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Full-Text Articles in Entire DC Network
The Effectiveness Of The Dialectical Behavior Therapy Module Of Interpersonal Effectiveness Compared To Traditional Assertiveness Training: A Randomized Control Trial., Daniella Difabio
Theses and Dissertations
This study examined the efficacy of the Dialectical Behavior Therapy (DBT) module of Interpersonal Effectiveness compared to Traditional Assertiveness Training. In recent years, DBT has become one of the most effective psychotherapeutic treatments for individuals with borderline personality disorder (Linehan et al., 1991). DBT has been determined to be effective across inpatient, outpatient, and school settings and across multiple populations (i.e., BPD, PTSD, eating disorders, etc.). Traditional Assertiveness Training has been forgotten despite some of its skills being similar or identical to DBT (Goldfried et al., 2017). In the past, Assertiveness training was found to be effective across various populations. …
Development Of Whole-Cell Biosensors For Early Detection Of Oral Squamous Cell Carcinoma, Sharona Adina Priyev
Development Of Whole-Cell Biosensors For Early Detection Of Oral Squamous Cell Carcinoma, Sharona Adina Priyev
Theses and Dissertations
Accurate and timely diagnosis is crucial in preventing progression to advanced disease stages and in improving survival rates of oral squamous cell carcinoma (OSCC). Using synthetic biology tools, we aim to integrate synthetic biological circuits into the construction of a novel, whole-cell biosensor (WCB) that will detect salivary biomarkers of OSCC. In treating biological parts and genetic circuits as modular pieces, we can intentionally rearrange selected domains of interest to create new transcription factors that will enable the detection of molecules of interest. Our end-goal is the creation of portable devices carrying living cells that express our synthetic genetic circuits …
Increasing Mental Health Treatment-Seeking In Emerging Adult College-Student Survivors Of Sexual Assault: A Randomized Controlled Trial Of An Online Intervention, Jessica Huntt
Theses and Dissertations
The prevalence of sexual violence, particularly in emerging adult women, is alarming (Sinozich & Langton, 2014; Smith et al., 2017), and rates of treatment seeking are low (e.g., Smith et al., 2010). Engagement strategies and motivational interviewing have garnered support in mitigating barriers to mental health treatment-seeking (e.g., Lerch et al., 2017). However, young college women often do not seek treatment for symptoms following sexual violence due to additional barriers such as shame and institutional betrayal (Holland, 2019; Logan et al, 2005). Lack of treatment can lead to long-term detriments (e.g., Halpern et al., 2018) and there is little research …
Overexpression Of Abcc1 And Abcg2 Confers Resistance To Bmn-673, A Poly (Adp-Ribose) Polymerase (Parp) Inhibitors, Qiuxu Teng
Theses and Dissertations
Cancer remains a growing public health challenge worldwide. Although the development of chemotherapies has effectively reduced the cancer death rate and improved patients’ prognosis, the frequent occurrence of multi-drug resistance (MDR) in cancer has caused impairments on the efficacy of many structure-unrelated anticancer agents, leading to treatment failure and recurrence. One of the most common causes of MDR is the overexpression of ATP-binding cassette (ABC) transporters on cancer cell membranes, which transport anticancer drugs out of cancer cells, thereby reducing the intracellular drug concentration. BMN-673 (talazoparib) is a potent poly (ADP-ribose) polymerase (PARP) inhibitor that is approved for BRCA-mutated HER2-negative …
Mancozeb Exposure Results In Oxidative Stress And Disruption Of Mitochondrial Complexes Iii & Iv In Transformed Human Colon Cells, Amanda Dhaneshwar
Mancozeb Exposure Results In Oxidative Stress And Disruption Of Mitochondrial Complexes Iii & Iv In Transformed Human Colon Cells, Amanda Dhaneshwar
Theses and Dissertations
The ethylene bisdithiocarbamate pesticides, a subclass of the dithiocarbamate pesticides, are broad spectrum organometallic fungicides used on a variety of crops. The fungicide Mancozeb is comprised of an ethylene bisdithiocarbamate backbone complexed to the metals manganese and zinc. Ingestion of food containing pesticide residue and occupational exposure are common routes of Mancozeb exposure. Previous work demonstrated that Mancozeb exposure to HT-29 colon cancer cells resulted in cytotoxicity, apoptosis, and disruption of mitochondrial complex I, II, and V activity. The current study investigated the effect of Mancozeb exposure on mitochondrial complex III and IV activity and oxidative stress parameters in the …
