Digital Commons Network^™

On The Rebound: Resilience And Subjective Cognitive Symptoms In Cancer, Giuliana V. Zarrella

Theses and Dissertations

Recent studies have shown a strong connection between resilience and subjective cognitive symptoms in clinical populations. However, there is limited understanding of this relationship in cancer survivors, and no studies examine whether resilience training could alleviate subjective cognitive symptoms in these patients. This study examined the relationship between subjective cognitive function and resilience in non-CNS cancer survivors who participated in a resiliency training intervention, at baseline and from pre- to post-intervention, as well as investigated potential influences of change in subjective cognition. Adult cancer survivors (N=275) participated in the Stress Management and Resilience Training-Relaxation Response Resilience Program (SMART-3RP) …

Investigating Black Emerging Adult Health And Model Of Care Choices, Alexandra Wynn

Theses and Dissertations

This mixed methods study aimed to analyze the health profiles of Black emerging adults (who do not seek medical care for chronic condition management) college students to identify factors influencing their use of preventive services and their choices in healthcare plans. The study revealed distinct profiles of Black emerging adults based on patterns of factors related to their engagement with healthcare, such as barriers to care, insurance access, usual source of care, self-rated health, intention to seek care, discrimination, trust in physician, medical mistrust, and sex-assigned at birth. Interviews were conducted to investigate the similarities and differences among all participants …

Biodistribution Comparison Of Fentanyl And Morphine Following Acute And Repeated Expsoure, Rosamond M. Goodson

Theses and Dissertations

The ongoing opioid crisis constitutes a dire public health threat that has resulted in staggering loss of life. In 2021, opioids were implicated in over 75% of the approximately 107,000 deaths attributed to drug overdose (CDC), and synthetic opioids such as fentanyl and its analogues are key drivers of the surge in opioid fatalities in recent years. Although fentanyl is a μ opioid receptor agonist, it has several distinct attributes compared to other drugs in this category, such as morphine. These include enhanced lipophilicity, heightened potency to induce respiratory depression, more rapid entry into the central nervous system, reduced sensitivity …

Disparities Between Native Americans And White Individuals In Trajectories Of Community Participation Over The 5 Years After Traumatic Brain Injury, Jack Watson

Theses and Dissertations

Traumatic brain injury (TBI) disproportionately affects minoritized populations within the U.S., especially Native Americans who are more likely to experience a more severe or fatal TBI than White individuals. The current study used a subsample of 63 Native Americans with TBI from the TBI Model Systems (TBIMS) database matched by age, sex, and injury severity to 63 White individuals to examine disparities in community participation, as measured by the Participation Assessment with Recombined Tools—Objective (PART-O), over the five years following TBI. Analysis of variance (ANOVA) and chi-square tests revealed Native Americans were less likely to be employed prior to injury, …

The Sexually Dimorphic Role Of Connexin 43 In Bone Remodeling And Disuse-Induced Bone Loss, Gabriel A. Hoppock

Theses and Dissertations

Bone loss is frequently experienced by individuals undergoing long-term disuse, such as prolonged bedrest, immobilization due to paralysis or injury, and conditions such as spaceflight. Under normal physiological conditions, bone remodeling is balanced by bone-forming osteoblasts and bone-resorbing osteoclasts, and the activity of osteoblasts and osteoclasts is orchestrated by osteocytes. Osteocytes are the most abundant cell type found in bone and ample evidence suggests they are bone’s main mechanosensory cell type. Therefore, understanding osteocyte biology and responses to mechanical signals, or lack thereof during unloading, may lead to new therapeutic targets to combat bone loss during disuse. Previous data has …

Associations Between Childhood Trauma And Tobacco Dependence Among Latine Adults: Testing The Protective Effects Of Compassion For Self And Others, Camila Tirado

Theses and Dissertations

Tobacco dependence has posed a significant public health challenge in the United States and disproportionately affects Latine adults' risk of developing a variety of adverse health conditions. Childhood trauma is a recognized risk factor for dependence, overall health, and mental health concerns. Still, the influence of compassion for self or compassion for others in this context remains unclear. This cross-sectional study investigated the moderating effects of self-compassion and compassion for others on the relationship between childhood trauma and cigarette dependence among Latine adults. Data was collected through questionnaires assessing childhood trauma, self-compassion, cultural values and factors, compassion for others, and …

Optimizing Deep Inspiration Breath Hold Technique For Personalized Breast Cancer Radiotherapy, Srinidhi Rajagopalan

Theses and Dissertations

The purpose of this research is entrenched in advancing the practice of 3D Conformal Radiation Therapy (3D CRT) for breast cancer patients by meticulously evaluating the impact of different Deep Inspiration Breath Hold (DIBH) techniques on dosimetric parameters. This study aims to ascertain the quantitative benefits of varied breathing techniques, primarily focusing on the 'Ultimate DIBH' method's efficacy in sparing critical organs such as the heart and lungs.

