Digital Commons Network^™

Digital Health Design For Improving Treatment Decisions, Akanksha Singh

Theses and Dissertations

In the age of artificial intelligence and large datasets, information retrieval by querying large databases is an impossible task for the common user due to the information overload. Recommender Systems (RS) for commercial applications like YouTube, Amazon and Netflix were designed to support users by finding items of interest based on their user profiles and various filtering techniques. Health Recommender Systems (HRS) is a category of RSs that provides immense opportunities for application across several healthcare domains and contexts including treatment decision support. Unlike RS applications that focus on analyzing consumer choices, a key differentiator for HRS applications is the …

Mechanisms Of Social Stress Susceptibility And Resilience In Female Rats, Brittany Sara Pate

Theses and Dissertations

Social stress is the most common form of stress humans experience and often precipitates the onset of several comorbidities, including anxiety, depression, post-traumatic stress disorder, and cardiovascular diseases. While many individuals experience social stress and can respond, cope, and recover, some individuals are more likely to develop subsequent health conditions. Importantly, women are particularly susceptible to stress-related disorders, and the prevalence rates for these comorbid conditions are 2-3-fold higher among females compared to males. Epidemiological data suggest that cycling ovarian hormones may play a role in promoting stress susceptibility in females. Therefore, the current studies aimed to examine the effects …

Prevalence, Disparities, And Health Outcomes In Patients With Alzheimer’S Disease, Dementia, And Mild Cognitive Impairment, Xiaomo Xiong

Theses and Dissertations

Background: Alzheimer’s disease and related dementias (ADRD), an umbrella term to describe progressive neurodegenerative disorders linked to cognitive impairment and dementia, impose significant disease and economic burdens on the patients. Therefore, understanding the prevalence of these disorders is crucial, particularly for mild cognitive impairment (MCI), an intermediate phase between normal aging and dementia that may be reversible through early detection and intervention. Moreover, it is essential to identify the predictors of MCI to facilitate early detection. Additionally, addressing the existing health disparities in the prevalence and treatment of ADRD and MCI is imperative to help improve patients’ health outcomes. Meanwhile, …

Better Days: A Minority Student’S Pathway Toward Upward Social Mobility, Brandi Nichole Anderson

Theses and Dissertations

In the United States, many minority group members have lower social status and fewer economic resources than whites. In order to advance their social status, these individuals set goals that provide them access to more economic capital, many of which include obtaining a college degree. It must also be noted, however, that minority individuals, particularly those of African American and Hispanic descent, possess many alternative types of social and cultural capital that assist them in achieving their goals (Strayhorn, 2010). This qualitative study, designed to explore the types of cultural capital minority students use to achieve their career goals, analyzes …

Dissolved Oxygen Dynamics And Nutrient Cycling In Marine And Lacustrine Benthic Communities, Corrianna R. Boucher

Theses and Dissertations

The delivery of biodetritus to the sediment water interface supports a complex series of biogeochemical reactions collectively referred to as early diagenesis. From the abyssal ocean to littoral freshwater ecosystems, this work explores the dynamics of these reactions in deep ocean detrital aggregates and lacustrine benthic algal mats. In the ocean, periods of increased export flux to abyssal depths increase the organic carbon export as aggregates to the seafloor while in littoral freshwater, proliferations of benthic algae such as Microseira wollei have grown to fill much of the shallow water column they inhabit.

Data collected at Station M (Sta. M) …

One Training Is Not Enough: The Effects Of A Cultural Humility Training On Mentors’ Verbal Behavior, Anna Flitner

Theses and Dissertations

Youth mentoring has been used as a method of prevention and intervention related to social, psychological, and academic outcomes for youth and adolescents, many of whom come from minoritized or low SES backgrounds. Although more diverse than other helping professions, mentors in formal programs are often white which can lead to potential cultural incongruence. To help mentors understand their own identities and work with youth of diverse backgrounds, mentoring programs have begun implementing cultural humility trainings. The current study examines the effects of a cultural humility training in mentoring. Mentors were randomly assigned to the control or training condition in …

Contextualizing Search: An Analysis Of The Impacts Of Construal Level Theory, Mood, And Product Type On Search Engine Activity, Jackson Everitt Carter