Measurement Of Desmosine By Liquid Chromatography–Tandem Mass Spectrometry And Its Application To Chronic Obstructive Pulmonary Disease, Michael Fagiola
Measurement Of Desmosine By Liquid Chromatography–Tandem Mass Spectrometry And Its Application To Chronic Obstructive Pulmonary Disease, Michael Fagiola
Theses and Dissertations
The mechanical properties of lung elastic fibers are derived from the specialized features of their core elastin protein, which contains distensible, coiled peptides that store the energy needed to expel air from the lungs. Elastin crosslinks provide structural support for the fibers and play an important role in determining the morphologic features of the lung. Degradation of elastic fibers in lung disease is associated with the release of desmosine, a unique amino acid that can be readily identified and quantified in body fluids and solid tissue using LC–MS-MS. The purpose of this study was to explore the role of desmosine …
Perceptions Of Mentoring Kings And Effects Of The Hochman Method On High School Boys Of Color, Kelly Mckay Downing
Perceptions Of Mentoring Kings And Effects Of The Hochman Method On High School Boys Of Color, Kelly Mckay Downing
Theses and Dissertations
The purpose of this study was to examine the effect of the Hochman Method’s Sequence for Notetaking Instruction on male high school students of color. This method of notetaking was an integral part of the curriculum offered by the Mentoring Kings Initiative, a critical mentoring program providing formal and informal mentoring to male students of color. Specifically, the study explored how bolstering the Hochman Method’s explicit notetaking instruction with critical mentoring and culturally responsive pedagogy intrinsic to the Mentoring Kings Initiative affects student comprehension, self-efficacy, and notetaking mastery. Perceptions of the Mentoring Kings Initiative among these male high school students …
The Unstoppable Anthropocene Engine: Animal Studies In Literature And The Lack Of Individual Animal Study, Paul Spampanato
The Unstoppable Anthropocene Engine: Animal Studies In Literature And The Lack Of Individual Animal Study, Paul Spampanato
Theses and Dissertations
Animal studies is a growing field in the Humanities and, in particular, Literature studies. This dissertation, The Unstoppable Anthropocene Engine, focuses on canonical literature of the fin de siècle and Modernist eras that utilize animals in their narratives. Thomas Hardy’s Tess of the D’Urbervilles, H.G. Wells’ The Island of Dr. Moreau, Joseph Conrad’s Heart of Darkness, T.S. Eliot’s The Wasteland, Virginia Woolf’s Mrs. Dalloway, and Djuna Barnes’ Nightwood are the literary texts examined throughout the dissertation to discuss the importance of looking at specific animals that represent particular groups. Through these novels and poem, readers will see that when we …
Feminism And Identity In Victorian Novels Of Brontës, The Interchangeability Of The Binaries: Center And Margin, Reality And Appearance, Original And Copy, Mutsuko Takahashi
Feminism And Identity In Victorian Novels Of Brontës, The Interchangeability Of The Binaries: Center And Margin, Reality And Appearance, Original And Copy, Mutsuko Takahashi
Theses and Dissertations
The dissertation approaches feminism and identity in the novels of the Brontë sisters, in which characters have struggled with the tension between outsider and insider. The study will discuss, in Part I, Charlotte Brontë’s Jane Eyre (1847) and Villette (1853), and in Part II, Emily Brontë’s Wuthering Heights (1847) and Anne Brontë’s The Tenant of Wildfell Hall (1848), seen through multiple lenses such as feminism, psychoanalysis, postcolonialism, etc. Various versions of powerless male protagonists in the Brontës are examined, for they help illuminate the situation of the female protagonists. Marginal males try to take over the central position by using …
Insight Into Eleutherodactylus Coqui Resilience And Anuran Hypoxia Tolerance Utilizing Pincho, Randy Ortiz
Insight Into Eleutherodactylus Coqui Resilience And Anuran Hypoxia Tolerance Utilizing Pincho, Randy Ortiz
Theses and Dissertations
The onset of high-throughput RNA-sequencing (RNA-seq) technology allowed research into transcriptomics to accelerate exponentially aided by the rapid advancement of bioinformatic pipelines. The Pincho workflow, my first research endeavor, is a transcriptomic workflow developed to create an avenue of high-quality reconstructions from RNA-seq data. High-quality reconstruction standards entail longer transcripts, more complete transcripts, and more raw data utilization. We have discovered an ideal trio of assemblers between transABySS, rnaSPAdes and TransLiG that would best reconstruct next-generation sequencing data according to these standards. We utilized Pincho to drive two distinct experiments: (1) exploring the genetic basis for the successful invasion of …
