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Comparing The Effectiveness Of Telehealth Training For Parents Using “Help Is In Your Hands”: Joint Attention And Mands, Vivian Desiree Cortez Dominguez Apr 2026

Comparing The Effectiveness Of Telehealth Training For Parents Using “Help Is In Your Hands”: Joint Attention And Mands, Vivian Desiree Cortez Dominguez

Theses and Dissertations

This study aimed to compare the effects of remote parent training for parents of autistic children in Peru, ages 2-4 years old. Using the Spanish version of the digital program called “Help is in Your Hands” (Rogers & Stahmer, 2026; 3C Institute, 2026), three mothers were trained on how to support their child's ability to participate in joint attention and mand. Autism is a condition in which children present with challenges in engaging with others, such as sharing joint attention and using mands. Several evidence-based trainings target these difficulties. However, accessing these trainings can be expensive and time-consuming. In less-developed …


Shame On You! The Socialization Of Self-Conscious Emotions In Early Childhood, Ashton K. Allen Apr 2026

Shame On You! The Socialization Of Self-Conscious Emotions In Early Childhood, Ashton K. Allen

Theses and Dissertations

This study examined how parents and children discuss self-conscious emotions across early childhood. Self-conscious emotions such as shame, guilt, embarrassment, awe, and pride play a critical role in children's social and emotional development. Although prior research has demonstrated links between parent and child emotion talk about basic emotions such as happiness, anger, disgust, fear, sadness, less is known about how parents and children talk about self-conscious emotions. Participants for the current study were 247 parent-child dyads. The dyads completed a wordless storybook task designed to elicit discussion of five self-conscious emotions (shame, guilt, embarrassment, awe, and pride) annually across three …


Utah Secondary English Language Arts Teachers And The Use Of Body Diverse Young Adult Literature, Katy Johnson Bigham Apr 2026

Utah Secondary English Language Arts Teachers And The Use Of Body Diverse Young Adult Literature, Katy Johnson Bigham

Theses and Dissertations

Representation in young adult (YA) literature has expanded significantly in recent years, but body size diversity - specifically the inclusion of fat protagonists - is still minimal and understudied in secondary English language arts (ELA) classrooms. Research shows that diverse literature plays a crucial role in helping students see themselves and other reflected in the texts they read, as shown in the metaphor of literature as "windows, mirrors, and sliding glass doors" (Bishop, 1990). So how does this apply to the representation of body size diversity in the ELA classroom? This study explores how secondary ELA teachers in Utah perceive …


"A Politics Of Its Own": Reading Adelaide Procter's Poetry In The Context Of The English Woman's Journal, Rachel Diane Gouff Apr 2026

"A Politics Of Its Own": Reading Adelaide Procter's Poetry In The Context Of The English Woman's Journal, Rachel Diane Gouff

Theses and Dissertations

Victorian poet Adelaide Anne Procter, a devout Catholic and a nineteenth-century feminist and social activist, was hugely popular in her lifetime for her devotional and sentimental poetry. However, scholars who have looked closely at her work have recognized that her poetry contains moments of tension that suggest they may be more than they appear on the surface. Such tensions and ironies are often glossed over or misread by readers whose expectations of Christian devotional messaging and domestic sentiment overshadow the contradictions. In this paper, I propose that one of the most effective ways to more fully understand the nuance and …


Subversive Speculative Theology In Women's Stories From The Mormon Home Literature Movement, Rachel Meibos Helps Apr 2026

Subversive Speculative Theology In Women's Stories From The Mormon Home Literature Movement, Rachel Meibos Helps

Theses and Dissertations

In the 1910s, Mormon women used sentimental speculative fiction published in official Relief Society Magazine to engage theological questions often reserved for male ecclesiastical authority. This paper examines three short stories: Edna Coray's "A Quitter–Almost." (1918), Lucy May Green's "A Whiff of Ether" (1919), and Laura Jenkins's "Beyond the Portals" (1916), each of which depicts a woman's encounter with the spirit world at the moment of death or near-death. Drawing on the Mormon Home Literature movement and the broader tradition of sentimental fiction as political and moral discourse, I argue that these authors used narrative to fill gaps in official …


Tracing Microplastics From Polymer-Coated Urea: Urban To Agricultural Pathways And Environmental Fate, Caden Joseph Seely Apr 2026

Tracing Microplastics From Polymer-Coated Urea: Urban To Agricultural Pathways And Environmental Fate, Caden Joseph Seely

