Digital Commons Network^™

Contribution Of Metabolic Cell Swelling On Microcirculatory Perfusion In Septic Shock, Charles E. Payne

Theses and Dissertations

Sepsis, a systemic immunological response that leads to organ-dysfunction, the development of septic shock, and death has mortality rate of 15-25%. A subset of sepsis, septic shock, has an in-hospital mortality rate of 30-50%. Sepsis and its treatment are the most expensive healthcare problem in the United States with the US Agency for Healthcare Research and Quality estimating annual costs over $20 billion. Hypoxia experienced in septic shock induces metabolic cell and tissue swelling leading to further microcirculatory dysfunction and poor tissue perfusion. Reversing metabolic cell swelling corrects these perfusion defects. Two models were used in rats to induce septic …

Combining Novel Direction Modulated Brachytherapy Tandem-And-Ovoids Applicators For Treatment Planning Of Multi-Institutional Cervical Cancer Cases: Removing Needles In Intracavitary-Interstitial Techniques, Sharmin Alam

Theses and Dissertations

Lack of standard guidelines for optimal needle insertion during high-dose-rate (HDR) intracavitary-interstitial (IC-IS) brachytherapy of the cervix means a sophisticated and technical skillset of inserting needles next to IC applicators must be developed to enhance plan quality. This study sought to evaluate the performance of two separate direction modulated brachytherapy (DMBT) tandem applicators used in conjunction with one set of novel DMBT ovoids, to effectively obviate the need for IS needles.

A cohort of 32 retrospective clinical HDR brachytherapy plans was re-planned with Varian’s BrachyVision^® treatment planning system, using VEGO^® inverse optimization algorithm, with dose heterogeneity accounted for …

Assessing The Perceived Impact Of A Local, Community-Engaged Mural Project On Preservice Art Educators In Foundational Coursework, Caitlin M. Black

Theses and Dissertations

This qualitative study merged the methodological frameworks of qualitative case study and narrative inquiry (Sonday et. al, 2020) to assess the perceived impact of a local, community-engaged mural art project (Mending Walls) on undergraduate preservice art educators in foundational coursework. The study was grounded in existing research in three areas: community-engaged murals, community-engaged pedagogy, and community-engaged teacher preparation. These concepts were used to frame the study and provide further rationale for the inquiry. The purpose of this case study was to understand how undergraduate preservice art educators perceived the impact of using a local, community-engaged mural project (Mending Walls) in …

Acculturative Stress And Quality Of Life Among Older Korean Immigrants: Do Religiosity And Resilience Matter?, Sunghwan Cho

Theses and Dissertations

The impact of acculturative stress on the quality of life among older adults has been widely acknowledged in previous literature. However, few studies have explored the role of religiosity and resilience in this relationship among older Korean immigrants. This dissertation explores the relationships between acculturative stress, religiosity, resilience, and quality of life among 300 older adults aged 65 years and over who live in an ethnic Korean enclave of Queens, New York. The study employs path analysis and multiple regression analyses to test hypothesized relationships among these variables.

The key findings of the study are as follows: (1) higher acculturative …

Wifi Sensing At The Edge Towards Scalable On-Device Wireless Sensing Systems, Steven M. Hernandez

Theses and Dissertations

WiFi sensing offers a powerful method for tracking physical activities using the radio-frequency signals already found throughout our homes and offices. This novel sensing modality offers continuous and non-intrusive activity tracking since sensing can be performed (i) without requiring wearable sensors, (ii) outside the line-of-sight, and even (iii) through the wall. Furthermore, WiFi has become a ubiquitous technology in our computers, our smartphones, and even in low-cost Internet of Things devices. In this work, we consider how the ubiquity of these low-cost WiFi devices offer an unparalleled opportunity for improving the scalability of wireless sensing systems. Thus far, WiFi sensing …

The Type Iv Pilus Secretin Bfpb: Structural Analysis And Binding Interactions, Janay I. Little

Theses and Dissertations

Enteropathogenic Escherichia coli (EPEC) causes severe diarrhea in young children. The type IV pilus (T4P) of EPEC, known as the bundle-forming pilus (BFP), plays an important role in EPEC pathogenesis. T4Ps are a family of surface appendages that are important for adhesion, colonization, biofilm formation, virulence, twitching motility and many other functions. One essential component of the BFP system is the secretin, BfpB. Secretins are a large family of integral outer membrane proteins found in T4Ps as well as type II and type III secretion systems, and filamentous phages. Details of the secretin structure have been limited to the overall …