Counterstories Of Sife Experiences: A Critical Analysis Of Students With Interrupted Or Inconsistent Formal Education, Erica Flores
Counterstories Of Sife Experiences: A Critical Analysis Of Students With Interrupted Or Inconsistent Formal Education, Erica Flores
Theses and Dissertations
Students with Interrupted or Inconsistent Formal Education (SIFE) are positioned in our society in such a way that many SIFE cannot advocate for themselves (Advocates for Children of New York, 2010; Linville, 2016), and they must rely on educators to speak on their behalf and address the inequities they face (Advocates for Children of New York, 2010; Linville, 2016; Olivares-Orellana, 2020). Teachers are working to navigate these challenges; however, local and state programs and policies have had a negative impact on the academic success of SIFE in the traditional high school setting (Hos, 2020; Olivares-Orellana, 2020). This study uses Critical …
Cytotoxicity Of Copper (Ii) Octanoate On Mouse Hippocampal Astrocytes, Ali A. Shohatee
Cytotoxicity Of Copper (Ii) Octanoate On Mouse Hippocampal Astrocytes, Ali A. Shohatee
Theses and Dissertations
Copper, as an essential trace element, is crucial for various biological processes but has also been utilized as a constituent of various pesticides for decades. Copper (II) octanoate is a pesticide utilized as a fungicide and is approved for use in the production of certified organic foods. Previous studies have implicated copper as an inducer of oxidative stress and activator of the Nrf2-ARE pathway. Nrf2 is essential in regulating the transcription of various genes to alleviate toxicity such as those involved in glutathione synthesis and detoxification. Due to the limited toxicological data, this study into the potential induction of oxidative …
When Do Therapist Characteristics Matter Or Do They?, Han Lim Kim
When Do Therapist Characteristics Matter Or Do They?, Han Lim Kim
Theses and Dissertations
This research aims to establish that considerable differences exist between therapists on how much their clients improve in treatment and understand the factors that contribute to such variability. Therapists’ sex, personality, and similarity of their personality with their clients’ personality were examined as moderators of change in treatment outcome. Findings must be interpreted with caution due to limitations of the dataset which make therapists effects hard to separate from client effects. There is variation around the amount of change therapists produce in their clients; however, this variation is much smaller compared to the variance among clients. Female therapists consistently had …
The Role Of Child Maltreatment On Personality From Adolescence To Young Adulthood, Morgan T. Cohen
The Role Of Child Maltreatment On Personality From Adolescence To Young Adulthood, Morgan T. Cohen
Theses and Dissertations
Historically, a defining feature of personality characteristics has been their stability and consistency across time. However, research over the past decade has established patterns of personality change across the lifespan, with the most mean-level trait change occurring between 20 to 40 years old (Roberts & Mroczek, 2009), making young adulthood a fruitful developmental period to study personality change. There are several factors that can influence personality trait change and some literature has suggested that major life events such as childhood adversity can impact the stability and change of personality traits across time. The present study uses two waves of data …
When Crying Turns To Hitting: Examining Maternal Responses To Negative Affect, Brooke Edelman
When Crying Turns To Hitting: Examining Maternal Responses To Negative Affect, Brooke Edelman
Theses and Dissertations
Most children exhibit some form of physical aggression in the first years of life, and physical aggression is particularly common in toddlerhood (Hay, 2005; Lorber et al., 2017; Lorber et al., 2019; Nærde et al., 2014; Tremblay & Nagin, 2005). Further, aggression is conceptualized as a byproduct of frustration and related negative affect (Berkowitz, 1989), and early physical aggression is empirically linked to anger (Lorber et al., 2015). The current study is part of a body of research examining early aggression and will explore the mechanisms by which children’s negative affect escalates to aggression in a brief conflict episode. Given …