Theses and Dissertations

Polymer-coated urea (PCU) is widely used as a slow-release nitrogen (N) fertilizer because it improves N use efficiency and reduces losses through leaching, denitrification, and volatilization. However, the polymer coating raises concerns about potential microplastic (MP) transport to surface waters following fertilizer application. This thesis evaluates the off-site transport of MPs and associated nutrient and sediment losses from PCU in both urban landscape and agricultural systems. In the urban landscape study, treatments included sod, mulched beds, and water-efficient ground cover receiving uncoated urea, PCU, or liquid slow-release N at 225 kg N ha⁻¹ (with reduced rates for beds and ground …


Toward A Horizonal "I": The Infinite Subject In William Wordsworth's The Prelude, Gabriella Lee Schwartz Apr 2026

Toward A Horizonal "I": The Infinite Subject In William Wordsworth's The Prelude, Gabriella Lee Schwartz

Theses and Dissertations

In an 1805 letter to Sir George Beaumont describing his autobiographical poem The Prelude, William Wordsworth remarked that it was "a thing unprecedented in literary history that a man should talk so much about himself." Since then, critics have only affirmed Wordsworth's reputation as a poet, if not the poet, of selfhood and consciousness. Perhaps the most renowned scholarship on Wordsworthian subjectivity was produced by the so-called "Yale School" of the late twentieth century, as J. Hillis Miller, Harold Bloom, Geoffrey Hartman, and Paul de Man all published influential works on the topic. The latter two staked out stances on …


Evaluating Measurement Invariance Frameworks: A Comparison Of Mg-Cfa, Alignment Optimization, & Bayesian Approximate Measurement Invariance Using The Brigham Young University Counseling And Psychological Services Client Satisfaction Survey, Heidi Lula Lindsey Apr 2026

Evaluating Measurement Invariance Frameworks: A Comparison Of Mg-Cfa, Alignment Optimization, & Bayesian Approximate Measurement Invariance Using The Brigham Young University Counseling And Psychological Services Client Satisfaction Survey, Heidi Lula Lindsey

Theses and Dissertations

Researchers must establish measurement invariance (MI) before comparing latent constructs across groups to ensure construct validity. However, traditional multi-group confirmatory factor analysis (MG-CFA) may impose overly strict equality constraints in applied settings. Alternative MI frameworks are less familiar to researchers, which limits their use. This study compares MG-CFA, alignment optimization (AO), and Bayesian approximate measurement invariance (BAMI) using archival data from the Brigham Young University Counseling and Psychological Services Client Satisfaction Survey (N = 1,278). Participants completed an exit survey after receiving individual (n = 1,063), couple (n = 83), or group (n = 132) therapy, answering 16 five-point Likert …


Implementing The Safe System Approach For Speed Management In Utah, Kezia Isabelle Tripp Apr 2026

Implementing The Safe System Approach For Speed Management In Utah, Kezia Isabelle Tripp

Theses and Dissertations

Speed management is central to reducing fatal and serious injury crashes. The Safe System Approach, an emerging roadway safety paradigm in the United States, recognizes human error and vulnerability and focuses on minimizing crash severity through coordinated policy, design, and operational strategies. This thesis examines how Safe System Approach principles can be applied to speed management, with a focus on identifying practical countermeasures and implementation strategies relevant to the Utah Department of Transportation (UDOT). A compendium of practice was conducted to evaluate speed management countermeasures and document how cities and state Departments of Transportation are implementing Safe System Approach-based strategies. …


A Holistic Assessment Of Osteopathic Medical Student Well-Being And Self-Perceived Levels Of Happiness, Stress, And Satisfaction With Life, Brittany A. Mitchell Apr 2026

A Holistic Assessment Of Osteopathic Medical Student Well-Being And Self-Perceived Levels Of Happiness, Stress, And Satisfaction With Life, Brittany A. Mitchell

Theses and Dissertations

The purpose of this quantitative study was to assess the well-being of medical students and identify the primary factors influencing their well-being. In this manuscript-style dissertation, the empirical article assesses the well-being of medical students through the dimensions of wellness and investigates the significance of differences between each dimension and self-perceived levels of happiness, stress, and satisfaction with life. The practitioner article provides recommendations to practitioners to further support the well-being of osteopathic medical students. The sample for this study was medical students at an osteopathic medical school in the Philadelphia region. Data was collected using seven validated survey instruments: …


Biophysical Insights Into A Cryptic, Hydrophobic Binding Site On Pcna, Alexis Dispensa Apr 2026

