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Electrical Characterization Of Germanium Tin Alloys And Devices For Space Reliability, Kevin K. Choe
Electrical Characterization Of Germanium Tin Alloys And Devices For Space Reliability, Kevin K. Choe
Theses and Dissertations
GeSn (germanium tin) alloys are potentially well suited for near-mid infrared space optoelectronic applications. Alloys of GeSn have similar properties to group III-V and mercury-cadmium-telluride semiconductors and are compatible with cost-effective complementary metal oxide semiconductor (CMOS) manufacturing technology. Recent progress in non-equilibrium remote plasma-enhanced chemical vapor deposition (RPECVD) has enabled the crystalline growth of GeSn with Sn concentrations of up to 10% without Sn surface segregation. Several experimental studies in previous literature report CVD- or molecular beam epitaxy (MBE)-grown GeSn alloys achieving a direct bandgap with 6%-9% Sn content. This novel growth technique opens opportunities for a cost-effective, next-generation optical …
Automation Of Lcmc Logistics Processes: A Delphi Approach, Kline M. Alt
Automation Of Lcmc Logistics Processes: A Delphi Approach, Kline M. Alt
Theses and Dissertations
As the U.S. Air Force confronts growing complexity in system acquisition, the implementation of digital models in system design and logistics process management allows the incorporation of digital tools and the possibility for automation of portions of logistics processes. This thesis investigates where these technologies can be most effectively integrated within the Air Force Life Cycle Management Center logistics enterprise (AFLCMC). Using a three round Delphi study, AFLCMC logistics subject matter expert (SME) opinions were solicited from program-level senior logisticians, program managers to identify high-need areas, key success factors, and potential barriers to adoption. Quantitative consensus from Likert-scale and ordinal …
Designing An Experiment To Create And Evaluate Behavioral Changes In Air Force Pilots' Fuel Efficiency, Jackson Macias
Designing An Experiment To Create And Evaluate Behavioral Changes In Air Force Pilots' Fuel Efficiency, Jackson Macias
Theses and Dissertations
Fuel represents over 70% of the logistical resupply demand within the Department of Defense, with the United States Air Force accounting for most of that consumption. While prior fuel efficiency efforts have primarily focused on technical upgrades, this research explores how behavioral interventions can influence pilot decision-making and operational energy outcomes. Using the Theory of Planned Behavior (TPB) as a guiding framework, this study investigates the effects of targeted behavioral strategies on pilots’ attitudes, subjective norms, perceived behavioral control, intentions, and actual fuel-efficient behaviors. A quasi-experimental design was applied through a controlled pilot study using simulator flights. Six participants were …
Multi-Fidelity Machine Learning Modeling For Aerodynamic Response Prediction Of Aerospace Vehicles, Ethan S. Jackman
Multi-Fidelity Machine Learning Modeling For Aerodynamic Response Prediction Of Aerospace Vehicles, Ethan S. Jackman
Theses and Dissertations
Hypersonic vehicle design requires understanding complex aerodynamic phenomena across the full flight regime. This study presents a novel MF surrogate modeling methodology that enables the prediction the full field response across a vehicle’s surface. A Space-Filling Curve (SFC) is used to convert unstructured data into 1D vectors. The a Convolutional Autoencoder is used with transfer learning to reduce the dimensionality of the data. An Emulator-Embedded Neural Network (E2NN) combines multi-fidelity data for fast, accurate predictions. A benchmark analytical example and hypersonic application are used to evaluate the methodology. Using various numbers of samples and sampling strategies it is found that …
Low-Cost Transfers For Cislunar Liaison Navigation, Ka'eo J. Swartzmiller
Low-Cost Transfers For Cislunar Liaison Navigation, Ka'eo J. Swartzmiller
Theses and Dissertations
CubeSats have an inherent limitation on volume due to their small form factor. Naturally, this extends to the capacity of on-board ΔV, thus limiting the maneuverability of the satellites. This limited maneuverability makes it extremely important to be intentional when planning out mission trajectories. The cislunar region subjects these trajectories to the gravitational forces of both the Earth and the Moon, making it all the more necessary to deliberately plan out maneuvers. The Circular Restricted Three Body Problem (CR3BP) provides a simpler model for estimating the motion of spacecraft within the cislunar region, allowing for the gravitational forces to be …
