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Progressive Neurochemical, Neuroinflammatory And Cognitive Deficits In An Experimental Model Of Gulf War Illness, Hannah Elizabeth Burzynski

Theses and Dissertations

Gulf War Illness (GWI) is a multi-symptom illness that presents with cognitive disturbances and immune dysregulation and continues to affect over 25% of Gulf War veterans. While soldiers were exposed to several hazards in the Gulf, the prophylactic use of the acetylcholinesterase inhibitor, pyridostigmine bromide (PB) and war-related stress have been identified as chief factors in GWI pathology. As both PB and stress alter acetylcholine (ACh), a critical mediator of cognition and inflammation, the focus of my dissertation work was investigating the lasting effects of PB and stress on peripheral and central cholinergic signaling. Specifically, I assessed hippocampal-dependent learning and …

From Oceans To Public Health: Impact Of Climate Change And Socioecological Factors On Non-Cholera Vibrio Spp., Karlen Enid Correa Vélez

Theses and Dissertations

Climate change-induced stressors, such as temperature, salinity, pH, and wildfire, are contributing factors to the increase in frequency of Vibrio infections, altering Vibrio geographical constraints. At the same time, the expansion of the coastal population is resulting in increased input of treated municipal wastewater into areas that are also experiencing Vibrio proliferation. Given that increases in ocean temperature and sea level coupled with increases in human activity in coastal waters support greater Vibrio-human interactions, it is important to examine factors and mechanisms within this socio-ecological coupled system that may further strengthen this interaction. This study aimed to better understand the …

Leveraging Inflammatory Responses Toward Advancing Alzheimer’S Disease Treatments And Biomaterial Implantation, Mihyun Lim Waugh

Theses and Dissertations

Inflammation is a body’s physiological response to pathogens, foreign materials, or tissue injury. When immune system is triggered, activated leukocytes produce cytokines and chemokines that promote migration of neutrophils and macrophages to the inflammatory regions. At early stages of injury, acute inflammation occurs immediately to fight off the pathogens and restore tissues to homeostasis. However, if the inflammation-inducing stimulus is not removed and thus cells and tissues do not return to its homeostatic state, the prolonged inflammatory responses become a chronic condition. Recent studies have indicated that the receptor for advanced glycation end-products (RAGE), a key receptor of innate immune …

Structural, Functional And Biochemical Studies To Elucidate The Molecular Basis Of Xenobiotic Metabolism Of Tetranychus Uritcae, A Major Agricultural Pest, Ricardo Hernandez Arriaza

Theses and Dissertations

The two-spotted spider mite, Tetranychus urticae, is a major cosmopolitan pest that feeds on more than 1,100 plant species, including 150 crops. Such a wide host range indicates this mite’s unparalleled xenobiotic responsiveness that is also coincident with their ability to rapidly develop resistance to pesticides. An unprecedently large detoxifying machinery is one of the main biological traits responsible for their extraordinary adaptation potential and devastating effect on crops. Availability of the whole genome sequence revealed expansions in all major detoxifying families and demonstrated that this genome has been enriched by horizontally transferred genes from bacteria and fungi. Motivated by …

Contemporary Vocal Pedagogy In The Choral Ensemble Rehearsal: A Guide For Secondary Educators, Luke Lee Browder

Theses and Dissertations

The field of contemporary commercial vocal pedagogy is relatively new, with serious academic study primarily taking place over the last twenty-five years. In that time, however, a growing body of research has shown that the function of the vocal mechanism operates in essentially the same manner across classical and contemporary commercial music (CCM) genres, but the application of vocal function is what differentiates classical and CCM singing. Since secondary music educators often represent the only vocal training their students will ever receive, it is helpful for them to know the differences in vocal techniques and how to effectively train singers …

Transdisciplinary Approaches To Community Engagement, Research Translation And Science Communication Through Application Of The Socio-Environmental Report Card Process And Product In Murrells Inlet, South Carolina, Ekaterina Negodyaeva Altman

Theses and Dissertations

Public health and environmental sustainability are interlinked. Three pillars of sustainable development are society, environment, and economy are supported and reinforced by healthy populations. Balancing these values in a long-term vision and application requires active involvement of communities and stakeholders in decision-making process of management of environmental resources and personal health choices. Transdisciplinary sustainability science provides a framework for addressing complex issues in sustainability and generates actionable knowledge to link science and policy and involved stakeholders in the scientific process. Transdisciplinary research processes use co-design, co-production, and co-implementation framework to create and re-integrate useful knowledge into practice on a local …

