Digital Commons Network^™

Experiences Of Stigma, Social Support, And Anxiety In People Living With Hiv In South Carolina, Sarah J. Miller

Theses and Dissertations

People living with HIV (PLHIV) experience numerous psychosocial stressors, including HIV-related stigma and heightened prevalence of mental health disorders such as depression, substance use disorders, and anxiety. However, limited research has investigated predictors of anxiety within this population. This study aimed to explore the relationship between HIV-related stigma and anxiety symptoms among PLHIV in South Carolina (SC) and to examine the role of social support as a mediator for this relationship. A total of 402 PLHIV receiving HIV care at large immunology center in SC completed a paper and pencil survey, reporting sociodemographic variables, as well as experiences of HIV-related …

Nutrition Facts Label Use Among U.S. Adolescents, Jennifer Beth Mandelbaum

Theses and Dissertations

Despite the promise of Nutrition Facts label (NFL) use as a population-level intervention with broad reach, few studies have examined determinants of adolescents’ NFL use, and how this label use may be associated with nutrition behaviors. This study used data from the International Food Policy Study, an online cross-sectional survey of trends in dietary patterns and policy-relevant behaviors in the U.S. and five other countries. First, this study examined 1) whether NFL use was associated with healthy eating efforts and 2) whether there were sociodemographic differences in NFL use among U.S. adolescents. Results demonstrated that NFL use was positively associated …

Changes In The Regulation Of The Unfolded Protein Response During Aging In Peromyscus, Elham Soltanmohammadi

Theses and Dissertations

Endoplasmic reticulum (ER) stress has been linked to various metabolic pathologies, neurodegeneration, and aging. Although various mechanistic aspects of the resulting unfolded protein response (UPR) have been elucidated, its regulation in genetically diverse populations remains elusive. In the present study we evaluated the expression of chaperones BiP/GRP78, GRP94 and calnexin (CANX) in the lungs, liver, and brain of 7 months old and 2–3 years old outbred deer mice P. maniculatus and P. leucopus. Chaperones’ _expression was highly variable between species, tissues and ages suggesting that levels of expression of individual chaperones do not change consistently during aging. Despite this variation, …

Development Of Peptidomimetic Inhibitors Targeting The Polo Box Domain Of Plk1 As Potential Cancer Therapeutics, Jessy Mariam Stafford

Theses and Dissertations

PLK1 overexpression has shown to be associated with tumor progression and an unfavorable prognosis in a wide variety of cancer types. Interfering with PLK1 genetically and chemically induces apoptotic cell death in cancer cells thus confirming PLK1 as a validated anticancer target. From a drug discovery perspective, PLK1 offers two functionally distinct, essential, and interconnected target sites in one molecule. These are the ATP binding kinase domain (KD) and the unique Polo Box Domain (PBD), where the interplay between these results in dynamic structural regulation of catalytic activity and sub cellular localization. Since the KD is conserved among kinases and …

Characterization Of The Interaction Between Grx4-Bol2 And The Iron-Responsive Transcription Factor Aft1 In Candida Glabrata, Evan A. Talib

Theses and Dissertations

Iron is an indispensable protein cofactor that plays a critical role in biological functions such as cellular respiration. However, excess iron causes cellular damage via the generation of reactive oxygen species. To obtain optimal intracellular iron levels, eukaryotic cells have developed mechanisms to tightly regulate iron levels. The molecular mechanism for iron regulation in the pathogenic yeast Candida glabrata has not yet been explored, although this yeast bears iron regulation pathways that are very similar to the model yeast Saccharomyces cerevisiae. Understanding how C. glabrata regulates iron levels is critical for the treatment of infections caused by this opportunistic …

Topics In Multilevel Mediation Analysis, Chung Li Wu

Theses and Dissertations

A proper study design assures adequate power to detect statistically significant differences. Existing power calculations for multilevel mediation analysis make a strong distributional assumption of normality. However, binary outcomes are commonly seen in real-world study. Motivated by this fact, we conduct a simulation-based power study for a multilevel mediation analysis with binary outcomes. The numbers of participants needed to achieve 80% power are summarized in tables for future reference.