Investigating The Impact Of Forest Vegetation On Nuclear Weapon Prompt Radiation Energy Deposition, Paul A. Clement
Investigating The Impact Of Forest Vegetation On Nuclear Weapon Prompt Radiation Energy Deposition, Paul A. Clement
Theses and Dissertations
This work seeks to answer the unstudied questions “Does a layer of vegetation impact the prompt radiation energy deposition in the soil from an atmospheric nuclear detonation?” and “If yes, by how much?” A new methodology was developed to repeatably automate and streamline a process of generating a three-dimensional geometry for subsequent radiation transport simulations and statistical analysis. The methodology streamlined three diverse applications: a three-dimensional mesh generator, a radiation transport simulation code, and a sensitivity analysis & uncertainty quantification software. The methodology was tested by simulating the quantitative influence that vegetation has on changing the energy deposition into the …
Spin State Of Positronium In Two Dimensions, Emille Bryant
Spin State Of Positronium In Two Dimensions, Emille Bryant
Theses and Dissertations
We investigate the spin state of the electron-positron system positronium to determine experimental criteria that can identify a positronium anyon. Anyons have been posited to be the basis for a truly fault-tolerant quantum computer, but they have not been indisputably observed in experimental systems. Through the analysis of the fully relativistic symmetry group of fermions and bosons in three dimensions, we investigate the symmetry of its subgroups to determine that positronium in two dimensions behaves as a scalar with respect to rotations. We conclude that positronium in two dimensions has an arbitrary relative spin orientation of annihilation photons and only …
An Antioxidant Approach To Ameliorate The Effects Of Radiation And Chemotherapy On Cognition, Raymond Anan Otoo
An Antioxidant Approach To Ameliorate The Effects Of Radiation And Chemotherapy On Cognition, Raymond Anan Otoo
Theses and Dissertations
Acute Lymphoblastic Leukemia (ALL) is a hematologic malignancy that primarily affects children and young adults. While advancements in treatment—including chemotherapy and cranial irradiation—have significantly improved 5-year survival rates in children to nearly 90%, radiation-induced cognitive impairment (RICI) remains a persistent and debilitating side effect. The brain, particularly the hippocampus, is highly susceptible to radiation-induced oxidative stress and inflammation. In the treatment of ALL, the combined use of chemotherapy and radiotherapy contributes to a heightened oxidative burden, exacerbating the risk of cognitive dysfunction. Although previous studies have linked radiation exposure to neurocognitive decline, the molecular mechanisms underlying RICI and chemotherapy-induced cognitive …
The Relationship Between Effort Cost Decision Making, Consummatory/Anticipatory Pleasure, And Health Behaviors In Schizotypy, Adriann Lai
Theses and Dissertations
Motivational and hedonic deficits are not well studied in schizotypy as they relate to health behaviors. Nonclinical undergraduate participants (n= 247) completed self-report measures and a behavioral task (EEfRT) that assessed effort cost decision making. Social anhedonia was positively associated with increased effort but simultaneously reduced responsiveness to increasing rewards, indicating inefficient effort allocation. Consummatory pleasure was the more relevant hedonic predictor of effort, rather than anticipatory pleasure. In exploratory analyses, higher positive schizotypy scores were significantly associated with greater consummatory pleasure, while disorganized schizotypy was unrelated to pleasure indices or effort performance. In secondary hypothesis analyses, all schizotypy traits …
Exploring The Effects Of Culturally Relevant Pedagogy On Literacy Achievement, Sarah Fisher
Exploring The Effects Of Culturally Relevant Pedagogy On Literacy Achievement, Sarah Fisher
Theses and Dissertations
This study examined the impact of culturally relevant pedagogy and how multicultural mentor texts could support a third grade student who has been identified as a struggling reader over the course of six weeks. This study was guided by these research questions: What happens when a struggling reader receives culturally relevant pedagogy? How does culturally relevant instruction impact engagement in literacy? What specific literacy skills improve based on culturally relevant instruction? The findings indicate that the student who participated in this study demonstrated growth in engagement and higher order comprehension skills.
