Digital Commons Network^™

Effects Of Mmp14 Overexpression On Cardiac And Ovarian Connective Tissue And Myocyte Size In Pregnant And Post-Partum Mice, Emily Catherine Walliser

Theses and Dissertations

The main protein component of extracellular matrix is collagen, which fills spaces and supports cells. In the heart, collagen provides the scaffolding for cardiomyocytes and aids in contractile forces. In the ovary, collagen gives follicles their structural support. MMP14 or membrane type 1 matrix metalloproteinase is a membrane bound proteinase that cleaves extracellular matrix proteins, including collagen I and III. Recent studies have shown that overexpression of MMP14 influences collagen content in the heart, and elevated MMP14 has also been linked to ovarian cancer. In the current study, we investigate the effects of overexpression of a human MMP14 (hMMP14) transgene …

Institute Of Enslavement: Enslaved Lives At South Carolina College, Jill Found

Theses and Dissertations

“Institute of Enslavement: Enslaved Lives at South Carolina College” argues that enslaved people used the structure of the school, their own knowledge, and connections to other individuals and institutions to negotiate the terms of their enslavement. It examines how enslaved people on campus influenced their daily lives to the best of their abilities, in ways that were similar and different to other forms of enslavement. “Institute of Enslavement” considers how the unique structure of enslavement on a college campus, with multiple potential masters creating inconsistent authority for the school officials over enslaved people, created opportunities as well as moments of …

Design Of An Artificial Transcription Factor For Inducing Potent Interferon-Γ Signals, Ashley King

Theses and Dissertations

Cytokines are small immune signaling proteins responsible for cellular communication and their levels are tightly regulated throughout immune recognition and defense. Interferon gamma is a key cytokine responsible for upregulation of antigen presentation and supports the differentiation of pro-inflammatory effector cells. Due to its role in regulation, excess interferon gamma is cleared from the body limiting the success of interferon gamma immunotherapies. This study reports the design and validation of an artificial transcription factor (ATF) that induces endogenous interferon gamma expression. The transcription factor contains zinc finger proteins to recognize the interferon gamma gene and an activation domain to promote …

Using Differentiated Gamification To Teach Systems Interactions: Impacts On Ninth Grade Biology Students' Academic Achievement And Cognitive, Behavioral, And Emotional Engagement, Stephanie Morgan Ruiz

Theses and Dissertations

The purpose of this action research was to evaluate the impact of differentiated gamification on student cognitive, behavioral, and emotional engagement, and academic performance within the unit of plant and animal systems for ninth grade biology students. Scientific literacy is considered a key component of education, as it contributes to societal innovation, economic production, and an informed public. Comprehension of biological concepts and processes, such as plant and animal systems, provide a greater understanding of the living world, and contributes to overall scientific literacy. Although a vital component to science education and literacy, students continue to struggle with the concepts …

Queer Eye For Costume Design: An Insight Into The Creative Process From The Perspective Of An Lgbtq+ Designer, Andrew Simon Burns

Theses and Dissertations

From the page to the stage, the creative process manifests itself differently for every theatre artist. During my time in the Costume Design and Technology Program at the University of South Carolina, I have analyzed and adapted my design process through rigorous curriculum and experiential learning. This thesis explores my artistic and professional growth by showcasing my production designs in educational and professional practice. Through these experiences, I was able to acquire a well-rounded set of skills in construction, pattern making, draping, and costume rendering that aide and elevate my designs and ability to communicate effectively with production teams. My …

The Disruption Of Kinship: Interracial Relationships, Displacement, And Marginalized Mixed-Race Families In Korean War Literature, Hyunwook Kim

Theses and Dissertations

The Korean War (1950–1953) left a profound mark on the Korean peninsula, its people, and their diaspora, with its impact still felt today. Korean War literature serves as a vital source for understanding the war's social and cultural ramifications, particularly for marginalized groups, including military sex workers, mixed-race children, and mixed Korean adoptees. Emphasizing the role of interraciality in their experiences, the dissertation delves into literary representations that depict encounters between Korean women and American soldiers, leading to the formation of novel mixed-race families both within military camp towns in Korea and domestic spaces in the United States. While much …

On The Use Of Cfd Modeling And Analytic Methods To Describe Pressure Drop In Highly Dense Structured Adsorbents In Gas Separation Processes And Fundamentals Of Adsorption, Ryan Timothy Sanders

