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Role Of Fyn And Lyn In Igg-Mediate Immune Responses, Yves Falanga Jul 2012

Role Of Fyn And Lyn In Igg-Mediate Immune Responses, Yves Falanga

Theses and Dissertations

Anaphylaxis is a rapid, life-threatening hypersensitivity reaction. Until recently, it was mainly attributed to histamine released by mast cells activated by allergen crosslinking (XL) of FcεRI-bound allergen-specific IgE. However, recent reports established that anaphylaxis could also be triggered by basophil, macrophage and neutrophil secretion of platelet activating factor subsequent to FcγR stimulation by IgG/Ag complexes. I have investigated the contribution of Fyn and Lyn tyrosine kinases to FcγRIIb and FcγRIII signaling in the context of IgG-mediated passive systemic anaphylaxis (PSA). I found that mast cell IgG XL induced Fyn, Lyn, Akt, Erk, p38 and JNK phosphorylation. Additionally, IgG XL of …


Behavioral Phenotyping Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Drug Clozapine In 129s2/Hsv Mice, Kevin Webster Jul 2012

Behavioral Phenotyping Of The Discriminative Stimulus Properties Of The Atypical Antipsychotic Drug Clozapine In 129s2/Hsv Mice, Kevin Webster

Theses and Dissertations

The 129S2 inbred mouse strain is often used as a background strain in the production of genetically altered mice (i.e. knockout and transgenic mice). It is important to establish the behavioral phenotype of wild-type mice before making comparisons to genetically altered mice. Also, those comparisons can assist in the evaluation and interpretation of the in vivo effects of drugs. The drug discrimination assay measures the subjective effects of drugs and provides a measure of underlying neuropharmacological mechanisms responsible for the discriminative stimulus properties of drugs. The present study established the atypical antipsychotic drug clozapine as a discriminative stimulus in male …


Relationship Of Demographic Characteristics And Bmi With Health Literacy In Pacific Islander Care-Giving Adults, Sharla E. Morgan Jul 2012

Relationship Of Demographic Characteristics And Bmi With Health Literacy In Pacific Islander Care-Giving Adults, Sharla E. Morgan

Theses and Dissertations

Purpose: Health literacy and obesity are major global issues. Vulnerable populations, such as those with low health literacy, have the highest rates of obesity. Native Hawaiian and other Pacific Islander (NHOPI) nations have the highest prevalence of obesity in the world. This study describes the relationship between health literacy and demographic variables in a sample of NHOPI caregiving adults. Methods: We conducted a correlational study of 364 NHOPI adults. Each was a caregiver of at least one NHOPI child. Data were collected at grocery stores and a preschool in two Hawaiian Islands (n=209) and at NHOPI events in Utah (n=155). …


The Relationship Between Select Demographic Characteristics And Body Mass Index Among Native Hawaiian And Other Pacific Islander Caregiving Adults, Katrina Duncan Jul 2012

The Relationship Between Select Demographic Characteristics And Body Mass Index Among Native Hawaiian And Other Pacific Islander Caregiving Adults, Katrina Duncan

Theses and Dissertations

Purpose: Native Hawaiian and other Pacific Islanders (NHOPIs) have the highest prevalence of overweight and obesity in the world. This study identified the proportion of our NHOPI sample in each body mass index (BMI) category and explored relationships between demographic characteristics and BMI. Design: This descriptive correlational study included 364 NHOPI caregiver adults in Utah (n=155) and Hawaii (n=209). We gathered demographic information with a questionnaire. Height and weight were measured for BMI calculations. Results: According to the CDC's BMI categories, 84.3% of our sample was overweight (BMI=25.0-29.9) or obese (BMI ≥30). Participants in Utah had significantly higher BMIs than …


Cohort Membership, Dental Insurance And Utilization Of Dental Services In Adults Age 47 And Over Receiving Dental Care At Virginia Commonwealth University’S School Of Dentistry, Patricia Brown Bonwell Jun 2012

Cohort Membership, Dental Insurance And Utilization Of Dental Services In Adults Age 47 And Over Receiving Dental Care At Virginia Commonwealth University’S School Of Dentistry, Patricia Brown Bonwell