Investigation Of Discrepancies In South Carolina Traffic Collision Forms, Jackson Wegmet

Theses and Dissertations

The aim of this thesis is to improve the accuracy of information recorded in the South Carolina traffic collision forms. To accomplish this, it examines 200 forms containing information about fatal crashes in work zones between 2014 and 2020 to determine how many discrepancies exist between the written narrative and other fields. In addition to obtaining these statistics, this thesis seeks to identify factors that influence discrepancies. To test the hypothesis that crash complexity and weather influence the investigating officer’s level of processing (a theory developed by Craik and Lockhart in 1972), and consequentially his/her ability to complete the traffic …

Broken Bottles: Understanding The Relationship Between Alcohol Outlet Availability And The Proximity To Alcohol Outlets With Binge Drinking Behaviors In College Fraternity Men At Southeastern Public Universities, Jarod Alan Holt

Theses and Dissertations

Alcohol use among fraternity affiliated men presents a concerning trend with harmful consequences (DeSimone, 2009; Hingson et al., 2017; McCreary et al., 2021; Nuwer, 2001; Patrick et al., 2022; Ranker & Lipson, 2022). The availability theory of alcohol-related problems suggests alcohol use could be influenced based on the availability and proximity of alcohol outlets in the environment (Dimova, 2023; Kypri et al., 2008; Scribner et al., 2008; Single, 1984; Weitzmann et al., 2003). However, no existing studies of fraternity-affiliated students have examined the relationship of binge drinking and access to alcohol through alcohol outlet availability or proximity. This study examined …

Supporting Improvement In Academic Outcomes And Self-Efficacy For Black Male Varsity Athletes, Katherine M. Currie

Theses and Dissertations

Athletics can have a profoundly positive impact on high school students and can be an avenue for the athletes to attend college. However, some athletes struggle to cope with the demands of athletics and this is especially true for Black male athletes who are already members of a historically marginalized community. The purpose of this study is to examine the support that the Academic Success Center (ASC) offers for students and its impact on their academic outcomes and self-efficacy. A mixed methods data analysis revealed three themes: positive impact on academic outcomes, positive impact on self-efficacy and student frustration with …

From The City To The Countryside – Gentrification Across The Us: Conceptualizing Displacement Pressure, Constructing Novel Measurement Methodology, And Exploring Connections To Health, Parthenia Louise Luke

Theses and Dissertations

In an era marked by profound neighborhood transformation, the phenomenon of gentrification emerges as a dominant force. This dissertation undertakes a holistic exploration of gentrification, unraveling its diverse typologies and consequential impacts on health outcomes. Manuscript 1 details the concept of displacement pressure, exploring the multi-faceted experiences of residents in transforming neighborhoods while highlighting psychological and physiological repercussions beyond mere physical relocation. Manuscript 2 leverages the innovative methodology of repeated measures latent profile analysis (RMLPA) to investigate the multiple manifestations of gentrification. Revealing five metropolitan and four nonmetropolitan profiles among gentrified neighborhoods, this analysis interrogates the complexity inherent in both …

The Effect Of Instructionally Embedded Cognitive Reframing On Students’ Self-Beliefs Of Their Mathematical Competence, Kelly Eyre Frazee

Theses and Dissertations

Many students lack the ability to maintain positive perceptions of their mathematical self-belief, resulting in undesirable social, emotional, and academic outcomes. The purpose of this study was to investigate the impact of a cognitive reframing strategy on third and fourth grade math intervention students’ perceptions of their mathematical competence. This study sought to understand the impact of this emotional regulation strategy on students’ ability to autonomously regulate their negative or irrational thoughts related to their mathematics abilities, as well as the impact on their self-beliefs. Data for this study were collected through semi-structured interviews with students, student reflections, and researcher …

Infection Intensity And Prevalence From Perkinsus Marinus In The Eastern Oyster, Crassostrea Virginica (Gmelin 1791) And Their Association With Salinity, Temperature, And Sex In South Carolina Estuaries, Deja E. Best

Theses and Dissertations

This project aimed to identify the associations between the infection intensity and prevalence of Perkinsus marinus infection (i.e., Dermo ) in the Eastern oyster, Crassostrea virginica (Gmelin), with extrinsic environmental factors such as changes in salinity and temperature along with oyster host factors such as sex ratio. The objectives of the study were to: (1) identify significant associations between the dependent variables, P. marinus prevalence and infection intensity, in relation to salinity and water temperature which may be affected by climate change; and (2) identify any intrinsic factors related to sex (i.e., male, female, intersex, and indeterminant) that may affect …

