Digital Commons Network^™

Exploring The Immune System’S And Silybin’S Impact On Cancer Cachexia, Patrice Cunningham

Theses and Dissertations

Cancer cachexia is a complex syndrome that is characterized by the unintentional loss of body weight with or without fat loss. During cancer cachexia, there is an increase in inflammation consistent with various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), Interleukin-1 beta (IL-1β ), and interleukin-6 (IL-6); all of which are known to increase proteolysis and aid in the progression of muscle loss and weakness. Immune cells such as macrophages are increased during cachexia and are known to have varying effects on muscle inflammation, regeneration, and the progression of fibrosis in a disease state. However, therapies aimed solely at …

The Effect Of Covid-19 Restrictions On The Social Support Experiences Of Black Women Giving Birth In South Carolina Hospitals During The First Year Of The Covid-19 Pandemic (2020) As Compared To A Previous Birth, Tiffany Eva Byrd

Theses and Dissertations

The United States is experiencing a maternal health crisis, which disproportionately affects Black women. Black women die from pregnancy-related causes two to three times as often as their White counter parts, and the majority of maternal death are preventable. In recent years, public health and national governing authorities have devoted resources to monitoring the health crisis and raising the public’s knowledge of warning signs; however, maternal mortality rates continue to rise. Noted contributors to Black maternal mortality include, but are not limited to, racism, delayed treatment and response to health emergencies, and lack of social and emotional support during childbirth, …

Assessing Obgyn Residents’ Knowledge, Attitudes, And Current Practices For Carrier Screening, Aubrey Morgan Surian

Theses and Dissertations

Obstetricians and gynecologists (OBGYNs) are the main providers that order carrier screening on a regular basis, so it is important to understand their knowledge, attitudes, and current practices regarding this screening. There are two primary professional organizations that have established practice guidelines for carrier screening, the American College of Obstetrics and Gynecology (ACOG) and American College of Medical Genetics (ACMG). With the growth of pan-ethnic carrier screening, these guidelines have become remarkably different. This study aimed to assess resident OBGYN’s utilization of pan-ethnic carrier screening, discern any discrepancies between knowledge, attitudes, and current practices, identify possible practice resources that may …

“I’M Speaking”: Black Women Leading School Public Relations, Managing Communications And Personal Challenges, Keisa Gunby

Theses and Dissertations

Operationalizing feminist communication theory with a critical lens, this research analyzes virtual, semi-structured interviews with 13 Black women who are integral to impacting organizational culture through the brand management and narratives to the stakeholder groups of employees, parents and community members for a public school district. This study aims to describe the oppression and invisibility of Black women in school public relations and amplify their voices as they lead the communication, marketing, and promotional efforts in public school districts across the United States. The interview transcripts were analyzed utilizing NVivo software through the first round of coding initial and the …

Reading Ecogothic Memory In Contemporary Southern Swamp Novels, Megan Caroline Brockhard Knight

Theses and Dissertations

The ecogothic is a lens through which to engage memory, southern constructivism and identity, environmental intervention, and the literature of the American Southeast. This project establishes a framework of literary criticism that defines the ecogothic, interprets memory as truth imagined, and identifies the position of memory in the environment as a construction with which it is necessary to grapple to understand identity. This framework, compiled of existing and original scholarship, is then applied to three contemporary swamp narratives written by three different southern women writers. The swamp setting creates a unique microcosm of gothic liminality, neither fully land nor water, …

Estuarine Microbial Community Composition And Efficiency Changes In Response To Vibrio Parahaemolyticus Exposure, Sarah Mulligan

Theses and Dissertations

Vibrio parahaemolyticus is a pathogenic bacterium whose full impact on natural estuarine phytoplankton communities has not been fully resolved. The primary goal of this research was to test how the addition of V. parahaemolyticus to a natural estuarine microbial community would impact the other microbes present. We hypothesized V. parahaemolyticus exposure would reduce phytoplankton biomass and alter the composition of phytoplankton and bacterial communities. Experimental bioassays (60h) were used to assess the effects of the presence of V. parahaemolyticus . Samples for measurements of chemotaxonomic photopigment concentrations, 16S sequencing-based community composition, photosynthetic efficiency, cell density, and V. parahaemolyticus abundance were …

