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Spatial And Temporal Distributions Of Larval Clupeid Fishes In A Tidal Freshwater Marsh Complex, Philip Reid Anderson

Theses and Dissertations

Tidal freshwater wetlands provide valuable ecosystem services such as nutrient cycling, coastal flood control, and reproductive habitat for early life stages of economically and ecologically important fishes. The nutrient rich environments that tidal freshwater wetlands occur in support high levels of primary productivity of phytoplankton and vegetation that provide essential reproductive habitat for anadromous clupeid fishes (Alosa spp., Brevoortia tyrannus) in Chesapeake Bay tributaries. Seasonal retention of clupeid eggs and larvae within tidal freshwater habitats may enhance early growth, survival, and year class strength. The primary goal of the present study was to characterize the relative importance of …

Glial Cell Mechanisms Regulate Alcohol Sedation In Drosophila Melanogaster, Kristen M. Lee

Theses and Dissertations

Approximately 16 million people in America are diagnosed with Alcohol Use Disorder (AUD) but no efficacious medical treatments exist. Alcohol-related behaviors can be studied in model organisms, and changes in these behaviors can be correlated with either (i) a risk for alcohol dependence or (ii) a symptom/feature of AUD itself. Although AUD is a disease of the central nervous system, a majority of research has focused on the neuronal underpinnings, leaving glial contributions largely undescribed. We used Drosophila melanogaster (fruit fly) to identify genes whose expression in glia regulates alcohol sedation. Mammals and Drosophila have conserved behavioral responses to alcohol …

The Relationship Between Cell Phone Use And Motivation To Exercise In College Students, Ryan Eric Doree

Theses and Dissertations

Past research suggests that high cell phone usage is related to sedentary behavior, poor physical fitness, and poor mental health. College students cell phone usage has increased over previous years while physical activity levels have declined, but due to little research, this relationship is still unclear. The purpose of this study was to examine the relationship between college student's smartphone usage, exercise motivation, and physical activity. College students completed an electronic survey (n=157; female = 135; age = 20.01±1.49; BMI = 24.39) that assessed exercise motivation, physical activity, smartphone usage, height and weight (to calculate BMI), depression, anxiety, stress and …

Temporal Trends In The Standing Broad Jump Test Performance Of United States Children And Adolescents, Bridget Kate Pinoniemi

Theses and Dissertations

Muscular fitness is a very important indicator of health. Using a systematic review strategy, the aim of this study was to estimate the temporal trends in broad jump performance of United States youth. Broad jump data on apparently healthy United States youth (aged 10–17 years) were located through a systematic electronic database search and by pearling reference lists, topical systematic reviews and personal libraries. Sample-weighted temporal trends (expressed as percent and standardized trends) were estimated for separate age-sex groups using best-fitting regression models relating the year of testing to mean jump performance. Mean trends standardized to the year 1985 were …

Temporal Trends In The Grip Strength Of Children And Adolescents, Faith Lavoy Dooley

Theses and Dissertations

Objective: To estimate national and international temporal trends in the handgrip strength of children and adolescents, and to examine relationships between trends in handgrip strength and trends in health-related and sociodemographic indicators.

Methods: Data were obtained in two ways: (a) through a systematic electronic database search for studies reporting on temporal trends in the handgrip strength of apparently healthy 9–17-year-olds, (b) pearling reference lists, topical systematic reviews and personal libraries, and (c) by examining large national fitness datasets suitable to temporal trends analysis. Sample-weighted temporal trends were estimated using best-fitting regression models relating the year of testing to mean handgrip …

Linking Communicative Interaction To Cognitive Functioning: Implications For Older Adults, Denise Calhoun

Theses and Dissertations

As the percentage of older adults within the U.S. steadily increases, long-term care options are being impacted with growing numbers of seniors to provide for. The reality of these elevated numbers have sparked an interest in researchers to conduct studies on human development, plasticity in the brain, and training and intervention programs in search for ways to halt or lessen the cognitive and communicative decline, in older adults. As an alternative path to help older adults maintain quality of life, this study proposes to examine the link between communicative interaction and cognitive functioning to educate family members and healthcare providers …