Replenishment Of Essential Natural Resources: An Assessment Of The Ability Of Freshwater Algae To Enhance Crop Quality And Soil Health, Lala Christina Ek

Theses and Dissertations

Disregard for soil, an essential natural resource, hinders global food production. Food insecurity is a major concern for both public health officials and environmental scientists due to soil quality decline, pollution, and climate change. Alternatives or targeted additions to chemical fertilizers can bolster soil quality, improve crop yields, lengthen crop shelf life, and mitigate environmental pollution. One potential alternative to chemical fertilizers is replacement of them with biological soil amendments, including algae, to enhance crop growth and improve soil health. Research was conducted at the University of South Carolina-Columbia campus garden to determine impacts of non-toxic freshwater algae on crop …

An Examination Of Physical Literacy: Learning Through A Technology Integrated, Flipped Classroom Approach., Euan M. S. Frew

Theses and Dissertations

Technology integrated, flipped classroom design offers opportunities to engage students on various levels and through meaningful ways. Introducing this learning environment to students at an early age is likely to change their motivation for learning towards physical literacy and influence their lifelong participation in physical activity. The purpose of this action research was to evaluate the implementation of a new technology integrated, Flipped Classroom in a physical education class, to increase eighth -grade students’ physical literacy at an international middle school. The following research questions guided this study: (a) How and to what extent does a technology integrated, flipped classroom, …

Dietary Inflammatory Index During Pregnancy And Changes Over Time: Associations With Post-Partum Sleep Duration And Quality And Depressive Symptoms., Nowrin Tamanna

Theses and Dissertations

STUDY OBJECTIVES: Sleep and mental health are two important factors for a new mother, as adequate sleep and a healthy mind help her prioritize self-care, seek support when needed, and create a nurturing environment for both her and her baby. Among various plausible theories exploring the etiology of sleep disturbances and depression, the concept of inflammation is gaining attention. This study examined the hypothesis that more pro-inflammatory diets during pregnancy are associated with a decrease in sleep quality and duration, abnormal sleep timing and higher Edinburg Postnatal depression score (EPDS) scores 6 months and 12 months post-partum.

METHODS: A secondary …

Causes And Consequences Of The Risk Of Generalizability Biases In Health Behavioral Interventions, Lauren Von Klinggraeff

Theses and Dissertations

Preliminary testing of health behavior interventions (e.g., pilot, feasibility studies) are used to evaluate intervention viability prior to additional testing and resource investment (e.g., larger trials). This initial testing provides valuable information, but promising estimates of effectiveness produced during early testing are rarely reproduced in larger studies, stalling the development of effective, scalable health interventions. In the obesity intervention literature, external validity biases, features of the intervention that are not (or cannot) transfer to the larger study, are associated with these diminished effects. These study features, such who delivers the intervention, the characteristics of the population receiving the intervention or …

Correlates Of Immunization Timeliness In Three South Asian Countries: Secondary Analysis Of Demographic And Health Surveys, Tanzir Ahmed Shuvo

Theses and Dissertations

Despite the availability of effective vaccines, 1.5 million children under the age of 5 years die every year because of vaccine preventable diseases. Improvements in vaccine delivery infrastructure have resulted in relatively high coverage of vaccines, but many children are not receiving their vaccines on a timely basis. Timely administration of routine vaccines recommended by the Expanded Programme on Immunization (EPI) ensures maximum efficacy. It is vital to explore rates of vaccination timeliness and the correlates of timely vaccination among children to design targeted interventions for improving both coverage and timeliness. We conducted a secondary data analysis of the Demographic …

Piloting Brief, Just-In-Time Training Videos For Mentors: Expanding And Strengthening Motivational Interviewing For Youth, Mackenzie J. Hart

Theses and Dissertations

Having paraprofessional providers, such as youth mentors, deliver evidence-based services, has been posited to increase the reach of youth services given the affordability and ubiquity of mentors in school settings. Further, examinations of mentor-delivered Motivational Interviewing (MI) have shown promise in increasing youth mentees’ academic performance and wellbeing. Yet, traditional methods used for training mentors to use MI effectively and sustainably can be costly and time-consuming processes. Previous work has suggested the value of asynchronous, brief, just-in-time trainings (JITTs) to help offset these challenges; however, MI JITTs for mentors have not yet been formally evaluated. As such, the present study …