The comprehensive analysis of different DIBH techniques in this research is not merely an academic exercise but is geared towards substantiating the hypothesized advantages of these techniques with empirical data. By generating …

From Temporary Nurse Aide To Certified Nurse Aide: Examining Temporary Nurse Aides’ Perceptions Of Situated Learning As Preparation For The National Nurse Aide Assessment Program Examination, Amy Taloma

Theses and Dissertations

The Covid-19 pandemic exacerbated Certified Nurse Aide (CNA) staffing shortages in Long Term Care (LTC) facilities. To address these shortages, the Centers for Medicare and Medicaid Services (CMS) authorized LTC facilities to employ Temporary Nurse Aides (TNA). The American Health Care Association (AHCA) and the National Center for Assisted Living (NCAL) developed free online training for individuals which is much shorter than traditional nurse aide training and does not require hands-on skill training or a clinical practicum. The Federal Public Health Emergency (PHE) ended in October 2022. As a result, TNAs are no longer authorized to work in LTC Facilities …

Evaluation Of Cervical Dentin Removal After Orifice Shaping In Maxillary Premolars: A Micro Ct Study, Abdulaziz Mallik

Theses and Dissertations

Objective: The research aims to compare the volume and percentage of pericervical dentin removed by Gates Glidden Drills, ProTaper SX, and a 20-06 Rotary File.

Methods: A total of 24 extracted two-rooted maxillary first premolars were divided into three groups (n=8) and were coronally flared using either Gates-Glidden Drills, ProTaper Gold SX, or a 20-06 Brasseler Endosequence CM Rotary File. Pre- and post-flaring micro-CT scans were obtained. The dentin volume of the buccal canals was measured from the chamber floor and 2 mm apically in the buccal canal only. Data were analyzed using the ANCOVA test to compare dentin removal …

“Black Wom(B)Anhood”: An Explorative Analysis Of Black Women's Narratives Of Healthcare Encounters During And After Pregnancy, Janae A. Baker

Theses and Dissertations

This qualitative study explores the intricate dynamics of patient-provider relationships within the context of prenatal care among Black women and how these experiences may affect their perinatal mental health. The study was conducted using a methodology consisting of structured interviews with 12 participants, snowball sampling facilitated recruitment. Thematic analysis revealed six prominent themes encapsulating the multifaceted interactions between Black women and their healthcare providers during the perinatal period. The findings illuminate nuanced aspects of the patient-provider relationship, shedding light on issues such as: (a) Anticipation of Low Quality Care, (b) Lack of Communication, (c) Listening, (d) Stereotype Threat, (e) Colorism, …

Exploring The Experiences Of Refugee Youth In Public Schools: An Ethical Phenomenological Inquiry, Hilary T. Stim

Theses and Dissertations

The study outlined in this dissertation focuses on the intersection between refugee youth between the ages of 13-18 and the United States public school, specifically the manner in which refugee youth experience institutionalized education. It utilizes ethical phenomenology as a means to amplify the voices of refugee students and to centralize the students' experiences, thoughts, and ideas related to education The study was framed by one research question that is addressed to the participants: “What is it like being a student in a public school?” Seven students took part in the study. Collaborative dialogues took place with the participants across …

Online Racism And Mental Health Symptomatology Among Black Adolescents: A Longitudinal Examination, Stephen M. Gibson

Theses and Dissertations

Online racism (i.e., racism perpetrated and embedded within media and platforms on the Internet) is increasingly becoming a public health concern. Recent empirical evidence demonstrates that over a three year period, Black adolescents reported experiencing at least one online racial discriminatory incident, including exposure to racist images or videos within digital spaces (Tynes et al., 2020). One way in which Black adolescents are exposed to online racism is through the consumption of digital news media on the coverage of racially traumatic events (e.g., murders of Black men and women by police officers, racial hate crimes committed against Black people) and …