Rethinking The Red Zone: Risk Factors Of College Student Dating Violence Victimization During The Fall Semester, Alexandra Nicoletti
Rethinking The Red Zone: Risk Factors Of College Student Dating Violence Victimization During The Fall Semester, Alexandra Nicoletti
Theses and Dissertations
College students experience dating violence (DV) victimization at alarmingly high rates, which is associated with a variety of negative outcomes (Brewer & Thomas, 2019; Choi et al., 2017; Leemis et al., 2022). To implement effective prevention programming, it is important to understand the risk factors associated with DV victimization on college campuses. Further, college students report the highest rates of one type of DV victimization—sexual victimization—during the fall semester, also known as the “red zone” (Carey et al., 2018, Cranney, 2015). This study utilized the socioecological model to understand which individual-, relationship-, and community-level risk factors were associated with DV …
Development Of Novel Small Molecules As Potential Anti Cancer Agents, Robert John Chitren
Development Of Novel Small Molecules As Potential Anti Cancer Agents, Robert John Chitren
Theses and Dissertations
This doctoral thesis explores the discovery and characterization of two novel small molecules, designated as KS100 and (R,S’)-MNF, with potential anti-cancer properties. The study encompasses a comprehensive investigation into the molecular mechanisms underlying the anti-cancer effects of these compounds, as well as their therapeutic potential in preclinical models. These findings highlight the potential of KS100 and (R,S’)-MNF as lead candidates for cancer therapy, paving the way for further preclinical development and clinical translation.
Cultivating Climate And Culture: New Jersey Principals' Use Of Sel In Pk-12 Schools, Michelle Papa
Cultivating Climate And Culture: New Jersey Principals' Use Of Sel In Pk-12 Schools, Michelle Papa
Theses and Dissertations
The purpose of this qualitative, intrinsic case study is to explore how PK-12 principals in New Jersey perceive their approaches to leadership through their own social and emotional learning (SEL). With growing demands placed on school leaders, the study examines how principals integrate the five SEL competencies (self-awareness, self- management, social awareness, relationship skills, and responsible decision-making) into their leadership practices to positively impact school climate and culture. Through semi- structured interviews and document analysis, ten principals revealed that SEL is not only essential for student and staff well-being but also central to their own leadership development. Findings indicate that …
Analytical Characterization Of Artemisinin And Its Derivatives Using High Performance Liquid Chromatography, Electrochemistry Reduction, And Fluorescence, Faraja Ombwayo
Theses and Dissertations
Artemisinin and derivatives were subjected to 37°C and room temperature conditions. When HPLC-UV analysis of both conditions was performed, there were differences in both conditions which suggested that artemisinin and derivatives degrade at 37°C. When artemisinin was electrochemically reduced, new peaks were generated and LC-MS analysis of the reduced artemisinin indicated that either new molecules or molecular reorganization was formed. These electrochemical reduction molecules (products) were deemed analogous to the artemisinin reduction occurring in-vivo after oral administration. Fluorescence analysis of artemisinin and derivatives were performed in the presence of dipyridamole. Dipyridamole intensity was observed to decrease when artemisinin or its …
Engineering Protein Linkers For Optimized Telsam-Darpin Fusion And Crystallization With Electric Field-Based Polymer Orientation, Maria Jose Pedroza Romo
Engineering Protein Linkers For Optimized Telsam-Darpin Fusion And Crystallization With Electric Field-Based Polymer Orientation, Maria Jose Pedroza Romo