Animal Instinct: Radical Black Feminism And The Virtue Of The Demonic, Amity S. Nathaniel
Animal Instinct: Radical Black Feminism And The Virtue Of The Demonic, Amity S. Nathaniel
Theses and Dissertations
The impossible strive towards “human” has dominated much of Black feminist studies, but there are scholars such as Sylvia Wynter, Zakiyyah Iman Jackson, Alex Weheliye, and Octavia Butler who've re-configured the concept of humanity in their work by embracing different species and technologies that could provide liberation for Black women. My dissertation explores these new spaces, using Wynter’s “demonic ground” theory as a backbone, to conceptualize Black post-humanism, animality, and the embracing of the “demonic” as radical tools of empowerment. My dissertation aims to establish the consistent and perpetual violence that Black women—from past to present—have endured by living on …
Regulation Of P53 By Trpm6 And Trpm7, Thomas Whitbread
Regulation Of P53 By Trpm6 And Trpm7, Thomas Whitbread
Theses and Dissertations
TRPM6 and TRPM7 are two divalent metal cation channels that also possess a serine/threonine kinase domain. They both play critical roles in cellular and organismal metal homeostasis, and are necessary for proper embryonic development and human health. They may function independently in homomeric units, or act together as heterotetramers that display unique characteristics compared to the homomeric channels. These channel-kinases have increasingly been linked to cancer, displaying altered expression levels in a variety of human cancers and contributing to disease progression. Prior work has shown that TRPM6 and TRPM7 can participate in cancer-related signaling pathways. Here, the potential for TRPM6 …
Madness Is The Emergency Exit: A Survey Of Super Trauma, Justine Nicole Wilson
Madness Is The Emergency Exit: A Survey Of Super Trauma, Justine Nicole Wilson
Theses and Dissertations
This dissertation is a survey of trauma as depicted within the Batman mythos. The first chapter, “The Serious House,” explores the history of New York State’s insane asylum system and its relationship to the creation of the fictional Arkham Asylum. The opening chapter also features a close reading of Grant Morrison’s Arkham Asylum: A Serious House on Serious Earth (2005) and employs Michel Foucault’s Discipline and Punish (1995) and Madness and Civilization (1988) as critical frameworks. The dissertation's second chapter, “There is no Sanity Clause,” is a detailed examination of the Joker’s character. The Joker is an advocate for the …
Predictors And Mediators Of Eating Disorder Pathology In Individuals With Eating Disorders, Alexandra Allam
Predictors And Mediators Of Eating Disorder Pathology In Individuals With Eating Disorders, Alexandra Allam
Theses and Dissertations
Over the past decade there has been accumulating evidence that attention-deficit/hyperactivity disorder (ADHD) and eating disorders frequently co-occur, but little is known about the possible mechanisms that might account for their co-occurrence. Likewise, relatively little research has examined the ways such comorbidities impact the maintenance of or recovery from eating disorder (ED) symptoms after treatment. In this cross-sectional study, we recruited 95 adult participants who had received an ED diagnosis and 24-hour treatment for an ED in the past 10 years, and obtained measures of ADHD symptoms and ED symptoms to explore their association and possible mediators thereof. In particular, …
Covid-19: Social Support Among The Bereaved, Fernande Nanda Mamane
Covid-19: Social Support Among The Bereaved, Fernande Nanda Mamane
Theses and Dissertations
Bereavement is a universal experience. Presently, there have been over 1,024,611 deaths in the United States alone related to the COVID-19 virus and this number is growing (Centers for Disease Control and Prevention, 2022). With the significant rise in deaths, as well as subsequent societal health and safety measures due to the pandemic, social support for the bereaved is expected to be severely impacted. Limited access to social spheres, as well as adjustments to typical funeral practices, may impact the perception of support by those grieving. The purpose the study was to gain a better understanding of bereaved individual’s experiences …
Adaptations Of World War I Stories Into Screen Dramas: The New “Heritage Films”, Elizabeth Carroll
Adaptations Of World War I Stories Into Screen Dramas: The New “Heritage Films”, Elizabeth Carroll
Theses and Dissertations