Theses and Dissertations

The scope of this work can be divided into two main thrusts on topics found within adsorption. The first, and primary, topic is the use of CFD and analytical modeling to describe the flow of gas through a parallel, structured adsorbent channel which is described in Chapters 1 and 2. Chapter 1 establishes a non-experimental methodology based on using a 3D Navier-Stokes (NS) computational fluid dynamics (CFD) model in lieu of experiments, for developing 1D axial pressure drop correlations for structured adsorbents with parallel channels. Chapter 2 utilizes the methodology established in Chapter 1 in order to develop a new …

The Effect Of Covid-19 Restrictions On The Social Support Experiences Of Black Women Giving Birth In South Carolina Hospitals During The First Year Of The Covid-19 Pandemic (2020) As Compared To A Previous Birth, Tiffany Eva Byrd

Theses and Dissertations

The United States is experiencing a maternal health crisis, which disproportionately affects Black women. Black women die from pregnancy-related causes two to three times as often as their White counter parts, and the majority of maternal death are preventable. In recent years, public health and national governing authorities have devoted resources to monitoring the health crisis and raising the public’s knowledge of warning signs; however, maternal mortality rates continue to rise. Noted contributors to Black maternal mortality include, but are not limited to, racism, delayed treatment and response to health emergencies, and lack of social and emotional support during childbirth, …

“I’M Speaking”: Black Women Leading School Public Relations, Managing Communications And Personal Challenges, Keisa Gunby

Theses and Dissertations

Operationalizing feminist communication theory with a critical lens, this research analyzes virtual, semi-structured interviews with 13 Black women who are integral to impacting organizational culture through the brand management and narratives to the stakeholder groups of employees, parents and community members for a public school district. This study aims to describe the oppression and invisibility of Black women in school public relations and amplify their voices as they lead the communication, marketing, and promotional efforts in public school districts across the United States. The interview transcripts were analyzed utilizing NVivo software through the first round of coding initial and the …

Beyond The Plastic Facade: Unveiling The Multifaceted Discourse And Impact Of Barbie In Film, Sarah Johnson

Theses and Dissertations

This paper presents an exploration into the multifaceted dimensions of public discourse surrounding Barbie, the film released in 2023 directed by Greta Gerwig, by leveraging advanced natural language processing techniques. Employing BERTopic for topic modeling, I analyzed conversations embedded in YouTube comments from Warner Bros.'s own promotional content as well as third-party YouTube content pre- and post- the film’s release to unearth the themes and sentiments associated with the iconic character. Our primary objective was to look beyond the stereotypical perception of Barbie as a two-dimensional figure and shed light on the diverse and complex discussions surrounding her cinematic representation. …

Investigation Of The Environmental Factors Regulating The Biomass And Toxin Production Of The Benthic Cyanobacterium Microseira Wollei In Lake Wateree, South Carolina, Kara Clyburn

Theses and Dissertations

Impacts from anthropogenic activities and climate change are significantly altering nitrogen (N) cycling processes and biological productivity along the freshwater to marine continuum, and the acceleration rate of excessive N and phosphorus (P) concentrations entering aquatic environments is unprecedented. As a result, nutrient pollution is contributing to the increasing magnitude and duration of cyanobacterial harmful algal blooms (cHABs), oxygen (O2) depletion, loss of biodiversity, and impacts to human and ecosystem health. Lake Wateree, South Carolina (SC) is a freshwater drinking and contact recreational water resource with elevated symptoms of eutrophication, including the increasing prevalence of the N2 fixing benthic cyanobacterium …

Reading Ecogothic Memory In Contemporary Southern Swamp Novels, Megan Caroline Brockhard Knight

Theses and Dissertations

The ecogothic is a lens through which to engage memory, southern constructivism and identity, environmental intervention, and the literature of the American Southeast. This project establishes a framework of literary criticism that defines the ecogothic, interprets memory as truth imagined, and identifies the position of memory in the environment as a construction with which it is necessary to grapple to understand identity. This framework, compiled of existing and original scholarship, is then applied to three contemporary swamp narratives written by three different southern women writers. The swamp setting creates a unique microcosm of gothic liminality, neither fully land nor water, …

Estuarine Microbial Community Composition And Efficiency Changes In Response To Vibrio Parahaemolyticus Exposure, Sarah Mulligan