Paleoecology Of Northern Great Plains Bison: Inferences From Stable Isotopes And Dental Calculus, Gaimi Lynn Davies

Theses and Dissertations

The purpose of this study is to infer Northern Great Plains bison (Bison bison) paleoecology through the analysis of stable isotopes and dental calculus from bison skeletal remains. Bison used to roam in the millions throughout most of North America but today they are primarily kept in confined and isolated populations. Little is known about their ancestral ecology. The abundance of bison in the archeological record provides a unique opportunity to study their remains on a broad temporal and spatial scale. This research uses the archeological record of bison in North Dakota to study bison diet and environment from the …

The Exploration Of Parent Self Efficacy And Parent Involvement In Early Education, Brionie Dixon-Elliott

Theses and Dissertations

In America, children from urban communities come to kindergarten lacking the basic skills in literacy to be successful learners in life (Jumpstart, 2009). Students are unprepared and parents are becoming less knowledgeable of the requirements for early education and diminished confidence in their ability to prepare and assist their children is occurring. Therefore, there is a need to understand the underlying drivers of parents' low self-efficacy and what can be done to support them. The purpose of this case study was to develop an understanding of a means to support parents of early education students enrolled in an urban learning …

Leadership Strategies To Improve Healthcare Outcomes, Roxanne Smith

Theses and Dissertations

The disparities in health care and the challenges of healthcare leaders in achieving positive health outcomes are a priority in America. Much discourse and policy is currently evolving in the legislative and executive branches of government. The United States has the highest health expenditures in the world and is classified as one of the unhealthiest countries. Many factors contribute to the disparities. These factors include socioeconomic, cultural competency, social determinants, policy, and health leadership. The challenge for health leaders is to identify strategies to improve the trends and the status of health quality and well-being for all Americans. This study …

A Manualized Parent Psychoeducation And Nutrition Program And Its Impact On A Sense Of Community: A Pilot Study, Nahaal Binazir

Theses and Dissertations

Parenthood is an experience that is both joyful and anxiety provoking. Amidst a number of pressures, new parents may encounter depressed feelings, consistent anxious thoughts or various other stressors. These factors can also lead to the development of poor nutritional habits, which further exacerbate psychological symptoms and can create a destructive cycle in their lifestyles. Research indicates that one’s sense of community (or conversely social isolation) can further impact parental experiences - which include one’s sense of competence, affect directed towards their children and their overall satisfaction. In considering this, a quantitative and partially qualitative pilot study was conducted to …

Detecting Subtle Brain Injury In College Students, Bryant Steury

Theses and Dissertations

Clinicians at University Counseling Centers (or UCCs) are at the epicenter of a unique demographic in that they may encounter individuals from diverse backgrounds in every sense of the term. In addition to the “traditional” college student, they may also provide clinical care to student-athletes and current or returning military personnel. One injury that impacts every demographic grouping a counselor will treat is head trauma. Traumatic brain injuries (TBIs) have become a subject of increasing interest among clinicians with an emphasis on proper diagnosis and post-concussive care. TBIs have been shown to negatively impact cognitive capacity, emotional regulation, frustration tolerance, …

Metaproteomic Investigation Of The Vaginal Microbiome In Pregnancy, Zaneera Hassan

Theses and Dissertations

The development of early diagnostics and prevention strategies for preterm birth is an important global health challenge with the potential to impact over 15 million children annually, by improving health outcomes and reducing economic burden. Advances in microbial sequencing technology have opened the door to 16S rRNA gene survey, whole metagenomics, and whole transcriptomics, providing molecular evidence that the composition of the vaginal microbiome affects pregnancy outcomes in women, particularly those of African descent. A current gap in our molecular level understanding of the vaginal microbiome as it relates to healthy pregnancies is the metaproteome which comprises proteins from both …

The Infectivity Of Naegleria Fowleri Cysts In Vivo And In Vitro, And Mediation Of Encystment By Camp, Anna L. Evdokiou