Theses and Dissertations
Fusing a variant of the sterile alpha motif domain of the human translocation ETS leukemia protein (TELSAM) to a protein of interest significantly enhances crystallization and diffraction quality. TELSAM is a pH-dependent, polymer-forming crystallization chaperone that, when covalently fused to a protein, forms a well-ordered crystal lattice. However, the success of this method depends on two factors: 1) the design of the linker connecting TELSAM to the target protein, which influences both crystal packing and target orientation, and 2) the prevention of TELSAM polymer flipping, a phenomenon that disrupts lattice periodicity and impairs structure determination. To address the first challenge, …
Oxidation Resistance And Osmotic Energy Harvesting Applications Of Reduced Graphene Oxide Forward Osmosis Membranes, Michael Appiah-Kubi
Oxidation Resistance And Osmotic Energy Harvesting Applications Of Reduced Graphene Oxide Forward Osmosis Membranes, Michael Appiah-Kubi
Theses and Dissertations
Reduced graphene oxide (RGO) forward osmosis (FO) membranes have emerged as promising candidates for efficient wastewater management and osmotic energy harvesting, due to their enhanced chemical stability and superior FO performance for low-energy waste brine treatments, such as volume reduction of oxidative chromium brine for cost-effective disposal. This dissertation first examines the oxidation resistance of RGO forward osmosis membranes against chromate Cr (VI). Our findings reveal that both the water flux and the reverse salt flux of RGO membranes are suppressed, accompanying an enhanced reverse flux selectivity after exposure to an acidic medium of Cr (VI) (pH 2.0-7.0). Meanwhile, the …
Satellite-Based Identification Of Mesoscale And Submesoscale Eddies And Fronts In The Gulf Of Mexico, Ethan Cruz
Satellite-Based Identification Of Mesoscale And Submesoscale Eddies And Fronts In The Gulf Of Mexico, Ethan Cruz
Theses and Dissertations
Mesoscale and submesoscale processes in the Gulf of Mexico (GoM) are fundamental in shaping the region’s physical and biogeochemical ocean dynamics. Advances in high-resolution satellite observations now allow detailed detection of submesoscale (< 25 km radius) and mesoscale eddies and ocean fronts, which drive heat, nutrient, and carbon fluxes. This dissertation integrates two complementary investigations: (1) a comparison of eddy-tracking algorithms: Contour Tracing (CT) and Temperature Thresholding (TT), applied to Optimum Interpolation Sea Surface Temperature (OISST, 1/4°) and Operational Sea Surface Temperature and Ice Analysis (OSTIA, 1/20°) products; and (2) a comparative evaluation of three ocean front detection algorithms: Canny Edge Detection (Canny), the Cayula–Cornillon Algorithm (CCA), and the Belkin–O’Reilly Algorithm (BOA), across multiple satellite-derived parameters, including sea surface temperature (SST), sea surface salinity (SSS), chlorophyll-a (Chl-a), and altimetry-derived absolute dynamic topography (ADT). The eddy-tracking analysis shows that the higher-resolution OSTIA consistently detected more eddies than OISST, with TT performing best during winter when SST gradients were strongest. The front detection analysis, incorporating datasets from the Surface Water and Ocean Topography (SWOT) and Plankton, Aerosol, Cloud, Ocean Ecosystem (PACE) missions, was evaluated under diverse conditions, including flood and drought periods, Loop Current phase changes, and extreme weather events. A machine learning–based Gaussian Mixture Modeling (GMM) approach was also developed, providing a novel framework for dynamic front detection. By benchmarking traditional and machine learning methods, this integrated study identifies optimal algorithm–dataset combinations for resolving submesoscale and mesoscale features in the GoM, with applicability to other regions.