Mixed-effect regression is commonly used in multilevel analysis for panel data. Yet, the estimated coefficients from the random-intercept model could represent either purely between-cluster, purely within-cluster, or weighted-average effects. Therefore, we …

Identifying Racial Differences In Colorectal Polyp Profile At Screening Colonoscopy Using Traditional Regression And Machine Learning Approaches, Yuqi Wu

Theses and Dissertations

Background

Colorectal cancer (CRC), the second leading cause of cancer and cancer deaths in the United States, can largely be prevented by screening the age-appropriate adult population with colonoscopy to remove precancerous lesions. However, despite the encouraging annual, population-wide decline in CRC incidence and mortality in recent decades, and widespread adoption of screening colonoscopy since 2000 (~60% population coverage rate), the Black population has consistently suffered higher CRC incidence and mortality than Whites, currently 20% and 40% respectively, little changed from the 2000 rats of 26% and 52%.

The reason for this is thought to be that the Black population …

Analysis Of Selected Pieces Influenced By Taiwanese Aboriginal Music For Solo Violin And String Quartet, Isabel Hsin-Yi Ong

Theses and Dissertations

This is an analysis of three pieces that contribute to solo violin and string quartet repertoire through the lens of intervallic relationships, rhythmic and gestural motifs, and instrumental technique. Briefly delving into the Aboriginal history of Taiwan and illuminating aural concepts inherent within each tribe, the research blends musicological research, theoretical analysis, and intuitive performance-based interpretations to meld and expand the technical and musical possibilities of the violin with the essence and impact of these songs.

Sleep Challenges And Temperament Among Infants At Elevated Likelihood Of Autism Spectrum Disorder, Miranda Hope Foster

Theses and Dissertations

The current study used parent report in a prospective longitudinal design to examine the relationship between early sleep difficulties and temperament among infants with an older sibling diagnosed with ASD (EL-ASIB, n = 32), those born pre-term (EL-PT, n = 24) and those with no familial history of ASD (LL, n = 28) across the first year of life. At 3, 4, 6 and 12 months, caregivers completed the Short Form of the Infant Behavior Questionnaire-Revised (IBQ-R) (Putnam et al., 2014). To understand how sleep difficulties are related to temperament, a new scale of Sleep Challenges was created with items …

Human Activity Recognition (Har) Using Wearable Sensors And Machine Learning, Chrisogonas Odero Odhiambo

Theses and Dissertations

Humans engage in a wide range of simple and complex activities. Human Activity Recognition (HAR) is typically a classification problem in computer vision and pattern recognition, to recognize various human activities. Recent technological advancements, the miniaturization of electronic devices, and the deployment of cheaper and faster data networks have propelled environments augmented with contextual and real-time information, such as smart homes and smart cities. These context-aware environments, alongside smart wearable sensors, have opened the door to numerous opportunities for adding value and personalized services to citizens. Vision-based and sensory-based HAR find diverse applications in healthcare, surveillance, sports, event analysis, Human-Computer …

“Even The Little Things Matter:” A Phenomenological Study On Factors Impacting Student Motivation During And After Covid-Related Disruptions In Education, Jennifer Ferris-Crisafulli

Theses and Dissertations

The COVID-19 pandemic brought about unprecedented disruptions in education, as schools were forced to make a rapid transition to virtual learning in March 2020. Students’ motivation seemed to decline significantly during and after this virtual learning period, which ranged from months to over a year in various areas of the United States. This study seeks to understand the factors impacting student motivation during and after this virtual learning period.

This action research study was conducted using a qualitative, phenomenological approach. Data was collected from open-ended surveys and semi-structured interviews during Spring 2021 and Spring 2022. Data was analyzed through the …

Predicting Therapists’ Intentions To Use An Innovation: The Role Of Innovation-Specific, Individual, And Organizational Factors, Jonathan KuʻUhoaepilipono Ahuna

Theses and Dissertations

Understanding factors that contribute to an individual’s decision to use an innovation can increase the public health impact of innovations in children’s mental health services. Objective. This study examined whether and to what extent therapists’ innovation-specific judgements (e.g., innovation is easy to use, socially desirable) were associated with intentions to use an innovation using constructs from one of the most robust theories of innovation use–the Unified Theory of Acceptance and Use of Technology (UTAUT). Method. Two aims were addressed using data collected from 95 therapists and 28 supervisors who participated in a multi-site cluster randomized trial. Therapists used either a …