Pms And Gas Pollutants Removal By Electret Filter Media And Metal-Organic Frameworks (Mofs), Yu Zhang

Theses and Dissertations

Indoor air quality (IAQ) has been becoming a major concern worldwide because statistical data showed that the indoor concentrations of gas pollutants, e.g., volatile organic compounds (VOCs) and particulate matters (PMs) are often 2–5 times higher than that of outdoors. Especially, people spend 87% of their time indoors and increasing to more than 90% during COVID-19 pandemic. The high concentration of these indoor air pollutants is mainly due to the reduced air exchange rate for the design of energy-efficient building construction and the increased usage of furnishings, glues, paints, furnaces, etc., leading to VOC outgassing and particle emission. Evidence has …

Using A Single Measure To Assess Adherence And Differentiation In Family Therapy For Adolescent Externalizing Problems, Stephanie Violante

Theses and Dissertations

Family therapy is considered a well-established treatment approach for adolescent externalizing problems; however, research examining its effectiveness when delivered in routine practice settings has produced mixed results. The accurate interpretation of these inconsistent results requires an understanding of what therapeutic techniques were delivered, including those that were prescribed (i.e., adherence) and those that were non-prescribed (i.e., differentiation), suggesting the need for a measure that can concurrently assess treatment adherence and differentiation. The current study examined the extent to which an observational measure of an array of therapeutic techniques for youth emotional and behavioral problems (the Therapy Process Observational Coding System …

A Longitudinal Analysis Of Academic Self-Concept Among Preclinical Medical Students, Meagan Rawls Lewis

Theses and Dissertations

Medical school plays a pivotal role in the training of future physicians. Academic Self-Concept (ASC) represents a person’s beliefs about their academic ability, and it has been documented across educational contexts as an important factor in relation to academic performance. Despite decades of research into the relationship between ASC and academic performance, this relationship remains underexplored in medical education. The purpose of this study was to examine the ASC of preclinical medical students using longitudinal data to explore both the relationship between ASC and performance and ASC throughout the preclinical phase of medical school. Survey data from three cohorts of …

Characterization Of A Solid-State Detector For Dosimetry In The Diagnostic Energy Range With Verification Via Monte Carlo Estimation Of Average Breast Dose In Mammography, Areej Aljabal

Theses and Dissertations

This dissertation aims to develop a simplified QA metric for estimating radiation dose in mammography. This metric, the Mid-Breast Dose (MDB) Index, maybe be proposed as an alternative dose index, consistent with average glandular dose (AGD), for routine QA. MBD was obtained using “Phantom mid-point Air Kerma (AK) measurement” for conventional mammography. The advantage of this method is that MBD can be measured directly without requiring multiple conversion factors. The accuracy of clinical measurements in computing the MBD was assessed by comparing it with the AGD estimated by the Dance formalism experimentally and Monte Carlo simulation.

MBD methodology relies on …

The Environment Of Interprofessional Education In Graduate Education: Exploring Professional Programs Of Occupational Therapy, Physician Assistant, And Physical Therapy, Allison R. Kaczmarek

Theses and Dissertations

Interprofessional education (IPE) is an educational approach of increasing popularity in professional schools for the preparation of a collaborative ready healthcare workforce. The accrediting bodies of professional education programs in occupational therapy (OT), physician assistant (PA), and physical therapy (PT) have incorporated standards for outcomes addressing IPE. Although they have endorsed the Health Professions Accreditors Collaborative (HPAC) consensus document on quality IPE, we do not have a contemporary snapshot of the IPE environments in the curriculum of their accredited programs. This dissertation, a collection of three distinct inquiries, has two aims: first, to provide a description of IPE as it …

Access To Hiv Prevention, Care, And Treatment Services In The Us: The Role Of Primary Care, Jessica S. Kiernan

Theses and Dissertations

This dissertation examines the role of access to primary care in benefitting HIV outcomes through increased access to HIV prevention, care, and treatment services, among populations disproportionately affected by HIV in the US. Over 30,000 individuals are newly diagnosed with HIV annually in the US and diagnoses are concentrated in specific populations. At an individual-level, ~ 70% of new diagnoses are among gay and bisexual men and of those diagnoses, 70% are among Non-Hispanic Black and Hispanic gay and bisexual men. At a community-level, over 50% of new HIV diagnoses occur in less than 2% of US counties (48), Washington, …