Acoustic Characterization And Modeling Of Heated Supersonic Tactical Jet Aircraft And Launched Rockets, Logan Troy Mathews
Acoustic Characterization And Modeling Of Heated Supersonic Tactical Jet Aircraft And Launched Rockets, Logan Troy Mathews
Theses and Dissertations
Understanding and accurately modeling the acoustic sources and propagation of high-intensity tactical jet aircraft and rocket noise is essential for vehicle design, environmental impact assessment, and mitigation strategies. Despite progress in the understanding of these sources, significant challenges persist in both predictive modeling and noise mitigation. This dissertation advances both the characterization of full-scale supersonic tactical jet aircraft noise sources and the development of modern empirical prediction models for rocket launch noise. Across multiple measurement campaigns and modeling efforts, the work integrates advanced array signal processing, high-fidelity field measurements, and improved empirical methods to expand the physical understanding of source …
Magnetic Ordering And Dynamics In Assemblies Of Magnetite Nanoparticles Throughout The Superparamagnetic Transition, Johnathon Michael Rackham
Magnetic Ordering And Dynamics In Assemblies Of Magnetite Nanoparticles Throughout The Superparamagnetic Transition, Johnathon Michael Rackham
Theses and Dissertations
Magnetic nanoparticles are used in nanotechnologies and biomedical applications, such as drug targeting, hyperthermia treatment, MRI contrasting agents, and bio-separation of compound solutions. Magnetite (Fe3O4) nanoparticles stand to be effective in these roles due to the non-toxic nature of magnetite and its strong magnetization. To this end, a greater understanding of the magnetic behavior of the individual magnetite nanoparticles is needed when a collection of them is used. This research seeks to discover the local magnetic ordering and dynamics of fluctuations of ensembles of magnetite nanoparticles at various stages of the magnetization process, throughout the superparamagnetic blocking transitions, and for …
Evaluating Adjustment And Proficiency Disparities In Virtual Reality, Mohammad Jahed Murad Sunny
Evaluating Adjustment And Proficiency Disparities In Virtual Reality, Mohammad Jahed Murad Sunny
Theses and Dissertations
The rapid integration of VR in various application domains necessitates a deeper understanding of how levels of user experience impact user performance and task efficiency. This study investigates the relationship between experience with VR, expertise in 3d computer gaming, and physiological skills across multiple performance metrics, such as task-completion time, task load, accuracy, manipulation speed, and related spatial requirements. In a comprehensive analysis of multiple levels of VR experience and 3d computer-game expertise, we identified key trends that indicate increased experience in both domains significantly enhances task efficiency while at the same time reduces perceived workload and improves task accuracy. …
Exposure To Zinc Oxide Nanoparticles Reveals A Death Resistance Mechanism In Dictyostelium Discoideum, Zoya Nadeem Faruqui
Exposure To Zinc Oxide Nanoparticles Reveals A Death Resistance Mechanism In Dictyostelium Discoideum, Zoya Nadeem Faruqui
Theses and Dissertations
Zinc oxide nanoparticles (ZnO NPs) are very versatile due to their multifunctional properties including unique physicochemical and antimicrobial characteristics. They are widely utilized across various fields such as biomedical, industrial fields, environmental remediation, and agriculture. Therefore, their cytotoxic effects on biological systems necessitate a deeper understanding of the cellular responses to nanoparticle exposure. This project primarily investigates the impact of ZnO NPs on the model organism Dictyostelium discoideum AX4 (social amoeba) which has not been examined before unlike a vast variety of organisms in the literature. The cytotoxic effects of ZnO NPs on Dictyostelium discoideum AX4 cells are compared with …
Mitigating Ultrasonic Attack On Drones Using Meta-Material Acoustic Resonators, Corey Thomas Churgin
Mitigating Ultrasonic Attack On Drones Using Meta-Material Acoustic Resonators, Corey Thomas Churgin
Theses and Dissertations
