Chemotherapy Drug Release From Hollow Core Polyethyleneimine Nanoparticles, Brian Boyle

Theses and Dissertations

Novel anticancer delivery vehicles are arising from engineered nanostructured materials. This work involved the synthesis, characterization, and release of novel hollow core polymeric nanoparticles (HCPNPs) for controlled drug delivery. Polyethyleneimine (PEI) was bound to AuNPs, forming polymer-shell nanoparticles with dissolution of the gold core via iodine forming HCPNPs with drug intercalated DNA bound to the surface. A high density (85 molecules/particle) of DNA intercalated with daunorubicin was conjugated. Particles were spherical with an average diameter of 105.7 ± 17.3 nm and zeta potential of 20.4 ± 3.54 mV. We hypothesize the DNA backbone electrostatically condensed to the primary amines on …

Design, Fabrication, And Characterization Of Multifunctional Cellular Structures For Enhanced Impact Energy Mitigation Performance, Kazi Zahir Uddin

Theses and Dissertations

This dissertation investigates the relationship between the structural design of cellular solids and their macroscopic behavior and focuses on the customization of properties through advanced fabrication techniques. The concepts of density gradation and their integration in both non-ordered and ordered cellular structures have been proposed. The investigation focuses on the development of functionally graded foam materials (FGFMs) and mechanical metamaterials to obtain tunable mechanical performance. One significant focus is the fabrication of density-graded foam stacks with various interface adhesives. From the insights gained from the study of interfaces in density-graded foams, certain design and fabrication principles are applied to enhance …

Developing A General Methodology To Enhance Simulation Modeling Capabilities Using Process Mining, Rahul Mudliar

Theses and Dissertations

This thesis introduces a methodology that integrates process mining with Discrete Event Simulation (DES) to improve the accuracy and applicability of simulation models. Traditional DES models often face challenges due to manual process mapping and subjective assumptions, leading to inaccuracies. By leveraging data from systems like ERP through process mining, this research generates precise process maps and high-quality data for DES modeling. The structured DES model incorporates real-time data feeds and iterative refinements to enhance model reliability. Process Mining tool is used to visualize and analyze actual process flows, identify bottlenecks, and provide performance metrics for model validation. This research …

Study Of Polymer-On-Polymer Cold Spray Deposition Windows Under Apparently Similar Conditions, Ülar Tiitma

Theses and Dissertations

The purpose of this thesis is to explore and expand the capabilities of polymer-on-polymer cold spray demonstrated herein using polyamide 6 (PA6)-based powder and substrates. Experiments were conducted using three different cold spray systems described in this work, permitting more in-depth examination of process response to different cold spray process control parameters, such as nominal system pressure and temperature. Two specific responses of interest were the deposition window (DW) and deposition efficiency (DE) of PA6. The DW was determined by performing several sprays at different calculated particle impact velocities and temperatures. The composite result from these experiments was identification of …

Burning Torches, Eyes, And Empires: A Visual Rhetorical Analysis Of The Modern American Fascist Aesthetic, Caleb Lawler

Theses and Dissertations

Allegiance to the ideology of fascism is growing in the United States. Racist, misogynist, and xenophobic sentiments are prevalent throughout far-right groups in America. Despite fighting fascism worldwide in World War I and World War II, powerful American figures have and still hold strong ties to fascism. To consolidate control, fascists construct an aesthetic of themselves and their ideological opponents. Using visual rhetorical theory and Marxist theory, I will conduct three visual rhetorical analyses on three images from modern American political events to examine how the fascist aesthetic expresses itself in different situations.

Application And Development Of Ceragenins In Medical Device Coatings For Clinical Settings, Elliot E. Sherren

Theses and Dissertations

Hospital-acquired infections (HAIs) pose a significant and increasing threat to global health. One primary cause of this threat is increasing antibiotic resistance. As traditional antibiotics continue to grow less effective, there is an urgent need for novel antimicrobial strategies. This work explores the potential of ceragenins, also known as cationic steroid antimicrobials (CSAs), as a promising alternative to combat HAIs. Specifically, we investigated potential roles that CSAs can play in the context of multiple medical device coatings in healthcare settings. Ceragenins are synthetic mimic of antimicrobial peptides (AMPs) which exhibit broad-spectrum antimicrobial activity against many common pathogens that have been …