Cancer Screening For Patients With Intellectual Disability: Exploring Parent And Caregiver Perspectives, Jennifer Ryan

Theses and Dissertations

Intellectual disability (ID) is defined as a combination of deficits in cognitive and adaptive function, both of which must be present early in life. Adults with ID frequently have unique healthcare needs; however, they also require care that is routine for all adults. This includes cancer screening. The goal of this study was to evaluate whether or not adults with ID are undergoing cancer screening, understand the barriers they have faced in obtaining screening, and collect recommendations from parents and caregivers on ways to improve access to and facilitate screening for this population. We surveyed parents and caregivers of adults …

Four Essays On Banking, Bank Management, And Bank Lending, Jiarui Guo

Theses and Dissertations

This abstract synthesizes findings from four studies examining the liquidity creation, bank-borrower relationships, corporate capital structure, and managerial impact on firm performance, particularly within the context of banking and financial crises, including the COVID-19 pandemic.

The research first identifies the dual shocks of the pandemic—disease and policy-driven (government shutdowns)—on bank liquidity creation. I find that these shocks prompted banks to reallocate liquidity creation from assets (decreasing loans) to liabilities (increasing liquid deposits), which reduced profits and heightened risks.

In exploring bank-borrower relationships, the study highlights the role of banks in utilizing soft private information, such as the moral character of …

Histories Of Stress: A Life Course Approach To Population Health In Late Medieval And Early Modern Berlin, Emily Brennan

Theses and Dissertations

Given our current climate crisis and urban population increases, researchers are increasingly interested in the health outcomes at the intersection of climate change and urbanization. Since climate change and urbanization affects human health in a variety of ways, more work is needed in diverse cultural contexts to understand temporal and geographic variations of such phenomena more fully. Using skeletal individuals from 13^th – 18^th century Berlin (n = 387), this project analyses demographic and health trends from the founding of the city in the late medieval period (c. 1200 – 1500) to the early modern period, when the …

Impaired Waters: New Treatments And Improved Methods For Pfas And Algae Toxins, Alexandria Forster

Theses and Dissertations

Per- and polyfluoroalkyl substances (PFAS) are high-profile environmental contaminants, many having long persistence in the environment and widespread presence in humans and wildlife. Following phase-out of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) in North America and restrictions in Europe, PFAS replacements are now widely found in the environment. While liquid chromatography (LC)-mass spectrometry (MS) is typically used for measurement, much of the PFAS is missed. To more comprehensively capture organic fluorine, we developed sensitive and robust methods using activated carbon adsorption, solid phase extraction, and combustion ion chromatography (CIC) to measure total organic fluorine (TOF) in industrial wastewaters, river …

Dysregulation Of Dopamine Dynamics Through Monoamine Transporters By The Hiv-1 Protein Transactivator Of Transcription, Sarah Davis

Theses and Dissertations

Prevalence of HIV-1 Associated Cognitive Disorders (HAND) persists in the era of combined antiretroviral therapies, causing impaired memory, motor function, and decreased quality of life. Evidence from clinical samples of persons with HAND has implicated dopamine, as well as the HIV-1 viral protein transactivator of transcription (Tat) as key molecules associated with disease progression. Through molecular modeling, in vitro and in vivo mutagenesis our lab has characterized Tat as a negative allosteric modulator for monoamine transporters, including the dopamine transporter (DAT), vesicular monoamine transporter (VMAT-2), and norepinephrine transporter. While this work has shed light on how Tat impacts the function …

State Estimation And Prediction Based On Simplified First Principle Model Of Lithium-Ion Batteries In Lebesgue Sampling Framework, Enhui Liu

Theses and Dissertations

State-of-charge (SOC) and remaining-dischargeable-time (RDT) are critical states of Lithium-ion batteries (LIBs). SOC indicates the available charge stored in LIBs compared to the total charge capacity of LIBs, while RDT refers to the remaining dischargeable time that LIBs can support under given loading profiles. Accurate SOC estimation and RDT prediction play important roles in guaranteeing the safe and efficient operation of batteries in real applications.