Biophysical Insights Into A Cryptic, Hydrophobic Binding Site On Pcna, Alexis Dispensa

Theses and Dissertations

Proteins are dynamic molecules whose functional landscapes extend beyond static structural representations. Transient cryptic pockets (buried cavities that emerge through protein motion) represent underexplored targets for allosteric regulation and drug discovery. General anesthetics are small, lipophilic, weakly polar molecules that are well suited to partition into such hydrophobic sites. In this work, environment-sensitive fluorescence, photoaffinity labeling, mass spectrometry, mutational analysis, and microsecond molecular dynamics simulations were integrated to discover and characterize a cryptic, highly apolar binding site within the hydrophobic core of human proliferating cell nuclear antigen (PCNA), a central scaffold in DNA replication and repair. Using the solvatochromic fluorescent …


Family Processes As A Protective Factor Between Adverse Childhood Experiences And Adolescent Delinquency, Tessa Johnson Apr 2026

Family Processes As A Protective Factor Between Adverse Childhood Experiences And Adolescent Delinquency, Tessa Johnson

Theses and Dissertations

This study explores whether family processes (i.e., parental attachment and parental discipline/monitoring) serve as protective factors between the relationship of adverse childhood experiences (ACEs) and adolescent delinquency. Prior research has established an association between ACEs and many negative life outcomes, including delinquent behavior, while strong parental attachment and parental discipline/monitoring are linked to lower rates of delinquency. However, the interplay of these three factors has been understudied. Drawing on data from the 2024 Florida Youth Substance Abuse Survey (FYSAS) (N=22,016), this study examines the relationship between ACEs, family processes, and delinquency using negative binomial regression models. Results indicate that parental …


Understanding The Role Of Tiktok As A Source Of Support For Cyberbullying Victims, Saba Iqbal Apr 2026

Understanding The Role Of Tiktok As A Source Of Support For Cyberbullying Victims, Saba Iqbal

Theses and Dissertations

Cyberbullying poses a significant threat to teenagers and young adults, who often seek support and advice online. Little is known about the support and advice shared online for victims of cyberbullying and whether it is helpful. In this study, we used qualitative thematic analysis to examine a sample of 150 TikTok videos that give support or advice for cyberbullying victims. We identify 33 unique pieces of support and advice across 5 categories, with differences in tone and delivery among different types of videos. We then evaluated the quality of 33 unique pieces of cyberbullying advice in a user study with …


Hybrid Bermudagrass Dormancy Management In A Cool-Season Climate, Clarissa H. Peterson Apr 2026

Hybrid Bermudagrass Dormancy Management In A Cool-Season Climate, Clarissa H. Peterson

Theses and Dissertations

Hybrid bermudagrass (Cynodon dactylon [L.] Pers. × C. transvaalensis Burtt Davy) (HBG) is a water efficient warm-season turfgrass increasingly adopted in cool-season and semi-arid regions due to climate change and the demand for reduced irrigation inputs. However, prolonged winter dormancy limits its visual quality (verdure) and seasonal performance. This thesis evaluated multiple management strategies to modify dormancy dynamics and improve off-season turf quality in a cool-season environment. Field experiments assessed the effects of growth covers, fertilizers, colorants, surfactants, organic acids, and overseeding with cool-season species on HBG dormancy over two seasons. Dormancy responses were quantified using normalized difference vegetation index …


Real-Time Data Collection System For Low-Cost Diesel Emissions Monitoring, Zachary Driskill Apr 2026

Real-Time Data Collection System For Low-Cost Diesel Emissions Monitoring, Zachary Driskill

Theses and Dissertations

Diesel trucks are a major source of pollutants, including particulate matter (PM) and NO$_x$. Roadside emissions monitoring can identify high-emitting diesel vehicles, but conventional sensing systems rely on expensive, complex sensing instruments that limit widespread deployment. Low-cost sensors offer increased scalability due to their small size, low cost, and low power consumption, but they have lower accuracy and slower response time. This thesis presents the design and evaluation of a low-cost roadside emissions monitoring system, establishing the foundation for a scalable and widely deployable alternative. We apply machine learning calibration to roadside emission monitoring to improve the usability of low-cost …


Practical, Scalable, And Cost-Effective Nanolc-Ms Workflow For Single-Cell Proteomics, Siqi Huang Apr 2026

Practical, Scalable, And Cost-Effective Nanolc-Ms Workflow For Single-Cell Proteomics, Siqi Huang