Exploring The Relationship Of Intact Limb Knee Joint Loading With Step Lengths And Step Length Symmetry In Individuals With Lower Limb Amputation, Edward D. Syrett

Theses and Dissertations

Individuals with unilateral lower limb amputation (LLA) frequently experience intact limb knee pain, dysfunction, and osteoarthritis. These problems can worsen pre-existing reductions in mobility and quality of life that this population regularly experiences. It is widely accepted that knee joint loading is implicated in the development of knee joint issues, and intact limb knee joint load alterations are thought to be widespread in individuals with LLA. Prior work suggests that gait deviations frequently present in this population may be a contributory cause of these altered forces. These deviations can take many forms, but individuals with LLA commonly demonstrate alterations in …

Fitbit Engagement In An Health Physical Activity Intervention For Young Adult Cancer Survivors: A Secondary Analysis Of The Impact Randomized Controlled Trial, Jessica Gomez Smith

Theses and Dissertations

Wearable devices allow for objective remote and real-time data collection and have been increasingly popular among the general public and in mHealth activity (PA) interventions. Despite this, our knowledge of feasibility and efficacy for using wearable devices to increase PA among a particularly vulnerable population—young adult cancer survivors age 18-39 (YACS)—is limited. Engaging in physical activity while undergoing cancer treatment contributes to reduced risk for recurrence and secondary cancers, and can also help to manage treatment side effects. However, there are a multitude of barriers to PA engagement among cancer survivors, with YACS in particular demonstrating low rates of PA. …

Spatial Transcriptomics Unravels Palmitoylation And Zonation- Dependent Gene Regulation Of Aeg-1 In Mouse Liver, Alissa Saverino

Theses and Dissertations

Obesity-induced metabolic dysfunction-associated steatohepatitis (MASH) leads to hepatocellular carcinoma (HCC). Astrocyte-elevated gene-1/Metadherin (AEG-1/MTDH) plays a key role in promoting MASH and HCC. AEG-1 is palmitoylated at residue cysteine 75 (Cys75) and a knock-in mouse representing mutated Cys75 to serine (AEG-1-C75S) showed activation of MASH- and HCC-promoting gene signature when compared to wild-type littermates (AEG-1-WT). The liver consists of 3 zones, periportal, midlobular, and pericentral, and zone-specific dysregulated gene expression impairs metabolic homeostasis in the liver, contributing to MASH and HCC. Here, to elucidate how palmitoylation influences AEG-1-mediated gene regulation in regards to hepatic zonation, we performed spatial transcriptomics (ST) in …

Development Of A Validity Scale For The Icd-11 Personality Disorder Measure (Psi-11), Rae Lutz

Theses and Dissertations

Invalid responding is a significant issue in the utilization of self-report information. Invalid responding can be assessed by stand-alone validity measures or embedded validity scales. The International Classification of Diseases (ICD) is one of two major diagnostic systems which provide guidance on diagnosing personality disorder, with the most recent version (ICD-11) providing a fully dimensional model for personality disorders. No existing measures aimed at assessing dimensional personality pathology have addressed the combination of PD severity and trait qualifiers that were based upon ICD-11 guidelines. To address this gap, Clark et al. (2021) developed the ICD-11 Personality Disorder Measure (PSI-11). However, …

Community Informant And Mental Health Provider Perspectives On Access To Mental Healthcare For Lgbtqia+ Communities In Virginia, Chariz Seijo

Theses and Dissertations

The existing literature on mental health disparities for lesbian, gay, bisexual, transgender, queer, intersex, and asexual (LGBTQIA+) populations suggests members of LGBTQIA+ populations are at greater risk of mental health disorders than cisgender and heterosexual individuals. The COVID-19 pandemic has also exacerbated mental health disparities for many, including LGBTQIA+ populations. Combined with mental health provider shortages and anti- LGBTQIA+ bills across the country, inequities in mental healthcare are a significant concern. This qualitative study was designed to gather unique perspectives of key community informants and mental health providers on their experiences with mental healthcare provision to LGBTQIA+ communities in Virginia. …