Theses and Dissertations

This cross-sectional, non-experimental study evaluates associations between cohort membership, type of dental coverage, and utilization of dental services in all patients age 47 and over who received dental care at Virginia Commonwealth University’s (VCU) School of Dentistry in 2011. Structural Lag Theory poses that society’s institutions lag behind the actuality of a healthy and capable older adult population. The two dynamisms of the Structural Lag Theory were used for this study. The Dynamism of Changing Lives is represented by Cohort differences. Cohort differences include cohort size, people living longer and retaining more of their natural teeth along with different attitudes …


Development And Comparison Of Risk-Adjusted Models To Benchmark Antibiotic Use In The University Healthsystem Consortium Hospitals, Omar Moh'd Musa Ibrahim Jun 2012

Development And Comparison Of Risk-Adjusted Models To Benchmark Antibiotic Use In The University Healthsystem Consortium Hospitals, Omar Moh'd Musa Ibrahim

Theses and Dissertations

Background. Infectious diseases societies recommend that hospitals risk-adjust their antimicrobial use before comparing it to their peers, a process called benchmarking. The purpose of this investigation is to apply and compare 3 risk-adjustment procedures for benchmarking hospital antibacterial consumption (AbC). Two standardization of rates procedures, direct and indirect standardization, are compared with one another as well as with regression modeling. Methods. Total aggregate adult AbC for 52 systemic antibacterial agents was measured in 70 hospitals that subscribed to the University HealthSystem Consortium Clinical Resource Manager database in 2009 and expressed as days of therapy (DOTs) per either 1000 patients days …


The School-Based Family: Coaches And Teachers As Parental Figures For Orphans And Vulnerable Children In Ugandan Schools, Angela Warren Jun 2012

The School-Based Family: Coaches And Teachers As Parental Figures For Orphans And Vulnerable Children In Ugandan Schools, Angela Warren

Theses and Dissertations

The purpose of this study was to qualitatively examine the possible formation of surrogate families within Ugandan schools to provide a context for positive development experiences, especially for orphans who lack positive development opportunities provided by parents. The sample for this study consisted of 66 Ugandan Secondary School students from eight schools in the Mukono district of Uganda. This study found a potentially widespread family formation pattern between students and their teachers/coaches. More than 75% of students self-identified their teacher and/or coach as family. The results provide insight concerning why orphans and vulnerable children are forming surrogate families with staff …


An Agent Based Model Of Tumor Growth And Response To Radiotherapy, Nicole O'Neil May 2012

An Agent Based Model Of Tumor Growth And Response To Radiotherapy, Nicole O'Neil

Theses and Dissertations

An agent based model was developed to examine the growth of a tumor in a healthy cell population. Response to radiation and impact of mutation and bystander effects were studied. In the growth model, the cancer cells proliferated outward becoming invasive. The mass of cancer cells developed a necrotic core. Various treatment protocols of radiation were compared. Timing of treatments was critical to the success of therapy. The event of mutation was rare. When mutation occurred, either unsuccessful treatment or re-growth could result. Multiple rounds of radiation potentially led to increased mutation. Low levels of the bystander effect had little …


The Effects Of Aspirin And Cyclosporine On Canine Platelet Function And Cyclooxygenase Expression, John Metcalfe Thomason May 2012

The Effects Of Aspirin And Cyclosporine On Canine Platelet Function And Cyclooxygenase Expression, John Metcalfe Thomason

Theses and Dissertations

Immune-mediated hemolytic anemia (IMHA) is one of the most common causes of anemia in dogs. Despite aggressive therapy, there is a 50% mortality rate in IMHA patients, and the most common cause of death is thromboembolic disease, particularly pulmonary thromboembolism. With the high thromboembolism rate in dogs with IMHA, anti-platelet therapy with aspirin can be a life-saving preventative therapy. Along with anti-platelet therapy, immunosuppressive therapy is needed to decrease erythrocyte destruction. Cyclosporine has become a popular medication for immunosuppression in IMHA patients. Unfortunately, recent human reports have suggested that cyclosporine could activate platelets and contribute to a hypercoagulable state. With …


Roles Of Vitamin D And Calcium In Cancer And Diet History Of Vitamin D And Calcium In Cancer Patients And Participants Without Cancer, Gwendolyn Mcneely Howard May 2012

Roles Of Vitamin D And Calcium In Cancer And Diet History Of Vitamin D And Calcium In Cancer Patients And Participants Without Cancer, Gwendolyn Mcneely Howard