Applications Of Machine Learning For Improved Patient Selection And Therapy Recommendations, Brendan Elochukwu Odigwe

Theses and Dissertations

The public health domain continues to battle with illness and the growing need for continuous advancement in our approach to clinical care. Individuals experiencing certain conditions undergo tried and tested therapies and medications, practices that have become the mainstay and standard of care in clinical medicine. As with all therapies and medications, they don't always work the same way and do not work for everyone. Some Treatment regimens, like Hydroxyurea medication, which is commonly administered to Sickle cell anemia patients, come with some adverse side effects due to the chemotherapeutic nature of the drug. This would be particularly disappointing if …

A Holistic Approach To Culturally Relevant Education In Biology To Examine Student Engagement, Robyn Brooke Biery

Theses and Dissertations

Recognizing that many students were disengaged in my grade-level biology class, this study sought to improve student engagement as a result of the implementation of CRE-enriched instruction and to describe themes associated with CRE and engagement. This qualitative action research study used a survey, exit tickets, and observations to discover emergent themes as a result of implementing CRE-enriched lessons. This action research study used member checking and disconfirming evidence to increase rigor and transferability. The results were that the use of CRE-enriched lessons increased the engagement of grade-level students in biology, and that engagement requires a two-pronged approach – cultural …

Achieving Sustainability In Urban Transit And High-Occupancy Vehicle Systems Through Emerging Technologies And Operations, Ruixiao Sun

Theses and Dissertations

It is critical to reduce road transportation emissions, as it is the major source contributing to greenhouse gas emissions (GHGs) and air pollution. However, the increasing travel demand due to the rise of population and economy makes the task challenging. Mathematically, road transportation emissions can be minimized in the manner of reducing total vehicle miles traveled (VMT) and lowering vehicle emission rate. Many strategies have been proven viable for achieving transportation sustainability. For example, the total VMT can be reduced by switching low-occupancy transportation modes (i.e., driving alone) to high-occupancy transportation modes (i.e., public transit, ridesharing). The development of alternative-fuel …

Exploring Mindfulness As A Social And Emotional Learning [Sel] Intervention: An Action Research Case Study, Matthew T. Griffith

Theses and Dissertations

Children appear to be faced with more stressors today than ever before, and schools are tasked with providing social and emotional support and instruction to help their students navigate life’s ups and downs. The purpose of this mixed methods action research case study was to explore the effectiveness of mindfulness-based practices as a social and emotional learning (SEL) intervention for a small group of three second grade students at a rural elementary school. These students were identified by their teacher as having weaknesses in the areas of self-control, emotional regulation, and sustained attention that required more targeted intervention than the …

An Intersectional Lens To Covid-19: Promoting Youth Well-Being In The Midst Of Social-Political Stressors, Magdalena S. Moskal

Theses and Dissertations

Guided by interpretative phenomenological methodology and intersectionality theory, this thesis aims to uncover the mental health experiences of youth surrounding the COVID-19 pandemic. This study also seeks to situate these experiences with the subsequent stressors that young people face in the current social-political context (e.g., witnessing trauma in the media, uprisings to address racism and the resulting backlash, rhetoric of the 2020 presidential election). Furthermore, this thesis aims to give insight and voice how intersectionality shapes the COVID-19-related experiences of youth in South Carolina. Data was collected through semi-structured interviews with 23 participants aged 16-21 years old in South Carolina. …

Fostering The Development Of Instructor Cultural Competence: A Mixed Methods Action Research Study, Jennifer Lilly Engle

Theses and Dissertations

The purpose of this action research study was to understand the impact purposeful professional development has on the levels of higher education instructors’ cultural competence. The training developed as an intervention for this study included two 75-minute sessions and an independent book study over a five-week period. Fourteen faculty members participated in this mixed methods study. Quantitative data was collected via pretest and posttest scores on the Cultural Intelligence Scale (CQS) and analysis of the statistical significance was performed to gauge the effectiveness of the intervention and its impact on instructors’ cultural competence. Open-ended responses from participants on a three-item …