Theses and Dissertations

This dissertation explores the world of search from the human perspective. While search engine research, both corporate and academic, has seen a growth in relevance in recent years, the relative novelty of the area in the advertising world means that many important questions remain unanswered. This work aims to expand the current state of search engine research by examining the combined impact of mood, construal level theory applications, and product type on search behavior. Additionally, this research seeks to examine psychophysiological responses from these interreacting frameworks using webcam eye-tracking technology, which was developed recently and has not been previously used …

Examining The Associations Of The Kidney Allocation System With Patient Sensitivity, Wait Time To Transplant, And Donor Distance, Shamika Danielle Jones

Theses and Dissertations

Background

The Kidney Allocation System (KAS) was created in 2014 to address long wait times for a kidney transplant, inappropriately matched kidneys, and high re-transplantation rates. This research examines the associations of the KAS with the percentage of sensitized patients receiving a kidney transplant, wait time to transplant and the distance between donor and recipient hospitals.

Methods

Data from the Scientific Registry of Transplant Recipients (SRTR) was used for this research. The study population included adults over 18 in the United States who received a kidney transplant between December 4, 2009, and December 4, 2018. Patients simultaneously waitlisted for other …

Leveraging Church Environments To Promote Rural Physical Activity And Healthy Eating, Kelsey Rothera Day

Theses and Dissertations

Rural residents experience a greater burden of chronic disease related to physical inactivity and poor diet than their urban counterparts. A promising strategy to improve these health behaviors in rural areas is to leverage existing structures that may support physical activity and healthy eating, such as churches, in public health interventions. Three studies were conducted as part of this dissertation. They were designed to: 1) examine whether the walkability and healthy food density of neighborhoods surrounding rural and urban churches are associated with race, socioeconomic status, and rural/urban status; 2) examine rural church leaders’ views on the role of faith-based …

The Mechanism Of Pda-Peg/Copper Selectively Killing Cancer Cells And Its Application In Treating Triple-Negative Breast Cancer And Advanced Ovarian Cancer, Xiangxiang Hu

Theses and Dissertations

Cancer is one of the leading modality diseases. The number of cancer patients has increased in the last decades due to radiation, aging, stress condition, and other reasons. There are three traditional cancer therapies (radiation therapy, chemotherapy, and surgery). Even though these treatments improve the life span of cancer patients, many cancer patients still lost their lives due to the development of tolerance. Thus, it is urgent to develop new kinds of treatments to extend the life span of patients. In recent decades, nanomedicine, which utilizes nanotechnology to deliver chemotherapy agents into tumor sites and improve the anticancer effect and …

The Impact Of Progerin On Genome Maintenance In Mammalian Cells, Liza Alexandra Joudeh

Theses and Dissertations

Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic condition characterized by accelerated aging. The cause of HGPS is a point mutation in the LMNA gene, which encodes lamins A and the splice variant lamin C. Lamins are components of the nuclear lamina, a complex that plays structural and catalytic roles in the nucleus that are essential to chromatin organization, DNA replication, and DNA repair. The mutation associated with HGPS activates a cryptic splice donor site which alters the lamin A protein in a way that does not allow prelamin A to be fully processed, and ultimately results in the accumulation …

Sleep, Physical Activity, And Sedentary Time In The First Year Postpartum, Erin Elizabeth Kishman

Theses and Dissertations

The postpartum period is a unique time for women, where many women experience changes in sleep and activity patterns. Sleep, physical activity, and sedentary time have all been associated with health outcomes, but there is limited research on how these behaviors change throughout the postpartum period. The purpose of the first aim (Study 1) of this dissertation was to examine trajectories of sleep characteristics in Black and White women during the first year postpartum and to examine if there were any racial differences. The purpose of the second aim (Study 2) was to examine trajectories of the percentage of time …