Theses and Dissertations

Vibrio parahaemolyticus is a pathogenic bacterium whose full impact on natural estuarine phytoplankton communities has not been fully resolved. The primary goal of this research was to test how the addition of V. parahaemolyticus to a natural estuarine microbial community would impact the other microbes present. We hypothesized V. parahaemolyticus exposure would reduce phytoplankton biomass and alter the composition of phytoplankton and bacterial communities. Experimental bioassays (60h) were used to assess the effects of the presence of V. parahaemolyticus . Samples for measurements of chemotaxonomic photopigment concentrations, 16S sequencing-based community composition, photosynthetic efficiency, cell density, and V. parahaemolyticus abundance were …

Becoming Musical: Towards A Typology Of Non-Musical Sounds In Recorded Popular Music, Jacob David Mccooey

Theses and Dissertations

There are many instances in popular music in which traditionally non-musical sounds are used musically. There is currently no research on the types and functions of non-musical sounds used musically (NMSUMs). I have collected and organized a collection of example tracks that contain these NMSUMs and analyzed their functions to determine a typology of these sounds. The analysis of the NMSUMs focused on intertextuality, intratextuality, form, texture, and how the sounds relate to traditional, musical sampling. Throughout the course of the analysis, several trends were distinguished amongst the many tracks gathered, and these trends form the basis of the typology.

Medieval To Modern: Morgan Le Fay As Folk Icon Of Women In Power In Modern King Arthur Stories, Colleen Victoria Etman

Theses and Dissertations

This dissertation interrogates the ways that society views women with/in power through Arthurian adaptation. The body of work that makes up the Arthurian story is a sort of folk legend, a myth being told and retold by various authors in their own way. By using folk studies to analyze both medieval and modern texts, we can dissect what is important enough to remain over time. This signifies cultural values; things that have remained over time are reflective of the values of the writers producing these works, as well as the audiences consuming them. By interrogating these stories, we can make …

Characterizing The Role Of The Escherchia Coli Monothiol Glutaredoxin, Grxd, As An Iron-Sulfur Cluster Carrier Protein, Claire Elizabeth Fisher

Theses and Dissertations

Iron-sulfur (Fe-S) clusters are important cofactors with a primary role of electron transport that are required by proteins involved in wide range of biological pathways such as respiration, photosynthesis, and DNA repair. In Escherichia coli (E. coli), the assembly and transfer of these clusters to their target apo-protein is a highly coordinated process encoded by the multiprotein systems iscRSUAhscBAfdx and sufABCDSE operons. These clusters are assembled on a scaffold protein, where they are then transferred to a carrier protein that will deliver the cluster to the target apo-protein. The Isc and Suf systems contain their own carrier proteins IscA …

Simultaneous Crack & Wave Propagation And Acoustic Emission Signal Modelling Using Peri-Elastodynamic, Md Mushfiqur Rahman Fahim

Theses and Dissertations

This work presents the use of Peri-Elastodynamic, a guided wave simulation method based on meshfree non-local Peridynamics theory. To model simultaneous crack and wave propagation simulation and its application on Acoustic Emission (AE) signal modelling, a new formulation is presented. The field of nondestructive evaluation (NDE) and structural health monitoring (SHM) is slowly embracing the advancement in Machine Learning (ML) / Artificial Intelligence (AI) for better and cost-effective assessment of structures and damage prediction. AI/ML can revolutionize the NDE/SHM field by automating the data collection and analyzing processes. However, the big challenge is that the model needs a sheer amount …

Cancer Screening For Patients With Intellectual Disability: Exploring Parent And Caregiver Perspectives, Jennifer Ryan

Theses and Dissertations

Intellectual disability (ID) is defined as a combination of deficits in cognitive and adaptive function, both of which must be present early in life. Adults with ID frequently have unique healthcare needs; however, they also require care that is routine for all adults. This includes cancer screening. The goal of this study was to evaluate whether or not adults with ID are undergoing cancer screening, understand the barriers they have faced in obtaining screening, and collect recommendations from parents and caregivers on ways to improve access to and facilitate screening for this population. We surveyed parents and caregivers of adults …

An Emic Conceptualization Of Veteran, “You're Either One Of Two Things; You're Captain America Or You're Broken”, Steven Wahle

Theses and Dissertations

The Global War on Terror (GWOT) conflicts have been sustained by an all-volunteer force for over 20 years. There have been no drafts, war bond drives, nor rationing. This is a departure from previous prolonged military conflicts in U.S. history. Volunteers with veteran status are often venerated publicly to express gratitude for their voluntary military service. However, the criterion for veteran status is inconsistent.