Taking advantage of high fidelity of simplified first principle (SFP) model of LIBs, this research aims to accurately estimate SOC and predict RDT. Firstly, this research establishes an SFP model to describe the battery internal …

Use Of Improvement Science To Build The Instructional Capacity Of Faculty In A Community College, Marianne Yohannan

Theses and Dissertations

Up to 78% of Science, Technology, Engineering and Mathematics (STEM) students experience poor academic achievement as defined by course grades of D, F and W in college. Students entering these fields are often not prepared (Chen & Soldner, 2013) and struggle to succeed in gateway STEM courses, with one-third of them possibly failing (Freeman et al., 2011). The success rates are lower among first-generation, low-income, and underrepresented minoritized groups (Doerschuk et al., 2016). At Tri-County Technical College, 30-40% of introductory biology students are unsuccessful and receive low grades (Institutional Research, n.d.). Low academic achievement has a huge impact on our …

Associations Between Infant Vagal Regulation, Early Social Communication, And Socidemographic Risk, Tessa Djiko

Theses and Dissertations

Respiratory sinus arrythmia (RSA), a measure of parasympathetic nervous system activation, has been linked to socioemotional and language development (Porges, 2007; Thayer & Lane, 2000). Children diagnosed with autism spectrum disorder (ASD) show lower RSA (Patriquin et al., 2011) while both children with ASD and children from lower SES backgrounds show differences in early social-communication development (Jones-Mason et al., 2018). However, little is known about interactions between sociodemographic risk and physiological regulation within the context of ASD and social-communication development. The present study addresses this gap by examining the relationship between RSA (as indexed by RSA suppression and resting-state RSA), …

Developing A Curriculum For An Online Group Piano In The Philippines: An Ideological, Historical, And Practical Approach, Lady Abigail Imperio

Theses and Dissertations

Online distance learning, a modern educational practice, has permeated music pedagogy in the past several decades. It involves synthesizing interdisciplinary studies in philosophy, music, technology, and sociology. In this study, the integrated approach aims to develop a unique curriculum for an online group piano in the Philippine setting. This goal involves coalescing ideological, historical, and practical perspectives to develop a coherent, learner-centered approach.

The ideological approach surveys educational philosophies, music learning theories, cooperative learning theories, online learning theories, and socio-cultural perspectives relevant to forming a unique framework. The nature of online distance music learning itself presents complex challenges of international …

Enslaved Women: Reproductive Choices And Medicine, Adedoyin Adekunle

Theses and Dissertations

Enslavement in the American South persisted as a form of subjugation that endured into the nineteenth century. The origins of slavery stemmed from enslavers’ aspirations for dominance. This compelled displacement involved the removal of Africans from their native lands and their subsequent transport as chattels to America. Slavery gave rise to paternalism, an attempt to justify exploitation to resolve the fundamental contradiction inherent in slavery. Paternalism gave rise to the false idea of ultimate submission, which historians have agreed that most enslavers never attained because of slave resistance. However, the study of slave resistance had been primarily focused on enslaved …

Addressing A Crisis In Nursing Practice: Exploring The Impact Of Multimedia Case-Based Learning On The Clinical Judgment Of Undergraduate Nursing Students, Macy Jenette Bennett

Theses and Dissertations

Clinical judgment is a priority nursing skill to ensure the delivery of safe and effective nursing care. New graduate nurses and nursing students lack the clinical judgment skills that are necessary for entry-level nursing practice. Nurse educators must therefore implement teaching strategies that facilitate clinical judgment. This study evaluated the clinical judgment of undergraduate nursing students after the implementation of multimedia case studies related to the concept of perfusion. Two research questions guided this study: (a) in what ways do undergraduate nursing students demonstrate clinical judgment after completing a series of perfusion-related multimedia case studies and (b) to what extent …

A Discussion Of The Tubman Arias From The Opera Harriet Tubman: When I Crossed That Line To Freedom, Mahari Allene Marie Freeman

Theses and Dissertations

Nkeiru Okoye (1972-) is an American composer of operas and orchestral works whose concert and theatrical compositions have gained extensive recognition in recent years. Harriet Tubman: When I Crossed that Line to Freedom is Okoye’s most well- known opera for which she composed the music and penned the libretto. Through her compositions, Okoye bravely addresses political and racial issues and tells the stories of well-known Black figures, such as Harriet Tubman.