Theses and Dissertations

The free-living amoeba and causative agent of Primary Amoebic Meningoencephalitis, Naegleria fowleri, has three life stages: the trophozoite, the flagellate, and the cyst. This study examined the ability of the cyst to attach to, excyst upon, and destroy cell cultures grown to confluent monolayers, and to cause Primary Amoebic Meningoencephalitis in a murine animal model. The co-culture of cysts with P388D.1, CHME3, Vero, human nasal epithelial, and rat primary mixed glial cells resulted in destruction of the monolayer of all cell types once the cysts attached and excysted. One day post exposure to cysts, the mixed glial cells exhibited …

The Efficacy Of A Fluoride-Containing Orthodontic Primer In Preventing Demineralization, Alyssa G. Ricci

Theses and Dissertations

Purpose: To evaluate the efficacy of a fluoride-containing orthodontic primer in preventing demineralization adjacent to brackets and compare the quality of enamel on tooth surfaces that received interproximal reduction (IPR).

Methods: Patients at the VCU Orthodontic clinic who consented to orthodontic treatment involving extraction of at least 2 premolars were recruited to this pilot clinical study. Brackets were bonded to premolars using one of two primers, fluoride-containing experimental or control. IPR was also performed, and the experimental primer was applied to randomly selected teeth. Extracted teeth were analyzed visually for the presence of white spot lesions (WSLs). Micro-CT analyses were …

Proteinic Geontopower, Agustine Zegers

Theses and Dissertations

PGP is a study of how we come into intimate contact with capitalism through our digestive tract. It is a study of the increasing valuing of protein in contemporary diet culture, focusing on how this phenomenon has resulted in mass-scale global soya production. Protein synthesis and distribution are rearticulated in this work as a set of molecular transactions enacted within/out bodies, moving loosely through ligaments and industrial machinery.

PGP is a speculative exercise in communing with a damaged planet through our daily ingestions.

Perceived Stress, Salivary Cortisol, And Depression In Adults Diagnosed With Postconcussion Syndrome; A Pilot Study, Christine Fish-Huson

Theses and Dissertations

Traumatic Brain Injury (TBI) affects approximately 1.7 million persons in the United States annually, 75% are categorized as mild (mTBI). Most persons who experience mTBI will recover, however an estimated 10% will develop Postconcussion Syndrome (PCS). Evidence supports a relationship between perceived stress, salivary cortisol, and depressive symptoms in persons after TBI; however, there are no known studies exploring these relationships in the PCS patient population. A sample of 17 men and women diagnosed with PCS were recruited from Southwest and Central Virginia. Data collection included the Rivermead Postconcussion Questionnaire, Perceived Stress Scale-10, Center for Epidemiological Studies-Depression Scale and the …

Characterization Of The Novel Interaction Between Neisseria Gonorrhoeae Tdfj And Its Human Ligand S100a7, Stavros Maurakis

Theses and Dissertations

Neisseria gonorrhoeae is an obligate human pathogen that causes the common STI gonorrhea, which presents a growing threat to global health. The WHO estimated 78 million new cases of gonorrhea worldwide in 2017, with estimates of 820,000 new cases in the United States alone according to the CDC. High-frequency phase and antigenic variation inherent in N. gonorrhoeae, coupled with its natural ability to rapidly acquire and stably integrate antimicrobial resistance factors into its genome, have culminated in an infection against which there is no effective vaccine, and for which the list of viable therapeutic options is quickly shrinking. Moreover, no …

My Clothing Is Me: Embracing Adhd In Traditional Qatari Apparel, Rabab Abdulla

Theses and Dissertations

Children diagnosed with Attention Deficit Hyperactive Disorder (ADHD) are often secluded from society, as the condition is perceived to be a defect. These children constantly fidget, move, lose track of time, and forget to complete tasks, leading them to struggle within existing social environments. Additionally, in Qatar there is a need to educate society about ADHD. This research explores wearable solutions that alter behaviors through physical interactions and sensory engagements. In response to the challenges faced by ADHD, Qatari traditional attire has been customized to support children with time management, and communication between child, parent, and society. Additionally, these wearables …