In the U.S., former military members tend to be regarded on one of two ends of a spectrum as archetypes in attempts to honor such service. On one end is the veteran hero veteran to be …

Optimal Limb Regeneration Strategies In Hemigrapsus Sanguineus, Laura S. Fletcher

Theses and Dissertations

Diet quality and energy allocation influence an individual’s life-history traits by determining how much energy is available for processes such as growth and reproduction. One common method of assessing diet quality involves measuring gut length or size, which is typically inversely related to diet quality. However, this often requires animal sacrifice and time- consuming dissections. Similarly, many traditional bioenergetics models fail to capture the context-dependence of energy allocation, as these models rely on fixed energy allocation rules. One such rule is the κ-rule of dynamic energy budget theory, which assumes a fixed proportion (κ) of assimilated energy is always allocated …

Feature Engineering For Grain Boundaries And Other Variable-Sized Atom Clusters, C. Braxton Owens

Theses and Dissertations

Obtaining microscopic structure-property relationships for grain boundaries are challenging because of the complex atomic structures that underlie their behavior. This has led to recent efforts to obtain these relationships with machine learning, but representing a grain boundary structure in a manner suitable for machine learning is not a trivial task. There are three key steps common to property prediction in grain boundaries and other variable-sized atom clustered structures. These are: (1) describe the atomic structure as a feature matrix, (2) transform the variable-sized feature matrices of different structures to a fixed length common to all structures, and (3) apply machine …

Wind-Carved Wonders: An Aerial Study Of Yardangs In The Puna, Argentina Using Drone And Satellite Imagery, Derek Gordon Ashliman

Theses and Dissertations

Yardangs, elongated landforms sculpted by wind erosion, are prominent features in the Campo de Piedra Pomez (CPP) region of the Puna-Altiplano Plateau, Argentina. This study explores their formation and evolution through the examination of a 6 km by 0.5 km area captured in 2019 and a 5 km by 0.5 km area in 2024. High-resolution drone imagery and satellite data were employed to classify and quantify yardangs, gravel, and underlying bedrock across a vast study area. The research reveals a variation in yardang distribution and morphology from northwest (windward) to southeast (leeward), noting a significant decrease in yardang and bedrock …

Fission Product Thermodynamics, Solubility, And Extraction In Molten Salts And Lead, Richard Lee Fitzhugh

Theses and Dissertations

Chemical behavior of fission products in systems relevant to two major advanced nuclear reactor systems, namely the lead-cooled fast reactor (LFR) and molten-salt reactor (MSR), has been studied with a heavy emphasis on thermodynamics. The behavior of fission products in molten salts is examined from a theoretical perspective, with an emphasis on the standard state used to define the thermodynamic activity. A standard state extrapolated from infinite dilution behavior, which is fairly common practice in electrochemistry, is found to facilitate faster, easier, and simpler analysis while retaining much of the accuracy of the complex Modified Quasichemical Model. Inductively-coupled plasma mass …

Dynamics Of Dissolved And Particulate Trace Metals In A Snowmelt-Dominated Stream, Provo River, Utah, Usa, Kendra Louise Caskey

Theses and Dissertations

Trace element concentrations vary substantially during snowmelt runoff, with changes in the dissolved versus particulate fractions potentially impacting their movement at the catchment scale. To investigate trace element behavior in a snowmelt dominated stream, we measured concentrations in different size fractions in the Provo River (northern Utah, USA). We sampled the river at three locations during water years 2016-2018 and 2021-2023 for trace metal and major ion concentrations. During the final year, we collected three fractions (unfiltered, <0.45 µm filtered, and <0.22 µm filtered) for trace metal chemistry and calculated the particulate concentration as the difference between the unfiltered and 0.45 µm fraction. Stream measurements included pH, discharge, turbidity, and fluorescent dissolved organic matter (fDOM). We also sampled water sources (soil water, ephemeral streams, and snowpack) to compare trace metal concentrations across the watershed with the stream. Trace metal (Al, Be, Fe, Pb) and rare earth element (REE +Y) concentrations had the highest particulate and dissolved concentrations during snowmelt runoff. In contrast, major cations were primarily found in the dissolved fraction with lowest concentrations during snowmelt runoff. Major cation and particulate metal concentrations increased from upstream to downstream. The increased trace metal and REE + Y concentrations during snowmelt relative to baseflow may be explained by increased discharge and associated increased turbidity and fDOM. A comparison with water sources suggests that dissolved and particulate trace metals in the stream are sourced from flushed soil water, as trace metal transport through the watershed is facilitated by suspended sediment and dissolved organic matter. For most of the trace metals and REE +Y, concentrations were similar in the <0.45 µm and <0.22 µm fractions. Yet Al tended to have higher concentrations in the <0.45 µm fraction, suggesting a colloidal form of Al between 0.22 µm and 0.45 µm may exist. Differences from upstream to downstream may be related to changes in pH, from ~7 at the upper site to ~8 at the lower sites, which would change sorption capacity, saturation indices, or speciation. Our study demonstrates that trace metal concentrations are variable during snowmelt as the metals interact with suspended particles or dissolved organic matter and are influenced by changing water chemistry, with implications for understanding water quality impairments in snowmelt-dominated streams.