Synthesis Of Streptococcus Pneumoniae Serotypes 6a And 6b Di- And Trisaccharides As Propargyl Glycosyl Antigens For Glycoconjugate Vaccines, Tianyao Meng

Theses and Dissertations

Streptococcus pneumoniae (Spn) is a globally prevalent Gram-positive pathogen responsible for invasive pneumococcal diseases (IPD). Among its over 90 serotypes, Spn serotypes 6A (Sp6A) and 6B (Sp6B) are two of the most common causes of IPD around the world and are more frequently isolated from infections than most of the other serotypes. Our group has previously developed a method for making immune responses to bacterial glycans T cell-dependent, involving attachment of short synthetic glycans to a virus-like nanoparticle (VLP), and in combination with a natural killer T cell (NKT cell) adjuvant. This strategy enhanced immune responses by facilitating T cell …

Jinetes De La Tormenta: The Invasive Influence Of Gender Constructs On The Journey Towards Selfhood And Societal Progress, Marissa Nicole Luquette

Theses and Dissertations

The novel Jinetes de la tormenta, written by Spanish author, Javier Castañeda de la Torre, presents gender as an obstacle to individuals in the ongoing process of self-discovery (as it relates to personal identity) and as the underlying source of human discontent in the technological age. Jinetes represents gender as a hindrance to the developing self through masculine and feminine binaries in European colonial languages and through the performative behavioral expectations tethered to the gendered body the theoretical works of Jacques Lacan and Hélène Cixous. The theoretical works of Jacques Lacan and Hélène Cixous establish the argument surrounding linguistic gender …

Women Gaze Back: Affect And Apparatic Disintegration In Funeral Parade Of Roses And Perfect Blue, Jessi Ivie

Theses and Dissertations

This thesis explores how films Funeral Parade of Roses (1969) by Toshio Matsumoto and Perfect Blue (1997) by Satoshi Kon subvert the male gaze of the camera by having the female main characters look back at the audience. The characters Mima (Perfect Blue) and Eddie (Funeral Parade) take control of the camera to subvert the hierarchical relationship between apparatus, audience, and characters. Through the lenses of apparatus and affect theory, these films show how the world of film includes the audience instead of precluding them. Experimental editing and heightened emotional situations unsettle the audience's voyeuristic position, bringing them closer to …

Potent And Selective Small Molecule Mcl-1 Inhibitor Demonstrates Anti-Myeloma Activity And Overcomes Chemotherapy Resistance, Omar Sami Faleh Al-Odat

Theses and Dissertations

Despite a record number of clinical studies investigating various anti-myeloma treatments, the 5-year survival rate for multiple myeloma (MM) patients in the US is only 55%, and nearly all patients relapse. Poor patient outcomes demonstrate that myeloma cells are "born to survive” which means they can adapt and evolve following treatment. Thus, new therapeutic approaches to combat survival mechanisms and target treatment resistance are required. Importantly, Mcl-1, anti-apoptotic protein, is required for the development of MM and treatment resistance. This study looks at the possibility of KS18, a selective Mcl-1 inhibitor, to treat MM and overcome resistance. Our investigation demonstrates …

Integration Of Machine Learning In Structural Health Monitoring For Damage Identification And Response Prediction In Bridges, Naga Lakshmi Chittitalli Ravuri

Theses and Dissertations

Machine learning-based structural health monitoring (ML-SHM) plays a pivotal role in enhancing structural resilience. By recognizing potential hazards, implementing resistance measures, facilitating swift recovery, and continuously monitoring structural health, ML-SHM ensures proactive maintenance and minimizes recovery delays post-events. Leveraging machine learning algorithms and sensor data, ML-SHM enables early detection of anomalies, prediction of failures, and adaptive responses, enhancing the structure's ability to withstand and recover from adverse conditions. This integrated approach not only improves the structure's performance and adaptability but also contributes to overall safety and longevity. This thesis presents a comprehensive exploration of structural health monitoring (SHM) techniques for …

Implementing 1.5 Millimeter Internal Diameter Columns And A Portable Capillary Column Instrument Into Monoclonal Antibody Analytical Workflows, Benjamin Libert

