Digital Commons Network^™

Regulatory Analysis Of Vimentin Expression In Metastatic Versus Nonmetastatic Breast Cancer Cell Lines, Danielle N. Bird

Theses and Dissertations

The intermediate filament gene family, composed of six classes, shows both tissue and development-specific expression. Vimentin is a unique member of the intermediate filament protein family: although it is expressed in cells of mesenchymal origin, vimentin may also be expressed with other intermediate filament proteins during early stages of development. In some cases, as differentiation continues, vimentin is normally down-regulated whereas other intermediate filament proteins, like desmin, glial fibrillary acidic protein, or neurofilaments are turned on in muscle, glial cells, or neurons, respectively. In some metastatic cancers, including breast and prostate cancers, vimentin is aberrantly expressed, despite the embryonic origin …

Expression, Purification And Characterization Of Hepatitis C Virus Core Protein From E.Coli Using A Chemically Synthesized Gene (1), And Cloning, Expression, Purification And Characterization Of The Major Core Protein (P26) From Equine Infectious Anaemia Virus, Ashley James Birkett

Theses and Dissertations

The hepatitis c virus (HCV) core gene has been chemically synthesized and used to direct the expression of core protein in Escherichia coli (E.coli). When cloned downstream of the inducible T7 promotor the core gene directed the expression of a soluble protein with a molecular weight of 22 kDa. Under native conditions the protein behaved in a manner consistent with the formation of a multimeric structure, which may represent assembled core particles. Further, when examined by electron microscopy a heterogeneous mixture of nucleocapsid-like particles were visible. Core protein was specifically recognized by antibodies present in HCV infected serum, suggesting that …

Cloning, Expression, Purification And Characterization Of Domain B Of Wheat Germ Agglutinin, Ann C. Rice

Theses and Dissertations

Wheat germ agglutinin (WGA) belongs to a family of dimeric chitin binding lectins specific for N-acetyl-D-glucosamine (GlcNAc) and N-acetyl-D-neuraminic acid (NeuNAc). The polypeptide chain consists of a tandem repeat of four conserved 4.3 kDa domains (A, B, C, D) stabilized by four disulfide bonds. Saccharide binding occurs in the dimer interface where domains of different subunits are in contact (A with D, B with C). An aromatic amino acid rich pocket on one domain (sufficient for saccharide binding) and a polar region on the contacting domain constitute a complete binding site. Saccharide binding affinities may differ among the four unique …

Utilization Of Advanced Technology For Computer-Aided Instruction Involving Large-Scale Databases, Bryan C. Hahn

Theses and Dissertations

No abstract provided.

A Suicide Profile Of Native Americans In North Dakota, Duane L. Gourneau

Theses and Dissertations

No abstract provided.

Adsorption Of 2,4-Dichlorophenoxyacetic Acid By Peat Using A Continuous Flow Column System, Steven L. Johnson

Theses and Dissertations

No abstract provided.

A Spatial Analysis Of An Urban Fishery : A Case Study Of Winnipeg, Manitoba, Ian H. Kitch

Theses and Dissertations

No abstract provided.

Buying Rebellion : The Conservative Uses Of Heavy Metal Music By College Students, Scott Edward Foster

Theses and Dissertations

No abstract provided.

Axial Particle Loading In A Circulating Fluidized Bed, William Burgess Fox

Theses and Dissertations

No abstract provided.

Retention Of Foster Parents Providing Care To Adolescents In North Dakota, Jodi L. Tescher

Theses and Dissertations

No abstract provided.

Medication Errors In An Acute Care Setting, Cynthia S. Siders

Theses and Dissertations

No abstract provided.

The Predictive Value Of Family Dynamics, Attitudinal, And Situational Measures In Assessing Proclivity To Sexually Aggress In College Males, Margo R. Norton

Theses and Dissertations

No abstract provided.

A Course On The Structural Integrity Of Geriatric Aircraft Based On A Modular Delivery System, George Lee

Theses and Dissertations

No abstract provided.

Reliability Of The Scoring Criteria Of The Test Of Problem Solving-Adolescent, James R. Culbertson

Theses and Dissertations

No abstract provided.

An Analysis Of The Use Of Apologia In Crisis Management, Dana Lynn Bohn

Theses and Dissertations

No abstract provided.

Vincerò : A Play In Two Acts, Jan Delovage Blount

Theses and Dissertations

No abstract provided.

A Selective Medium For Isolation Of Corynebacterium Species, Hua Tu

Theses and Dissertations

No abstract provided.

Criteria-Based Content Analysis Of Children's Statements About A Mock Crime Compared With The Evaluations Of Naive Subjects, Marcus Jacques Choi Tye

Theses and Dissertations

No abstract provided.

A Comparative Analysis Of Student Perceptions Of A Computer Multimedia College Catalog And A Printed College Catalog, David N. Yearwood

Theses and Dissertations

No abstract provided.

General Media Publicity And Jury Deliberations, Steven A. Westby

Theses and Dissertations

No abstract provided.

An Evaluation Of The Chromoskedasic Pseudosolarization Method For Incorporation Into A Photographic Course, Lisa M. Lundsten

Theses and Dissertations

No abstract provided.