Theses and Dissertations

Single-cell proteomics provides a novel research strategy for decoding cellular heterogeneity, revealing the molecular mechanisms of rare cell subpopulations, and studying the dynamic responses of cells to external stimuli. However, compared to transcriptomics, single-cell proteomics faces even more challenging technical challenges: extremely low protein amount in single cells, wide dynamic range, significant adsorptive losses during sample preparation, and the complex matrix and trace sample injection demanding extremely high stability and sensitivity from the separation and detection systems. Mass spectrometry-based bottom-up proteomics has become an important tool for analyzing complex biological systems, and nano-flow liquid chromatography-mass spectrometry (nanoLC-MS) exhibits unique advantages …


"Deep In The Trenches": A Multi-Perspective Interpretive Phenomenological Analysis Of Student Mothers Navigating The Hidden Realities Of Postpartum Anxiety, Rhonda Harris Apr 2026

"Deep In The Trenches": A Multi-Perspective Interpretive Phenomenological Analysis Of Student Mothers Navigating The Hidden Realities Of Postpartum Anxiety, Rhonda Harris

Theses and Dissertations

Despite availability of effective treatments women with postpartum anxiety (PPA) commonly go untreated because of barriers to care. Student mothers are a particularly vulnerable subgroup of women as they tend to be younger, are less likely to be married, and have lower incomes than non-student mothers. As anxiety rates in college women are higher than the general population and higher than college men, student mothers are at high risk of the adverse effects of untreated PPA. There is a paucity of existing literature about student mothers and mental health. The aim of the current study is to understand the help-seeking …


Transcriptomic Analysis Of Xeroderma Pigmentosum Group C Skin Samples, Austen N. Gleave Apr 2026

Transcriptomic Analysis Of Xeroderma Pigmentosum Group C Skin Samples, Austen N. Gleave

Theses and Dissertations

Xeroderma Pigmentosum is a rare genetic disorder caused by defective DNA damage repair enzymes. This condition results in an increased risk of developing skin cancer and other symptoms in those affected. In this thesis, we examined the effects of Xeroderma Pigmentosum on gene expression in patient skin biopsy samples. To accomplish this, we utilized statistical analysis of spatial transcriptomic and single-cell RNA sequencing techniques to discover differences between patient and heterozygous carrier skin samples. We found that the skin samples from Xeroderma Pigmentosum patients showed elevated levels of inflammation, immune activation, and cellular stress, while the carrier skin samples leaned …


No Principal Left Alone: Exploring Elementary Principals' Relationships With Their Full-Time Assistant Principals, Shauna Worthington Apr 2026

No Principal Left Alone: Exploring Elementary Principals' Relationships With Their Full-Time Assistant Principals, Shauna Worthington

Theses and Dissertations

Elementary school principals are often the only administrator in their building; therefore they are left to face the adverse circumstances of their job without the support of an administrative colleague at their school. However, U.S. nationwide data suggests that school districts are more frequently hiring elementary assistant principals. This paper explores perceptions of elementary principals about the nature and dynamic of their relationships with their full-time assistant principals, including accompanying benefits and challenges. This qualitative inquiry utilizes an exploratory, descriptive, phenomenological approach and features the results of in-depth interviews with 20 elementary school principals in two large suburban public school …


Fallow Ground, Eli Kerns Apr 2026

Fallow Ground, Eli Kerns

Theses and Dissertations

Fallow Ground refers to the agricultural practice of intentionally leaving a field unseeded for a year or more in order to restore fertility and interrupt cycles of depletion. Although fallowing is a beneficial and necessary practice, the term has also come to signify waste or a lack of productivity. This double meaning is central to the work, reflecting a central contradiction: that withdrawal can be as vital as effort, and that rest, like labor, can function as a deliberate and sustaining act. The question I explore in this work is how to organize, understand, and live with these contradictions. Through …


Empirical Benchmarks For Interpreting Effect Sizes In Violent Crime Interventions, Kohta James Matsukawa Hansen Apr 2026

Empirical Benchmarks For Interpreting Effect Sizes In Violent Crime Interventions, Kohta James Matsukawa Hansen

Theses and Dissertations

Criminal justice researchers apply Cohen’s (1988) benchmarks to classify effect sizes as small, medium, or large, despite these standards never being meant for broad, decontextualized use (Cohen, 1988; Gies et al., 2024; Goulet-Pelletier & Cousineau, 2018; Lakens, 2013; Milner et al., 2023). Repeatedly doing so may weaken statistical validity, distort findings, and impede effective policymaking. This study introduces the first effect size benchmarks specifically designed for violent crime interventions.

