Digital Commons Network^™

Symptom Self-Management In Adolescents Following A Concussion, Amanda Hodges

Theses and Dissertations

Background: Adolescents experience a variety of symptoms following a concussion that affect their everyday life. Initial management consists of physical and cognitive rest followed by a gradual return to activities while monitoring symptoms. Managing concussion symptoms in adolescents is a challenge due to their lifestyle and developmental needs but it is the key to improving adolescents’ lives. Symptom self-management is the prevention and control of symptoms and has been shown to improve health outcomes but has not been studied in adolescents with concussion symptoms. Using the Individual and Family Self-Management Theory (IFSMT), the purpose of this study was to …

Sensitization To A Milk Allergen Induces Differential Behavioral And Neurological Responses In Allergic C57bl/6j And Balb/Cj Mice, Nicholas Smith

Theses and Dissertations

Studies have highlighted an association between food allergies and neuropsychiatric disorders such as anxiety, depression, and attention deficit hyperactivity disorder. Though the precise mechanism behind this relationship is unknown, it marks a potential novel therapeutic strategy outside of traditional neuropharmacological intervention. Food allergy is a heterogeneous disorder of the immune system characterized by an immune response that occurs reproducibly to a given food. Chronic allergen exposure in patients with mild or non-anaphylactic food allergies may cause or exacerbate psychiatric conditions. However, the variability in food allergies due to factors like genetic background introduces selection bias for individuals with overt anaphylactic …

Lonidamine Is A Novel Inhibitor Of Fatty Acid Oxidation, Tianhai He

Theses and Dissertations

In this thesis project, we examined the hypothesis that lonidamine is an effective inhibitor of FAO in mammalian cells, underling its inhibitory effects on bioenergetic production and anti-cancer action. We compared its effects on FAO and glycolysis in multiple human cancer cell lines of different lineages.

An Evaluation Of Ci Asteroid Regolith As A Plant Growth Medium For Space Crop Production, Steven Jon Russell

Theses and Dissertations

Asteroids are small, undifferentiated bodies that materialized during the formation epoch of the solar system. With a concerted effort to establish a long-term presence in space, crewed missions to asteroids should not be ignored. A critical aspect of human missions is self-sustainability, primarily growing crops via in-situ resource utilization. CI carbonaceous asteroids are a primitive type of asteroid that retain elements found during that early solar system formation. More importantly, the regolith on these asteroids contains soluble elemental nutrients, such as phosphorous and potassium, that crops can use for growth and development. This thesis focuses on the ability of CI …

“Sometimes Education Will Help You Lead The Life That You Really Want To Lead”: Factors Influencing Undergraduate Women’S Motivation To Pursue A Bachelor’S Degree, Debra Lynne Radi

Theses and Dissertations

As a collective, women’s experience in higher education has been disparate and differential to some men’s experience over the last two centuries, fundamentally based on the societal influences of the time. In the formative years of higher education women attended higher education institutions for social stratification reasons or for marital choice opportunities and to a lesser degree for college outcomes. This study’s purpose was to explore the current motivations of freshmen individuals who identified as female undergraduate students in their first year of pursuing a bachelor’s degree in higher education. This study used a qualitative research design with semi-structured interviews …

Criterion-Referenced Cut-Points For Handgrip Strength To Detect Metabolic Syndrome In U.S. Adults, Wyatt Wutz

Theses and Dissertations

Purpose: To establish gender- and age-group specific criterion-referenced cut-points for handgrip strength (HGS) associated with metabolic syndrome (MetS) in United States (U.S.) adults. Methods: A secondary analysis of data from the 2011–12 and 2013–14 cycles of the National Health and Nutrition Examination Survey was performed on U.S. adults aged 20 years and older. HGS was measured using handheld dynamometry. MetS was measured as the presence of three or more cardiometabolic risk factors according to the American Heart Association criteria. Crude and fully adjusted receiver operating characteristic (ROC) curves were used to identify gender- and age group-specific cut-points for HGS associated …

Effect Of Adolescent Sleep Quality On Appetite, Dietary Intake, And Body Mass Index, Janell Faye Juelich

Theses and Dissertations

Purpose and Background: Several factors have been associated with excess weight gain in adolescents, including loss of sleep. The purpose of this study was to examine the effect of sleep quality, quantity, latency, and hygiene on appetite, dietary intake, and body mass indices (BMI) of adolescents.