Novel Approach To In-Situ Mocvd Oxide/Dielectric Deposition For Iii-Nitride-Based Heterojunction Field Effect Transistors, Samiul Hasan

Theses and Dissertations

III-Nitride-based compound semiconductors have unique properties such as high bandgap and high breakdown field, which make them attractive for a variety of applications, including high-power and high-frequency electronics and optoelectronics. The most common types of III-Nitride-based field effect transistors (FETs) are aluminum gallium nitride (AlGaN)/gallium nitride (GaN) based, which suffer from some inherent problems such as virtual gate effect, current collapse, gate leakage, etc. The solution to this problem can be the inclusion of a dielectric passivation layer under the gate. However, the addition of the dielectric layer impacts one of the most critical device-controlling parameters, “threshold voltage”, which suffers …

The Effect Of Antibiotics On Immune Cell Infiltration Of Colon In A Mouse Model Of Early Onset Colorectal Cancer, Valerie Hinsch

Theses and Dissertations

Early onset colorectal cancer (EOCRC) is an aggressive form of colorectal cancer diagnosed before the age of 50. While colorectal cancer cases in patients 50 years and older have been declining, EOCRC cases have been steadily increasing globally in the last few decades, and the cause is unknown. Many agents, called exposomes, have been associated with EOCRC based on their emergence and prevalence prior to and in parallel with the rise in EOCRC cases. Among these are antibiotics (Abx). Abx are indispensable in our fight against infectious diseases, however their overuse is becoming a global epidemic. They are prescribed globally, …

Using Critical Reflection To Mitigate Racial Implicit Bias And Enhance Cultural Humility: A Nursing Faculty Action Research Study, Teresa Stafford Cronell

Theses and Dissertations

Formal American nursing education has existed since the late 19th century, but its historically deep-seated white framing continues to influence how current nurses are educated, enculturated, and professionalized. Insufficient inclusivity and diversity deficit have endured despite decades-long demands to do otherwise. To most nursing educators, the white frame is invisible. This unseen framing allows ongoing harmful implicit biases and microaggressions towards underrepresented nursing students and colleagues to persist. Nursing students are taught to provide culturally humble, unbiased patient care. Should not nursing faculty likewise demonstrate the same unbiased attitudes and humility towards their students? Faculty risk perpetuating the white frame …

Effects Of Ai Voice Assistants’ Messages On Pro-Environmnetal Consumer Behavior: Message Content And Voice Attributes, Somang Min

Theses and Dissertations

The hospitality and tourism industry has increasingly prioritized environmental concerns, driving the adoption of green practices and communication strategies. This dissertation investigates the role of AI voice assistants in hotel rooms in promoting pro-environmental behavior, recognizing the importance of fostering environmental mindfulness through technology and behavioral interventions. This research explores the influence of voice attributes and message content on consumers' pro-environmental behavior when conveyed through AI voice assistants. It specifically focuses on the marketing cue of Kindchenschema cuteness by examining how a baby-like voice in AI voice assistants may enhance pro-environmental communication, a topic rarely addressed in the hospitality and …

Creative Insights On The Commissioning, Analysis, And Performance Of Four New Works For Saxophone, Andrew Joseph Hutchens

Theses and Dissertations

This document explores, in detail, four works for saxophone, which the author commissioned. These pieces were performed on the author’s degree recitals prior to the writing of this document. The selected works are At the Seams by Baljinder Singh Sekhon II, Intrepid by Russell Wharton, Unity Synonym by Michael Laurello, and Third Rail / Revelation by Stephen Karukas. This document focuses on the commissioning process, musical performance, and theoretical aspects of these four pieces. Interviews were conducted virtually via Zoom and then transcribed for inclusion in this document. There have been no previous studies that have explored these four works. …

Decoding Trustworthiness And Helpfulness Of Online Reviews In Hospitality: A Reader-Centric Perspective, Xiaonan Zhang

Theses and Dissertations

Online review is an ongoing popular topic for both researchers and practitioners. Consumers’ decision-making is largely influenced by the online reviews, especially those that are perceived as trustworthy and helpful given the information overload issue and existence of fake reviews. This dissertation consists of three independent but closely related studies focusing on trustworthiness and helpfulness of online reviews in hospitality industry. The objectives of this dissertation are to explore the factors affecting review trustworthiness and helpfulness as identified in previous research and determine their relevance to consumers' real-world reading and decision-making experiences, as well as the impact of message framing …