Void Formation During Liquid Composite Molding Under Varied Pressure With Mechanical Properties Validation, Neil Russell Thompson

Theses and Dissertations

Composite materials have revolutionized products and how they are manufactured. Most large-scale aerospace companies utilize a carbon fiber pre-impregnated with a resin in conjunction with an autoclave to minimize voids, but it is very expensive and requires a great amount of space. The less expensive alternative to prepreg-autoclave processes is known as Liquid Composite Molding (LCM), in which the resin is brought into a mold via overpressure on the resin supply or by a vacuum in the mold. But this process is more prone to voids due to bubble formation. Voids are a critical issue as common failure modes such …

Linguistic Perspectives In Ecuadorian Amazonian Kichwa, Max Nathan Jensen

Theses and Dissertations

Despite the fact that Amazonian Kichwa speakers consider themselves to be both linguistically and culturally distinct from their highland counterparts (Ennis 2020; Wroblewski 2012), relatively little has been done to document their language attitudes and how these attitudes are reflected in their speech. This study shows this to be a valid line of questioning. Using commentary from interviews with Amazonian Kichwa people, I show that views on the status and future of the language are divided, as well as perspectives on the role of non-Kichwa sources like schools and governments in language maintenance. Older and native speakers of Kichwa are …

Deep Learning For Source Localization In A Laboratory Tank, Corey Emerson Dobbs

Theses and Dissertations

Deep learning has been applied to underwater acoustics problems in many forms. One difficulty in applying deep learning techniques to ocean acoustics is the spatially and temporally varying environmental properties. Another challenge is the lack of labeled data for training large networks. The overall goal of this work is to develop deep learning approaches for source localization that can be adaptable to different conditions. In this work, a convolutional neural network was trained on acoustic data measured in a water tank, while the water was at room temperature, to predict source-receiver range. Tests were done to ascertain ideal quantities of …

An Investigation Of University General Education Assessment Practice, Joseph H. Hanks

Theses and Dissertations

Many-facets Rasch modeling (MFRM) is an effective way to compensate for rater effects (e.g., rater leniency/severity) in the ratings assigned during rater-mediated assessment. While a fully crossed MFRM rating design, in which all raters rate every rating object, is the ideal from a psychometric standpoint; fully crossed designs are rarely implemented in practice because of the resource burden they impose on assessment personnel. Thus, incomplete rating designs, where each rater does not rate all rating objects, are the norm. However, unless assessment personnel consciously attend to a variety of aspects of rating design, incomplete rating designs may suffer from design …

Emergent Leadership, L2 Oral Proficiency, And Social Networks During Study Abroad, Nicole C. Whitby

Theses and Dissertations

Research shows that study abroad (SA) provides a unique, yet varied outcome for students seeking to improve their target language oral proficiency during study abroad SA (Freed et al., 2004). Contemporary work in second language acquisition (SLA) during SA has looked beyond individual behaviors of sojourners to analyze social networks as a structure with significant influence on outcomes, yet emergent leadership has not been addressed within social network analysis in SA. To address this gap the current study employed a computational social network approach. This mixed methods study analyzes the social networks of 30 SA sojourners from a large private …

Linking Geospatial Trends And Geochemical Fingerprints To Anthropogenic Phosphorus Dust Deposition In Subalpine Soils, Austen Michael Lambert

Theses and Dissertations

This study shows that fugitive emissions associated with the surface mining of phosphate rock are a significant phosphorus (P) source to surface soils in northeastern Utah. Phosphorus is a nonrenewable resource essential for all life. Anthropogenic alterations to the P-cycle have led to widespread P pollution, and the unsustainable management of P has led to the threat of global depletion of P resources. Thus, accounting for both natural and anthropogenic flow paths of P is essential for the conservation and pollution reduction of P. One such source of human alteration to the P-cycle is the mining of phosphate rock. Mining, …