Using a quasi-meta-analysis framework, 1,605 effect sizes from 104 violent crime intervention studies from the CrimeSolutions clearinghouse were converted to Cohen’s d. Three new discrete benchmarking methods were created using a …


Artificial Intelligence For Better Inclusive Higher Education: A Study Of A Private University In Cairo, Shereen Ismail Apr 2026

Artificial Intelligence For Better Inclusive Higher Education: A Study Of A Private University In Cairo, Shereen Ismail

Theses and Dissertations

This study explores how artificial intelligence (AI) tools relate to accessibility for visually impaired students in Egyptian higher education, focusing on University Y in Cairo. Grounded in the Social Model of Disability and Universal Design for Learning, it examines visually impaired students’ lived experiences of AI mediated access and the institutional conditions that shape these experiences. A qualitative phenomenological design was used, with semi-structured interviews conducted with visually impaired undergraduate students and key staff involved in assistive technology, teaching and learning, and student wellbeing; data were analyzed thematically. The findings indicate that participants experience AI tools (e.g., chatbots, transcription and …


Observational Diagnostics And Spectroscopic Detection Of Tropospheric Trace Gases And Oxidation Processes, Callum E. Flowerday Mar 2026

Observational Diagnostics And Spectroscopic Detection Of Tropospheric Trace Gases And Oxidation Processes, Callum E. Flowerday

Theses and Dissertations

The troposphere is governed by photochemical and radical-mediated processes that control atmospheric oxidation capacity, secondary pollutant formation, and the chemical lifetime of gases. Quantitative understanding of these processes requires both robust observational frameworks capable of resolving complex precursor–product relationships and instrumentation with sufficient sensitivity and selectivity to detect reactive and low-concentration species. This dissertation advances atmospheric chemistry through the parallel development of quantitative observational methodologies and refined spectroscopic measurement techniques. The first component of this work evaluates atmospheric oxidation systems using long-term monitoring data and empirical diagnostics. Multi-year analyses of ozone and particulate matter trends were conducted to characterize variability …


Parental Perspectives On Preparedness Of Young Adults With Intellectual Disabilities For Transition To Adulthood, Oretha Bennett-Spence Mar 2026

Parental Perspectives On Preparedness Of Young Adults With Intellectual Disabilities For Transition To Adulthood, Oretha Bennett-Spence

Theses and Dissertations

Abstract Oretha Bennett-Spence PARENTAL PERSPECTIVES ON PREPAREDNESS OF YOUNG ADULTS WITH INTELLECTUAL DISABILITIES FOR TRANSITION TO ADULTHOOD 2026 JoAnn Manning, Ed.D. Doctor of Education The transition from high school to adulthood presents significant challenges for young adults with intellectual disabilities and their families. Although schools are required to provide transition services, limited research has examined parents’ lived experiences navigating this process. This qualitative study explored how parents perceive their child’s preparedness for adulthood and postsecondary life. Guided by Schlossberg’s (1981) 4S Transition Framework and Interpretative Phenomenological Analysis (IPA), the study examined the experiences of six parents whose young adults were …


A Study Of Early Childhood Coaches’ Preparedness To Implement Lgbtq+ Affirming Social–Emotional Practices, Nicole Lynn Muñoz Mar 2026

A Study Of Early Childhood Coaches’ Preparedness To Implement Lgbtq+ Affirming Social–Emotional Practices, Nicole Lynn Muñoz

Theses and Dissertations

This qualitative collective instrumental case study examined how early childhood consultation specialists (coaches) perceive and implement LGBTQ+ affirming practices in early learning environments serving children from birth to five. Although legal and policy advancements have increased recognition of LGBTQ+ identities, early childhood education remains an underexamined context for inclusive practice. Grounded in a constructivist and interpretivist paradigm and informed by Queer Theory, Transformative Leadership Theory, Practice-Based Coaching, and the Pyramid Model, data were collected through interviews, surveys, and reflective field notes with a purposeful sample of New Jersey coaches. Findings highlight how coaches define inclusion, navigate organizational conditions, and identify …


Database-Driven Revelations In Epilepsy: Patient Reporting Accuracy And The Circadian Timing Of Seizures, Ithay Biton Mar 2026

Database-Driven Revelations In Epilepsy: Patient Reporting Accuracy And The Circadian Timing Of Seizures, Ithay Biton