Natural Hazard Uncertainty Characterization And Risk Assessment For Pressurized Water Reactor Safety Based On System Level Reactor Safety Analysis Models, Tao Liu

Theses and Dissertations

Natural hazard accidents, especially the Fukushima Daiichi accident that occurred in 2011, have brought up significant safety concerns regarding the nuclear power plant (NPP) under external natural hazards. As a result, external natural hazards have been identified as one of the potentially most significant risk contributors to the core damage frequency of the NPPs, highlighting the need for a better understanding of the natural hazards and their associated uncertainties for probability risk assessments (PRAs). However, there are limited computational models and analysis tools to support the probabilistic evaluation of external hazards in PRAs, especially for natural hazards such as floods …

I. Preparation Of Strategic Synthetic Building Blocks For World Health Organization Essential Medicines. Ii. Applying The Principles Of Process Intensification To The Synthesis Of Fluoroquinolone Antibiotics., Jeffrey M. Noble

Theses and Dissertations

The synthesis of active pharmaceutical ingredients is often a time-consuming and expensive process. Due to the nature of pharmaceutical manufacturing, these costs are carried forward to the final purchase price by the consumer. Although there are many factors which are involved in the final costing of a pharmaceutical, the cost associated with the synthesis is the primary one which can be managed by chemists and engineers.

This work discusses the synthetic routes of four active pharmaceutical ingredients as well as the synthetic techniques and equipment used with an emphasis on how the application of specific techniques can be applied to …

Intrinsic Efficacy As A Determinant Of Opioid Effectiveness In Treatment Of Pain-Depressed Behavior, Edna Santos

Theses and Dissertations

Pain is a major public health concern that is commonly associated with behavioral depression, and a major goal in pain treatment is alleviation of pain-related behavioral depression. High-efficacy mu opioid receptor (MOR) agonists (e.g. fentanyl, morphine, oxycodone) are effective to treat pain, but their use is limited by side effects that not only endanger the patient but may also obscure analgesic rescue of pain-depressed behavior. The ongoing epidemic of opioid abuse and overdose deaths has stimulated research to discover non-opioid alternative analgesics; however, this search neglects the clinical potential of safer intermediate-efficacy MOR agonists (e.g. buprenorphine). The objective of the …

Variability In Causal Effects On A Binary Outcome And Noncompliance In A Multisite Randomized Trial, Xinxin Sun

Theses and Dissertations

Noncompliance to treatment assignment is widespread in randomized trials and presents challenges in causal inference. In the presence of noncompliance, the most commonly estimated effect of treatment assignment, also known as intent-to-treat (ITT) effect, is biased. Of interest in this setting is the complier average causal effect (CACE), the ITT effect among compliers. Further complication arises when the outcome variable is partially observed.

My research focuses on estimating the distribution of a site-specific CACE in a multisite randomized controlled trial (MRCT) by maximum likelihood (ML). Assuming compliance missing at random (MAR). We express the likelihood as an integral with respect …

Exploring The Role Of Institutional Culture In Student Affairs Assessment Practitioners’ Experiences Implementing Equity-Centered Assessment, Jaime L. Williams

Theses and Dissertations

Student affairs assessment is a field in higher education that emphasizes the measurement of effectiveness and student learning in student serving programs that take place outside of the classroom. Outcomes-based assessment is the basis of most assessment practices in student affairs, and focuses on the continuous improvement of out-of-classroom programs, services, and student learning. Many assessment practices stem from traditional research methods, which have been developed by people who hold mostly majority identities. These methods were not created with the rapidly changing demographics of today’s college-going students in mind. To help address the increasing diversity of college students and the …

Unraveling The Consequence Of Adult Onset Sulfatide Depletion: Its Implications In Myelin And Axonal Heath In The Context Of Neurodegenerative Disease, Elizabeth Dustin

Theses and Dissertations

Multiple Sclerosis is an immune mediated disease of the CNS. MS is diagnosed through detection of demyelinated regions. However, recent studies demonstrate that Normal Appearing White Matter (NAWM) contains substantial pathology. One such pathology observed in the NAWM is the reduction of sulfatide. The proper stoichiometry of lipids in myelin acts to maintain rapid conduction velocity, provide trophic support to the neuron, and protect the axon from degeneration. We previously characterized a mouse lacking sulfatide’s synthesizing enzyme, CST through constitutive gene disruption and demonstrate that sulfide is required for proper stability of the myelin sheath. However, since MS is typically …