The purpose of this research was to reproduce ultrasonic attacks on consumer drone gyroscopes and mitigate the attacks using specifically designed meta-material acoustic resonators. Drones use a Micro Electrical Mechanical Systems (MEMS) Gyroscope for collecting flight data, due to the mechanical nature of these gyroscopes they are susceptible to being resonated at specific frequencies. For these MEMS gyroscopes the majority have a resonance frequency in the ultrasonic range, making attack imperceptible by humans. (1) A Laser Doppler Vibrometer was used to accurately measure the frequency which affects the drone’s gyroscope. (2) To mitigate the effects of the attacks acoustic resonators …
Registered Nurses' Autism Knowledge And Preparedness To Care For Autistic Patients, Bronte Elisa Weissman
Registered Nurses' Autism Knowledge And Preparedness To Care For Autistic Patients, Bronte Elisa Weissman
Theses and Dissertations
Autistic individuals frequently report negative experiences during healthcare interactions and numerous provider-level barriers to accessing quality care, including stereotyping, perceived lack of autism knowledge, challenges with communication, and insufficient accommodations. Reports of healthcare providers’ experiences caring for autistic patients in the U.S. have largely come from physicians, who endorse inadequate training, resources, and practical guidelines. Although patients spend far more time with nurses than other healthcare providers, registered nurses (RNs)’ perspectives on caring for autistic patients in the U.S. are largely unknown and autism-focused trainings for nurses are minimal. In the current study, a survey was nationally disseminated to a …
Detailed Modelling And Analysis Of A Shake Table Comprising Hybrid Actuation And Load-Balancing Mechanism, Xavier Reni Prasad
Detailed Modelling And Analysis Of A Shake Table Comprising Hybrid Actuation And Load-Balancing Mechanism, Xavier Reni Prasad
Theses and Dissertations
Catastrophic earthquakes endanger human lives by severely damaging critical infrastructure such as nuclear plants, bio-laboratories, and bridges. Developing earthquake-resistant structures is vital to mitigate these risks. Shake tables replicate recorded earthquake ground motions to assess structural performance. This research presents a novel three-legged, six degrees of freedom (6-DOF) hybrid shake table with a cost-effective design and decoupled motion control, offering a viable alternative to conventional six-legged models.
This architecture effectively decouples actuator motions by employing hydraulic actuators for 3-DOF spatial movement and electromechanical actuators for 3-DOF planar motion. Servo-hydraulic actuators support the static payload against gravity, while lightweight electromechanical actuators …
Hindcasting The Occurrence Time Of Major Earthquakes Using Machine Learning And Time Series Analysis, Rubidha Devi D
Hindcasting The Occurrence Time Of Major Earthquakes Using Machine Learning And Time Series Analysis, Rubidha Devi D
Theses and Dissertations
An earthquake is an intense shaking of the ground that typically occurs when tectonic plates move beneath the surface of the Earth. Scientists analyze historical seismic records and geophysical and atmospheric signs to build models estimating the probability of major earthquakes by detecting patterns and anomalies in data such as ground deformation and seismic waves. This study would help in predicting earthquakes to minimize risks of people and buildings.
The present study investigates the devastating earthquakes along the Chilean subduction zone in South America, linking non-seismic data to machine learning predictions of Outgoing Longwave Radiation (OLR) and Relative Humidity (RH) …
Encountering And Mitigating Selfish Mining In Bitcoin Mining Pools, Jeyasheela Rakkini M J
Encountering And Mitigating Selfish Mining In Bitcoin Mining Pools, Jeyasheela Rakkini M J
Theses and Dissertations
Blockchain, an innovative decentralized distributed, disrupting programming paradigm embodies key principles such as decentralization, data provenance, immutability, and transparency. At its core blockchain begins with the genesis block and progresses with each subsequent block containing the hash of the previous block, Merkle root, timestamp, a coin base transaction address, and a nonce. Miners compete to discover a target hash value (hash value of the previous block and nonce) for the current block, that is less than or equal to the difficulty value set by the system, a process known as mining.