This dissertation examines both written and filmic texts to determine the way World War I trauma was depicted in the postwar period and how it is now presented to a modern audience. This study begins with texts written in the immediate postwar period: Virginia Woolf’s Mrs. Dalloway, Vera Brittain’s war memoir Testament of Youth and R.C. Sherriff’s play and novel Journey’s End and draws comparisons to their twentieth and twenty-first century film adaptations. A coda also examines the novel and film The Hours. Using psychology, history, literary criticism, and film theory, I conclude the films are generally more invested in …
Adapting Higher Education: Revamping Curricula For The Inclusion Of Theatre Students With Disabilities, Kevin Kemler
Adapting Higher Education: Revamping Curricula For The Inclusion Of Theatre Students With Disabilities, Kevin Kemler
Theses and Dissertations
Equity, Diversity, and Inclusion initiatives in higher education have been largely driven by administrators who have little to no contact with the students for whom they are working for. This top-down approach negatively impacts marginalized students and disproportionately affects the quality of experience for students with Disabilities, an often-overlooked demographic. For Disabled students enrolled in performance programs, barriers to access and inclusion don’t just exist at the institutional level, they also exist in the traditional classroom or studio as well. Through a dismantling of ableist structures inherent within higher education (i.e., American grading practices, the Western and Theatrical Canons), I …
Exploring The Impact Of Covid-19 On Adults With Intellectual And Developmental Disabilities In The United States, Sarah Lineberry
Exploring The Impact Of Covid-19 On Adults With Intellectual And Developmental Disabilities In The United States, Sarah Lineberry
Theses and Dissertations
Like most disasters, the COVID-19 pandemic has disproportionately impacted people from historically marginalized communities. People with intellectual and developmental disabilities (IDD) have faced higher rates of infection, hospitalization, and death compared to people without disabilities, as well as significant disruptions to the services that support them to participate in the community. A relative lack of research about the experiences of people with IDD may have contributed to this risk and continues to limit our understanding of the impacts of COVID-19. This three-paper dissertation is guided by the theory of epistemic injustice (Fricker, 2007) to understand the impacts of COVID-19 on …
Utilization Of Intraoral Scanners For Fabrication Of Obturators For Patients Born With Cleft Lip/ Palate (Clp), Swara Fadnis
Utilization Of Intraoral Scanners For Fabrication Of Obturators For Patients Born With Cleft Lip/ Palate (Clp), Swara Fadnis
Theses and Dissertations
Objective: The goal of this cross-sectional study was to assess the knowledge and attitude of providers regarding incorporating a digital scanner for impression taking in children born with cleft lip and/or palate (CLP). Methods: A survey was sent out to members of the American Association of Pediatric Dentistry (AAPD). The survey included questions regarding the providers’ perception of incorporating digital intraoral scanners for impressions for fabrication of obturators. The survey also included questions about the providers’ reservations in using this technology in practice, what their experience has been with the incorporation of this technology into practice, and what is …
A Prevention Strategy For Children Receiving Full Mouth Dental Rehabilitation Under General Anesthesia: A Randomized Controlled Trial, Jessica Gonzalez
A Prevention Strategy For Children Receiving Full Mouth Dental Rehabilitation Under General Anesthesia: A Randomized Controlled Trial, Jessica Gonzalez
Theses and Dissertations
Purpose: This two-arm, parallel-group randomized controlled trial aims to compare the effectiveness of a new prevention strategy versus traditional verbal education and post-operative instructions in increasing caregivers’ compliance to follow-up of their children who have had full mouth dental rehabilitation (FMDR) under general anesthesia (GA). Methods: Caregivers of children who presented for FMDR under GA were recruited and randomly assigned to either the control or treatment groups. Caregivers in the treatment arm received oral health anticipatory guidance through a combination of motivational interviewing, individualized goal setting, visual aids, and verbal education. Caregivers in the control arm received the same information …