Theoretical Framework: Orem’s Self-Care Deficit Theory guided this study to examine the relationship of adolescents’ sleep effects on their appetite, dietary intake, and BMI.

Specific Aims: 1. To analyze demographics, sleep quality, sleep quantity, sleep latency, and sleep hygiene of adolescents and determine the levels of appetite, dietary intake, and BMI levels of adolescents. …

Building Active Intersectional Allyship In Middle School Youth, Maura Ferguson

Theses and Dissertations

This thesis explores how an understanding of concepts of the framework of intersectionality may build resilience and increase ability for middle schoolers to learn to be active, effective allies for one another. Allyship is discussed as a necessary skill to learn and not a label one can self-select. A literature review is presented with a specific focus on intersectionality; trauma, resilience, and long-term impact of childhood trauma; and active allyship. These concepts are then framed through a social work lens, focusing on micro, mezzo, and macro levels. As human connection is critical for psychosocial health, this thesis then presents a …

An Assessment Of Remotely Piloted Aircraft Training Methods And Measures, Zachary Waller

Theses and Dissertations

The collegiate aviation programs of higher education are seeking to adapt their capabilities and expertise toward educating a generation of airmen who will operate Remotely Piloted Aircraft (RPA). The collection of studies presented in this dissertation address this interest as higher education programs investigate the value of modalities and pedagogies, tune the application of instructional aids, and assess novel measurements for how students interact with their training. Three studies were completed in building this program of research. Study I, Waller et al. (2016), was published in a peer-reviewed journal and is adapted for reprint with permission. Study I established the …

Criterion-Referenced Cut-Points In Cardiorespiratory Fitness Associated With Metabolic Syndrome In Adult Americans, Nicholas Gabriel Kavadas

Theses and Dissertations

Purpose: To identify criterion-referenced cut-points in cardiorespiratory fitness (CRF) associated with metabolic syndrome (MetS) in a nationally-representative sample of young- and middle-aged American adults. Methods: The analytic sample comprised 3302 Americans aged 20–49 years who participated in the 1999–2000, 2001–2002, and 2003–2004 cycles of the National Health and Nutrition Examination Survey. CRF was assessed by a submaximal run/walk test on a treadmill. MetS was determined using American Heart Association criteria, measured as the presence of three or more risk factors (high waist circumference, high blood pressure, high fasting triglycerides, high fasting glucose, and low high-density lipoprotein cholesterol). Receiver operating characteristic …

Eating Disorder Symptoms On Female Collegiate-Level Athletes And Non-Athletes, Kennedy Victoria Kidd

Theses and Dissertations

In previous research, it found that the risk of developing an eating disorder (ED) is much higher in females compared to males (Dunca, Ziobrowski & Nicol, 2017; Raevuori, Keski-Rahkonen, & Hoek, 2014; Lewinsohn, Seeley, Moerk, & Striegel-Moore, 2002). Similarly, research has shown that the prevalence of EDs is much higher in female athletes compared to male athletes (Johnson, Powers, & Dick, 1999). Despite the risk of developing an ED being higher in females, research has not provided a strong understanding of the prevalence of EDs comparing female student-athletes and female student non-athletes. There is research that shows that athletes may …

Giving Birth On Foreign Soil: A Phenomenological Study Of Somali Women Giving Birth In North Dakota And Minnesota, Tracy Jo Enger

Theses and Dissertations

Health disparities continue to exist in minority populations in the United States. People ofcolor have a higher incidence of negative birth outcomes; and view their experiences with less satisfaction. The purpose of this study was to explore what Somali Muslim have women have experienced during their labor and delivery in Minnesota and North Dakota. This research was conducted to improve our understanding of the needs of Somali women during labor and delivery in order to provide nursing care that is culturally sensitive. Phenomenological data was collected from personal interviews with Somali women who had given birth in North Dakota and …

Developing Computer Aided Algorithms For Automatic Assessment Of Psoriasis Disease Severity Using Digital Images, Intisar Rizwan I Haque