Theses and Dissertations

For over thirty years, patients have been visiting the Arkansas Epilepsy Program for diagnosis and treatment for seizures and seizure-like episodes. As part of their clinical evaluation, patients often undergo ambulatory EEG (electroencephalogram) monitoring. This routine process produces valuable data for treating the patient. In this study, over 2000 ambulatory EEG reports from 1998 to 2016 were reviewed. A large database of seizures was created from the reports, with information on 407 patients, 1611 EEG-confirmed seizures, and 1726 patient-reported seizures (IRB Protocol #17-093). The database was used to address two important issues in epilepsy. The first topic of the study …


Tunable 3d-Printed Biomaterials For Perfused In Vitro Models Of The Blood-Brain Barrier, Louis Salvatore Paone Mar 2026

Tunable 3d-Printed Biomaterials For Perfused In Vitro Models Of The Blood-Brain Barrier, Louis Salvatore Paone

Theses and Dissertations

In vitro models have tremendous utility for improving our understanding of complex physiological and pathophysiological processes in a more controlled environment than animal models, in addition to incorporating human cells to overcome species-specific disparities. This dissertation describes innovations in biomaterial-based fabrication processes that advance in vitro models of the blood-brain barrier, providing the opportunity to evaluate the effects of cell-matrix interactions on barrier integrity, additives to reduce viscous drag of blood flow, and molecular mechanisms underlying the cellular response to amyloid beta in the context of Alzheimer’s disease. The core technology underlying this advance is a biomaterial compatible with digital …


Synthesis And Characterization Of Transition Metal Carbide (Max) And Mxene Nanoflakes For Energy Storage And [email protected], Srikanth Ragunath B Mr Mar 2026

Synthesis And Characterization Of Transition Metal Carbide (Max) And Mxene Nanoflakes For Energy Storage And [email protected], Srikanth Ragunath B Mr

Theses and Dissertations

Rapid growth in population and industrialization created a huge demand for superior energy storage devices. Thus, the researchers are in constant search of developing exotic materials towards energy harvesting and storage devices. Batteries, supercapacitors, and fuel cells received a great attention to meet the global demand for energy storage. Among them, supercapacitors are widely preferred as energy storage devices due to higher power density, longer cycle life, and fast charging. The performance of the supercapacitors highly depends on the choice of electrode materials and electrolyte.

Recently, “MXenes”  a new class of layered a new class of layered a new …


Development Of Hypergraph Based Deep Neural Framework For Precise Cancer Subtyping And Meta Visualization, Pooja G Ms Mar 2026

Development Of Hypergraph Based Deep Neural Framework For Precise Cancer Subtyping And Meta Visualization, Pooja G Ms

Theses and Dissertations

Accurate Cancer Subtyping is a cornerstone of modern oncology essential for effective diagnosis and guiding personalized treatment. Histopathological Images (HIs) which capture the microscopic structure of tissues are widely used for cancer detection and subtyping. Even though deep learning has made significant advances, existing HI based subtyping methods often focus on specific cancer types, lacking a generic framework.

A unified framework that can classify multiple cancers with high specificity is desperately needed. In response to these limitations, this thesis proposes a robust multi-cancer, multi-class subtyping framework called DSHGNet (Depthwise Separable Hypergraph Convolutional Neural Network) which integrates Depthwise Separable Convolutional Neural …


Combinatorial Therapeutic Strategies To Combat Multidrug-Resistant Acinetobacter Baumannii, Tope A. Aderibigbe Mar 2026

Combinatorial Therapeutic Strategies To Combat Multidrug-Resistant Acinetobacter Baumannii, Tope A. Aderibigbe

Theses and Dissertations

Acinetobacter baumannii is an opportunistic Gram-negative pathogen that poses a significant global health threat due to its remarkable ability to acquire multidrug (MDR) and extensively drug-resistant (XDR) phenotypes. Therapeutic failures are increasingly common as strains develop resistance to nearly all available antibiotics, including carbapenems, polymyxins, and tigecycline, leaving clinicians with limited treatment options. This study aimed to investigate combinatorial therapeutic approaches capable of revitalizing antibiotic efficacy against MDR/XDR A. baumannii clinical isolates. We evaluated the synergistic potential of durlobactam-sulbactam in combination with twelve commonly used antibiotics, including amikacin, rifampin, tobramycin, tigecycline, cefiderocol, and others. Initial screening using the disc diffusion …