This work encounters selfish mining attacks in bitcoin mining …
Impact Of Ionic Liquids On The Treatment Of Various Derivatives Of Prosopis Juliflora For Removing Toxic Pollutants From Wastewater, Karthikeyan A
Impact Of Ionic Liquids On The Treatment Of Various Derivatives Of Prosopis Juliflora For Removing Toxic Pollutants From Wastewater, Karthikeyan A
Theses and Dissertations
Water resources are increasingly contaminated by toxic pollutants, particularly industrial effluents, posing significant environmental concerns. Addressing the toxicity of these pollutants, especially those released from textile industries, presents challenges due to their harmful effects on living organisms. Various treatment methods are employed to mitigate this issue, including coagulation, flocculation, membrane filtration, photocatalytic degradation, adsorption, anaerobic processes, and chemical oxidation. Among these, adsorption emerges as an effective and economical method due to its minimal secondary contamination, negligible sludge production, and the use of inexpensive agricultural and marine waste materials.
This study examines the ability of Prosopis juliflora treated with imidazolium-based ionic …
Artificial Intelligence-Based Adaptive Data-Driven Techniques For Disruption Prediction In Tokamak, Priyanka M
Artificial Intelligence-Based Adaptive Data-Driven Techniques For Disruption Prediction In Tokamak, Priyanka M
Theses and Dissertations
Tokamaks are nuclear fusion reactors designed to generate sustainable energy by confining plasma, yet plasma disruptions remain a major obstacle as they can damage reactor components and interrupt fusion reactions. Addressing this challenge requires reliable models that can classify plasma discharges and predict disruptions in advance. This thesis develops machine learning and deep learning approaches to improve both classification and forecasting.The first contribution is a semi-supervised active learning framework, Nearest Margin-Ranked Batch Mode Active Learning (NM-RBMAL), integrated with an ensemble model.
Unlike traditional classifiers that operate on static training data, this approach continuously adapts to new plasma conditions, reducing model …
Design And Investigation Of Deep Eutectic Solvent-Assisted Extractive Fermentation Of Biomolecules, Ramya M
Design And Investigation Of Deep Eutectic Solvent-Assisted Extractive Fermentation Of Biomolecules, Ramya M
Theses and Dissertations
The increasing demand for sustainable and efficient bioprocessing techniques has prompted the development of novel separation strategies integrating bioproduction with downstream processing. Extractive fermentation has emerged as a promising process intensification to overcome product inhibition and enhance productivity by constantly removing target biomolecules from the fermentation medium. Although the extractive fermentation of acids and alcohols has been extensively studied, less attention has been focused on green solvents and their compatibility, phase-forming abilities, and reactor configurations.
Therefore, advancing extractive fermentation technology necessitates comprehensive studies on solvent systems and the development of modified bioreactor configurations to aid future optimization. Initially, 22 DESs …
Fabrication Of Protein-Based Nanomicelle Against Inflamed Synoviocytes In Rheumatoid Arthritis, Madhumithra Thangadurai
Fabrication Of Protein-Based Nanomicelle Against Inflamed Synoviocytes In Rheumatoid Arthritis, Madhumithra Thangadurai
Theses and Dissertations
Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovial inflammation, progressive cartilage and bone destruction, and systemic complications. 1% of the global population are affected by RA, when their immune system targets synovial tissues, leading to joint pain, swelling, and functional disability. Standard treatments, such as disease-modifying antirheumatic drugs (DMARDs) like methotrexate (MTX), are limited by systemic toxicity and inconsistent patient responses, highlighting the need for improved therapies. This research work explores protein-glycosaminoglycan nanomicelles engineered using Zein with Chondroitin or carboxymethylated Dextran Sulfate as targeted drug delivery vehicles for RA.
MTX was encapsulated within these nanomicelles to …