Harriet Tubman (1822-1913) was a prolific American hero that led runaway slaves toward freedom. For approximately a decade, she risked her life traveling to and from the South to …

Simulation Study On Count Data Based On Double Poisson Distribution, Chao Ma

Theses and Dissertations

This thesis delves into the double Poisson distribution. Regression based on the double Poisson distribution, as proposed by Efron in 1986, offers an alternative approach that allows for more accurate regression models when dealing with discrete data that exhibit either over- or under-dispersion compared to the Poisson distribution. In this thesis, two methods of calculating the exact double Poisson density are compared: one utilizes the exact probability with the normalizing constant c(mu, theta) by definition or the “finite sum” method, while the other employs an approximation of the normalizing constant c(mu, theta). Furthermore, a simulation was …

Transcending The Family-Teacher Partnership: Utilizing Teaching Methods And Digital Platforms Proven Effective During The Pandemic, Amanda Katherine Mcclain

Theses and Dissertations

The unprecedented challenges during the COVID-19 pandemic led teachers to innovatively shift their teaching methods. These pioneering practices inspired this study’s Elevated Family-Teacher Partnership intervention to provide equitable guidance and communication for all families. This dissertation, in practice, measured the effects the intervention created in a first-grade classroom setting in Hanahan, South Carolina. A mixed-methods research design analyzed the intervention's effects on the family-teacher relationship and each child’s academic achievement. The data indicated increased parental efficacy, engagement, and academic growth during the 12-week intervention for all families participating.

Improving Equity In Communication: Building Collaborative Partnerships Between Teachers And Spoken Language Interpreters, Angela J. Rush

Theses and Dissertations

In today’s increasingly diverse educational landscape, equitable communication is essential for fostering meaningful parent engagement and ensuring all students have an equal opportunity for a comprehensive education. However, language barriers can pose significant challenges for English Learner/Emergent Bilingual students and parents in the educational context. This improvement study underscores the crucial need for educational systems to address language barriers through targeted support mechanisms, such as quality language access services. The study draws upon the principles of improvement science to design, implement, and examine the transformative potential of a professional development program to enhance collaboration between teachers and interpreters and inform …

A Study Of Direct Sensitivity Method Solving Optimal Control Problems With Single And Multiple Time Grids With An Application In An Experimental Hybrid System, Hainan Wang

Theses and Dissertations

Computational methods for optimal control are important for dealing with bottlenecks in industries. By implementing optimal operation strategies obtained from the computational methods into dynamic systems, objectives such as saving energy, reducing cost, exploiting potential, and improving efficiency can be achieved. Computational methods for optimal control have been used in a broad range of disciplines, including aeronautics and astronautics, oil and chemical engineering, power systems, clean energy, biomedical engineering, economics, and management. Due to the great application value of optimal control, its computational methods have drawn worldwide attention. Direct methods are most effective in computational methods for optimal control. Direct …

The Importance Of Sense Of Community In Recovery For Individuals Living With Serious Mental Illness, Natalia Gomez

Theses and Dissertations

People with serious mental illness face a variety of barriers to participating in community life. Some of these barriers include limits in social functioning which can then affect social relationships and life satisfaction (Sanchez et al, 2016). Devaluation based on mental health status is an important barrier to address due to its connection to stigma and relationships. The more an individual fears that they will be undervalued and discriminated against, the more they may fear interacting with others. They may hide that they are in mental health treatment or avoid social encounters that they consider as possibly rejecting. These behaviors …

Planning And Adapting In The Design Process, Lindsay Kay Wilkinson

Theses and Dissertations

The costume design and technology program at the University of South Carolina requires that students extensively learn each area of the profession. The largest growth-inducing experiences and some of the highlights for me were the opportunities to adapt when challenging changes or unexpected twists and turns arose with each production or project. Through my time at the university, I have gained a better understanding of balance between time and stress management, a system for understanding and completing costume-based research, digital rendering, I have improved the communication of my ideas with a director, working out a cohesive look with a production …