Applying Visual Information Management Software For Electric Utilities Automated Mapping, Barry J. Owens

Theses and Dissertations

No abstract provided.

Personality And Demographic Characteristics Of Victims Of Sexual Abuse And Self-Mutilation, Shirley J. Rader

Theses and Dissertations

The purpose of this study was to compare demographic and personality characteristics of a group of inpatients at a psychiatric hospital in New York State who were sexually abused and who were self-mutilators (N = 64) with: a group of sexually abused inpatients (N = 42); a group of self-harming inpatients (N = 25); and a group of selected general psychiatric inpatients (N = 25). All subjects were 18 years of age or older at the time of the study and over 90% of the participants were females.

It was hypothesized that sexually abused/self-mutilating patients would show greater similarity to …

Shock Wave Interaction With L-Shaped Structures, Richard C. Miller

Theses and Dissertations

This study investigated the interaction of shock waves with L-shaped structures using the CTH hydrodynamics code developed by Sandia National Laboratories. Computer models of shock waves traveling through air were developed using techniques similar to shock tube experiments. Models of L-shaped buildings were used to determine overpressures achieved by the reflecting shock versus angle of incidence of the shock front. An L-shaped building model rotated 45 degrees to the planar shock front produced the highest reflected overpressure of 9.73 atmospheres in the corner joining the two wings, a value 9.5 times the incident overpressure of 1.02 atmospheres. The same L-shaped …

Developing Realistic Cooperative Behaviors For Autonomous Agents In Air Combat Simulation, Dean P. Hipwell

Theses and Dissertations

This thesis investigated, developed and implemented cooperative decision-making behaviors in an air combat simulation by using a knowledge-based system. Knowledge-based systems were well suited for this task because of built- in features such as inference engines and rule-based constructs. This thesis addresses the specific problem of generating autonomous forces for inclusion in the Advanced Research Projects Agency Distributed Interactive Simulation program. Existing autonomous forces implementations lacked flexibility, realistic behaviors, real-time planning and other features. The simulation system in this thesis addresses the problem of realistic behavior by modeling pilot decision processes rather than aircraft platforms. The system is based on …

Vulnerability Assessment Using A Fuzzy Logic Based Method, Richard W. Fleming

Theses and Dissertations

This thesis demonstrates the feasibility of using qualitative analysis methods to evaluate computer security vulnerabilities. Although many risk analysis systems exist, few provide for the adequate analysis of identified vulnerabilities. While the main focus of this thesis is to evaluate computer security vulnerabilities, the methods involved have application in other areas requiring evaluation using qualitative methods. It is proposed, and demonstrated by this thesis, that the use of qualitative analysis using linguistic variables to describe the impact of computer security vulnerabilities is not only feasible, but intrinsically easier to understand and use than quantitative methods.

An Object-Oriented Database Interface For Ada, Anthony D. Moyers

Theses and Dissertations

Object data management ODM is currently at the forefront of research and development efforts in the database community. In order to take advantage of ODM technology, the Department of Defense DoD needs to ensure that these systems are accessible to Ada programmers. The Air Force Institute of Technology AFIT is conducting research towards the development of an Ada ODM interface to existing ODM systems. The design goals are portability, transparency, and completeness for Ada programmers. Portability means that the ODM system can be changed without affecting any existing application programs. Transparency means that Ada programmers can use the interface without …

A Study Of Two Dimensional Tapered Periodic Edge Treatments To Reduce Wideband Edge Diffraction, Russell A. Burleson

Theses and Dissertations

This is a brief summary of a study to reduce diffraction from an infinite two dimensional edge using tapered periodic surfaces. The concept is to use the impedance characteristics of a periodic surface to create a tapered impedance much like a tapered resistance commonly used for diffraction reduction. This approach has several advantages over. tapered resistive treatments to include ease of fabrication, better engineering control of the impedance and negligible loss absorbed by the ta per. In this study, four periodic tapers were design, built and tested. These tapers were also modeled using a variety of numerical techniques. The results …

Shielded Coil Electrodynamic Propulsion (Scep). A Feasibility Study, Richard J. R. Ladouceur

Theses and Dissertations

This study investigated Shielded Coil Electrodynamic Propulsion SCEP. The use of the earths magnetic field as a propulsion source has been previously investigated. It was found that a significant amount of power and long conductors were required. A more compact propulsion concept which requires significantly less power is proposed. This concept relies on the feasibility of significantly reducing the magnetic force induced by the earths magnetic field on selected segments of a coil. An experiment design to support the theoretical findings was conducted. The experiment results support the theoretical model.

Guidelines For Ensuring Software Supportability In Systems Developed Under The Integrated Weapon System Management Concept, Forrest F. Butts Iii, Anthony C. Johndro

Theses and Dissertations

This thesis studied the software maintenance planning and practices of the pilot Integrated Weapon System Management IWSM programs. Before IWSM, a System Program Office SPO acquired an Air Force weapon system then passed it to an Air Logistics Center ALC for follow-on support. The ALC was forced to maintain the software despite its questionable maintainability. The SPO de- emphasized maintainability because maintenance was an ALC responsibility and building maintainable software increased development costs and lengthened schedules. The IWSM philosophy closes the gap between development and maintenance. A System Program Director SPD, who oversees both system development and maintenance, has an …