At The Table; An Investigation Of How Growing, Cooking, And Sharing Food Together Can Bring A Wealth Of Benefits, Angeline M. Troilo

Theses and Dissertations

MOTIVATION: The value of family mealtime has been well documented by decades of academic research. Children from families, (regardless of race, class or income), that routinely sit down to a meal together, suffer less depression, obesity and substance abuse. They also stay healthier and do better in school (Benefits 2018). There are nutrition, health, social, and mental benefits to eating with others. Research has shown that people eat more fruits and vegetables and other nutrient-rich foods when they share a meal with others. They also drink less soda and eat less fried foods (Benefits 2018). Eating meals together teaches children …

In A Building, A Stairwell, A Room Speaks, Tsz Wai Wallis Cheung

Theses and Dissertations

Working toward a personal definition of womanhood while progressing with my research in feminist discourse, I frame biographical events alongside the intricate use of language surrounding feminist theory. Experimenting with material specificities that speak to my personal narratives and cultural significance, my work seeks to address the interlacing operations of subjectivity expanding on the intersection of class, gender and race.

The Wheel House - An Intergenerational Space Creating Bonds Between At-Risk Teens And Seniors, Jessica M. Keegan

Theses and Dissertations

MOTIVATION

Two main groups in American society today are floundering: adolescent children of low income families and the elderly.

Between the hours of 3:00 and 6:00 p.m., one in five children are unsupervised. Left to their own devices, many become involved in negative behaviors such as drug and alcohol abuse, sexual activity or in the worse cases, delinquency (Afterschool Alliance, 2016). It is proven that when children are alone after school, they not only miss out on valuable learning opportunities, but also their parents are affected as well by having to lose as many as eight work days annually to …

Erasure: An Additive And Subtractive Act, Margaret Davids

Theses and Dissertations

MOTIVATION In the simplest form, a pencil mark on a page is removed by a traditional rubber eraser. However, the marks are often never fully removed, and the paper thins with each attempt to rub out an old idea.

But how does one erase a chair? A pilaster? A room? A building?... More importantly, how does the subtractive act of erasing become an additive one?

The historical fabric of a building is important; it is also imperative that it does not remain stagnant. Erasing is an opportunity to design an interior environment that both acknowledges the traces of the pencil …

An Evaluation Of Induced Shear Stress On Endothelial Cellular Adhesion Molecules, Edward B. Crabb

Theses and Dissertations

The pathophysiology of atherosclerotic cardiovascular disease (CVD) is highlighted by vascular dysfunction and low-grade vascular inflammation. Furthermore, the site-specific distribution of atherosclerosis throughout the arterial vasculature is primarily determined by local hemodynamic force. Therefore, this dissertation outlines three experiments designed to investigate the role of acute mental and physical (i.e., aerobic exercise), and vascular wall shear stress (SS) on the inflammatory aspects of atherosclerosis. Chapter 2 examines the effect of acute laboratory-induced mental stress on intracellular pro-inflammatory signaling pathways in peripheral blood mononuclear cells. Chapter 3 investigates the impact of acute laboratory-induced mental stress and maximal aerobic exercise on the …

The Role Of Tumor And Tumor Microenvironment On Breast Cancer-Associated Adipocyte Plasticity, Janina V. Pearce

Theses and Dissertations

Cancer-associated cachexia is a condition defined by a sustained net-negative energy imbalance. Although the different types of adipose tissue – white, beige, and brown – have been implicated in contributing to cancer-associated cachexia, the mechanisms of these maladaptive changes and their impact on whole-body energy expenditure have not been fully elucidated. Using breast cancer as our model, we demonstrate white adipose tissue browning in murine and human breast cancer; furthermore, we demonstrate that this effect is extremely localized and takes place early in tumor progression. We utilized in vitro cell culture techniques and demonstrate that cancer secreted factors and cross-talk …

Young Adults With Disabilities Financial Skills And Goals: A Mixed Methods Strengths And Needs Assessment, Allison D'Aguilar