The Effects Of High Fat Diet On Lipid Deposition In Skeletal Muscle, Alexander Huss

Theses and Dissertations

By the year 2030, almost 50% of adults in the United States are expected to be obese. Obesity has been shown to increase the risk of several chronic metabolic diseases, several cancers, and is associated with impaired skeletal muscle function and metabolism. Despite this, little it is known about the role of altered muscle lipid homeostasis, lipid droplet dynamics, and lipid droplet-mitochondrial interactions in contributing to muscle dysfunction in obesity. Therefore, we sought to investigate the impact of high-fat diet induced obesity on overall skeletal muscle lipid deposition, intramyocellular lipid droplet content and morphology, and lipid droplet-mitochondrial contact. Male C57/BL6 …

Learning Through Discourse: Impacting Fractional Understanding Through Virtual Discourse, Laurie A. Gentry-Goodale

Theses and Dissertations

There is a strong need for fifth-grade students to become proficient in mathematical problem-solving using fractional computations because it will have a lasting impact on student achievement. Traditionally, mathematics is taught inside a brick-and-mortar classroom, grounded in rote memorization of facts, rules, and formulas. In recent years, more elementary students have enrolled fully in online learning environments, which emphasize on students becoming problem-solvers, specifically in fractional computation. The NCTM strongly encourages using mathematical discourse as an instructional method but employing mathematical discourse, but its applicability to online math learning is not well understood. This study addressed students' problem-solving skills, mathematical …

Layers Of Support: Cognitive, Psychological, And Social Factors That Contribute To Success In The High School-To-College Transition, Paige Cristine Mckeown

Theses and Dissertations

The future of individual and societal progress is largely dependent on students’ success following completion of K-12 education. For most traditionally aged students, this entails a journey into higher education at colleges and universities. This transition is rife with pitfalls that may lead students to stop out, fail out, or make inadequate progress towards completion – which further compounds social, psychological, financial, and personal challenges they may be facing. However, the challenges that contribute to these outcomes can be addressed and interventions can be designed to best support students in transition. This dissertation addresses these factors through a thematic literature …

Impacts Of Covid-19 And Taliban Takeover On U.S. Afghan Refugee Women’S Mental Health: A Socio-Ecological Approach To Resilience Resources, Atefeh Aghaei

Theses and Dissertations

In response to the escalating global refugee crisis, intensified by ongoing conflicts and environmental changes, this dissertation research focuses on the mental health of Afghan refugee women in the United States (U.S.), particularly in the context of the COVID-19 pandemic and the 2021 Taliban takeover. With over 114 million people displaced globally, Afghan refugees, notably women, encounter heightened mental health risks due to violence, deprivation, systemic persecution, and the challenges of migration. This vulnerability is exacerbated by recent mass traumatic events, including the pandemic and political upheaval in Afghanistan. Our study, conducted through semi-structured interviews with Afghan refugee women and …

Examining Systems To Improve Third Grade Literacy: Focus On Schools With High Poverty Index, Brenda Kelley

Theses and Dissertations

This improvement project was designed to ensure students enrolled in elementary schools with a high poverty index received literacy instructional strategies that promoted literacy achievement. When analyzing Graham County School data, I noticed third-grade students attending high poverty elementary schools were not achieving literacy success at the same rate as third-grade students attending low poverty elementary schools. An improvement team, consisting of myself, administration, and teachers at a high poverty elementary school implemented the improvement science framework to further study the root causes of this problem. Utilizing the six principles of the improvement science framework, problem focused and user centered, …

Eco-Domestic Femininity: The Collapse Of Domestic And Wild In Southern Women’S Writing, Christina Xan

Theses and Dissertations

When the Agrarians set out to assert their definition of southern in I’ll Take My Stand (1930), they planted roots deep in the ground of the south that slowly wrapped its tendrils around its descendants. In the years that have followed, southern women have had to push back against these limiting boundaries. Their individual stories are linked by the communal lineage of the south, specifically the binary of domestic and wild. Traditionally, southern women have had to stay in the boundaries of the home, cultivating domesticity, ordering the space, and warming the hearth. The land itself, posed as opposite from …