Family-Based Support As Social Determinants Of Health Protective Factor On Depression Of Parents Of Children With Autism Spectrum Disorder, Bisola E. Duyile

Theses and Dissertations

All parents experience challenges in their caregiving roles (Barańczuk & Pisula, 2020). However, parents raising a child/children with disabilities experience different social barriers (Oliver, 1996) that may also contribute to additional stressors in their caregiving role (Tomeny, 2016). Although these parents, on average, have reported greater symptoms of depression than parents of typically developing children, research shows that parents who reported receiving social support had lower symptoms of depression and stress (Das et al., 2017; Singh et al., 2017). Through the social determinants of health (SDOH) framework (ODPHP, 2022), the present study investigated informal/family-based support and its protective impact on …

Black Racial Identity And Externalizing Symptoms: The Regulatory Role Of Dyadic Relationships, Sultan A. Hubbard

Theses and Dissertations

This study explored caregiver impact on Black racial identity (BRI) and externalizing through the integration of BRI, racial socialization (RS), and social support theoretical frameworks. The study used 85 Black undergraduates (Mean age =19.3, SD=3.43) who rated three caregivers, respectively. Restricted maximum likelihood estimation was conducted to estimate variance components. BRI, RS, internalizing, and externalizing variables reflected significant trait effects and dyadic effects. However, racial centrality and public regard did not reflect significant dyadic effects. Participant burden due to randomization of caregivers and items likely suppressed dyadic effects. Moreover, caregivers who evoked private regard were perceived as having high cultural …

Synthesis And Application Of Redox-Active Covalent Organic Frameworks In Rechargeable Batteries, Mohammad K. Shehab

Theses and Dissertations

Synthesis and Application of Redox-Active Covalent Organic Frameworks in Rechargeable Batteries

Mohammad K. Shehab

Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, United States

Abstract

In recent years, lithium-ion batteries (LIBs) have been considered the dominant energy storage devices for portable electronics and electric vehicles due to their high energy density, low self-discharge rate, and long cycle life. In LIBs, the traditional positive electrodes employed are mainly derived from metal-containing inorganic compounds composed of cobalt, iron, nickel, or manganese (LiCoO₂, LiMn₂O₄, and LiFePO₄) coupled with graphite as the negative electrode. Despite …

Addressing Death Distress In Caregivers Of Patients With Malignant Glioma, Kelcie D. Willis

Theses and Dissertations

The field of psychosocial oncology seeks to improve the quality of life of patients and families affected by cancer. This task becomes increasingly important when there are limited, non-curative treatment options, a high probability of recurrence, and rapid functional decline, such as in the case of a malignant glioma (MG). Indeed, the diagnosis of a MG is associated with negative sequalae that often translates to higher caregiver burden. Caregivers—who must manage the functional decline of the patient, changes within the family, and a complicated medical system—often feel overwhelmed, isolated, and ill-equipped to handle these myriad responsibilities. While they also report …

Quantitative Changes In Hippocampal Ccr5+ Microglia With The Administration Of Maraviroc (Mvc): Does Sex Matter?, Ama S. Boakye-Agyei

Theses and Dissertations

Human immunodeficiency virus type-1 (HIV-1) has been greatly studied in recent decades. Combined anti-retroviral therapy (cART), the development of drug treatments such as maraviroc, and the wider availability of support for those in resource-rich environments have been instrumental in improving the prospects of people living with HIV (PLWH). It is well- documented that PLWH can suffer from a host of cognitive deficits collectively known as HIV- associated neurocognitive disorders (HAND). Moreover, the role of biological sex in the development of HAND and other cognitive deficits is still being studied. C-C chemokine receptor type 5 (CCR5) is one of the two …

Demonstrated Sensitivity, Kate Crankshaw

Theses and Dissertations

Flameworking is a tedious process that demands all of your attention and focus. Making multiples of a shape in this process allows my body and mind to fall into a rhythm. During these times, it allows my anxious mind to be quieted and helps me dive into processing past memories, trauma, and grief. It is commonly suggested in Dialectical Behavioral Therapy practices to find an activity to do that is both physical and repetitive to work through grief. This stimulates the physical and mental parts of the body, both areas where the effects of grief and trauma are held. Relaxing …