Peromyscus Maniculatus Bairdii And Peromyscus Maniculatus Sonoriensis Polymorphisms, Matthew Dixon Lucius

Theses and Dissertations

Sequencing technology has advanced greatly over the past couple of decades. This has led to many studies developing hypotheses based on genomic data. This requires many genomic studies to have up-to-date information on the species’ or subject’s genome being investigated. If a study does not have accurate or up-to-date background information, then they cannot fully develop their theories that are being established. In this study, I utilize outbred Peromyscus maniculatus, deer mice that are genetically diverse, to record the polymorphisms that are found throughout the Peromyscus maniculatus genome. I first explore the differences between the polymorphisms found in Peromyscus …

Too Feminine For Execution?: Gender Stereotypes And The Media’S Portrayal Of Women Sentenced To Death, Kelsey M. Collins

Theses and Dissertations

Traditional gender norms prescribing women as more nurturing and less aggressive than men have led to both the reluctance to view women as capable of violence, as well as a greater willingness to execute men than women in the United States. To make sense of the instances where women are sentenced to death, the media often pathologizes and/or demonizes them. Scholars have found that demonizing and dehumanizing those executed is a necessity to the implementation of capital punishment, both in cases of male and female defendants. To better understand how the news media have framed the gender and racial narratives …

Genomic Analysis Workflows To Identify Mutational Signatures And Structural Variations In Ovcar8 Cells And Rad51d-Deficient Mouse Embryonic Fibroblasts, Manli Yang

Theses and Dissertations

Specific genomic profiles associated with exposure to DNA damaging agents have been identified in cancer related genes, revealing that mutational patterns can be carcinogen- specific. However, there have been limited efforts to demonstrate similar clear relationships for endogenous mutational processes. One endogenous source of mutations is contamination of the deoxynucleotide pool with damaged bases that, if incorporated into DNA, cause mutations.

The Catalog of Somatic Mutations In Cancer (COSMIC) represents an international effort to characterize mutations in cancer. A mutational signature is the pattern of mutations generated by a mutational process. Each mutational process contains two parts: DNA damage and …

Elucidating The Interdependence Of Motor-Cognitive Development And Performance, Thomas Cade Abrams

Theses and Dissertations

As the development of complex coordination and control (i.e., motor development) involves the integration of neuromotor, psychological, social, and cognitive processes (i.e., executive functions), a better understanding of how these processes are embedded and manifest across stages of development throughout the lifespan is needed. The long-term processes associated with the acquisition and development of motor competence (MC), specifically, effortful practice and performance of various locomotor and object control skills, provide direct mechanisms for contributing to executive function (EF) development via different learning-related (e.g., synaptogenesis, hippocampal neurogenesis) as well as exercise-related (e.g., exercise-mediated neurogenesis, angiogenesis) mechanisms. However, traditional MC assessments use …

Uncrewed Aircraft Systems For Autonomous Infrastructure Inspection, Michail Kalaitzakis

Theses and Dissertations

Uncrewed Aircraft Systems (UAS) are becoming increasingly popular for infrastructure inspections since they offer increased safety, decreased costs and consistent results, compared to traditional methods. However, there are still many open challenges before fully autonomous, reliable, and repeatable UAS inspections. While a UAS platform has increased mobility and can easily approach hard to reach areas, it has limited range and payload capacity and is susceptible to environmental disturbances. Therefore, current operations are limited to Visual Line of Sight (VLOS) manual inspections that usually result in just a qualitative (visual) assessment of the structure.

The objective of this work is to …

Monitoring Titanium Dioxide Engineered Particles In Rural And Urban Surface Waters, Md Mahmudun Nabi

Theses and Dissertations

Quantifying and characterizing engineered particles in environmental systems is key for assessing their risk but remains challenging and requires the distinction between natural and engineered particles. The Ph.D. dissertation research described in this thesis contributes to the current attempts to improve environmental nanoparticle analysis and better understand nanoparticle behavior in natural systems, with the focus being on natural streams, and the application of single particle inductively coupled plasma-time of flight-mass spectrometry (SP-ICP-TOF-MS) for distinguishing and tracing the origins of environmental nanoparticles. The objective of this dissertation is to characterize and quantify the concentrations of titanium dioxide engineered particles in urban …