Theses and Dissertations

Vitamin D and calcium play major roles in our bone health in addition to roles in tissues and cells. These roles in tissues and cells are associated with some cancers. The purpose of this study was to determine attitudes of cancer patients towards their dietary intakes of vitamin D and calcium. A questionnaire was completed by 128 volunteers (mean age=53.5 years±16.6, 94 women, 34 men) from the Montgomery Cancer Clinic in Montgomery, Alabama. Cancer-reporting participants (n=59) were likely to agree more (p=0.048) to the statement, “I try to eat healthy every day” compared to non-cancer reporting participants (n=69) on a …


Salmonella Source And Rate Of Colonization In Two Newly Constructed Commercial Broiler Houses And The Effect Of Used Litter Inoculation In A New House, Lauren Elizabeth Dodds May 2012

Salmonella Source And Rate Of Colonization In Two Newly Constructed Commercial Broiler Houses And The Effect Of Used Litter Inoculation In A New House, Lauren Elizabeth Dodds

Theses and Dissertations

The prevalence of Salmonella within poultry environments and on poultry products has been well documented. However, there has not been a study documenting the effect of utilizing used litter in newly constructed commercial broiler houses on Salmonella status or on the rate and source of Salmonella contamination within new houses. Objectives of this study are to 1) determine environmental source and rate of Salmonella spp. colonization in two newly constructed broiler houses 2) to evaluate the effect of mixing used broiler litter with clean litter in a new broiler house. Results of this study suggest that Salmonella contamination of the …


Description Of Spatial And Temporal Water Quality And Nitrogen Dynamics In A Split-Pond Aquaculture System, Andrew William Mcdonnell May 2012

Description Of Spatial And Temporal Water Quality And Nitrogen Dynamics In A Split-Pond Aquaculture System, Andrew William Mcdonnell

Theses and Dissertations

Production limits have been maximized in earthen pond (EP) aquaculture. Pond design innovations may increase limits of catfish production by enhancing nitrogen processes. The split-pond system (SPS) partitions a pond into fish (20%) and waste treatment/oxygen production compartments (80%). In 2010, an SPS and EP were stocked (March) and harvested (October) with 25,000 catfish ha-1. Water quality (DO, pH, temp, ORP, CHL-a), nitrogen dynamics (TN, TAN, NO2-, NO3-), nitrogen pathway estimation, and nitrogen budgets were compared. In the waste treatment compartment, maximum DO concentrations exceeded 40 mg L-1, whereas ORP values provided favorable denitrification conditions. October EP NO2- concentrations were …


Population Based Model Of Gonorrhea And Interventions Against Increased Antibiotic Resistance, Courtney Henry May 2012

Population Based Model Of Gonorrhea And Interventions Against Increased Antibiotic Resistance, Courtney Henry

Theses and Dissertations

Gonnorrhea is an infectious sexually transmitted disease (STD) caused by the bacterium Neisseria gonorrhoeae that commonly reproduces in the reproductive tract.The Centers of Disease Control and Prevention (CDC) estimate that more than 700,000 individuals in the U.S. contract new gonorrheal infections per year. During recent years, there has been a progressive global increase of drug-resistant strains of gonorrhea. Therefore, there exists the necessity for health organizations to encourage the monitoring, research and development of innovative treatment regimens. We have developed multiple mathematical models to explore the gonorrheal disease state. The first objective of model formulation was to fit the model …


Expression Of Foreign Genes In The Pseudomonas Bacteriophage Pf3, Krystin Weathers May 2012

Expression Of Foreign Genes In The Pseudomonas Bacteriophage Pf3, Krystin Weathers

Theses and Dissertations

Filamentous bacteriophages were engineered to express foreign genes with the ultimate purpose of displaying transmission control anti-malarial peptides as in phage display. It was hypothesized that expression of foreign genes would be possible using the phage’s promoters. This hypothesis was tested by assuming that promoters for the phage major coat protein (MCP) gene would also promote the expression of any foreign gene inserted downstream of the MCP gene. As proof of principle, the bacteriophages Pf3, Pf1, and M13 were engineered in this way to successfully synthesize Enhanced Green Fluorescent Protein (EGFP). Type 88 phage display on the EGFP recombinant Pf3 …


Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan Apr 2012

Engineering Of Polyamidoamine (Pamam) Dendrimers For Gene And Drug Delivery, Quan Yuan