Perspectives, Motivations, And Resistance: Investigating Employee Responses To Employer-Sponsored Diversity Training, Robert Kerlin

Theses and Dissertations

This qualitative action research study investigated employee reactions, motivations, and perspectives toward employer-sponsored diversity training programs. Through a qualitative exploratory case study, this research study explored the perceptions of how a diverse sampling of people individually, negotiate identities in corporate and education fields where those in control must both accommodate and placate in order to maintain institutional objectives. In order to further explore this topic, a theoretical framework consisting of self-determination theory and culturally relevant pedagogy served as the primary method to guide the research question, literature reviews, and data design, collection, and analysis process. Self-determination theory provided the primary …

Probabilistic Cable Aging Diagnosis And Prognosis With Reflectometry And Capacitance Methods, Xuan Wang

Theses and Dissertations

Safe and reliable operation of power plants and power transmission are critical to economy and society. Cables in power generation and transmission are subject to various thermal, chemical, and mechanical stresses, which generally lead to aging and degradation of cable insulation. It is reported that some cables with a projected lifetime of 40 years need to be replaced in 10-15 years. Poorly maintained aged cables can adversely affect power delivery and lead to catastrophic events, such as blackout, fires, and loss of lives. The current research on cable is mainly focused on the detection and localization of hard faults, which …

Exploring The Assembly Of Soluble Triphenylamine Bis-Urea Macrocycles; Synthesis Of Nsc243928 Derivatives For Triple-Negative Breast Cancer Treatment, Rahul Prakash

Theses and Dissertations

This dissertation is divided into two topics: I. Supramolecular polymerization of triphenylamine (TPA) bis-urea macrocycle behavior in solution, and II. Synthesis of fluorophore appended and biotinylated derivatives of NSC243928 for the treatment of triple-negative breast cancer. Supramolecular polymers are of interest due to their self-healing and stimuli responsiveness. Chapter 1 gives a brief overview of the importance of self-assembly to construct ordered structures from smaller building blocks, highlighting the mechanisms of self-assembly to form supramolecular polymers. The bis-urea macrocycle assembly unit is introduced and its assembly into tubular structures and crystals is highlighted, which are used as a control for …

Weathering The Covid-19 Pandemic: A Study Examining How The Lived Experience Affected English Learners, Mary Kathryn Maxwell

Theses and Dissertations

The COVID-19 pandemic profoundly impacted many students, especially the English learners who require specialized instruction and additional support to develop English language proficiency. This study examines how the pandemic created barriers that caused a decline in the academic achievement and engagement in the learning process of sixth-eighth grade English learners in an urban district in Ohio. In this mixed-methods study, using an explanatory sequential research design, quantitative data were collected through an online Likert survey while qualitative data were gathered from semi-structured interviews, artifacts, and researcher field notes. A total of 21 participants completed the survey and interviews. The merged …

Recovering Lost Exposure From The Majorana Demonstrator And Testing Data Selection Assumptions, Thomas Lannen

Theses and Dissertations

The Majorana Demonstrator recently concluded its search for neutrinoless double beta decay using an array of up to 40.4kg of germanium detectors, 27kg of which were enriched in ⁷⁶Ge and housed inside a copper and lead compact shield located at the 4850 foot level in a clean room in the Davis Campus of the Sanford Underground Research Facility (SURF) in Lead, South Dakota. This search proceeded from June 26, 2015 until March 3, 2021 and 64.5 kg yr of enriched active exposure was acquired while achieving a world leading energy resolution of 0.12% FWHM at 2039 keV, one of …

Water Quality Monitoring And Mapping Using Rapidly Deployable Sensor Nodes, Mohamed Abdelwahab

Theses and Dissertations

Efficient and continuous monitoring of water quality parameters plays a pivotal role in responding to pollution incidents and ensuring the safety of both human consumption and ecological resources. This research introduces an affordable and dependable in-situ water quality sensor package designed for seamless continuous monitoring, providing essential data to facilitate informed decision-making in water resource management. The sensor package enables comprehensive on-site assessment of key water characteristics, including pH, temperature, turbidity (measured in NTU), and total dissolved solids (TDS, measured in ppm). Spatial interpolation techniques, specifically Kriging, are employed to extrapolate variable values at unobserved locations based on nearby measurements. …