Theses and Dissertations

Using 1.5 mm inner diameter (i.d.) columns to bridge the gap between routinely used 2.1 mm i.d. columns and capillary bore columns allows for a sequential but significant increase in performance without the need for specialized equipment associated with very low dispersion liquid chromatography (LC) systems. These 1.5 mm i.d. columns balance an increase in sensitivity compared to 2.1 mm i.d. columns (theoretically doubling the time-domain peak area in mass sensitive detectors for the same mass load), while mitigating the efficiency losses due to extra-column dispersion effects that are commonly observed with 1.0 mm i.d. columns. Here, the use of …

Unlocking Understanding: Enhancing Scientific Literacy Through Interdisciplinary Reading Strategies In High School Science Classes, Nancy C. Hollenweger

Theses and Dissertations

This study investigated the intersection of literacy instruction and high school science teaching in response to low proficiency levels in these areas and interest in pursuing STEM careers among U.S. high school students. Participants reported using close reading practices combined with inquiry-based science instruction to enhance students’ science literacy and reading proficiency. Data were from document analysis, one-on-one interviews, and focus group discussions. Five significant themes showed teachers' journeys from recognizing a problem to implementing new instructional strategies while pursuing knowledge about how to continue growing their craft. The five themes included teacher awareness of students’ literacy struggles, the apprehension …

Chromosome-Scale Assemblies And A Pangenome Reveal Ltr Repeat Dynamics As A Major Driver Of Genome Evolution In Chenopodium, Kate E. Jaggi

Theses and Dissertations

The genus Chenopodium, which comprises around 150 species globally, is characterized by its wide geographic distribution and ecological adaptability, particularly in temperate regions. Some species, such as Chenopodium quinoa and Chenopodium pallidicaule, have served as domesticated staple crops in the Andean region of South America for centuries, valued for their robust nutritional profile and adaptability to adverse environmental conditions. In contrast, wild Chenopodium species exhibit broad geographic distributions and diverse niche adaptations, functioning as reservoirs for beneficial traits, including disease resistance and climate hardiness, essential for enhancing domesticated crops through introgression and breeding efforts. However, taxonomic classification within the genus …

Parent Involvement Programs And Latinx Families: An Evaluation Of The Parents + Schools = Successful Children Program, Katherine Woods Hancey

Theses and Dissertations

Parent's active involvement in their children's educational experience has been shown to have a positive impact on student outcomes, including academic achievement, attitude toward school, and improved skill-development. There is limited research, however, that explores how best to help parents become more involved in their children's schooling, especially across cultural groups. Currently, there are more than 14.4 million Latinx students in public elementary and secondary schools. Due to the recent increase in Latinx students within the U.S., there is a need to better understand and support Latinx parent involvement in schools. This study evaluated the effectiveness of the Parents + …

A Grounded Theory Analysis Of Honesty And Deception In Intimate Relationships, Lyndsey Kunzler Gerring

Theses and Dissertations

Although honesty is valued in intimate relationships, there has not been significant research on the range and different types of honesty and deception and their impacts on couples. The purpose of this study was to explore and define the role honesty plays in intimate relationships by examining the spectrum of honest and deceptive behaviors as described by participants. The study utilized qualitative methods to examine how romantic partners describe various types of honesty and deception in their relationships and the influence these have. The data was taken from part of a larger project on healthy and unhealthy relationships where semi-structured …

Cytotoxicity, Antibacterial And Anti-Inflammatory Properties Of A Synthesized Curcumin Analog And One Of Its Novel Derivatives, Marian Amir

Theses and Dissertations

This research aims to describe the synthesis, characterization, and the biological response via investigating the cytotoxic activity, hypoxic microenvironment response, antibacterial, and anti-inflammatory properties of the novel curcumin analog H-4073 and its succinate derivative (H-4073 SuD) in the context of hepatocellular carcinoma (HCC). The study also aimed to compare the effects of H-4073 and H-4073 SuD to assess their relative efficacy and potential as therapeutic agents. First, the cytotoxic effects of H-4073 and H-4073 SuD were evaluated on HEPG2 cell lines under normal conditions. Results revealed that H-4073 exhibited a significantly better cytotoxic effect than H-4073 SuD in normoxia. However, …

Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb

Theses and Dissertations

Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …

Internationalization In Egyptian Higher Education: Two Case Studies From Public Universities, Esraa Mostafa

Theses and Dissertations

In an increasingly globalized world, internationalization has emerged as a promising global trend to contribute to a more interconnected and diverse academic environment. By examining the stakeholders’ perceptions of two joint programs, this study presents a balanced assessment of the quality of education in internationalized programs based on the dual nature of opportunities and barriers associated with internationalization. This study highlights a research gap in the internationalization process of the learning landscape in Egypt. Filling this research gap would offer insightful information to academics, institutions, and policymakers in the field of higher education within the Egyptian context. The study’s findings …

Academic Success In First-Year Engineering Students At Private Higher Education Institutions In Egypt: Key Factors, Wassim Alexan

Theses and Dissertations

This research aimed to identify the key factors contributing to the success of first-year engineering students at private higher education institutions (HEIs) in Egypt. It specifically examined how various independent variables influence the success of these students, measured as the dependent variable. By analyzing these relationships, the study seeks to pinpoint key success factors (KSFs) for first year engineering students in this specific educational context. The research work employed a mixed methods approach, utilizing both quantitative and qualitative research methods. The quantitative analysis involved collecting data through a survey administered to a sample of first year engineering students at private …

Deciphering The Microbial Fingerprint Of Covid-19: A Multi-Layered Exploration Of The Oral And Gut Microbiome Dysbiosis, Iman Mostafa Sultan

Theses and Dissertations

The impact of SARS-CoV-2 infection on the human microbiome remains a dynamic and intricate puzzle. This study delves deeper into this mystery by revisiting the oral and gut microbial compositions of 53 COVID-19 patients before and after viral clearance, alongside comparisons to 76 healthy individuals. Through a comparative lens, we have emploed two distinct differential abundance methods – DeSeq2 and ANCOM – while drawing upon the thorough SILVA database encompassing the full-length 16S rRNA gene. The analysis underscores the crucial role of a diverse methodological choir in microbiome research. In certain instances, the congruence between DeSeq2 and ANCOM may exhibit …

Same Story, Different Narratives: The Influence Of Refugee Concerned Organizations On Egyptian Media, Shaimaa Gheith

Theses and Dissertations

It has been documented in the literature that media usually portrays refugees negatively, which affects how the public reacts to them. Consequently, organizations catering to refugees, referred to in this thesis as Refugee Concerned Organizations (RCOs), try to influence the media aiming to influence the public. So, they produce prepacked information and employ different communication tools. Using the agenda building theory, this research investigated the influence of communication tools used by RCOs on Egyptian media focusing on Facebook and news websites. Qualitative content analysis was conducted for 615 Facebook posts and 111 News reports and supplemented by semi-structured interviews with …

Gender Inequality Is Not A "Women Only" Issue: A Case Study Of Egyptian Private News Media, Amira Ahmed

Theses and Dissertations

Discrimination in the workplace among different genders is a significant issue in the news media sector globally. This study aims to determine and measure gender inequality in the Egyptian private news media sector through different indicators, including job payments, workload, promotions, media roles, work safety, and work flexibility, especially post-COVID. A mixed approach was used by conducting sixteen interviews and then a survey of 304 private news media sector participants. As inequalities can be a double-faced case, men's and women's perspectives have been considered in the study sample. Through descriptive and statistical analysis, the research findings revealed new insights to …

The Impact Of Rentietrism On Authoritarian Durability In The Gulf, Nadine Shawki

Theses and Dissertations

ABSTRACT

Ever since its discovery, oil and its rents have strongly impacted the development of the Gulf states. The debate on whether oil has been a blessing or a curse to those states has been a prevailing topic in the literature, with an abundance of available data on the relationship between the durability of authoritarianism in the Gulf region and rentierism. The literature has long claimed that the legitimacy of Gulf rulers is secured through rent distribution, a concept known as Rentier State Theory (RST). With the leaders of Gulf nations being the “owners” of the oil reserves, they have …