Biobehavioral Synchrony In Autism Spectrum Disorder, Carly Glenn Moser

Theses and Dissertations

Social communication difficulties are a core feature of autism and are associated with a range of long-term consequences, including persistent deficits in pragmatic language and fewer and poorer quality friendships. High-quality synchronous interactions between parents and their children play a crucial role in children’s social functioning. The theory of biobehavioral synchrony suggests that the dyadic coordination of behavioral and physiological processes is essential to maximally benefit from a communicative exchange. Respiratory sinus arrhythmia (RSA) serves as an indicator of physiological regulation and is reduced in those with autism; thus, dyadic coordination of RSA may also be impacted and could play …

Prenatal Depression And Breastfeeding Practices Healthy Start Participants, 2019-2022, Peyton Ashleigh Mosher

Theses and Dissertations

Background: Breastfeeding has health benefits for both mother and child, but breastfeeding practices among Black and lower-income women are the poorest in the United States. Few studies have examined the associations between maternal prenatal depression and breastfeeding duration, even fewer among a predominantly low-income Black population. Objective: To explore the association between prenatal depression and breastfeeding practices among low-income Black women during the COVID-19 pandemic.

Methods: Prospective cohort data from Midlands Healthy Start (MHS) was analyzed to examine women’s depression symptoms during pregnancy and their breastfeeding initiation and duration through two and six months. Perinatal depressive symptoms were identified using …

Pd-L1 Nano-Eraser: A Novel Intracellular Pd-L1 Degradation Approach And Its Application In Cancer And Alzheimer’S Disease Therapy, Mingming Wang

Theses and Dissertations

Nanoparticle-based targeted therapeutics have revolutionized the field of pharmaceutics by providing precise and efficient drug delivery systems. These therapeutics utilize nanoparticles as carriers to transport drugs selectively to the target site, reducing side effects and enhancing therapeutic efficacy. Although significant advancements have been made in nano-targeted therapies, there are many challenges that need to be addressed to fully realize their potential.

In this study, we proposed a novel approach to extend the potential application of anti-Programmed Death Ligand 1 (PD-L1) antibody (aPDL1) in cancer treatment and Alzheimer’s disease therapy by leveraging the Trim-Away pathway. aPDL1-based Trim-Away involves tagging target PD-L1 …

Comorbid Adhd And Pediatric Sickle Cell Disease: Prevalence And Risk Factors, Sarah Bills

Theses and Dissertations

Objective: Sickle cell disease (SCD) is a genetic blood condition that places youth at increased risk for deficits in attention and executive functioning suggestive of increased rates of Attention Deficit/Hyperactivity Disorder (ADHD). There is pronounced inconsistency in reported prevalence rates for attention deficits and ADHD diagnoses among youth with SCD, which is due in part to variability in methodology of previous studies. The primary aim of the present study is to use systematic screening to identify the prevalence of inattentive ADHD symptoms and ADHD diagnoses in a pediatric SCD population seen at a large hematology clinic. A secondary aim is …

Patient Experiences And Disparities In Telehealth Hiv Care During The Covid-19 Pandemic: Study Results From The Southern United States, Valerie Yelverton

Theses and Dissertations

Background: To maintain HIV care continuity during the COVID-19 pandemic, most HIV care facilities in the United States adopted telehealth. However, not everyone was participating in telehealth equally. This dissertation seeks to understand experiences with and the use of telehealth in HIV care, and decision processes guiding the selection of visit type during the COVID-19 pandemic.

Methods: Qualitative interviews explored people living with HIV’s (PWH) and HIV care provider’s experiences with telehealth HIV care and visit type decision processes. Quantitative analyses of electronic health record (EHR) data characterized patterns of and disparities in telehealth HIV care during the COVID-19 pandemic. …

Complementary And Integrative Health (Cih) And Opioid Use Among Adults With Chronic Noncancer Pain In The Us, Yi-Wen Shih

Theses and Dissertations

Chronic noncancer pain (CNCP) is defined as persistent pain lasting for more than three months due to conditions other than malignancy. This condition affects one in five American adults annually. The prescribing of opioids to individuals experiencing CNCP has been recognized as a critical contributor to the ongoing opioid crisis. In 2016, the Centers for Disease Control and Prevention (CDC) recommended Complementary and Integrative Health (CIH) as a nonpharmacologic treatment to be used among adults with CNCP. Despite the potential benefits of CIH for pain relief, there may be a discrepancy between individuals with CNCP and their insurance coverage for …

