 2018

The Association Of Hospital Practices To Breastfeeding Behaviors In South Carolina: Analysis Of 2013-2015 Pregnancy Risk Assessment Monitoring System (Prams) Data, Larisa Donnette Bruner

Theses and Dissertations

Objective: The purpose of this study was to determine whether hospital practices are associated with breastfeeding initiation and breastfeeding duration for ≥10 weeks.

Methods: We analyzed the 2013-2015 South Carolina Pregnancy Risk Assessment Monitoring System (PRAMS) data. The population of interest was mothers who delivered a single live birth in the hospital. The infant was alive and living with the mother at the time of the survey. Chi-square and logistic regression were used to examine breastfeeding initiation and duration among all women who delivered in a hospital and those who stated that they initiated breastfeeding while in the …


Identification Of The Mechanisms Through Which Botanicals Attenuate Pathogenesis Of Human Diseases, Esraah Alharris Oct 2018

Identification Of The Mechanisms Through Which Botanicals Attenuate Pathogenesis Of Human Diseases, Esraah Alharris

Theses and Dissertations

Plant products have been used for a long time in treatment of diseases. In fact, more than half of approved medicines are derived from plants or other natural products. Even though the synthetic drugs are effective in treating many human diseases, there is no cure against several clinical disorders. Moreover, a significant number of diseases can be prevented thereby causing less burden on societal healthcare costs as well as promoting healthy lifestyles. Thus, botanicals offer a unique opportunity to explore novel compounds to prevent and treat various clinical disorders as well as understand their mode of action so that new …


Sites Seen And Unseen: Mapping African American Women’S Public Memorialization, Alexandria Russell Oct 2018

Sites Seen And Unseen: Mapping African American Women’S Public Memorialization, Alexandria Russell

Theses and Dissertations

Beginning in the late nineteenth century, black clubwomen began naming organizations after formerly enslaved women like Phillis Wheatley to keep their public memory alive. In doing so, they created a culture of recognition that acknowledged the organizational namesake as well as the contributions of members. Named memorialization celebrated the very best of African American women and continued to expand as Jim Crow laws encroached on black citizenship. Catalyzed by African American women while also supported by black journalists and local bureaucracies, named memorialization was the primary public history medium used to honor the legacies of African American women in the …


The Role Of Cdk8 In Metastatic Growth Of Colon Cancer, Jiaxin Liang Oct 2018

The Role Of Cdk8 In Metastatic Growth Of Colon Cancer, Jiaxin Liang

Theses and Dissertations

Unresectable hepatic metastases of colon cancer poorly respond to existing therapies and are a major cause of colon cancer lethality. Transcription- regulating Mediator kinase CDK8, an early clinical stage drug target, is amplified or overexpressed in many colon cancers and CDK8 expression correlates with shorter patient survival. Here we show that CDK8 inhibition does not generally suppress proliferation of CDK8-overexpressing colon cancer cells but nevertheless CDK8 knockdown by shRNA or CDK8 kinase inhibition by a selective small-molecule drug candidate suppresses metastatic growth of mouse and human colon cancer cells in the liver. This effect is due at least in part …