Theses and Dissertations

Dendrimers are a class of polymers with a highly branched, three-dimensional architecture composed of an initiator core, several interior layers of repeating units and multiple surface groups. They have been recognized as the most versatile compositionally and structurally controlled nanoscale building blocks throughout the fields of engineering, materials science, chemistry, and biology, and they have been widely investigated for drug and gene delivery. Polyamidoamine (PAMAM) dendrimers have inherent properties for gene delivery because of their high buffering capacity, polycationic surface and numerous surface groups for biofunctionlization. This dissertation is organized into four independent sections. The first section investigates a series …


Semi-Interpenetrating Nanofiber Scaffolds For Transbuccal Drug Delivery, Donald Aduba Jr. Apr 2012

Semi-Interpenetrating Nanofiber Scaffolds For Transbuccal Drug Delivery, Donald Aduba Jr.

Theses and Dissertations

The oral buccal mucosa is a promising absorption site for drug administration because it is permeable, highly vascularized and allows ease of administration. Although there are many platforms that have been used for drug delivery, nanofiber scaffolds as a platform for local or systemic drug delivery through the oral mucosa have not been fully explored. In this thesis, we fabricated a biocompatible electrospun gelatin nanofiber scaffold for local drug delivery at the oral mucosa. To stabilize the electrospun gelatin nanofibers and allow non-invasive incorporation of therapeutics into the scaffold, photo-reactive polyethylene-glycol (PEG)-diacrylate was employed to crosslink the scaffold to form …


Assessing The Genotoxicity Of Triclosan In Tadpoles Of The American Bullfrog, Lithobates Catesbeianus., David Emery Apr 2012

Assessing The Genotoxicity Of Triclosan In Tadpoles Of The American Bullfrog, Lithobates Catesbeianus., David Emery

Theses and Dissertations

Amphibians are particularly sensitive to environmental degradation and, therefore, serve as effective environmental quality indicators. Research has suggested that amphibian declines are exacerbated by manmade environmental toxicants, especially those found in high concentrations in urban areas. The NIH has pinpointed genotoxicity as a major route of cancer causation, and has since developed stringent testing procedures for potentially hazardous chemicals. One such method, recognized for its simplicity and economy, is the micronucleus assay. A study was conducted assessing the genotoxicity of the widely used antimicrobial agent Triclosan to American Bullfrog tadpoles. Lithobates catesbeianus tadpoles were reared in glass aquaria containing ultra-high …


The Effectiveness Of Visual Aids In Motivational Counseling On Oral Health Literacy, Christian Peck Apr 2012

The Effectiveness Of Visual Aids In Motivational Counseling On Oral Health Literacy, Christian Peck

Theses and Dissertations

Purpose: The purpose of this study is to determine if motivational interviewing with written/illustrated infant oral health education provided to caregivers of pediatric dental patients increases caregivers’ oral health literacy compared to verbal only motivational instruction. Methods: This is a cohort study of caregivers and their child receiving oral health anticipatory guidance utilizing motivational interviewing with and without visual aids. Caregivers (N=20) of pediatric dental patients age 0-4 that presented to the Virginia Commonwealth University School of Dentistry for a new patient exam were recruited for the study. Caregivers were randomly assigned into 2 groups: the intervention group (IG), and …


Effect Of Local Anesthesia On Postoperative Pain With General Anesthesia, Belinda Campbell Apr 2012

Effect Of Local Anesthesia On Postoperative Pain With General Anesthesia, Belinda Campbell

Theses and Dissertations

Purpose: The aim of this study was to determine if the use of local anesthesia with general anesthesia results in less postoperative pain. The alternative hypothesis is that children will experience less postoperative discomfort when utilizing intraligamental local anesthetic during the intra-operative time period. Methods: Patients were recruited for this single blind, randomized, prospective cohort study with the following inclusion criteria: English speaking children age 3-6 years, ASA I/II requiring general anesthesia for dental treatment. Randomization was done to place patients in groups of no local anesthetic vs. local anesthetic administration. A Wong-Baker Faces Pain Scale was utilized to evaluate …


Exploring The Social Determinants Of Sexually Transmitted Disease And High-Risk Sexual Behaviors, River Pugsley Apr 2012

Exploring The Social Determinants Of Sexually Transmitted Disease And High-Risk Sexual Behaviors, River Pugsley