The Emergence And Predictive Utility Of Early Markers Of Social Anxiety In Young Children With Fragile X Syndrome, Conner James Black

Theses and Dissertations

Fragile X syndrome (FXS) is a monogenic neurodevelopmental disorder characterized by elevated rates of intellectual disability, autism, and anxiety. Social anxiety affects approximately 60 percent of individuals with FXS and is cited as one of the most impairing comorbid disorders in FXS; however, little is understood about the developmental patterns of social anxiety markers in young children with FXS. The current study investigates cardiac and behavioral markers of social anxiety across the first five years of life and tests the predictive utility of these variables on social anxiety symptomatology. Participants included 80 children with FXS and 50 neurotypical controls. Participants …

Mitigating Student Anxiety In The Secondary Classroom: A Culturally Sustaining Approach, Erin Hawley Cronin

Theses and Dissertations

This study emerged in response to broader trends of increasing anxiety among schoolchildren and my own observations as a teacher. Suicide is now the second-leading cause of death for youth (Curtin et al., 2022), and anxiety is a known factor in most deaths by suicide (Nepon et al., 2010). Teachers are often the first point of contact for anxious students, but a shortage of counselors in U.S. schools and other systemic barriers prevent widespread access to counseling services (Cratty, 2019). Moreover, identity-based anxieties are often misattributed to aggression or attention-seeking, and punished in school settings, instead of recognized and supported …

Tip Of The Iceberg In Changing School Culture: Acknowledging And Addressing Microaggressions, Nicole Lauren Becker

Theses and Dissertations

Providing a culturally responsive learning environment that allows students and faculty to feel safe and welcomed is essential. This action research study examined the harmful impact of microaggressions in the school and how providing targeted and comprehensive professional development sessions helped faculty members be able to acknowledge and address microaggressions. The research study was conducted in a large elementary school in the northeast United States that serves approximately 800 students. The researcher worked with the school administration team to identify microaggressions as a problem of practice. The focus group interviews, and six-week professional development series aided in the participants’ journey …

The Hero Within: Developing The Psychological Capital Of First-Generation Students, Mary Elizabeth Sewell

Theses and Dissertations

Psychological capital (PsyCap) is a higher-order construct comprised of four psychological resources: hope, efficacy, resilience, and optimism (HERO), and has been linked to academic achievement and engagement (Hazan Liran & Miller, 2019; Luthans, et al., 2012). Interventions designed to build PsyCap may be particularly helpful for firstgeneration (FG) students who face additional challenges in higher education. This study aimed to: (1) explore differences in PsyCap among FG and continuing generation (CG) students; (2) investigate relationships between PsyCap, GPA, and persistence; and (3) examine the impact of a 2-hour PsyCap micro-intervention (PCI) on FG students’ academic PsyCap, academic achievement (GPA), and …

Examining Recommended Strategies For Accommodating Negatively Worded Items, Jungsun Go

Theses and Dissertations

The purpose of this study was to investigate the effectiveness of four different models (bifactor, CTC(M-1), CTCU and unidimensional) as to optimal model selection when the wording effect associated with negatively worded items was present. A Monte Carlo simulation study was conducted to compare model-data fit and accuracy in parameter estimates of the four models. Design factors include: two true models (CTC(M-1), CTCU models) × three sample sizes (small N=250, moderate N=500, large N=1,000) × two item ratios (positive items:negative items = 2:1 or 1:1) × three distributions (distribution of negative items; symmetric, moderately asymmetric, and extremely asymmetric). The generated …

Exploring The Agenda-Setting Dynamics Between Traditional Newspapers And Twitter During Mass Shooting Event, Yujin Heo

Theses and Dissertations

The purpose of this dissertation is to explore the intermedia agenda-setting interplay between traditional news media and Twitter in the wake of mass shooting incidents. Applying Latent Dirichlet Allocation (LDA) topic modeling to data sourced from Twitter, national, and local news, the study investigated the distinct coverage patterns and the extent of their reciprocal influence over time. The findings of this study demonstrated that, in the immediate aftermath of a shooting incident, national news outlets exerted a significant agenda-setting influence on both local media and Twitter discourse. However, as time unfolds, a mutually influential dynamic emerged across all media platforms. …

Extending The Convolution In Graph Neural Networks To Solve Materials Science And Node Classification Problems, Steph-Yves Mike Louis

Theses and Dissertations

The usage of graph to represent one's data in machine learning has grown in popularity in both academia and the industry due to its inherent benefits. With its flexible nature and immediate translation to real life observed objects, graph representation had a considerable contribution in advancing the state-of-the-art performance of machine learning in materials.