Theses and Dissertations

The purpose of the research work was to develop image processing algorithms for automatic and objective assessment of psoriasis to aid in more effective management and treatment of patient symptoms. For this purpose, multiple classical machine learning-based unsupervised approaches are proposed which achieve a maximum average accuracy of ~94% on a dataset of 45 images of various resolutions. This accuracy improves performance by 14% in comparison to existing approaches reported in the literature on the same dataset of images. An alternative deep learning neural network-based approach was proposed that achieves an average accuracy of ~87% for the same set of …

Can The Circular Economy Concretize Sustainability? A Construal Level Approach To Encourage Sustainable Consumption., Jolie Gutentag

Theses and Dissertations

Despite a growing awareness and understanding of the impact our lifestyles have on the environment, most people have not adequately changed their consumption patterns. One possibility for the disconnect is the perceived abstractness of sustainability. Drawing on construal level theory, this research proposes that framing environmental sustainability as circularity, using the principles of the circular economy, reduces the perceived abstractness of sustainability. Four studies investigate the effects of circular framing on sustainable consumption behavior, including the moderating role of consumers’ chronic level of construal, an innate mindset reflecting a tendency to view information more concretely or abstractly. Findings provide initial …

Modeling Substance Use And Mental Disorder Comorbidity Using Latent Variable And Network Approaches, Courtney T. Blondino

Theses and Dissertations

Introduction. Substance use disorder (SUD) is a common condition that affects millions of Americans. Addressing SUD has been complicated by comorbid mental disorders and co-occurring substance use. Consequently, detailing and addressing SUD and comorbid SUD represent an important goal to improve the health of Americans.

Objective. The research goal of this dissertation was to characterize the comorbidity between substance use, including tobacco use, and mental disorder symptoms measured as negative affect and externalizing symptoms in a population-based sample using latent variable and network approaches.

Methods. Waves 1 – 3 from the Population Assessment of Tobacco and Health Study were used. …

Streptococcus Sanguinis: The Good, The Bad, And The Metal-Binding Lipoprotein, Cody Murgas

Theses and Dissertations

Streptococcus sanguinis is an opportunistic bacterium living beneficially in the human mouth. When S. sanguinis gains access to the bloodstream, it can result in colonization on damaged tissue and generate heart valve vegetations that can develop into infective endocarditis. It has been suggested that Mn and Fe are cofactors in the pathogenic capacity of this bacterium, and that these redox active metals are imported by the metal binding lipoprotein S. sanguinis adhesin B (SsaB). The SsaB lipoprotein is an integral part of SsaACB, an ATP-binding cassette (ABC) transport system in S. sanguinis. When SsaB is deleted, the resulting strain displays …

Kaleidoscope Wellness | Destigmatizing Mental Health For Teens By Design, Rhode L. Baptiste

Theses and Dissertations

Motivation

Mental health is a global public health crisis. (Marcus et. al, 2012; WHO, 2020). Although there is a growing acceptance of the complexities surrounding mental illness, care delivery for adolescents with mental health concerns remains highly stigmatized, which contributes to delays in care (Hoisington et. al, 2019; Burns & Birrell, 2014). Half of all mental illnesses can be detected prior to the age of 14 (National Alliance for Mental Health, 2020). While research exploring how the physical health care environment impacts health and well-being for patients has evolved immensely over the past two decades, research on how facility design …

Flourish: Combating Food Insecurity & Promoting Wellness On A College Campus, Jocelyn Zavala

Theses and Dissertations

MOTIVATION In the past, it has been assumed that students enrolled in college are fairly privileged individuals unlikely to face challenges associated with poverty (Haskett et al., 2020). That assumption has been challenged in the past few decades and a survey released last year by the Hope Center for College, Community and Justice indicated that 45% of today’s higher education students face food insecurity (Goldrick-Rab et al., 2019). According to VCU’s Dean of Students Office, it is a situation in which a student lacks access to enough nutritious food in order to live a healthy, active life. Food insecurity can …

Cloaca Palace, Connor Marie Stankard

Theses and Dissertations

In this thesis, I trace the compulsive fear of holes, known as trypophobia, from an uncontrollable obsession to a pleasurable preoccupation. The body’s physical porousness makes us receptive to our surroundings, allowing external matter in and destabilizing the boundaries of self and other. Matter invades us, encoding itself into our DNA and transforming humans into chimeric creatures.