Theses and Dissertations

Abstract 1: A multi-level assessment of disproportionate population sex ratios and high-risk sexual behaviors among STD clinic patients Low male-to-female sex ratios in a population may influence high-risk sexual behaviors, such as multiple sex partners and inconsistent condom use, which facilitate the transmission of STDs. This study used multi-level modeling to assess whether population sex ratios were associated with these two individual-level behaviors. All analyses were stratified by gender. Interview data were collected from patients (N = 9,203, 48% male) attending participating STD clinics. Interviews included information on socio-demographics and sexual behavior, including number of sex partners in the previous …


Characterization Of Truncated Yscf: Innate Immune And Proinflammatory Responsiveness, Melody N. Toosky Apr 2012

Characterization Of Truncated Yscf: Innate Immune And Proinflammatory Responsiveness, Melody N. Toosky

Theses and Dissertations

Yersinia pestis, the causative agent of plague, is a highly pathogenic gram negative bacterium that attenuates the host immune response by translocating effector proteins, known as Yops, directly from the bacterial cytoplasm into the eukaryotic cell cytoplasm using a Type III secretion system. The Type III secretion system uses a polymerized needle to translocate Yops into the eukaryotic cell. This self-polymerizing needle is composed of YscF. YscF has been tested as a possible vaccine alternative to other subunit vaccines. Wild type YscF has been previously shown to provide a low amount of protection against challenge with Y. pestis. The focus …


Demand For Sanitation And Hygiene In Rural Households In Cameroon: Case Of And Njinikom Village, Irin A. Njuakom Apr 2012

Demand For Sanitation And Hygiene In Rural Households In Cameroon: Case Of And Njinikom Village, Irin A. Njuakom

Theses and Dissertations

Inadequate sanitation and hygiene remain a major health concern in the world today with ill effects that are particularly debilitating in developing nations. Preventable diseases related to poor sanitation (inadequate human waste disposal) and lack of hygiene are estimated to kill some 3900 children daily and are the leading causes of increasing morbidity and mo1iality among the poor in the world. The issue of inadequate sanitation and hygiene has been construed as a problem of the poor. ln the impoverished village of Njinikom in Cameroon, the lack of access to basic sanitation and hygiene is apparent in the practice of …


Humanized Mice As A Model To Study Human Viral Pathogenesis And Novel Antiviral Drugs, Freddy Mauricio Sanchez Tumbaco Feb 2012

Humanized Mice As A Model To Study Human Viral Pathogenesis And Novel Antiviral Drugs, Freddy Mauricio Sanchez Tumbaco

Theses and Dissertations

Animal models have greatly contributed to the understanding of different aspects of human biology, as well as a variety of human-related pathogens and diseases. In order to study them, humanized mice susceptible to pathogens that replicate in human immune cells have been developed (e.g., humanized Rag2-/-γc-/- mice). These animals are engrafted with human hematopoietic stem cells (HSCs), resulting in the de novo development and maturation of the major functional components of the human adaptive immune system and the production of a variety of human cell types. Primary and secondary lymphoid organs in the mouse are populated with human cells, and …


Biomolecular Mechanisms And Functional Characterization Of Nanomaterials In Programmed Cancer Cell Death For Potential Applications In Medicine, Biomedical Sciences, And Bioengineering, Md. Zakir Hossain Feb 2012

Biomolecular Mechanisms And Functional Characterization Of Nanomaterials In Programmed Cancer Cell Death For Potential Applications In Medicine, Biomedical Sciences, And Bioengineering, Md. Zakir Hossain

Theses and Dissertations

Cancer bionanotechnology is an interdisciplinary area of research in applied biosciences, biomedical engineering, and nano-medicine. Currently, apoptotic cell death inducers and regulators are considered to have significant potential for cancer therapy. The ability to escape apoptosis is one of the key properties of human cancer. Pancreatic cancer that has the highest fatality rates of all cancers is prompt to evade apoptosis. Nanomaterials like Ni NWs have various novel properties that could be very useful in bio-medical applications at the molecular and cellular levels. The overall objective of this research was to investigate the antiproliferative and apoptogenic properties of Ni NWs …


The Impact Of Conflict Type On Child And Infant Mortality Rates: Evidence From Global Data, Ubah Abdulgani Adan Feb 2012

The Impact Of Conflict Type On Child And Infant Mortality Rates: Evidence From Global Data, Ubah Abdulgani Adan