An Introduction To Theatrical Scent Design As Compared To Traditional Design Areas With A Consideration For The Scientifically Notated Physical And Emotional Effects On The Human Body As It Potentially Relates To Future Creative Endeavors: A Framework, Katherine R. Holland
Theses and Dissertations
Traditional areas of theatrical design are established to the point of having a solid foundation for current and future designers to rely on as they strive to innovate. The same cannot be said for scent. I believe that art, like science, is a sector where the imagination is used to push the boundaries of what we currently know and can do. Artists are therefore entrusted with the responsibility to continue testing those boundaries, and that is what my topic lays the foundation for when it comes to scent. With my topic, I plan to look at the practical and ethical …
Romantic Nostalgia: Examining The Motivational And Relational Outcomes, Margaret Kneuer
Romantic Nostalgia: Examining The Motivational And Relational Outcomes, Margaret Kneuer
Theses and Dissertations
Romantic nostalgia, or the sentimental longing and wistful affection towards a romantic partner (Evans et al., in press), is a type of nostalgia pertaining to relationships that has not been addressed widely in the current literature. The goal of this research is to investigate whether romantic nostalgia buffers against conflict and promotes motivational benefits to the relationship. I extend the work on the restorative nature of nostalgia to close relationships and explore cognitive, motivational, and behavioral relationship maintenance strategies. Study 1 sampled university students currently in romantic relationships to examine the association between romantic nostalgia proneness and compassionate goals. Romantic …
Effects Of Hiv-1 Tat And Opiates On Gene Regulation Of Oligodendrocyte Lineage Cells: Identification Of Myrf As A Novel Target, Kelly M. Flounlacker
Effects Of Hiv-1 Tat And Opiates On Gene Regulation Of Oligodendrocyte Lineage Cells: Identification Of Myrf As A Novel Target, Kelly M. Flounlacker
Theses and Dissertations
HIV-associated neurocognitive disorders remain pervasive even with increased efficacy/use of antiretroviral therapies. Opioid use/abuse among HIV+ individuals is documented to exacerbate deficits. White matter (WM) alterations (myelin pallor, volume/structural) detected by diffusion tensor imaging, are common observations in HIV+ individuals. Using transgenic mice expressing HIV-1 Tat, we examined effects of 2-6 weeks of Tat/morphine exposure on WM using genomic/biochemical methods. RNA sequencing of striatal tissue after 2-weeks revealed robust changes in mRNAs associated with oligodendrocyte populations/myelin integrity, including Transferrin, Ndrg1, and myelin regulatory factor (Myrf/Mrf), an oligodendrocyte-specific transcription factor involved in differentiation/maturation. Immunoblots conducted after 6-weeks exposure in …
Material Extrusion-Based Additive Manufacturing: G-Code And Firmware Attacks And Defense Frameworks, Haris Rais
Material Extrusion-Based Additive Manufacturing: G-Code And Firmware Attacks And Defense Frameworks, Haris Rais
Theses and Dissertations
Additive Manufacturing (AM) refers to a group of manufacturing processes that create physical objects by sequentially depositing thin layers. AM enables highly customized production with minimal material wastage, rapid and inexpensive prototyping, and the production of complex assemblies as single parts in smaller production facilities. These features make AM an essential component of Industry 4.0 or Smart Manufacturing. It is now used to print functional components for aircraft, rocket engines, automobiles, medical implants, and more. However, the increased popularity of AM also raises concerns about cybersecurity. Researchers have demonstrated strength degradation attacks on printed objects by injecting cavities in the …
Blockchain Security And Applications, Phuc D. Thai
Blockchain Security And Applications, Phuc D. Thai
Theses and Dissertations
Cryptocurrencies, such as Bitcoin and Ethereum, have proven to be highly successful. In a cryptocurrency system, transactions and ownership data are stored digitally in a ledger that uses blockchain technology. This technology has the potential to revolutionize the future of financial transactions and decentralized applications. Blockchains have a layered architecture that enables their unique method of authenticating transactions. In this research, we examine three layers, each with its own distinct functionality: the network layer, consensus layer, and application layer. The network layer is responsible for exchanging data via a peer-to-peer (P2P) network. In this work, we present a practical yet …