Through paintings and multi-media installations, I encourage viewers to reflect on their own bodies as a series of holes, vulnerable receptors to the world. I use the figure of a woman to personify a human hole which has been infected by the outside, …

Urate Genetic Assessment In Asian And Pacific Islander Subgroups Of Pregnant Women: Implications For Personalized Medicine And Means To Reduce Health Disparities, Ali Alghubayshi

Theses and Dissertations

Gout is one of the most common rheumatic conditions and appears to have a higher prevalence in certain populations. Risk factors for gout and its precursor, hyperuricemia, are also significant risk factors for preeclampsia, major pregnancy-related morbidity. A retrospective cross-sectional study was conducted on 1059 pregnant women from different populations whom 100% reported their ethnicities from the Asian, Native Hawaiian, and Pacific Islander populations. Numerous uric acid (UA) genes and clinical conditions were addressed, and all study details were reviewed and exempted by the University of Hawaii human Studies Program (Protocol Number: 2018-00225). In this project, we hypothesized that UA …

Impact Of Physical Activity And Cardiorespiratory Fitness On Vascular Homeostasis In Premenopausal Women Consuming A Westernized High-Fat Meal, Lauren N. Pedersen

Theses and Dissertations

A large percentage of adults in industrialized nations consume a Westernized dietary pattern, which contributes to fasting dyslipidemia and increased risk for atherosclerotic cardiovascular disease. Evidence suggests that a single Westernized meal containing high saturated fat may induce alterations in blood lipids as well as disturb multiple factors regulating peripheral vascular homeostasis, including innate immune cell function, oxidative stress, and vascular function. Conversely, participation in acute and chronic exercise may beneficially impact an individual’s postprandial response. Therefore, this dissertation contains three manuscripts seeking to describe how acute exercise, cardiorespiratory fitness, and physical activity level impact the lipemic and vascular homeostatic …

Live Cell Biomass Tracking For Basic, Translational, And Clinical Research, Graeme Murray

Theses and Dissertations

Single cell mass is tightly regulated throughout generations and the cell cycle, making it an important marker of cell health. Abnormal changes in cell size can be the first indication of dysfunction in response to environmental stimuli such as cytotoxic drugs. Described here is the further development of high-speed live cell interferometry (HSLCI) to concurrently measure the changes in single cell mass of thousands of cells over time. Critically, the high-throughput nature of HSLCI provides realistic pictures of tumor heterogeneity. This throughput enabled HSLCI to correctly predict in vivo carboplatin sensitivity of three triple negative breast cancer patient derived xenografts, …

Examining The Effect Of Item-Writing Flaws On The Psychometric Parameters Of Pharmacy Therapeutics Examinations, Veronica P. Shuford

Theses and Dissertations

Colleges and schools of pharmacy (C/SOP) use direct measures of assessment to provide evidence of student learning, with multiple-choice questions (MCQs) being one the most common formats used in health sciences education to assess students’ knowledge, skills, and abilities (Pate & Caldwell, 2014). This study examined the occurrence of item-writing flaws (IWFs) in the Clinical Therapeutics Module (CTM) sequence of courses at a college of pharmacy at an academic health center in the southeastern United States. The goals of the study were to: (1) identify the most common item-writing flaws on examinations in the CTM sequence of courses, (2) determine …

Targeting Transferrin Binding Protein A For Vaccine Development In Neisseria Gonorrhoeae, Ashley Greenawalt

Theses and Dissertations

Neisseria gonorrhoeae, the causative agent of the sexually-transmitted infection gonorrhea, has recently been labeled a superbug. With dwindling treatment options, there is urgent need for a gonococcal vaccine. TonB-dependent transporters (TDTs) are important gonococcal virulence factors that allow the gonococcus to pirate metals directly from host proteins. The TDTs, TbpA and TbpB, are promising vaccine targets because both proteins are expressed and highly conserved in gonococcal strains, and they are not subject to high-frequency antigenic variation. Because the Tbps bind to host protein as their natural function, our immune system does not recognize them as foreign antigens; thus, immunogenicity is …