Expect: A Speculative Documentary Filmed In Vr Utilizing The Role-Playing Method To Explore Disabilities And Ableism In Science Fiction, Leilei Xia

Theses and Dissertations

Expect is a speculative documentary filmed in Virtual Reality (VR) that features Chinese actors with disabilities to explore, challenge and reimagine the conventional ableist Sci-Fi tropes and the transhumanistic tendency to “fix” or eradicate disabilities through technological enhancement. I invited people with disabilities who are interested in Sci-Fi to do a Role-Playing with me in Virtual Reality (VR), in which they imagine themselves to be living in a future civilization, an alien planet, or an alternate universe. The participants came up with their own fictional characters and built their own world views. I interacted with them by asking questions and …

The Collection: A Third-Place Community Library Design, Camille Rovani

Theses and Dissertations

TOPIC

This project explores the significance of “third places”— informal public gathering spaces like cafés, parks, and libraries — and how design strategies in these spaces can help foster community connection and enhance well-being in a modern context.

PERSONAL RELEVANCE

While working a remote job during the pandemic, I experienced an overwhelming disconnect from the people around me. Like many people during that time, I was depressed. I then took an interest in the positive impacts of community connection on our health and well-being. I became fascinated by the concept of “third places,” a term coined by sociologist Ray Oldenburg …

Levofloxacin Incorporated Extracellular Matrix Nanoparticles For Pulmonary Cystic Fibrosis Infections, Raahi Patel

Theses and Dissertations

Cystic fibrosis (CF) is a progressive genetic disorder that affects around 40,000 people in the United States. CF is characterized by a mutation in the CFTR protein that causes dysregulated ion transport across epithelial cells, producing viscous mucus in the lung that increases bacterial invasion, causing persistent infections and subsequent inflammation. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most common infections in CF patients that are resistant to antibiotics. One antibiotic approved to treat these infections is levofloxacin (LVX) that functions to inhibit bacterial replication, but can be further developed into tailorable particles. Nanoparticles are an emerging inhaled …

Considering Systems Of Power And Black And Latine Students’ Belonging In Stem, Korinthia D. Nicolai

Theses and Dissertations

This dissertation focuses on (a) exploring the need for and strategies to facilitate the integration of Critical Race Theory (CRT) and educational psychology and (b) supporting Black and Latine students through examining the impact of systems of power via the integration of belonging and Critical Race Theory. This dissertation follows a three-paper format. In Paper 1, we recognize that psychology researchers can use CRT to explore race and racism. However, psychology scholars may confront growing pains when integrating CRT due to their respective inquiry worldviews–postpositivism and critical–which result in several tensions. These tensions may limit the uptake of CRT in …

Inspiring A Ripple: A Case For Evidence-Based, Biophilic Design For Affordable Housing, Chelcey A. Dunham

Theses and Dissertations

ABSTRACT

RELEVANCE

Currently in the US, 4 million families in need of affordable housing are not housed in affordable units and are spending 30-50% of their monthly income toward rent (Aurand, 2023.) Due to this shortage of affordable housing and the trajectory of its growth, advocacy groups and policy makers are making a push to fund more affordable housing projects. What if the designs of these projects were informed in such a way that individual and community mental health and wellness could be addressed in addition to meeting the demand for affordable, safe shelter? In this way, the return on …

In Shame I Will Find Paradise, Taehee Whang

Theses and Dissertations

As a Korean American non-binary digital artist and designer, my recent explorations have focused on using voice as a medium to articulate nuanced feelings of displacement and the intricate relationships between language, identity, and expression. This journey expands beyond my personal experiences with gender dysphoria, delving into the lives of non-binary and transgender individuals undergoing gender-affirming voice therapy. Through my thesis research, I have developed interactive multimedia installations inspired by dialogues with individuals such as Umico Niwa, who traveled to Korea for voice feminization surgery, and Jeong Yoon Lee from Hyperlink Press, a four-year participant in Hormone Replacement Therapy (HRT). …

Sense Make Before Book, Bradley Sinanan

Theses and Dissertations

“Sense Make Before Book” is an Indo-Caribbean turn of phrase which refers to common sense being more important than book smarts. My sister sent me a post the other day on Instagram of an Trinidadian woman using this phrase, saying it was one of Indo-Caribbean origin. I was interested and asked my mom about it. My mom says that when she was younger my grandpa said it often around their house in Princes Town, Trinidad and Tobago. This adage feels charged thinking about the history of indenture and its effects on the Indo-Caribbean diaspora.