Digital Twins In Advanced Manufacturing To Enhance Manufacturing Efficiency, Max Kirkpatrick

Theses and Dissertations

Digital Twins of manufacturing systems are an emerging tool for improvement, optimization, and monitoring of physical manufacturing systems. The idea of representing physical systems with digital depictions has been prevalent since the early days of Computer Aided Design (CAD), but recently the concept of a Digital Twin has been expanded to encapsulate more than just a digital model of a design. Instead, the Digital Twin offers a unique, comprehensive, and real-time toolset for analysis and improvement of physical systems. These tools can be used to improve system efficiency, perform “what-if” analyses, virtually commission manufacturing equipment, analyze system performance in real …

Xenobiotic Exposures On Women’S Reproductive Health, Maria Zubizarreta Mcclam

Theses and Dissertations

Environmental and chemical exposures are continually introduced into our bodies. The female reproductive cycle is complex and particularly sensitive to toxic substances. A recent rise in infertility and reproductive diseases and cancers make reproductive toxicity a public health concern. The overall purpose of this dissertation is to explore how environmental and chemical exposures impact women’s reproductive health and overall wellbeing. To do this, a variety of topics related to women’s reproductive health are explored, including how environmental exposures can impact reproduction, methods for studying reproductive dysfunctions, fertility preservation among cancer patients, and the overall wellbeing of female cancer patients.

The …

The Use Of Social Justice Socioscientific Issues In Secondary Biology Classes: An Action Research, Stephanie Marilyn Bailey

Theses and Dissertations

The U.S. Education system is founded on a Eurocentric focus of curriculum, and students of color are not achieving as high as white students on the National Assessment for Education Progress in science. This research aims to repay the education debt owed to students of color by decolonizing science curriculum through the implementation of lessons centered around socioscientific issues grounded in social justice. An action research study was implemented in which 9 ^th grade Biology students participated in three instructional units centered on social justice issues. Data was collected through surveys, focus group interviews, student work, and journal reflections from …

First-Generation Support: A Mixed-Methods Approach To Understanding Imposter Phenomenon And University Belongingness, Julia Kathryn Hodge

Theses and Dissertations

This longitudinal mixed-methods study examines first-generation students (FGS) from a new angle, using the lens of the imposter phenomenon (IP) and the impact of a support program tailored to this population. The Opportunity Scholars Program (OSP) serves low-income, first-generation in-state students. The program promotes retention for low-income FGS. It is worthwhile to evaluate whether and to what degree such a program affects IP among FGS. At the beginning and end of the fall semester, 99 OSP first-generation students, general FGS, and non-FGS completed surveys on imposter phenomenon, academic self-efficacy, and test anxiety. Following the quantitative measures, 12 first-generation students participated …

Greenspace Across The United States: Exploring Equity And Associations With Physical Activity, Obesity, And Health-Related Quality Of Life, Ellen W. Stowe

Theses and Dissertations

Neighborhood greenspace is important for health and well-being but may not be equitably present in neighborhoods across the United States. Also, many adults are physically inactive, have obesity, and report poor health-related quality of life. Greenspace has been tied to these health conditions, but with mixed findings. The purpose of this study was to 1) use an environmental justice perspective to examine variations in 11 measures of greenspace by neighborhood race/ethnicity, income, and rurality in block groups across the contiguous United States and 2) examine 11 greenspace measures in connection to physical activity, obesity, and health-related quality of life in …

Orthographic Knowledge And Phonological Awareness In Children With Speech Sound Disorder, Anna Marie Ehrhorn

Theses and Dissertations

Speech sound disorder (SSD) puts children at risk for word reading difficulties but does not guarantee them. Research on early literacy skills in children with SSD has primarily focused on phonological awareness due to speech sound deficits associated with SSD. Researchers have begun to examine multiple factors beyond phonological awareness that may impact word reading and spelling development. Orthographic knowledge is another essential factor understudied in children with SSD. Previous research has shown that orthographic properties of words influence phonological awareness performance in skilled readers and children with reading difficulties. No known previous studies have examined whether orthography influences phonological …