Characterization Of Sphingosine-1-Phosphate Receptor Expression And Functionality In Niemann-Pick Type C Disease, Nathaniel-David I. Dizon

Theses and Dissertations

Niemann Pick Type C (NPC) is a recessively inherited lysosomal storage disorder for which there is currently no major treatment. It is widely acknowledged that the pathology of NPC is caused by a trafficking defect which leads to an accumulation of cholesterol in the late endosome/lysosome compartment (LE/L). In addition to cholesterol, multiple species of sphingolipids are observed to accumulate as well in the LE/L. Specifically, an accumulation of sphingosine is observed in NPC disease and is likely attributed to the decreased activity of an enzyme, sphingosine kinase 1 (SphK1), which is responsible for phosphorylating sphingosine into an important pro-survival …

Cone Beam Computed Tomographic Analysis Of Outcomes In Ridge Augmentation Using Titanium Mesh And Titanium Reinforced Ptfe Membranes, Lina Elnakka

Theses and Dissertations

Objective: The primary goal of this study is to evaluate and compare the average vertical and horizontal bone gain between titanium reinforced polytetrafluoroethylene (Ti-PTFE) and titanium mesh (Ti-mesh) using superimposition of preoperative and postoperative (CBCT). The secondary goal is to evaluate and compare the surgical outcomes between the two techniques.

Methods: A retrospective chart review was completed to assess the clinical and radiographic outcomes of patients who underwent ridge augmentation therapy using either Ti-PTFE or Ti-mesh. Preoperative and postoperative CBCT scans were superimposed using InVivo 3D imaging software. Vertical component of the augmented site (L1) was assessed along a vertical …

Practice Elements Delivered By Teachers To Support Children Who Display Challenging Behaviors In Business-As-Usual Early Childhood Settings, Navneet Kaur

Theses and Dissertations

Approximately 15-25% of children ages 3 to 5 years in early childhood settings display chronic challenging behaviors that increase their risk for developing an emotional and behavioral disorder. The early onset of emotional and behavioral disorders has long-term negative implications for these children. Therefore, it is vital to address these problems early on. One approach is through teacher-delivered practices (i.e., specific strategies, such as praise) and programs (i.e., manualized interventions that contain a collection of practices) in the classroom. Some practices and programs have shown positive outcomes for children. However, when practices and programs do not outperform business-as-usual group (BAU), …

Trans* Streamers On Twitch.Tv: The Intersections Of Gender And Digital Labor, R. Lawson

Theses and Dissertations

Twitch.tv is a live entertainment platform where individuals live stream events, including playing video games, playing board and tabletop games, creating art, and more. Twitch has a diverse base of streamers, but Twitch has just begun. The most common approach has focused on cisgender, heterosexual white men in the cases where it has been studied. Though these streamers should be studied in sociology, this focus leaves out the experiences of both cis women and Trans* streamers. This research proposal tries to situate the relationship of Trans* streamers with both the platform and their audience, seeing if these relationships affect their …

The Hepatic Immunological Pattern Shaped By Dominant-Subdominant Cellular Interactions Creates A Collective Function Beyond The Function Of Each Cellular Constituent To Orchestrate Progression Of Hepatocellular Carcinoma, Nicholas J. Koelsch

Theses and Dissertations

Abundance of data on the role of inflammatory immune responses in the progression or inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for HCC. This is largely because of taking reductionist approaches and missing the collective function of the hepatic immune system by focusing on specific immune cell types. To this end, we propose that focusing on the dominant-subdominant patterns of the immune cells would allow understanding of the mechanism by which a collective immune function emerges. To identify the collective immune function through a systems immunology perspective, we performed high-throughput analysis of snRNAseq data collected …

Interiorization And Localization: An Analysis Of Immigration Enforcement In Local Contexts, Manuel N. Leiva

Theses and Dissertations

Immigration and Customs Enforcement (ICE) is a federal agency that plays a large role in surveilling, apprehending, detaining, incarcerating, and deporting undocumented immigrants in the United States. Due to constraints on the number of ICE’s available personnel and resources, the agency relies on deputizing, or devolving to local law enforcement agencies the authority to enforce federal immigration policies. Prior to the 1990s, the enforcement of policies directed at controlling flows of undocumented immigrants was generally under the purview of federal law enforcement agencies and administrators, not state or local ones. The attacks on September, 11^th 2001 represented a flashpoint, …