Theses and Dissertations

Wars kill, destroy, cause havoc and leave lasting impacts on the societies affected. Infants and children are particularly susceptible to these shocks. This thesis looked at whether there is a differential impact across different types of war (civil and international) on child mortality rates among children in different age groups (neonatal, post neonatal, infant, ages 1-5, and under-5). An unbalanced dynamic panel dataset, from 155 countries covering a period of 30 years (1970-1999) was used in this analysis. The empirical results showed that international war contributed more to the rise of neonatal mortality than did civil war. Conversely, civil war …


African/Black Psychology: A Qualitative Investigation Of Distinguished Black Psychologists, Nichole J. Mckenzie Jan 2012

African/Black Psychology: A Qualitative Investigation Of Distinguished Black Psychologists, Nichole J. Mckenzie

Theses and Dissertations

Over the past 40 years, researchers have made numerous attempts to document and expand upon the literature surrounding the development of African/Black psychology. Yet little is known about the contextual factors that might have influenced individual decisions to become involved in the movement. This study examined the early life experience of 13 Black psychologists whose autobiographies were published in Robert Williams (2008) book, History of the Association of Black Psychologists: Profiles of Outstanding Black Psychologists. Data for this study were analyzed utilizing a qualitative research approach. Themes that arose from the analysis included: (a) direct exposure/awareness of oppressive social, political, …


Predictors Of Carbapenem Resistant Gram-Negative Bacteria In A Consortium Of Academic Medical Center Hospitals, Mera Ababneh Jan 2012

Predictors Of Carbapenem Resistant Gram-Negative Bacteria In A Consortium Of Academic Medical Center Hospitals, Mera Ababneh

Theses and Dissertations

Background: Gram-negative resistance is a growing problem worldwide. It is generally believed that rates of resistant bacteria within a hospital are a function of antibiotic use, resistant organisms brought into the hospital, infection control efforts, and underlying severity of patient illness. The relative contribution of each to a particular resistance phenotype is unclear. P. aeruginosa is responsible for many hospital acquired infections and it may become resistant to carbapenems. In addition, newer threats to the future utility of the carbapenems are carbapenemase-producing K. pneumoniae Purpose: To determine if there is an association between the volume and composition of antibiotic use, …


Psychology And People Living With Hiv/Aids: A Critical Review Of The Literature, David Fischer Jan 2012

Psychology And People Living With Hiv/Aids: A Critical Review Of The Literature, David Fischer

Theses and Dissertations

The implications of living with Human Immunodeficiency Virus (HIV) have evolved over the last 30 years. The view of HIV infection as an imminent death sentence has largely disappeared. From a practical perspective, HIV positive status is now medically treated as a chronic illness rather than as a terminal diagnosis. In response, the focus of psychological research and therapeutic practice has evolved to reflect the changing implications of living with HIV. This study documents how psychological literature regarding people living with HIV has changed over the course of the epidemic.


Biophotonic Imaging As A Novel Approach To Study Infectious Diseases In The Bovine, Jaime E. Curbelo Rodríguez Dec 2011

Biophotonic Imaging As A Novel Approach To Study Infectious Diseases In The Bovine, Jaime E. Curbelo Rodríguez

Theses and Dissertations

Conventional bacteriological methods to establish bacterial burden and distribution in infected tissues in vivo animal models typically require extensive bacteriological procedures and therefore are time consuming. An alternative approach has been suggested to use optical markers, such as luciferases, to labeled pathogens and monitor their progress and distribution in real time. The objective of the work presented in this document was to validate the use of Biophotonic Imaging (BI) through in vitro studies as a first step toward the development of in vivo models to study infectious disease in the bovine. For example, the feasibility of detecting bioluminescent Escherichia coli …


Response To And Recovery From Endotracheal Suctioning In Preterm Infants Using Routine Versus Four-Handed Care, Sharon Cone Dec 2011

Response To And Recovery From Endotracheal Suctioning In Preterm Infants Using Routine Versus Four-Handed Care, Sharon Cone

Theses and Dissertations

Neonatal Intensive Care Units have experienced profound advances in technology and treatment modalities over the last two decades. Infants born at the edge of viability are now surviving despite prolonged hospitalizations. These infants born preterm are prone to a high degree of stress from life sustaining and routine interventions. Much focus has been directed toward addressing noxious environmental factors such as noise, light, and infectious disease; however, little has been done to examine the stress experienced by the professional caregiver who work in these environments. Environmental press theory, which focuses on the interplay between human beings and their surroundings, is …