Theses and Dissertations

Young adults with disabilities face barriers that affect their financial capability and financial inclusion in the marketplace. Barriers include a lack of autonomy, skills, and opportunities. This mixed method strengths and needs assessment aimed to explain and explore the financial skills and goals of young adults with disabilities. A standardized scale captured young adults with disabilities financial skills, photovoice participatory action research documented their valued financial skills and goals, and semi-structured interviews notated parents financial aspirations and goals for their daughters and sons. The mixed methods analysis suggested young adults with disabilities underlying financial skills fell 25 percent below the …

Investigating Daily Writing Emotions, Attention Regulation, And Productivity: An Intensive Longitudinal Study, Eric Ekholm

Theses and Dissertations

Emotions pervade academic situations and influence the ways that learners think, behave, and achieve (Pekrun, 2006; Schutz & Lanehart, 2002). Writing may be a particularly emotion-laden activity, and especially so for students concentrating in fields that value writing production. However, very few studies have quantitatively investigated writers’ emotional experiences. The goal of the current study was to examine the writing-related emotions of graduate students enrolled in writing-intensive disciplines as well as how these emotions related to writers’ daily productivity and attention-regulation behaviors. To do so, the study employed a daily diary design (Gunthert & Wenze, 2012) in which participants completed …

Latent Growth Model Approach To Characterize Maternal Prenatal Dna Methylation Trajectories, Dana Lapato

Theses and Dissertations

Background. DNA methylation (DNAm) is a removable chemical modification to the DNA sequence intimately associated with genomic stability, cellular identity, and gene expression. DNAm patterning reflects joint contributions from genetic, environmental, and behavioral factors. As such, differences in DNAm patterns may explain interindividual variability in risk liability for complex traits like major depression (MD). Hundreds of significant DNAm loci have been identified using cross-sectional association studies. This dissertation builds on that foundational work to explore novel statistical approaches for longitudinal DNAm analyses. Methods. Repeated measures of genome-wide DNAm and social and environmental determinants of health were collected up to six …

The Effect Of Change In Medi-Cal Dental Coverage On Dental Care Utilization Among Medi-Cal Beneficiaries, Min H. Zhang

Theses and Dissertations

One of the most important factors in accessing dental care is having dental insurance. For people with low incomes, Medicaid is the main source of health insurance. Medi-Cal is California’s Medicaid program. Adult dental services were mostly eliminated in Medi-Cal in 2009 due to the economic downturn and partially restored in 2014. The objective of this study is to evaluate the effect of change in Medi-Cal dental coverage, specifically the partial restoration of adult dental coverage in 2014, on dental care utilization among Medi-Cal beneficiaries. The partial restoration significantly increased the utilization rates in dental clinics from 2014 to 2017 …

Eternal Enemies, Or Incidental Encounters? Structure And Patterns Of Interspecific Killing In Carnivora, Tor G. Bertin

Theses and Dissertations

Lethal interactions between carnivorans (interspecific killing) may influence their population dynamics, behavior, and other important aspects of their ecology. In this study, I expand upon previous research on the broad-scale patterns of interspecific killing in Carnivora (Palomares & Caro 1999, Donadio & Buskirk 2006) with a greatly expanded dataset (inclusion of scat and stomach data and more intensive sampling of the literature), and suggest avenues for future research. While like previous studies, I found a positive effect of relative body size between killer species and killed species on the likelihood of forming a killing interaction, I failed to find evidence …

Targeting Sphingosine Kinase 2 As A Treatment For Cholangiocarcinoma, Anthony D. Stillman

Theses and Dissertations

Cholangiocarcinoma (CCA) has a high mortality rate and its occurrence is rising. This increase prompts the need for improved CCA treatments. Studies have suggested that CCA is highly reliant on the sphingosine-1-phosphate-receptor-2 (S1PR2) and sphingosine kinase 2 (SphK2). Recently, a competitive SphK2 inhibitor, ABC294640, has been approved for clinical trial. ABC294640 has the potential to treat CCA, which is support by a phase I clinical study that was able to temporarily treat a patient suffering from metastasized CCA with ABC294640. To determine the viability of ABC294640 as a treatment for CCA, this study focused on determining the effects of ABC294640 …