The written word of archival history …

Obesity Knowledge And Bmi In Caregiver-Adolescent Dyads: A Descriptive Comparative Pilot Study, John Sykes, John Sykes

Theses and Dissertations

Abstract

Background: The prevalence of obesity and associated health risks and costs continue to increase. The majority of these health and cost ramifications manifest in adulthood, making it imperative to intercept the problem during childhood. Unfortunately, an overwhelming majority of the research surrounding adolescents and obesity to date involves subjects that are already overweight or obese, and the focus of those interventions are on secondary and tertiary prevention. Focusing on primary prevention of childhood obesity could ultimately decrease the incidence, prevalence, and disease-related burden to society. It is posited that the 20% difference in obesity prevalence between adults and children …

Drugging The Histone Acetyltransferase Ep300 Modulates Alternative Splicing At Schizophrenia Risk Genes, Shravani Malay

Theses and Dissertations

Purpose. We will evaluate the effects of drugging the epigenetic histone acetyltransferase (HAT) enzyme p300, encoded by the schizophrenia risk gene EP300, on genome-wide gene expression in neural cells. We hypothesize that drugging p300 will affect gene expression and alternative splicing of other schizophrenia risk genes. Our motivation is to identify potential new epigenetic treatment avenues for schizophrenia.

Methods. Prior to my joining the lab, an experiment was conducted using the novel p300 HAT inhibitor, A-485, to modulate genomic regulation in a neural cell line (SH-SY5Y). SH-SY5Y cells were exposed to 10μM of A-485 or vehicle (DMSO) for 24 …

Monte-Carlo Method For Identifying Aberrantly Expressed Genes In Cancer, Matthew M. Beltran

Theses and Dissertations

Gene expression provides insight into the functional variations on the cellular level that shape biological phenomena. Several recent sequencing technologies have produced an abundance of expression profiles spurring entirely new disciplines of biological study. With this myriad of data, the new task is deciding how to assess and extract meaningful insights. Identifying genes with expression changes in disease conditions is often the first step in finding potential biomarkers for diagnosis, and targets for pharmaceutical treatments. Parametric statistical tests at the individual gene level have been the conventional approach for finding differentially expressed genes. These tests exhibit high statistical power but …

Dune Dynamics- A Nature-Based Preschool, Aseel Alhaidari

Theses and Dissertations

Sustainability is a global issue that requires collaborative efforts. Environmental values and attitudes are shaped in adults by early exposure to nature. During the COVID-19 pandemic, remote learning increased the attention to nature-based learning from families and the press (Prochner, 2021).

Although many early childhood education approaches for the age group of 3-5 years recognize the importance of holistic development and focus on tailoring the learning experience to the developmental stage of young children, few emphasize the importance of integrating nature as one of the learning tools. Nature-deficit disorder in children means that children spend less time outdoors and in …

Mathematical Modeling And Analysis Of Inflammation And Tissue Repair: Lung Inflammation And Wound Healing In Corals Under Stress, Quintessa Hay

Theses and Dissertations

A variety of insults, including tissue injury and/or exposure to pathogen, elicit an immune response in many organisms. An improperly regulated immune response can result in deleterious effects to the organism. Here we present models for lung injury in young and old mice and models for wound healing in coral reefs.

It is well known that the immune response becomes less effective in older individuals. This is of particular interest in pulmonary insults such as ventilator induced lung injury (VILI) or lung infection. We extended a mathematical model for the inflammatory response to VILI and used experimental data to select …

Dynamic Mathematical Approaches To Understanding Pain In Sickle Cell Disease, Quindel Jones

Theses and Dissertations

In the last 50 years, pain in Sickle Cell Disease (SCD) has become more widely studied thanks to advancements in technology and awareness. Clinical studies, population surveys, pharmaceutical trials, and computational models have been created and conducted to elucidate the mechanisms, treatments, and prediction of Sickle Cell disease pain episodes. Computational models have become quite useful in unraveling disease pathology with the rise in data collection accessibility and advanced computational power. In particular, dynamic mathematical models have been used to investigate Sickle Cell disease pathology and treatment. In this work we conduct a literature review of mathematical models used in …