In this dissertation proposal, we discuss how machines can learn from graph encoded data and provide excellent results through graph neural networks (GNN). Notably, we focus our adaptation of graph neural networks on three tasks: predicting crystal materials properties, nullifying the negative impact of inferior graph …

Framing Police Brutality: An Analysis Of Newspaper Coverage Of Walter Scott’S Murder, Shamira S. Mccray

Theses and Dissertations

This research analyzes news articles about the killing of Walter Scott in 2015 to determine how frames changed over time and across platforms. Previous studies have found that news coverage of police violence against Black men has not always been fair. Instead, the narrative of official sources, like law enforcement, prove dominant. These same research articles typically focus on the way national news outlets frame incidents like Scott’s.

But this thesis takes a deeper look at how state newspapers framed Scott’s murder. I analyzed the frames and sources found in nearly 200 articles published by The Post and Courier and …

The Post-Tonal Evolution Of David Diamond: A Theoretic-Analytical Perspective, William John Ton

Theses and Dissertations

David Leo Diamond (1915–2005) was a prolific and highly esteemed American composer whose works were premiered by such notable conductors as Dimitri Mitropoulos, Eugene Ormandy, Serge Koussevitzky, Leonard Bernstein, and Gerard Schwarz. In addition to his significant output and a large circle of famous friends and professional acquaintances, his sphere of influence also included his tenure as professor of composition at the Juilliard School where he worked from 1973 until 1997. His impressive roster of students includes distinguished composers such as Lowell Liebermann, Eric Whitacre, and Vivian Fung. Despite his stature as a composer, however, there is a surprising lack …

Supporting Black Students In Sixth-Grade Science Through A Social Constructivist Approach: A Mixed-Methods Action Research Study, Kirk Anthony Heath

Theses and Dissertations

The purpose of this mixed-method action research study was to improve Black students’ performance in my sixth-grade science class by improving their ability to use the claim, evidence, and reasoning (CER) framework. Using criterion-based convenient sampling, I enlisted 17 Black participants, all of whom were underperforming in my science class at a suburban, middle-class, predominantly White public middle school serving Grades 6–8. As a teacher researcher, I implemented and assessed an intervention designed to improve their ability to use the CER framework. Using a mixed-method action research design, I simultaneously collected and triangulated quantitative and qualitative data.

This study may …

Feasibility Of A Parent-Focused, Stress Management Intervention To Decrease Adolescent Bmi, Reduce Stress, And Increase Well-Being Among African American Families, Colby J. Kipp

Theses and Dissertations

African American adolescents in the United States experience a higher prevalence of obesity as compared to their White counterparts. This health inequity presents a public health concern as consequences of weight-related chronic diseases often persist into adulthood and are increasingly problematic. As chronic stress has been found to be higher among African American youth compared to White adolescents, it presents as a potential barrier to participation for African American families in health promotion interventions. Additionally, it may be beneficial to target stress in health promotion programs as a modifiable factor in conjunction with health behaviors that may improve outcomes related …

A Bayesian Spatial Scan Statistic For Normal Data, Laasya Velamakanni

Theses and Dissertations

Scan statistics are useful methods for detecting spatial clustering. While they were initially developed to detect regions with an excess of binomial or Poisson events, spatial scan statistics have been extended to detect hotspots in other types of data including continuous data. They have many applications in different fields such as epidemiology (e.g. detecting disease outbreaks), sociology (e.g. detecting crime hotspots), and environmental health (e.g. detecting high-pollution areas). Spatial scan statistics identify a ‘most likely cluster’ and then use a likelihood ratio test to determine if this cluster is statistically significant. Spatial scan statistics have been extended to the Bayesian …