Il-36g Cytokine Induction In Oral Epithelial Cells Triggered By Treponema Denticola And Their Role In Chronic Periodontitis, Christopher Blake

Theses and Dissertations

Periodontal disease is a polymicrobial disease affecting 10-15% of the population. Periodontal disease affects the quality of life by reducing mastication and potentially causing tooth loss. Periodontal disease is also linked to more severe, systemic diseases such as cardiovascular disease and rheumatoid arthritis. Development of the diseased state occurs when the plaque biofilm shifts from healthy to dysbiotic. The shift to a dysbiotic biome brings with it a shift in bacterial presence, specifically an increase in gram-negative bacteria, such as T. denticola. T. denticola is a gram-negative, anaerobic spirochete whose relationship with oral epithelial cells is poorly understood. Preliminary data …

Using Literacy-Based Behavioral Intervention As A Strategy To Prevent Expulsion And Suspension In Preschool Classrooms, Karina Soto

Theses and Dissertations

Using Literacy-Based Behavioral Intervention as a Strategy to Prevent Expulsion and Suspension in Preschool Classrooms. Karina Soto, 2021: Applied Dissertation, Nova Southeastern University, Abraham S. Fischler College of Education and School of Criminal Justice. Keywords: expulsion, suspension, behavior problems, interventionExpulsion and suspension are exclusionary practices that were previously reserved for students in kindergarten to 12th grade. They have now become commonplace in preschool. Though researchers have been unable to identify the reasons why this is occurring, many have studied the classroom climate and other elements surrounding the child; however, to this date, no research exists that supports effective strategies implemented …

The Effects Of New Teacher Induction Programs On New Teacher Retention In Urban School Districts, Lisa Maria Smith-Sherrod

Theses and Dissertations

This applied dissertation was designed to determine the effect of new teacher inductions programs on new teacher retention in urban school districts. Teachers are leaving urban school districts at alarming rates. The expectation that every student will receive a quality educational experience is becoming increasingly less common for the neediest students, who are often minorities in rural or urban settings, or who have special needs (Snodgrass, 2018). Urban school districts and institutions of higher education need to determine strategies that will retain highly effective educators in the field. This applied dissertation was designed to provide insight into how to improve …

Exploring Behavioral Flexibility, Problem-Solving, And Innovation In Captive Asian Elephants (Elephas Maximus), Amanda Puitiza

Theses and Dissertations

Asian elephants encounter and adapt to changing environments by problem-solving and innovating. In this study, we assessed behavioral measures, such as persistence and motivation, to determine potential predictors of problem-solving success. This is the first examination of problem-solving in elephants with a multi-solution puzzle box.

Identification Of Genes That Determine Fitness, Virulence, And Disease Outcomes In Mastitis Associated Eschericia Coli, Michael Andrew Olson

Theses and Dissertations

Escherichia coli is an incredibly diverse group of bacteria that consist of both commensal and pathogenic strains that cause disease in a wide variety of tissues in many different animals. The current dogma, based on years of extensive molecular and genetic studies, is that individual strains have adapted to specific environments through acquisition of specific genes or come from lineages that are particularly suited to a unique tissue or host. However, mastitis-associated E. coli (MAEC) have thus far resisted such descriptions. The fitness and virulence factors of MAEC are poorly understood and molecular tools are rarely applied. This dissertation reports …

Coming Out Of The Shadows: Understanding Autism In Korean Culture, Yoojin Kim

Theses and Dissertations

Culture affects how the symptoms of Autism Spectrum Disorder (ASD) are perceived and addressed, and Korean culture has been affecting how individuals with ASD are perceived, diagnosed and treated in Korea, specifically the Republic of Korea. Stigmas about individuals with ASD have historically existed in Korean culture, and those stigmas have been affecting the diagnosis and social environment of individuals with ASD. Recent changes have been made to increase acceptance for individuals with ASD in Korea, but the literature has not yet brought this information together in a way that comprehensively portrays the current status of ASD perceptions, identification, intervention …