Effect Of Plumbagin On Chemo-Resistant Metastatic Retinoblastoma, John J. Soto

Theses and Dissertations

Retinoblastoma, which is an ocular malignancy, usually results in poor prognoses in pediatric patients worldwide. Retinoblastoma in some events, can develop metastatic phenotypes which can lead to secondary tumor formation, furthering deleterious patient outcomes. It is of paramount importance to identify and research potent novel compounds that can be used to increase the likelihood of remission. Plumbagin (PLB) is a plant-derived, neuroprotective agent, which exhibits significant anticancer activities during in vitro study. PLB has been shown to have a high therapeutic efficacy against chemoresistant sublines as well as their normal counterparts. We attempted to show that the chemoresistant ABCC1 could …

Evaluating The Influence Of Perfluorooctane Sulfonic Acid Exposure On Blood Glucose Levels: A Comprehensive Multiple Regression Analysis Considering Confounding Factors, Henry Mensah

Theses and Dissertations

Perfluorooctane sulfonate (PFOS) are widely used for industrial and commercial purposes and have received increasing attention due to their adverse effects on health. This thesis investigates the relationship between PFOS exposure and blood glucose levels, considering potential confounding factors. Regression analysis was conducted on a dataset comprising demographic, lifestyle, and biomarker data from a diverse population sample. Sex exhibited a significant role, with females demonstrating an 11.77% increase in blood glucose levels in response to PFOS exposure compared to males, supported by a p-value of 1.04 × 109. Body mass index (BMI) also played a pivotal role, revealing a 2.17% …

Beyond The Ivory Tower: The Underrepresentation Of African American Women In The Academe, Ashia Hall Muhammad

Theses and Dissertations

This dissertation addressed the underrepresentation of African American women attaining doctoral degrees at universities across the nation. It also explored the McNair Scholars Program, and the role the program played in preparing African American female students for graduate school and completion of the doctoral degree. In line with the phenomenology research design, semi structured interviews were conducted with five participants to gain a better understanding of their lived experiences. The interview protocol for this study was approved by the University of Arkansas at Little Rock Institutional Review Board. Thick descriptions of the participants' experiences were explored to gain insight on …

Federated Learning Based Autoencoder Ensemble System For Malware Detection On Internet Of Things Devices, Steven Edward Arroyo

Theses and Dissertations

New technologies are being introduced at a rate faster than ever before and smaller in size. Due to the size of these devices, security is often difficult to implement. The existing solution is a firewall-segmented “IoT Network” that only limits the effect of these infected devices on other parts of the network. We propose a lightweight unsupervised hybrid-cloud ensemble anomaly detection system for malware detection. We perform transfer learning using a generalized model trained on multiple IoT device sources to learn network traffic on new devices with minimal computational resources. We further extend our proposed system to utilize federated learning …

Integrated Computational Approaches: Elucidating Molecular Mechanisms Of Pathogenic Proteins And Designing Novel Inhibitors Against Mycobacterium Tuberculosis And Sars-Cov-2, Justin David Carbone

Theses and Dissertations

Chapter 1 introduces computational strategies in computer aided drug design (CADD), focusing on physics-based methodologies to enhance drug discovery. This chapter also discusses the theoretical foundations and practical applications of molecular dynamics (MD) simulations including free energy and stochastic kinetic analysis. In Chapter 2, CADD methods lead to development of inhibitors targeting the RNA Dependent RNA Polymerase (RdRP) of SARS-CoV-2. Inspired by the nucleotide inhibitor Molnupiravir, we aim to design a combinatorial library of 72 novel inhibitors capable of impeding a dual threat inhibition mechanism inducing lethal mutations along with stalling viral replication with specific selectivity to RdRp over Human …

Woosah! Minoritized Student Affairs Professionals: Navigating Racial Battle Fatigue At A Predominately White Institution, Julius J. Grayson

Theses and Dissertations

Using an interpretative phenomenological analysis this study explored the rich experiences of seven racially minoritized student affairs professionals (RMSAPs) who experienced racial battle fatigue (RBF) and the impact it had on their health at a predominantly white institution (PWI). Social psychological research has identified both blatant and subtle forms of racial discrimination have adverse which lead to deleterious mental health outcomes for racially minoritized individuals. The findings indicated that these racially minoritized student affairs professionals were experiencing racial microaggressions and racial battle fatigue at their predominately white institution. In order to reclaim their wellness, participants shared the strategies they used …